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Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 599 - 13
Infectious diseases have a profound impact on our health and many studies suggest that host genetics play a major role in the pathogenesis of most of them. We... 
GENETIC-VARIATION | ALPHA-ENOLASE | JAPANESE POPULATION | MULTIDISCIPLINARY SCIENCES | HERPES-ZOSTER | DISEASE | INNER-EAR MORPHOGENESIS | MIDDLE-EAR | STEM-CELL ANTIGEN | EXPRESSION | SECRETOR STATUS | Tonsillitis - genetics | Otitis Media - surgery | Hepatitis B - genetics | Humans | Candidiasis, Vulvovaginal - genetics | Male | HLA Antigens - genetics | Rheumatic Fever - genetics | Tuberculin Test | Tuberculosis - diagnosis | Case-Control Studies | Pharyngitis - genetics | Streptococcal Infections - genetics | Hepatitis A - genetics | Sinusitis - genetics | Female | Otitis Media - genetics | Warts - genetics | Pneumonia - genetics | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Urinary Tract Infections - genetics | Mumps - genetics | Common Cold - genetics | Middle Ear Ventilation | Rubella - genetics | Scarlet Fever - genetics | Infectious Mononucleosis - genetics | Chickenpox - genetics | Infection - genetics | Tuberculosis - genetics | Meningitis, Bacterial - genetics | Tonsillectomy | Herpes Labialis - genetics | Herpes Zoster - genetics | Tonsillitis - surgery | Measles - genetics | Chronic Disease | Rubella | Yeast | Hepatitis A virus | Scarlet fever | Pathogenesis | Chronic infection | Amino acids | Mapping | Genomes | Infections | Urinary tract | Immunity | Hepatitis | Embryogenesis | Sinus | Mononucleosis | Measles | Varicella | Bacteria | Meningitis | Genetics | Mumps | Hepatitis B virus | Children | Rheumatic fever | Antigens | Health risks | Pharynx | Loci | Fever | Embryonic growth stage | Warts | Herpes labialis | Tuberculosis | Infectious diseases | Ear | Histocompatibility antigen HLA | Gene mapping | Hepatitis A | Hepatitis B | Index Medicus
Journal Article
PLoS Genetics, ISSN 1553-7390, 06/2018, Volume 14, Issue 6, pp. e1007410 - e1007410
Journal Article
Oncogene, ISSN 0950-9232, 08/2012, Volume 31, Issue 34, pp. 3875 - 3888
Macrophages have a key role in tumor-associated pulmonary inflammation that supports the proliferation of tumor cells and promotes lung tumor growth. Although... 
lung cancer | macrophages | tumor microenvironment | transgenic mice | Forkhead transcription factor FoxM1 | monocyte migration | BIOCHEMISTRY & MOLECULAR BIOLOGY | FORKHEAD | CANCER | CELL BIOLOGY | EPITHELIAL-CELLS | ONCOLOGY | ROLES | BUTYLATED HYDROXYTOLUENE | GENETICS & HEREDITY | CIGARETTE-SMOKE | MICE | EXPRESSION | TUMORIGENESIS | PROGRESSION | Lung Neoplasms - chemically induced | Lung Neoplasms - metabolism | Matrix Metalloproteinase 12 - genetics | Monocytes - metabolism | Adoptive Transfer | Interleukin-1beta - genetics | Promoter Regions, Genetic - genetics | Cell Movement - genetics | Flow Cytometry | Monocytes - transplantation | Chemokine CCL3 - genetics | Cyclooxygenase 2 - genetics | Forkhead Transcription Factors - metabolism | Interleukin-1beta - metabolism | Pneumonia - chemically induced | Chemokine CXCL2 - genetics | Chemokine CCL3 - metabolism | Receptors, CXCR4 - genetics | Receptors, Cytokine - metabolism | Chemokine CXCL2 - metabolism | Interleukin-6 - metabolism | Receptors, Cytokine - genetics | Butylated Hydroxytoluene - analogs & derivatives | Pneumonia - genetics | Lung Neoplasms - genetics | Interleukin-6 - genetics | Macrophages - pathology | Matrix Metalloproteinase 12 - metabolism | Forkhead Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Receptors, HIV - genetics | Mice, Knockout | Receptors, CXCR4 - metabolism | Macrophages - metabolism | Animals | Nitric Oxide Synthase Type II - genetics | Receptors, HIV - metabolism | Cyclooxygenase 2 - metabolism | Protein Binding | Mice | Forkhead Box Protein M1 | Pneumonia - metabolism | CX3C Chemokine Receptor 1 | Nitric Oxide Synthase Type II - metabolism | Care and treatment | Transcription factors | Lung cancer | Patient outcomes | Physiological aspects | Development and progression | Macrophages | Properties | Health aspects | Methods | Cancer | Proteins | Gene expression | Transgenic animals | Pathogenesis | Rodents | Index Medicus | 3-Methylcholanthrene
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 6, pp. e20999 - e20999
Infection by Mycoplasma bovis (M. bovis) can induce diseases, such as pneumonia and otitis media in young calves and mastitis and arthritis in older animals.... 
LISTERIA-MONOCYTOGENES | MULTIPLEX-PCR | PROTEIN | REPLICATION | MULTIDISCIPLINARY SCIENCES | DAIRY CALVES | CLPC ATPASE | BACTERIAL | IDENTIFICATION | VIRULENCE | PNEUMONIA | Chromosomes, Bacterial - genetics | Molecular Sequence Data | DNA Repair - genetics | Phylogeny | Sequence Homology, Nucleic Acid | Mutagenesis, Insertional - genetics | Genome, Bacterial - genetics | Pseudogenes - genetics | Replication Origin - genetics | Virulence - genetics | Base Sequence | Mycoplasma bovis - pathogenicity | DNA Replication - genetics | Transcription, Genetic | Protein Biosynthesis - genetics | Tandem Repeat Sequences - genetics | Gene Transfer, Horizontal - genetics | Evolution, Molecular | Mycoplasma bovis - genetics | Mycoplasma bovis - metabolism | Genes | Genomics | Genomes | Membrane proteins | Proteases | Ligases | Analysis | Physiological aspects | Genetic research | Genetic aspects | Blood lipids | Health aspects | Nucleotidase | Biotechnology | Pneumonia | Disease | Laboratories | Fines & penalties | Virulence | Cysteine proteinase | Identification | Arthritis | Biosynthesis | Data bases | Proteins | Virulence factors | Cattle | Phylogenetics | Gram-negative bacteria | Localization | Bioinformatics | Transfer RNA | Pathogens | Mastitis | Immune response | Genomic analysis | Gene transfer | Nucleotide sequence | Glycerol | Calves | Pathogenicity | Immune systems | Lipoproteins | Pathogenicity islands | Otitis media | Open reading frames | Index Medicus
Journal Article
Journal Article
PLOS GENETICS, ISSN 1553-7404, 04/2019, Volume 15, Issue 4, pp. e1008114 - e1008114
Klebsiella pneumoniae has emerged as an important cause of two distinct public health threats: multi-drug resistant (MDR) healthcare-associated infections and... 
CRISPR-CAS SYSTEMS | CAPSULAR POLYSACCHARIDE | POLYSACCHARIDE SYNTHESIS | READ ALIGNMENT | HYPERVIRULENT | POPULATION GENOMICS | ESCHERICHIA-COLI | PLASMID | DISSEMINATION | GENETICS & HEREDITY | CARBAPENEM-RESISTANCE | Genome, Bacterial | Klebsiella Infections - drug therapy | Klebsiella pneumoniae - drug effects | Bacterial Capsules - metabolism | Humans | Gene Transfer, Horizontal | Klebsiella Infections - microbiology | Cross Infection - drug therapy | Lipopolysaccharides - genetics | Genetic Variation | Virulence - genetics | Klebsiella pneumoniae - pathogenicity | Cross Infection - microbiology | Bacterial Capsules - genetics | Klebsiella pneumoniae - genetics | Lipopolysaccharides - biosynthesis | Plasmids - genetics | Bacteriophages - genetics | Models, Genetic | Drug Resistance, Bacterial - genetics | Drug Resistance, Multiple, Bacterial - genetics | Evolution, Molecular | Klebsiella | Genetic transformation | Genetic research | Evolutionary genetics | Genetic aspects | Research | Natural history | Pneumonia | Bacterial pneumonia | Cloning | Genes | Genomics | Genomes | Disease susceptibility | Drug resistance | Polysaccharides | Analysis | Virulence (Microbiology) | Health aspects | CRISPR | Epidemics | Biotechnology | Recombination | Gene transfer | Multidrug resistance | Phages | Virulence | Infections | Biochemistry | Epidemiology | Infectious diseases | Hospitals | Plasmids | Phylogenetics | Evolution | Molecular biology | Bioinformatics | Public health | Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 09/2015, Volume 43, Issue 3, pp. 475 - 487
Interleukin-17 (IL-17) induces pathology in autoimmunity and infections; therefore, constraint of this pathway is an essential component of its regulation. We... 
negative regulation | Regnase-1 | fungal immunity | autoimmunity | signal transduction | IL-17 | Autoimmunity | Signal transduction | Fungal immunity | Negative regulation | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | IL-17 RECEPTOR | TARGET GENES | CANDIDA-ALBICANS | C/EBP-BETA | GENE-EXPRESSION | HOST-DEFENSE | NECROSIS-FACTOR-ALPHA | MESSENGER-RNA STABILITY | T-CELL | IMMUNOLOGY | Candidiasis - genetics | Oncogene Proteins - genetics | Humans | Encephalomyelitis, Autoimmune, Experimental - immunology | Immunoblotting | Male | Receptors, Interleukin-17 - genetics | Ribonucleases - metabolism | Host-Pathogen Interactions - immunology | Inflammation - metabolism | Lipocalins - genetics | Adaptor Proteins, Signal Transducing - immunology | Pneumonia - immunology | Candida albicans - physiology | Encephalomyelitis, Autoimmune, Experimental - genetics | Receptors, Interleukin-17 - metabolism | Interleukin-6 - metabolism | Pneumonia - genetics | Interleukin-6 - genetics | Oncogene Proteins - metabolism | Signal Transduction - genetics | Candida albicans - immunology | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Interleukin-17 - metabolism | Lipocalin-2 | Lipocalins - immunology | Interleukin-6 - immunology | Pneumonia - metabolism | Ribonucleases - genetics | Encephalomyelitis, Autoimmune, Experimental - metabolism | Receptors, Interleukin-17 - immunology | Interleukin-17 - immunology | Acute-Phase Proteins - genetics | Candidiasis - microbiology | Signal Transduction - immunology | HEK293 Cells | Female | Candidiasis - immunology | Nuclear Proteins - genetics | Oncogene Proteins - immunology | Lipocalins - metabolism | Cell Line | Acute-Phase Proteins - metabolism | Mice, Inbred C57BL | Cells, Cultured | Nuclear Proteins - metabolism | Inflammation - immunology | Nuclear Proteins - immunology | Animals | Ribonucleases - immunology | Adaptor Proteins, Signal Transducing - genetics | Inflammation - genetics | Adaptor Proteins, Signal Transducing - metabolism | Acute-Phase Proteins - immunology | Medical colleges | Nucleases | Interleukins | RNA | Cellular signal transduction | Inflammation | Proteins | Cytokines | Rodents | Fibroblasts | Infections | Kinases | Laboratory animals | Gene expression | Experiments | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 8, pp. e12402 - e12402
Treatment of non-small cell lung cancer (NSCLC) with radiotherapy or chemoradiotherapy is often accompanied by the development of esophagitis and pneumonitis.... 
BREAST-CANCER | ALLERGIC INFLAMMATION | TNF POLYMORPHISM | NORMAL TISSUE-REACTIONS | TRANSCRIPTION | BIOLOGY | FUNCTIONAL-ANALYSIS | NITRIC-OXIDE | NECROSIS-FACTOR-ALPHA | 3-DIMENSIONAL CONFORMAL RADIOTHERAPY | SINGLE-NUCLEOTIDE POLYMORPHISMS | Lung Neoplasms - genetics | Carcinoma, Non-Small-Cell Lung - radiotherapy | Genetic Predisposition to Disease | Radiation Pneumonitis - etiology | Carcinoma, Non-Small-Cell Lung - genetics | Humans | Middle Aged | Lung Neoplasms - radiotherapy | Male | Esophagitis - etiology | Radiation Injuries - etiology | Esophagitis - genetics | Radiation Injuries - genetics | Radiation Pneumonitis - genetics | Alleles | Survival Analysis | Inflammation - genetics | Female | Polymorphism, Single Nucleotide | Care and treatment | Pneumonia | Bacterial pneumonia | Genes | Lung cancer, Small cell | Genetic aspects | Inflammation | Single nucleotide polymorphisms | Lung cancer, Non-small cell | Radiotherapy | Transcription factors | Toxicity | Lung cancer | Radiation | Risk | Oncology | Arthritis | Single-nucleotide polymorphism | Epidemiology | Cancer therapies | Rodents | Bowel disease | Interleukin 1 | Tumor necrosis factor-TNF | Interleukin 8 | Genotypes | Lupus | Enzymes | Radiation effects | Non-small cell lung carcinoma | Esophagitis | Genetic diversity | Interleukin 13 | Radiation therapy | Gene expression | Patients | Radiation dosage | Genetic variance | Pneumonitis | Tumor necrosis factor | Biopsy | Nitric oxide | Cyclooxygenase-2 | Variation | Smoking | Cancer | Apoptosis | Index Medicus
Journal Article
Journal of Immunology, ISSN 0022-1767, 07/2011, Volume 187, Issue 1, pp. 434 - 440
Streptococcus pneumoniae is a leading cause of pneumonia, meningitis, and sepsis. Pneumococci can be divided into >90 serotypes that show differences in the... 
IN-VITRO | STREPTOCOCCUS-PNEUMONIAE | NONHEMOLYTIC PNEUMOLYSIN | VIRULENCE FACTORS | DISEASE | ACUTE LUNG INJURY | RECEPTOR | INFECTION | IMMUNOLOGY | CASPASE-1 ACTIVATION | NALP3 INFLAMMASOME | Inflammasomes - metabolism | Toll-Like Receptor 2 - genetics | Interleukin-18 - physiology | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Immunity, Innate - genetics | Streptolysins - biosynthesis | Toll-Like Receptor 9 - physiology | Pneumonia, Pneumococcal - genetics | Signal Transduction - immunology | Toll-Like Receptor 2 - deficiency | Toll-Like Receptor 4 - deficiency | Streptolysins - deficiency | Bone Marrow Cells - immunology | Female | Interleukin-1beta - biosynthesis | Genetic Variation - immunology | Macrophages - immunology | Carrier Proteins - physiology | Genetic Predisposition to Disease | Pneumonia, Pneumococcal - immunology | Macrophages - pathology | Mice, Inbred C57BL | Bacterial Proteins - genetics | Bone Marrow Cells - pathology | Myeloid Differentiation Factor 88 - genetics | Toll-Like Receptor 4 - genetics | Signal Transduction - genetics | Mice, Knockout | Carrier Proteins - genetics | Inflammasomes - physiology | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Myeloid Differentiation Factor 88 - deficiency | Pneumonia, Pneumococcal - pathology | Streptolysins - genetics | Bacterial Proteins - biosynthesis | Mice | Bone Marrow Cells - metabolism | Nod2 Signaling Adaptor Protein - physiology | Index Medicus | Abridged Index Medicus
Journal Article