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Nature communications, ISSN 2041-1723, 09/2017, Volume 8, Issue 1, pp. 599 - 13
Infectious diseases have a profound impact on our health and many studies suggest that host genetics play a major role in the pathogenesis of most of... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Tonsillitis - genetics | Otitis Media - surgery | Hepatitis B - genetics | Humans | Candidiasis, Vulvovaginal - genetics | Male | HLA Antigens - genetics | Rheumatic Fever - genetics | Tuberculin Test | Tuberculosis - diagnosis | Case-Control Studies | Pharyngitis - genetics | Streptococcal Infections - genetics | Hepatitis A - genetics | Sinusitis - genetics | Infections - genetics | Female | Otitis Media - genetics | Warts - genetics | Pneumonia - genetics | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Urinary Tract Infections - genetics | Mumps - genetics | Common Cold - genetics | Middle Ear Ventilation | Rubella - genetics | Scarlet Fever - genetics | Infectious Mononucleosis - genetics | Chickenpox - genetics | Tuberculosis - genetics | Meningitis, Bacterial - genetics | Tonsillectomy | Herpes Labialis - genetics | Herpes Zoster - genetics | Tonsillitis - surgery | Measles - genetics | Chronic Disease | Rubella | Yeast | Hepatitis A virus | Scarlet fever | Pathogenesis | Chronic infection | Amino acids | Mapping | Genomes | Infections | Urinary tract | Immunity | Hepatitis | Embryogenesis | Sinus | Mononucleosis | Measles | Varicella | Bacteria | Meningitis | Genetics | Mumps | Hepatitis B virus | Children | Rheumatic fever | Antigens | Health risks | Pharynx | Loci | Fever | Embryonic growth stage | Warts | Herpes labialis | Tuberculosis | Infectious diseases | Ear | Histocompatibility antigen HLA | Gene mapping | Hepatitis A | Hepatitis B | Index Medicus
Journal Article
by Juge, Pierre-Antoine and Lee, Joyce S and Ebstein, Esther and Furukawa, Hiroshi and Dobrinskikh, Evgenia and Gazal, Steven and Kannengiesser, Caroline and Ottaviani, Sébastien and Oka, Shomi and Tohma, Shigeto and Tsuchiya, Naoyuki and Rojas-Serrano, Jorge and González-Pérez, Montserrat I and Mejía, Mayra and Buendía-Roldán, Ivette and Falfán-Valencia, Ramcés and Ambrocio-Ortiz, Enrique and Manali, Effrosyni and Papiris, Spyros A and Karageorgas, Theofanis and Boumpas, Dimitrios and Antoniou, Katarina and van Moorsel, Coline H.M and van der Vis, Joanne and de Man, Yaël A and Grutters, Jan C and Wang, Yaping and Borie, Raphaël and Wemeau-Stervinou, Lidwine and Wallaert, Benoît and Flipo, René-Marc and Nunes, Hilario and Valeyre, Dominique and Saidenberg-Kermanac’h, Nathalie and Boissier, Marie-Christophe and Marchand-Adam, Sylvain and Frazier, Aline and Richette, Pascal and Allanore, Yannick and Sibilia, Jean and Dromer, Claire and Richez, Christophe and Schaeverbeke, Thierry and Lioté, Huguette and Thabut, Gabriel and Nathan, Nadia and Amselem, Serge and Soubrier, Martin and Cottin, Vincent and Clément, Annick and Deane, Kevin and Walts, Avram D and Fingerlin, Tasha and Fischer, Aryeh and Ryu, Jay H and Matteson, Eric L and Niewold, Timothy B and Assayag, Deborah and Gross, Andrew and Wolters, Paul and Schwarz, Marvin I and Holers, Michael and Solomon, Joshua J and Doyle, Tracy and Rosas, Ivan O and Blauwendraat, Cornelis and Nalls, Mike A and Debray, Marie-Pierre and Boileau, Catherine and Crestani, Bruno and Schwartz, David A and Dieudé, Philippe
The New England journal of medicine, ISSN 1533-4406, 12/2018, Volume 379, Issue 23, pp. 2209 - 2219
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 09/2015, Volume 43, Issue 3, pp. 475 - 487
Interleukin-17 (IL-17) induces pathology in autoimmunity and infections; therefore, constraint of this pathway is an essential component of its regulation. We... 
negative regulation | Regnase-1 | fungal immunity | autoimmunity | signal transduction | IL-17 | Autoimmunity | Signal transduction | Fungal immunity | Negative regulation | Life Sciences & Biomedicine | Immunology | Science & Technology | Candidiasis - genetics | Oncogene Proteins - genetics | Humans | Encephalomyelitis, Autoimmune, Experimental - immunology | Immunoblotting | Male | Receptors, Interleukin-17 - genetics | Ribonucleases - metabolism | Host-Pathogen Interactions - immunology | Inflammation - metabolism | Lipocalins - genetics | Adaptor Proteins, Signal Transducing - immunology | Pneumonia - immunology | Candida albicans - physiology | Encephalomyelitis, Autoimmune, Experimental - genetics | Receptors, Interleukin-17 - metabolism | Interleukin-6 - metabolism | Pneumonia - genetics | Interleukin-6 - genetics | Oncogene Proteins - metabolism | Signal Transduction - genetics | Candida albicans - immunology | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Interleukin-17 - metabolism | Lipocalin-2 | Lipocalins - immunology | Interleukin-6 - immunology | Pneumonia - metabolism | Ribonucleases - genetics | Encephalomyelitis, Autoimmune, Experimental - metabolism | Receptors, Interleukin-17 - immunology | Interleukin-17 - immunology | Acute-Phase Proteins - genetics | Candidiasis - microbiology | Signal Transduction - immunology | HEK293 Cells | Female | Candidiasis - immunology | Nuclear Proteins - genetics | Oncogene Proteins - immunology | Lipocalins - metabolism | Cell Line | Acute-Phase Proteins - metabolism | Mice, Inbred C57BL | Cells, Cultured | Nuclear Proteins - metabolism | Inflammation - immunology | Nuclear Proteins - immunology | Animals | Ribonucleases - immunology | Adaptor Proteins, Signal Transducing - genetics | Inflammation - genetics | Adaptor Proteins, Signal Transducing - metabolism | Acute-Phase Proteins - immunology | Medical colleges | Nucleases | Interleukins | RNA | Cellular signal transduction | Inflammation | Proteins | Cytokines | Rodents | Fibroblasts | Infections | Kinases | Laboratory animals | Gene expression | Experiments | Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 2010, Volume 5, Issue 8, pp. e12402 - e12402
Treatment of non-small cell lung cancer (NSCLC) with radiotherapy or chemoradiotherapy is often accompanied by the development of esophagitis and pneumonitis.... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Lung Neoplasms - genetics | Carcinoma, Non-Small-Cell Lung - radiotherapy | Genetic Predisposition to Disease | Radiation Pneumonitis - etiology | Carcinoma, Non-Small-Cell Lung - genetics | Humans | Middle Aged | Lung Neoplasms - radiotherapy | Male | Esophagitis - etiology | Radiation Injuries - etiology | Esophagitis - genetics | Radiation Injuries - genetics | Radiation Pneumonitis - genetics | Alleles | Survival Analysis | Inflammation - genetics | Female | Polymorphism, Single Nucleotide | Care and treatment | Pneumonia | Bacterial pneumonia | Genes | Lung cancer, Small cell | Genetic aspects | Inflammation | Single nucleotide polymorphisms | Lung cancer, Non-small cell | Radiotherapy | Transcription factors | Toxicity | Lung cancer | Radiation | Risk | Oncology | Arthritis | Single-nucleotide polymorphism | Epidemiology | Cancer therapies | Rodents | Bowel disease | Interleukin 1 | Tumor necrosis factor-TNF | Interleukin 8 | Genotypes | Lupus | Enzymes | Radiation effects | Non-small cell lung carcinoma | Esophagitis | Genetic diversity | Interleukin 13 | Radiation therapy | Gene expression | Patients | Radiation dosage | Genetic variance | Pneumonitis | Tumor necrosis factor | Biopsy | Nitric oxide | Cyclooxygenase-2 | Variation | Smoking | Cancer | Apoptosis | Index Medicus
Journal Article
PLoS pathogens, ISSN 1553-7374, 04/2012, Volume 8, Issue 4, pp. e1002614 - e1002614
Trehalose 6,6'-dimycolate (TDM), a cord factor of Mycobacterium tuberculosis (Mtb), is an important regulator of immune responses during Mtb infections.... 
Parasitology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Virology | Granuloma, Respiratory Tract - pathology | Protein Kinases - genetics | Toll-Like Receptor 2 - genetics | CD18 Antigens - immunology | Granuloma, Respiratory Tract - chemically induced | Lectins, C-Type - metabolism | Pneumonia - immunology | Neutrophils - metabolism | Neutrophil Infiltration - drug effects | Neutrophil Infiltration - immunology | Pneumonia - genetics | Granuloma, Respiratory Tract - immunology | CD18 Antigens - genetics | Membrane Proteins - genetics | Signal Transduction - genetics | Toll-Like Receptor 2 - metabolism | Tuberculosis, Pulmonary - pathology | Neutrophil Infiltration - genetics | Mice, Knockout | CD18 Antigens - metabolism | Signal Transduction - drug effects | Toll-Like Receptor 2 - immunology | Mice | Pneumonia - metabolism | Protein Kinases - metabolism | Tuberculosis, Pulmonary - metabolism | Adjuvants, Immunologic - pharmacology | Cord Factors - adverse effects | Lectins, C-Type - immunology | Pneumonia - pathology | Lectins, C-Type - genetics | Tuberculosis, Pulmonary - genetics | Adjuvants, Immunologic - adverse effects | Signal Transduction - immunology | CD11b Antigen - genetics | Adjuvants, Immunologic - chemistry | Pneumonia - chemically induced | Mycobacterium tuberculosis - chemistry | Lung - metabolism | Membrane Proteins - metabolism | Cord Factors - pharmacology | Mycobacterium tuberculosis - metabolism | Neutrophils - pathology | Granuloma, Respiratory Tract - genetics | Lung - pathology | CD11b Antigen - immunology | Gene Expression Regulation - genetics | Gene Expression Regulation - immunology | Cord Factors - chemistry | Neutrophils - immunology | Membrane Proteins - immunology | Gene Expression Regulation - drug effects | Tuberculosis, Pulmonary - immunology | Animals | Protein Kinases - immunology | Granuloma, Respiratory Tract - metabolism | CD11b Antigen - metabolism | Lung - immunology | Proteins | Flow cytometry | Tuberculosis | Microscopy | Rodents | Lipids | Ligands | Experiments | Immune system | Index Medicus
Journal Article
Pediatrics (Evanston), ISSN 0031-4005, 02/2013, Volume 131, Issue 2, pp. e629 - e634
.... We now report the immunologic details of this novel genetic cause of SCID and the response to targeted metabolic supplementation therapies... 
Cobalamin | Megaloblast | Hemolytic uremic syndrome | Folate | Immunodeficiency | Life Sciences & Biomedicine | Pediatrics | Science & Technology | Peripheral Nervous System Diseases - diagnosis | Leukopenia - diagnosis | Lipid Metabolism, Inborn Errors - genetics | Pneumonia, Pneumocystis - diagnosis | Humans | 3-Hydroxyacyl CoA Dehydrogenases - genetics | Vitamin B 12 - therapeutic use | DNA Mutational Analysis | Sulfadoxine - therapeutic use | Cardiomyopathies - diagnosis | Infant, Newborn | Cardiomyopathies - drug therapy | Mitochondrial Myopathies | Retinitis Pigmentosa - drug therapy | Trimethoprim - therapeutic use | Combined Modality Therapy | Bone Marrow Examination | Sequence Analysis, DNA | Retinitis Pigmentosa - diagnosis | Severe Combined Immunodeficiency - genetics | Pneumonia, Pneumocystis - genetics | Immunization, Passive | Leukopenia - drug therapy | Genetic Carrier Screening | Peripheral Nervous System Diseases - drug therapy | Mitochondrial Trifunctional Protein - deficiency | Anemia, Megaloblastic - genetics | Minor Histocompatibility Antigens | Lipid Metabolism, Inborn Errors - drug therapy | Leukopenia - genetics | Infant | Rhabdomyolysis | Cardiomyopathies - genetics | Anemia, Megaloblastic - diagnosis | Female | Drug Therapy, Combination | Peripheral Nervous System Diseases - genetics | Methylenetetrahydrofolate Dehydrogenase (NADP) - genetics | Hydroxocobalamin - therapeutic use | Pneumonia, Pneumocystis - drug therapy | Severe Combined Immunodeficiency - diagnosis | Lipid Metabolism, Inborn Errors - diagnosis | Severe Combined Immunodeficiency - drug therapy | Retinitis Pigmentosa - genetics | Opportunistic Infections - genetics | Opportunistic Infections - diagnosis | Exome - genetics | Opportunistic Infections - drug therapy | Anemia, Megaloblastic - drug therapy | 3-Hydroxyacyl CoA Dehydrogenases - deficiency | Drug Combinations | Nervous System Diseases | Care and treatment | Gene mutations | Research | Nucleotide sequencing | Diagnosis | Vitamin B12 | Hemolytic-uremic syndrome | DNA sequencing | Immunology | Vitamin B | Genetics | Mutation | Drug therapy | Metabolism | Index Medicus | Abridged Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 07/2012, Volume 7, Issue 7, pp. e40752 - e40752
.... To investigate the genetic basis of H9N2 influenza virus host range and pathogenicity in mammals, we generated a mouse-adapted H9N2 virus (SD16-MA... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Viral Matrix Proteins - genetics | Virus Replication - genetics | Adaptation, Biological - genetics | Humans | Reassortant Viruses - genetics | Influenza A Virus, H9N2 Subtype - pathogenicity | Orthomyxoviridae Infections - genetics | Lung - virology | Influenza A Virus, H9N2 Subtype - growth & development | Virulence - genetics | Madin Darby Canine Kidney Cells | Female | Influenza A Virus, H9N2 Subtype - enzymology | Cytokines - metabolism | Influenza A Virus, H9N2 Subtype - genetics | Viral Proteins - genetics | Mutation - genetics | Animals | Survival Analysis | Amino Acid Substitution - genetics | Mice | Mice, Inbred BALB C | Kinetics | DNA-Directed RNA Polymerases - metabolism | Orthomyxoviridae Infections - virology | Lung - immunology | Avian influenza | Avian influenza viruses | Genetic aspects | Virulence (Microbiology) | Genomics | Veterinary colleges | Pneumonia | Pandemics | Poultry | Virulence | Amino acids | Viruses | Infections | Genomes | Veterinary medicine | Epidemiology | Avian flu | Amino acid substitution | Proteins | Agriculture | Adaptation | Pathogens | Cytokines | Neutrophils | Mammals | Zoonoses | Pathogenicity | Polymerase | Lungs | Nitric oxide | Influenza | Host range | Replication | Mutation | Laboratory animals | Autoimmune diseases | Apoptosis | Index Medicus
Journal Article