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Nature, ISSN 0028-0836, 2013, Volume 501, Issue 7467, pp. 439 - 443
Broadly neutralizing antibodies reactive against most and even all variants of the same viral species have been described for influenza and HIV-1 (ref. 1).... 
IN-VITRO | MEMORY B-CELLS | TRACT DISEASE | MULTIDISCIPLINARY SCIENCES | HUMAN METAPNEUMOVIRUS | FUSION PROTEIN | ELECTRON-MICROSCOPY | INFECTION | RESPIRATORY SYNCYTIAL VIRUS | YOUNG-CHILDREN | F-GLYCOPROTEIN | Humans | Immunoglobulin Variable Region - chemistry | Paramyxoviridae - classification | Pneumovirus Infections - prevention & control | Molecular Sequence Data | Antibodies, Monoclonal - therapeutic use | Immunoglobulin Variable Region - immunology | Respiratory Syncytial Virus Infections - immunology | Viral Fusion Proteins - immunology | Murine pneumonia virus - immunology | Epitopes - immunology | Immunoglobulin Light Chains - chemistry | Antibodies, Neutralizing - immunology | Antibody Specificity - immunology | Paramyxoviridae Infections - virology | Viral Fusion Proteins - chemistry | Cattle | Antibodies, Neutralizing - therapeutic use | Respiratory Syncytial Virus Infections - prevention & control | Respiratory Syncytial Virus, Bovine - immunology | Respiratory Syncytial Virus Infections - virology | Antibodies, Monoclonal - chemistry | Antibodies, Monoclonal - immunology | Immunoglobulin Light Chains - immunology | Amino Acid Sequence | Metapneumovirus - immunology | Paramyxoviridae Infections - therapy | Models, Molecular | Antibodies, Monoclonal - isolation & purification | Cross Reactions - immunology | Pneumovirus Infections - virology | Antibodies, Neutralizing - isolation & purification | Paramyxoviridae Infections - immunology | Pneumovirus Infections - immunology | Paramyxoviridae - immunology | Animals | Respiratory Syncytial Virus, Human - immunology | Antibodies, Neutralizing - chemistry | Viral Vaccines - chemistry | Mice | Paramyxoviridae Infections - prevention & control | Respiratory Syncytial Virus Infections - therapy | Viral Vaccines - immunology | Monoclonal antibodies | Paramyxoviruses | Control | Health aspects | Proteins | Competition | Viruses | Glycoproteins | Infections | Mutation
Journal Article
Immunity, ISSN 1074-7613, 09/2012, Volume 37, Issue 3, pp. 463 - 474
Natural helper (NH) cells are innate lymphoid cells (ILCs) that produce T helper-2 (Th2)-cell-type cytokines in the lung- and gut-associated lymphoid tissues.... 
PROGENITORS | CYTOKINES | ROR-GAMMA-T | BONE-MARROW | TYPE-2 IMMUNITY | MICE | INNATE LYMPHOID-CELLS | DIFFERENTIATION | IMMUNOLOGY | EXPRESSION | Antigens, Ly - genetics | Male | Th2 Cells - immunology | Proto-Oncogene Proteins c-kit - immunology | Interleukin Receptor Common gamma Subunit - immunology | Flow Cytometry | Lymphocytes - immunology | Allergens - immunology | T-Lymphocytes, Helper-Inducer - immunology | Bone Marrow Cells - immunology | Bone Marrow Transplantation | Pneumonia - immunology | Female | Papain - immunology | Proto-Oncogene Proteins c-kit - genetics | Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics | Pneumonia - genetics | Lymphocytes - metabolism | Nuclear Receptor Subfamily 1, Group F, Member 3 - immunology | Nuclear Receptor Subfamily 1, Group F, Member 1 - immunology | T-Lymphocytes, Helper-Inducer - metabolism | Membrane Proteins - genetics | Mice, Inbred C57BL | Cells, Cultured | Membrane Proteins - immunology | Mice, SCID | Interleukin Receptor Common gamma Subunit - genetics | Th2 Cells - metabolism | Mice, Knockout | Animals | Antigens, Ly - immunology | Mice, Inbred NOD | Mice | Nuclear Receptor Subfamily 1, Group F, Member 1 - genetics | Bone Marrow Cells - metabolism | Cell Lineage - immunology | Allergens | Proteases | Lymphocytes | Oncology, Experimental | Bone marrow | Transplantation | Inflammation | Research | Cancer | Medical research | Lungs | Cytokines | Rodents | Gene expression | Small intestine | Experiments
Journal Article
Immunity, ISSN 1074-7613, 09/2015, Volume 43, Issue 3, pp. 475 - 487
Interleukin-17 (IL-17) induces pathology in autoimmunity and infections; therefore, constraint of this pathway is an essential component of its regulation. We... 
negative regulation | Regnase-1 | fungal immunity | autoimmunity | signal transduction | IL-17 | Autoimmunity | Signal transduction | Fungal immunity | Negative regulation | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | IL-17 RECEPTOR | TARGET GENES | CANDIDA-ALBICANS | C/EBP-BETA | GENE-EXPRESSION | HOST-DEFENSE | NECROSIS-FACTOR-ALPHA | MESSENGER-RNA STABILITY | T-CELL | IMMUNOLOGY | Candidiasis - genetics | Oncogene Proteins - genetics | Humans | Encephalomyelitis, Autoimmune, Experimental - immunology | Immunoblotting | Male | Receptors, Interleukin-17 - genetics | Ribonucleases - metabolism | Host-Pathogen Interactions - immunology | Inflammation - metabolism | Lipocalins - genetics | Adaptor Proteins, Signal Transducing - immunology | Pneumonia - immunology | Candida albicans - physiology | Encephalomyelitis, Autoimmune, Experimental - genetics | Receptors, Interleukin-17 - metabolism | Interleukin-6 - metabolism | Pneumonia - genetics | Interleukin-6 - genetics | Oncogene Proteins - metabolism | Signal Transduction - genetics | Candida albicans - immunology | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Interleukin-17 - metabolism | Lipocalin-2 | Lipocalins - immunology | Interleukin-6 - immunology | Pneumonia - metabolism | Ribonucleases - genetics | Encephalomyelitis, Autoimmune, Experimental - metabolism | Receptors, Interleukin-17 - immunology | Interleukin-17 - immunology | Acute-Phase Proteins - genetics | Candidiasis - microbiology | Signal Transduction - immunology | HEK293 Cells | Female | Candidiasis - immunology | Nuclear Proteins - genetics | Oncogene Proteins - immunology | Lipocalins - metabolism | Cell Line | Acute-Phase Proteins - metabolism | Mice, Inbred C57BL | Cells, Cultured | Nuclear Proteins - metabolism | Inflammation - immunology | Nuclear Proteins - immunology | Animals | Ribonucleases - immunology | Adaptor Proteins, Signal Transducing - genetics | Inflammation - genetics | Adaptor Proteins, Signal Transducing - metabolism | Acute-Phase Proteins - immunology | Medical colleges | Nucleases | Interleukins | RNA | Cellular signal transduction | Inflammation | Proteins | Cytokines | Rodents | Fibroblasts | Infections | Kinases | Laboratory animals | Gene expression | Experiments
Journal Article
Journal of Immunology, ISSN 0022-1767, 02/2013, Volume 190, Issue 3, pp. 1276 - 1284
Pseudomonas aeruginosa persists in patients with cystic fibrosis (CF) and drives CF lung disease progression. P. aeruginosa potently activates the innate... 
AIRWAY EPITHELIAL-CELLS | TRANSMEMBRANE CONDUCTANCE REGULATOR | IMMUNE-RESPONSE | TOLL-LIKE RECEPTOR-5 | ANTIINFLAMMATORY TARGET | INFLAMMATION | ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS | MICE | IMMUNOLOGY | TLR5 | LYMPHOCYTES | Pseudomonas aeruginosa - immunology | T-Lymphocyte Subsets - immunology | Flagella - physiology | Lung - microbiology | Pseudomonas Infections - etiology | Pseudomonas aeruginosa - isolation & purification | Humans | Pneumonia, Bacterial - etiology | Culture Media, Conditioned - pharmacology | Male | Flagellin - pharmacology | Young Adult | Pseudomonas aeruginosa - pathogenicity | Immune Tolerance - immunology | Myeloid Cells - immunology | Flagellin - genetics | Adult | Female | Flagella - immunology | Myeloid Cells - drug effects | Receptors, CXCR4 - genetics | Cells, Cultured - immunology | Flagellin - immunology | Pneumonia, Bacterial - microbiology | Disease Susceptibility | Cystic Fibrosis - microbiology | Gene Expression Regulation - immunology | Bacterial Proteins - genetics | Cystic Fibrosis - complications | Immunity, Innate | Pseudomonas Infections - microbiology | Pseudomonas Infections - immunology | Toll-Like Receptor 5 - immunology | Pseudomonas aeruginosa - genetics | Receptors, CXCR4 - biosynthesis | Receptors, CXCR4 - immunology | Up-Regulation - immunology | Adolescent | Th17 Cells - immunology | Pneumonia, Bacterial - immunology | Immune Evasion - immunology | Myelopoiesis - immunology
Journal Article
Clinical Infectious Diseases, ISSN 1058-4838, 3/2008, Volume 46, Issue 5, pp. 726 - 731
Protein D (PD) is a highly conserved 42 kDa surface lipoprotein found in all Haemophilus influenzae, including nontypeable (NT) H. influenzae. PD is involved... 
Polysaccharides | Conjugate vaccines | Epithelial cells | Review Article | Vaccination | Antibodies | Otitis media | Infections | Children | Haemophilus influenzae | Age groups | INFECTIOUS DISEASES | BRONCHIAL EPITHELIAL-CELLS | GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE | ESCHERICHIA-COLI | MICROBIOLOGY | PAF RECEPTOR | IMMUNOLOGY | PASSIVE-IMMUNIZATION | STREPTOCOCCUS-PNEUMONIAE | ACUTE OTITIS-MEDIA | D-BINDING PROTEIN | CHINCHILLA MODEL | IMMUNOGLOBULIN-D | Humans | Antigens, Bacterial - immunology | Rats | Pneumonia - microbiology | Virulence Factors - immunology | Chinchilla | Haemophilus Vaccines - immunology | Immunoglobulin D - immunology | Vaccines, Conjugate - immunology | Pneumococcal Infections - immunology | Animals | Otitis Media - immunology | Otitis Media - microbiology | Haemophilus influenzae - immunology | Pneumococcal Vaccines - immunology | Pneumonia - immunology | Bacterial Proteins - immunology | Haemophilus Infections - immunology | Lipoproteins - immunology | Carrier Proteins - immunology | Prevention | Respiratory tract infections | Proteolipids | Lipoproteins | Analysis | Development and progression | Blood lipoproteins | Hemophilus influenzae | Haemophilus Infections: immunology | Antigens | Bacterial: immunology | Haemophilus influenzae: immunology | Pneumococcal Infections: immunology | Medical and Health Sciences | Medicin och hälsovetenskap | Lipoproteins: immunology | Infektionsmedicin | Haemophilus Vaccines: immunology | Bacterial Proteins: immunology | Pneumococcal Vaccines: immunology | Carrier Proteins: immunology | Vaccines | Pneumonia: microbiology | Klinisk medicin | Conjugate: immunology | Otitis Media: microbiology | Clinical Medicine | Pneumonia: immunology | Otitis Media: immunology | Infectious Medicine | Virulence Factors: immunology | Immunoglobulin D: immunology
Journal Article
Journal Article
The Journal of Immunology, ISSN 0022-1767, 11/2009, Volume 183, Issue 10, pp. 6629 - 6638
Klebsiella pneumoniae causes extensive lung damage. TLR signaling involves adaptors TRIF and MyD88. However, the relative contribution of TRIF and MyD88... 
DOMAIN-CONTAINING ADAPTERS | LEGIONELLA-PNEUMOPHILA | TOLL-LIKE RECEPTOR-4 | INNATE IMMUNE-RESPONSES | PSEUDOMONAS-AERUGINOSA | ACUTE LUNG INJURY | CONTAINING ADAPTER PROTEIN | IMMUNOLOGY | NF-KAPPA-B | NEUTROPHIL RECRUITMENT | ESCHERICHIA-COLI PNEUMONIA | Tumor Necrosis Factor-alpha - metabolism | Lung - microbiology | Humans | Adaptor Proteins, Vesicular Transport - genetics | Mitogen-Activated Protein Kinase Kinases - immunology | NF-kappa B - immunology | NF-kappa B - metabolism | Chemokine CXCL5 - metabolism | Adaptor Proteins, Vesicular Transport - metabolism | Mitogen-Activated Protein Kinase Kinases - metabolism | Signal Transduction - immunology | Myeloid Differentiation Factor 88 - immunology | Tumor Necrosis Factor-alpha - immunology | Female | Neutrophils - microbiology | Chemokine CXCL2 - metabolism | Interleukin-6 - metabolism | Neutrophils - metabolism | Macrophages, Alveolar - immunology | Vascular Cell Adhesion Molecule-1 - immunology | Lung - pathology | Macrophages, Alveolar - microbiology | Klebsiella pneumoniae - immunology | Intercellular Adhesion Molecule-1 - immunology | Mice, Inbred C57BL | Myeloid Differentiation Factor 88 - genetics | Neutrophils - immunology | Adaptor Proteins, Vesicular Transport - immunology | Mice, Knockout | Chemokine CXCL2 - immunology | Intercellular Adhesion Molecule-1 - metabolism | Animals | Up-Regulation - immunology | Chemokine CXCL5 - immunology | Klebsiella Infections - immunology | Interleukin-6 - immunology | Pneumonia, Bacterial - immunology | Mice | Macrophages, Alveolar - metabolism | Vascular Cell Adhesion Molecule-1 - metabolism | Myeloid Differentiation Factor 88 - metabolism | Lung - immunology
Journal Article
Immunity, ISSN 1074-7613, 03/2014, Volume 40, Issue 3, pp. 425 - 435
Journal Article
The Journal of Immunology, ISSN 0022-1767, 11/2009, Volume 183, Issue 10, pp. 6489 - 6499
Chemerin is the ligand of the ChemR23 receptor and a chemoattractant factor for human immature dendritic cells (DCs), macrophages, and NK cells. In this study,... 
ADAPTIVE IMMUNITY | NATURAL-KILLER-CELLS | RESOLVIN E1 | COLONY-STIMULATING FACTOR | IN-VIVO | BONE-MARROW | HUMAN BLOOD | IMMUNOLOGY | CHEMOKINE RECEPTORS | INFLAMED LYMPH-NODES | PULMONARY ALVEOLAR MACROPHAGES | Receptors, G-Protein-Coupled - metabolism | Calcium - metabolism | Dendritic Cells - immunology | Bronchoalveolar Lavage Fluid - immunology | Calcium - immunology | Aequorin - immunology | Aequorin - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Chemotactic Factors - pharmacology | Peptides - metabolism | Chemotactic Factors - metabolism | Pneumonia - chemically induced | Killer Cells, Natural - immunology | Pneumonia - immunology | Dendritic Cells - drug effects | Bronchoalveolar Lavage Fluid - cytology | Chemotaxis - immunology | Neutrophils - metabolism | Apoproteins - metabolism | Dendritic Cells - metabolism | Macrophages - immunology | Disease Models, Animal | Recombinant Proteins - metabolism | Chemotactic Factors - immunology | Acute Disease | Lung - pathology | Mice, Inbred C57BL | Neutrophils - drug effects | Peptides - immunology | Neutrophils - immunology | Chemotaxis - drug effects | Mice, Knockout | Macrophages - metabolism | Animals | Recombinant Proteins - immunology | Intercellular Signaling Peptides and Proteins - pharmacology | Lipopolysaccharides - pharmacology | Macrophages - drug effects | Killer Cells, Natural - drug effects | Mice | Receptors, G-Protein-Coupled - genetics | Apoproteins - immunology | Killer Cells, Natural - metabolism | Pneumonia - metabolism | Chemokines | Intercellular Signaling Peptides and Proteins - immunology | Lung - immunology | Index Medicus | Abridged Index Medicus
Journal Article
PLoS Pathogens, ISSN 1553-7366, 07/2012, Volume 8, Issue 7, p. 24
Vaccines may help reduce the growing incidence of fungal infections in immune-suppressed patients. We have found that, even in the absence of CD4(+) T-cell... 
DEFENSE | ACTIVATION | MICROBIOLOGY | IL-23 | DECTIN-1 | RESPONSES | PNEUMOCYSTIS-CARINII | VIROLOGY | INTERLEUKIN-17 | IL-17 | PARASITOLOGY | TH17 CELLS | ANTIGEN | Lung - microbiology | Receptors, CCR6 - biosynthesis | Interleukin-17 - immunology | Fungal Vaccines - immunology | Blastomycosis - immunology | Lung Diseases, Fungal - microbiology | Histoplasmosis - immunology | CD4-Positive T-Lymphocytes - immunology | Lectins, C-Type - metabolism | Histoplasma - pathogenicity | Receptors, Immunologic - biosynthesis | Receptors, CCR6 - metabolism | Pneumonia - immunology | Blastomyces - pathogenicity | Immunologic Deficiency Syndromes - immunology | Immunologic Memory - immunology | Interleukin-12 - biosynthesis | Lung Diseases, Fungal - immunology | Signal Transduction | Mice, Inbred C57BL | Receptors, CXCR3 - biosynthesis | Hepatocyte Nuclear Factor 1-alpha | Neutrophils - immunology | Pneumonia - microbiology | Interleukin-17 - biosynthesis | Mice, Knockout | Histoplasma - immunology | Cell Differentiation - immunology | T Cell Transcription Factor 1 - biosynthesis | Animals | Interleukin-6 - immunology | Interleukin-6 - biosynthesis | Th17 Cells - immunology | Blastomyces - immunology | Mice | Immunocompromised Host | CD8-Positive T-Lymphocytes - immunology | Lung - immunology | Fungi | Medical research | Flow cytometry | Pneumonia | Cytokines | Lymphocytes | Rodents | Cytotoxicity | Vaccines | Fungal infections</