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Thrombosis and Haemostasis, ISSN 0340-6245, 09/2007, Volume 98, Issue 3, pp. 512 - 520
The plasminogen activation system is part of the fibrinolysis which is tightly regulated and protected against dysfunction by various activators and... 
Theme Issue Article | Bacterial infection | Inflammation | Plasminogen | Plasminogen activator inhibitor | Urokinase/receptor | BORRELIA-BURGDORFERI | ALPHA-ENOLASE | OUTER SURFACE PROTEIN | BINDING-PROTEIN | bacterial infection | BLOOD MONONUCLEAR-CELLS | plasminogen | GROUP-A STREPTOCOCCI | inflammation | YERSINIA-PESTIS | urokinase/receptor | UROKINASE RECEPTOR | PERIPHERAL VASCULAR DISEASE | plasminogen activator inhibitor | HEMATOLOGY | HELICOBACTER-PYLORI | PESTIS PLASMINOGEN-ACTIVATOR | Borrelia Infections - blood | Bacterial Infections - enzymology | Tissue Plasminogen Activator - metabolism | Humans | Plasminogen Activators - metabolism | Metalloendopeptidases - metabolism | Plasminogen - metabolism | Meningitis, Bacterial - blood | Receptors, Urokinase Plasminogen Activator | Borrelia Infections - microbiology | Plasminogen Activator Inhibitor 1 - metabolism | Bacterial Infections - microbiology | Disease Models, Animal | Pneumonia, Bacterial - blood | Bacteria - metabolism | Meningitis, Bacterial - microbiology | Pneumonia, Bacterial - microbiology | Meningitis, Bacterial - enzymology | Signal Transduction | Pneumonia, Bacterial - enzymology | Receptors, Cell Surface - metabolism | Fibrinolysis | Animals | Carrier Proteins - metabolism | Helicobacter pylori - metabolism | Urokinase-Type Plasminogen Activator - metabolism | Sepsis - enzymology | Bacteria - enzymology | Bacterial Proteins - metabolism | Bacteria - pathogenicity | Mice | Sepsis - blood | Bacterial Infections - blood | Borrelia Infections - enzymology | Sepsis - microbiology | Streptokinase - metabolism
Journal Article
PLoS Pathogens, ISSN 1553-7366, 03/2010, Volume 6, Issue 3, p. e1000804
During long-term cystic fibrosis lung infections, Pseudomonas aeruginosa undergoes genetic adaptation resulting in progressively increased persistence and the... 
BACTERIAL 2-HYBRID SYSTEM | REGULATES BIOFILM FORMATION | ESCHERICHIA-COLI | ANTIBIOTIC-RESISTANCE | MICROBIOLOGY | BURKHOLDERIA-CEPACIA | EXPERIMENTAL POPULATIONS | VIROLOGY | EXOPOLYSACCHARIDE PRODUCTION | CYSTIC-FIBROSIS PATIENTS | SWARMING MOTILITY | CELL-CYCLE | PARASITOLOGY | Pseudomonas aeruginosa - growth & development | Cyclic GMP - analogs & derivatives | Pseudomonas aeruginosa - metabolism | Periplasmic Proteins - genetics | DNA Transposable Elements - genetics | Bacterial Outer Membrane Proteins - genetics | Macrophages - immunology | Macrophages - microbiology | Pneumonia, Bacterial - microbiology | Phosphorus-Oxygen Lyases - genetics | Mice, Inbred C57BL | Pneumonia, Bacterial - enzymology | Cells, Cultured | Phagocytosis - physiology | Macrophages - cytology | Operon - genetics | Pseudomonas Infections - microbiology | Pseudomonas Infections - immunology | Caenorhabditis elegans | Phenotype | Animals | Escherichia coli Proteins | Bacterial Outer Membrane Proteins - metabolism | Cyclic GMP - metabolism | Pseudomonas aeruginosa - genetics | Pneumonia, Bacterial - immunology | Second Messenger Systems - physiology | Mice | Mutagenesis - physiology | Periplasmic Proteins - metabolism | Phosphorus-Oxygen Lyases - metabolism | Pseudomonas Infections - enzymology | Pseudomonas aeruginosa infections | Immune response | Physiological aspects | Pseudomonas aeruginosa | Development and progression | Genetic aspects | Research | Microbial colonies | Genotype & phenotype | Chemotherapy | Antibiotics | Microscopy | Mortality | Colonies & territories | Cystic fibrosis | Infections | Experiments | Bacteriology | Immune system
Journal Article
Respiratory Research, ISSN 1465-9921, 10/2016, Volume 17, Issue 1, p. 129
Journal Article
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 08/2015, Volume 53, Issue 2, pp. 193 - 205
Thiocyanate (SCN) is used by the innate immune system, but less is known about its impact on inflammation and oxidative stress. Granulocytes oxidize SCN to... 
Innate immunity | Nebulization | Glutathione sulfonamide | Antioxidant | Hypothiocyanous acid | OXIDATION | antioxidant | HYPOCHLOROUS ACID | BIOCHEMISTRY & MOLECULAR BIOLOGY | hypothiocyanous acid | ABSOLUTE RATE CONSTANTS | CELL BIOLOGY | AIRWAY | innate immunity | GLUTATHIONE | RESPIRATORY SYSTEM | HOST-DEFENSE | glutathione sulfonamide | LUNG-DISEASE | HYDROGEN-PEROXIDE | nebulization | HYPERTONIC SALINE | Pseudomonas aeruginosa - immunology | Lung - microbiology | Oxidative Stress | Male | Lung - enzymology | Cystic Fibrosis - immunology | Thioredoxin-Disulfide Reductase - metabolism | Thiocyanates - pharmacology | Anti-Inflammatory Agents - administration & dosage | Female | Thiocyanates - administration & dosage | Drug Evaluation, Preclinical | Cell Line | Anti-Inflammatory Agents - pharmacology | Cystic Fibrosis - metabolism | Pseudomonas Infections - drug therapy | Mice, Inbred C57BL | Pneumonia, Bacterial - enzymology | Administration, Inhalation | Pseudomonas Infections - immunology | Animals | Pneumonia, Bacterial - drug therapy | Pneumonia, Bacterial - immunology | Anti-Bacterial Agents - pharmacology | Anti-Bacterial Agents - administration & dosage | Cystic Fibrosis - drug therapy | Pseudomonas Infections - enzymology | Enzymes | Bacterial infections | Cytokines | Fluid | Cystic fibrosis | Antimicrobial agents | Infections | Inflammation | Metabolism | Studies | Metabolites | Chemokines | Methods | Original Research
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2012, Volume 287, Issue 42, pp. 34883 - 34894
Journal Article
Immunity, ISSN 1074-7613, 2009, Volume 31, Issue 6, pp. 974 - 985
Immunity to in humans and in mice requires interferon gamma (IFN-γ). Whereas IFN-γ has been studied extensively for its effects on macrophages in tuberculosis,... 
MOLIMMUNO | CELLIMMUNO | MACROPHAGE RESPONSES | HUMAN-FIBROBLASTS | DENDRITIC CELLS | TRYPTOPHAN-METABOLITES | NITRIC-OXIDE SYNTHASE | LUNG EPITHELIAL-CELLS | IFN-GAMMA | INDOLEAMINE 2,3-DIOXYGENASE | ENDOTHELIAL-CELLS | TOXOPLASMA-GONDII | IMMUNOLOGY | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | T-Lymphocytes, Helper-Inducer - microbiology | Bacteremia - immunology | Lung - microbiology | Oligonucleotide Array Sequence Analysis | Mycobacterium tuberculosis - immunology | Gene Expression Profiling | Interferon-gamma - metabolism | Indoleamine-Pyrrole 2,3,-Dioxygenase - immunology | Bacteremia - microbiology | Endothelial Cells - microbiology | Respiratory Mucosa - pathology | Respiratory Mucosa - microbiology | Interleukin-23 - metabolism | T-Lymphocytes, Helper-Inducer - immunology | Respiratory Mucosa - immunology | Female | Tuberculosis, Pulmonary - enzymology | Kynurenine - metabolism | Receptors, Interferon - genetics | Neutrophil Infiltration - immunology | Lung - pathology | Mice, Inbred C57BL | Pneumonia, Bacterial - enzymology | Cells, Cultured | Interleukin-23 - immunology | Mice, Knockout | Endothelial Cells - immunology | Interleukin-17 - metabolism | Tuberculosis, Pulmonary - immunology | Animals | Pneumonia, Bacterial - immunology | Mice | Endothelial Cells - pathology | Kynurenine - immunology | Lung - immunology
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 6, p. e21477
Chlamydia pneumoniae (CP) is an important human pathogen that causes atypical pneumonia and is associated with various chronic inflammatory disorders.... 
APOPTOSIS | INTERLEUKIN-1 | ACTIVATION | MICE DEFICIENT | IFN-GAMMA | IMMUNE-RESPONSES | MULTIDISCIPLINARY SCIENCES | INNATE | INDUCTION | BLOOD MONONUCLEAR-CELLS | NALP3 INFLAMMASOME | Lung - microbiology | Protein Biosynthesis | Chlamydia Infections - enzymology | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Caspase 1 - metabolism | Chlamydia Infections - immunology | Disease Models, Animal | Interleukin-1beta - secretion | Lung - pathology | Macrophages, Alveolar - microbiology | Pneumonia, Bacterial - complications | Pneumonia, Bacterial - enzymology | Chlamydia Infections - complications | Mitochondria - metabolism | Toll-Like Receptor 2 - metabolism | Immunity, Innate | Macrophages, Alveolar - enzymology | Animals | Carrier Proteins - metabolism | Caspase 1 - deficiency | Survival Analysis | Pneumonia, Bacterial - immunology | Mice | Myeloid Differentiation Factor 88 - metabolism | Lung - immunology | Phagocytosis | Chlamydophila pneumoniae - immunology | Nitric Oxide Synthase Type II - metabolism | Pediatrics | Oxidative stress | Pneumonia | Sexually transmitted diseases--STD | Immune clearance | Infections | Activation | Interleukin 1 receptors | Macrophages | Experiments | Caspase-1 | Mitochondria | Immunology | Chlamydia | Rodents | Interleukin 1 | Toll-like receptors | Bacteria | Alveoli | Immune system | Recombinant | Enzymes | Cytokines | Secretion | Mortality | Caspase | Protein biosynthesis | Pharmacology | Nitric-oxide synthase | Medicine | Signaling | Infectious diseases | Lungs | Protein synthesis | TLR2 protein | MyD88 protein | Potassium | Apoptosis | Reactive oxygen species | Sexually transmitted diseases
Journal Article
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, ISSN 0022-3565, 02/2013, Volume 344, Issue 2, pp. 447 - 458
Mer receptor tyrosine kinase (Mer) signaling plays a central role in the intrinsic inhibition of the inflammatory response to Toll-like receptor activation.... 
KAPPA-B ACTIVATION | NECROSIS | MULTIPLE-SCLEROSIS | APOPTOTIC-CELLS | INJURY | PHARMACOLOGY & PHARMACY | ALPHA-CONVERTING-ENZYME | TNF-ALPHA | TAM RECEPTORS | PROTEIN-S | METALLOPROTEASE INHIBITORS | ADAM17 Protein | Up-Regulation | Phosphorylation | Cell Count | Receptor Protein-Tyrosine Kinases - biosynthesis | Bronchoalveolar Lavage Fluid - immunology | Male | Proto-Oncogene Proteins - biosynthesis | Lung - enzymology | c-Mer Tyrosine Kinase | Hydroxamic Acids - administration & dosage | Bronchoalveolar Lavage Fluid - cytology | Electrophoretic Mobility Shift Assay | Lung - metabolism | Macrophages, Peritoneal - drug effects | Pneumonia, Bacterial - pathology | RNA - metabolism | Proto-Oncogene Proteins - metabolism | Lung - pathology | ADAM Proteins - antagonists & inhibitors | Dipeptides - therapeutic use | Enzyme-Linked Immunosorbent Assay | Pneumonia, Bacterial - enzymology | Cells, Cultured | Macrophages, Peritoneal - enzymology | Enzyme Induction | Receptor Protein-Tyrosine Kinases - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Macrophages, Alveolar - enzymology | Dipeptides - administration & dosage | Animals | Signal Transduction - drug effects | Macrophages, Alveolar - drug effects | Lung - drug effects | Lipopolysaccharides - pharmacology | Hydroxamic Acids - therapeutic use | Pneumonia, Bacterial - drug therapy | Mice | Mice, Inbred BALB C | Bronchoalveolar Lavage Fluid - chemistry | Enzyme Activation
Journal Article
The Journal of Immunology, ISSN 0022-1767, 03/2009, Volume 182, Issue 6, pp. 3866 - 3876
Several members of the matrix metalloproteinase (MMP) family function in various processes of innate immunity, particularly in controlling leukocyte influx.... 
AIRWAY EPITHELIAL-CELLS | ENDOTHELIUM IN-VITRO | LASER CAPTURE MICRODISSECTION | MATRIX METALLOPROTEINASES | INFLAMMATORY CELL EGRESSION | MATRILYSIN EXPRESSION | ALVEOLAR MACROPHAGES | NECROSIS-FACTOR-ALPHA | HERNIATED DISC RESORPTION | LEUKOCYTE ADHESION | IMMUNOLOGY | Macrophages, Alveolar - pathology | Bone Marrow Cells - enzymology | Male | Cell Migration Inhibition - genetics | Matrix Metalloproteinases, Secreted - deficiency | Chemotaxis, Leukocyte - genetics | Time Factors | Bone Marrow Cells - immunology | Inflammation Mediators - metabolism | Female | Inflammation Mediators - physiology | Pneumonia, Bacterial - pathology | Macrophages, Alveolar - immunology | Neutrophils - pathology | Neutrophils - enzymology | Mice, Inbred C57BL | Pneumonia, Bacterial - enzymology | Bone Marrow Cells - pathology | Cells, Cultured | Neutrophils - immunology | Cell Migration Inhibition - immunology | Macrophages, Alveolar - enzymology | Mice, Knockout | Pseudomonas Infections - immunology | Animals | Matrix Metalloproteinases, Secreted - genetics | Matrix Metalloproteinases, Secreted - physiology | Pseudomonas Infections - pathology | Pneumonia, Bacterial - immunology | Mice | Chemotaxis, Leukocyte - immunology | Pseudomonas Infections - enzymology | lung | matrix metalloproteinase | infection | Macrophages | chemokines | inflammation
Journal Article