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1. Full Text De-escalation therapy in ventilator-associated pneumonia
by Rello, Jordi and Vidaur, Loreto and Sandiumenge, Alberto and Rodríguez, Alejandro and Gualis, Belen and Boque, Carmen and Diaz, Emili
Critical Care Medicine, ISSN 0090-3493, 11/2004, Volume 32, Issue 11, pp. 2183 - 2190
OBJECTIVE:To evaluate de-escalation of antibiotic therapy in patients with ventilator-associated pneumonia. DESIGN:Prospective observational study during a... 
Hospital-acquired pneumonia | Therapy | De-escalation | Ventilator-associated pneumonia | Imipenem | INFECTIONS | ANTIMICROBIAL THERAPY | ACQUIRED PNEUMONIA | therapy | ventilator-associated pneumonia | SUSCEPTIBLE ORGANISMS | hospital-acquired pneumonia | ANTIBIOTIC-THERAPY | IMPACT | ILL PATIENT | imipenem | INTENSIVE-CARE-UNIT | de-escalation | PATIENT OUTCOMES | NOSOCOMIAL PNEUMONIA | CRITICAL CARE MEDICINE | Critical Care - methods | Sputum - microbiology | Prospective Studies | Critical Care - standards | Cross Infection - etiology | Humans | Middle Aged | Pneumonia, Bacterial - etiology | Cross Infection - mortality | Infection Control | Male | Empirical Research | Bronchoalveolar Lavage Fluid - microbiology | Microbial Sensitivity Tests | Anti-Bacterial Agents - therapeutic use | Respiration, Artificial - adverse effects | Time Factors | Pneumonia, Bacterial - mortality | Female | Bronchoscopy | Hospital Mortality | Comorbidity | Risk Factors | Treatment Outcome | Pneumonia, Bacterial - diagnosis | Evidence-Based Medicine | Cross Infection - drug therapy | Algorithms | Cross Infection - diagnosis | Pneumonia, Bacterial - drug therapy | Decision Trees | Practice Guidelines as Topic
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2. Empiric antimicrobial therapy for ventilator-associated pneumonia after brain injury
by Roquilly, Antoine and Feuillet, Fanny and Seguin, Philippe and Lasocki, Sigismond and Cinotti, Raphael and Launey, Yoann and Thioliere, Lise and Le Floch, Ronan and Joachim Mahe, Pierre and Nesseler, Nicolas and Cazaubiel, Tanguy and Rozec, Bertrand and Lepelletier, Didier and Sebille, Véronique and Malledant, Yannick and Asehnoune, Karim and ATLANREA Grp and ATLANREA group
European Respiratory Journal, ISSN 0903-1936, 04/2016, Volume 47, Issue 4, pp. 1219 - 1228
Issues regarding recommendations on empiric antimicrobial therapy for ventilator-associated pneumonia (VAP) have emerged in specific populations. To develop... 
RESPIRATORY SYSTEM | CARE-ASSOCIATED PNEUMONIA | RESISTANT BACTERIA | HOSPITAL-ACQUIRED PNEUMONIA | PREVENTION | SURVEILLANCE | RISK | STAPHYLOCOCCUS-AUREUS | COHORT | ANTIBIOTIC-TREATMENT | OUTCOMES | Severity of Illness Index | Multivariate Analysis | Predictive Value of Tests | Intensive Care Units | Prospective Studies | Area Under Curve | Humans | Middle Aged | Drug Resistance, Bacterial | Brain Injuries - complications | Male | Brain Injuries - therapy | Pneumonia, Ventilator-Associated - etiology | Incidence | Anti-Bacterial Agents - therapeutic use | Time Factors | Glasgow Coma Scale | Adult | Burns - therapy | Female | Burns - complications | Pneumonia, Ventilator-Associated - drug therapy
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3. Appropriateness and delay to initiate therapy in ventilator-associated pneumonia
by Luna, C.M and Aruj, P and Niederman, M.S and Garzón, J and Violi, D and Prignoni, A and Ríos, F and Baquero, S and Ganado, S and Apezteguía, C and Desmery, P and Matarucco, W and Pálizas, F and Menga, G and GANAR Grp and Grupo Argentino de Estudio de la Neumonía Asociada al Respirador group
European Respiratory Journal, ISSN 0903-1936, 01/2006, Volume 27, Issue 1, pp. 158 - 164
Inappropriate therapy (IT) and delayed initiation of appropriate therapy (DIAT) result in inadequate therapy in patients with ventilator-associated pneumonia... 
Delayed therapy | Adequate therapy | Antimicrobials | Nosocomial pneumonia | Resistant pathogens | Outcome | DIAGNOSIS | delayed therapy | nosocomial pneumonia | ILLNESS | antimicrobials | NOSOCOMIAL INFECTION | resistant pathogens | adequate therapy | PULMONARY INFECTION SCORE | IMPACT | RESPIRATORY SYSTEM | BRONCHOSCOPIC TECHNIQUES | ANTIBIOTIC-TREATMENT | OUTCOMES | CULTURES | outcome | SEVERITY | Severity of Illness Index | Intensive Care Units | Prognosis | Prospective Studies | Humans | Middle Aged | Pneumonia, Bacterial - etiology | Male | Treatment Outcome | Ventilators, Mechanical - adverse effects | Cross Infection - drug therapy | Bronchoalveolar Lavage Fluid - microbiology | Analysis of Variance | Time Factors | Pneumonia, Bacterial - mortality | Survival Analysis | Female | Pneumonia, Bacterial - drug therapy | Aged | Anti-Bacterial Agents - administration & dosage
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4. Full Text Duration of therapy of ventilator-associated pneumonia
by Dimopoulos, George and Matthaiou, Dimitrios K
Current Opinion in Infectious Diseases, ISSN 0951-7375, 04/2016, Volume 29, Issue 2, pp. 218 - 222
PURPOSE OF REVIEWVentilator-associated pneumonia (VAP) is a major cause of morbidity and mortality in the critical care setting. It incurs great additional... 
Gram-negative bacilli | Ventilator-associated pneumonia | Duration | Treatment | Optimization | duration | treatment | DIAGNOSIS | INFECTIOUS DISEASES | COSTS | optimization | ventilator-associated pneumonia | ICU | EPIDEMIOLOGY | ANTIBIOTIC-THERAPY | Recurrence | Time Factors | Humans | Survival Analysis | Treatment Outcome | Anti-Bacterial Agents - administration & dosage | Pneumonia, Ventilator-Associated - drug therapy | Randomized Controlled Trials as Topic
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5. Full Text Comparison of 8 vs 15 Days of Antibiotic Therapy for Ventilator-Associated Pneumonia in Adults: A Randomized Trial
by Chastre, Jean and Wolff, Michel and Fagon, Jean-Yves and Chevret, Sylvie and Thomas, Franck and Wermert, Delphine and Clementi, Eva and Gonzalez, Jesus and Jusserand, Dominique and Asfar, Pierre and Perrin, Dominique and Fieux, Fabienne and Aubas, Sylvie and for the PneumA Trial Group and PneumA Trial Grp and PneumA Trial Group
JAMA, ISSN 0098-7484, 11/2003, Volume 290, Issue 19, pp. 2588 - 2598
CONTEXT The optimal duration of antimicrobial treatment for ventilator-associated pneumonia (VAP) is unknown. Shortening the length of treatment may help to... 
ACINETOBACTER-BAUMANNII | MEDICINE, GENERAL & INTERNAL | PSEUDOMONAS-AERUGINOSA | CONSENSUS CONFERENCE | INTENSIVE-CARE UNITS | HOSPITALS | INFECTION | ORGAN FAILURE | ANTIMICROBIAL RESISTANCE | EPIDEMIOLOGY | NOSOCOMIAL PNEUMONIA | Bronchoscopy | Intensive Care Units | Prospective Studies | Cross Infection - etiology | Double-Blind Method | Drug Administration Schedule | Humans | Middle Aged | Pneumonia, Bacterial - etiology | Male | Treatment Outcome | Pneumonia, Bacterial - diagnosis | Cross Infection - drug therapy | Anti-Bacterial Agents - therapeutic use | Respiration, Artificial - adverse effects | Adult | Female | Pneumonia, Bacterial - drug therapy | Aged | Anti-Bacterial Agents - administration & dosage | Pneumonia | Antibiotics | Complications | Bacterial pneumonia | Dosage and administration | Drug therapy | Artificial respiration | Clinical trials | Patients
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6. Full Text Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society
by Kalil, Andre C and Metersky, Mark L and Klompas, Michael and Muscedere, John and Sweeney, Daniel A and Palmer, Lucy B and Napolitano, Lena M and O'Grady, Naomi P and Bartlett, John G and Carratalà, Jordi and El Solh, Ali A and Ewig, Santiago and Fey, Paul D and File, Thomas M and Restrepo, Marcos I and Roberts, Jason A and Waterer, Grant W and Cruse, Peggy and Knight, Shandra L and Brozek, Jan L
Clinical Infectious Diseases, ISSN 1058-4838, 09/2016, Volume 63, Issue 5, pp. e61 - e111
It is important to realize that guidelines cannot always account for individual variation among patients. They are not intended to supplant physician judgment... 
INFECTIOUS DISEASES | COMBINATION ANTIBIOTIC-THERAPY | PROTECTED SPECIMEN BRUSH | LOWER RESPIRATORY-TRACT | MICROBIOLOGY | PSEUDOMONAS-AERUGINOSA BACTEREMIA | RANDOMIZED CONTROLLED-TRIAL | IMMUNOLOGY | RESISTANT STAPHYLOCOCCUS-AUREUS | INTENSIVE-CARE-UNIT | GRAM-POSITIVE INFECTIONS | DE-ESCALATION THERAPY | CRITICALLY-ILL PATIENTS | Anti-Bacterial Agents - therapeutic use | Cross Infection - therapy | Pneumonia, Bacterial - therapy | Pneumonia, Ventilator-Associated - therapy | United States | Drug Resistance, Multiple, Bacterial | Humans | Cross Infection - diagnosis | Adult | Bacteriological Techniques | Pneumonia, Bacterial - diagnosis | Pneumonia, Ventilator-Associated - diagnosis | Ventilator-associated pneumonia | Care and treatment | Analysis | Practice guidelines (Medicine) | Medical care | Management | Protocols clínics | Pneumonia | Pneumònia | Malalties infeccioses | Estats Units d'Amèrica | Communicable diseases | Community-acquired pneumonia | Pneumònia adquirida a la comunitat | American Thoracic Society | Medical protocols | Assistència mèdica | Infectious Diseases Society of America | Idsa Guideline | Medical Guideline
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7. Full Text Ventilator-associated pneumonia in the ICU
by Kalanuria, Atul A and Zai, Wendy and Mirski, Marek
Critical Care, ISSN 1364-8535, 03/2014, Volume 18, Issue 2, pp. 208 - 208
DIAGNOSIS | PULMONARY INFECTION SCORE | METAANALYSIS | INTENSIVE-CARE-UNIT | HOSPITAL-ACQUIRED PNEUMONIA | STAPHYLOCOCCUS-AUREUS | SAFETY NETWORK | ATTRIBUTABLE MORTALITY | NOSOCOMIAL PNEUMONIA | ANTIBIOTIC-THERAPY | CRITICAL CARE MEDICINE | Cross Infection - therapy | Intensive Care Units - trends | Respiration, Artificial - adverse effects | Pneumonia, Ventilator-Associated - therapy | Humans | Respiration, Artificial - trends | Cross Infection - diagnosis | Pneumonia, Ventilator-Associated - epidemiology | Pneumonia, Ventilator-Associated - diagnosis | Cross Infection - epidemiology | Review
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8. Full Text Executive Summary: Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society
by Kalil, Andre C and Metersky, Mark L and Klompas, Michael and Muscedere, John and Sweeney, Daniel A and Palmer, Lucy B and Napolitano, Lena M and O'Grady, Naomi P and Bartlett, John G and Carratalà, Jordi and El Solh, Ali A and Ewig, Santiago and Fey, Paul D and File, Thomas M and Restrepo, Marcos I and Roberts, Jason A and Waterer, Grant W and Cruse, Peggy and Knight, Shandra L and Brozek, Jan L
Clinical Infectious Diseases, ISSN 1058-4838, 09/2016, Volume 63, Issue 5, pp. 575 - 582
It is important to realize that guidelines cannot always account for individual variation among patients. They are not intended to supplant physician judgment... 
Cross Infection - therapy | Pneumonia, Bacterial - therapy | Pneumonia, Ventilator-Associated - therapy | United States | Humans | Pneumonia, Bacterial - diagnosis | Pneumonia, Ventilator-Associated - diagnosis | Anti-Bacterial Agents - therapeutic use | Drug Resistance, Multiple, Bacterial | Cross Infection - diagnosis | Adult | Bacteriological Techniques | Practice Guidelines as Topic | Idsa Guideline | Medical Guideline
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9. Full Text Antibiotic therapy for ventilator-associated tracheobronchitis: a standard of care to reduce pneumonia, morbidity and costs?
by Craven, Donald E and Hudcova, Jana and Rashid, Jawad
Current Opinion in Pulmonary Medicine, ISSN 1070-5287, 05/2015, Volume 21, Issue 3, pp. 250 - 259
PURPOSE OF REVIEWThe present review draws our attention to ventilator-associated tracheobronchitis (VAT) as a distinct clinical entity that has been associated... 
Multidrug-resistant | Prevention | Improved patient outcomes | Ventilator-associated pneumonia | Length of ICU stay | Early appropriate therapy | Bacterial pathogens | Intravenous antibiotics | Ventilator days | Aerosolized antibiotics | aerosolized antibiotics | DIAGNOSIS | intravenous antibiotics | MANAGEMENT | length of ICU stay | AMIKACIN | ventilator-associated pneumonia | bacterial pathogens | early appropriate therapy | multidrug-resistant | NOSOCOMIAL TRACHEOBRONCHITIS | IMPACT | ventilator days | RESPIRATORY SYSTEM | ANTIMICROBIAL TREATMENT | COLISTIN | improved patient outcomes | OUTCOMES | prevention | Tracheitis - drug therapy | Humans | Bronchitis - economics | Pneumonia, Ventilator-Associated - economics | Morbidity | Pneumonia, Ventilator-Associated - diagnosis | Tracheitis - economics | Bronchitis - diagnosis | Tracheitis - diagnosis | Anti-Bacterial Agents - therapeutic use | Bronchitis - drug therapy | Bronchitis - pathology | Pneumonia, Ventilator-Associated - pathology | Tracheitis - pathology | Pneumonia, Ventilator-Associated - drug therapy
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10. Full Text Randomized controlled trial of nebulized colistimethate sodium as adjunctive therapy of ventilator-associated pneumonia caused by gram-negative bacteria
by Rattanaumpawan, Pinyo and Lorsutthitham, Jintana and Ungprasert, Puangpaka and Angkasekwinai, Nasikarn and Thamlikitkul, Visanu
Journal of Antimicrobial Chemotherapy, ISSN 0305-7453, 12/2010, Volume 65, Issue 12, pp. 2645 - 2649
Cases of ventilator-associated pneumonia (VAP) due to multidrug-resistant (MDR) Acinetobacter baumannii and Pseudomonas aeruginosa are common in hospitalized... 
Colistin | Healthcare-associated pneumonia | Inhaled therapy | INFECTIOUS DISEASES | PSEUDOMONAS-AERUGINOSA | healthcare-associated pneumonia | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | inhaled therapy | colistin | Pneumonia, Bacterial - microbiology | Colistin - analogs & derivatives | Humans | Middle Aged | Colistin - administration & dosage | Gram-Negative Bacterial Infections - drug therapy | Male | Treatment Outcome | Cross Infection - drug therapy | Gram-Negative Bacterial Infections - microbiology | Anti-Bacterial Agents - therapeutic use | Gram-Negative Bacteria - drug effects | Pneumonia, Ventilator-Associated - microbiology | Cross Infection - microbiology | Aged, 80 and over | Colistin - therapeutic use | Female | Pneumonia, Bacterial - drug therapy | Aged | Anti-Bacterial Agents - adverse effects | Colistin - adverse effects | Anti-Bacterial Agents - administration & dosage | Nebulizers and Vaporizers - utilization | Pneumonia, Ventilator-Associated - drug therapy | Bronchospasm | Hospitals | Antibiotics | Sodium | Clinical trials | ventilator-associated pneumonia | Gram-negative bacteria | Drug resistance | Kidney
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11. Full Text Ventilator-associated pneumonia: present understanding and ongoing debates
by Nair, Girish B and Nair, Girish B and Niederman, Michael S and Niederman, Michael S
Intensive Care Medicine, ISSN 0342-4642, 1/2015, Volume 41, Issue 1, pp. 34 - 48
Ventilator-associated pneumonia (VAP) is a common cause of nosocomial infection, and is related to significant utilization of health-care resources. In the... 
Hospital-acquired pneumonia | Pediatrics | Ventilator-associated pneumonia | Emergency Medicine | Intensive / Critical Care Medicine | Ventilator-associated complications | Prevention | Pain Medicine | Pneumology/Respiratory System | Antimicrobial treatment | Medicine & Public Health | Nosocomial pneumonia | Anesthesiology | RANDOMIZED-TRIAL | AUREUS NOSOCOMIAL PNEUMONIA | CLINICAL-PRACTICE GUIDELINES | PULMONARY INFECTION SCORE | INTENSIVE-CARE-UNIT | DE-ESCALATION THERAPY | EMPIRIC ANTIBIOTIC-THERAPY | CRITICALLY-ILL PATIENTS | CRITICAL CARE MEDICINE | Cross Infection - therapy | Intensive Care Units | Pneumonia, Ventilator-Associated - microbiology | Pneumonia, Ventilator-Associated - therapy | Cross Infection - microbiology | Humans | Cross Infection - diagnosis | Pneumonia, Ventilator-Associated - epidemiology | Pneumonia, Ventilator-Associated - diagnosis | Cross Infection - epidemiology | Complications and side effects | Care and treatment | Diagnosis | Artificial respiration
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