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International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2007, Volume 68, Issue 1, pp. 94 - 102
Purpose To investigate the rate of high-grade treatment-related pneumonitis (TRP) in patients with advanced non–small-cell lung cancer (NSCLC) treated with... 
Radiology | Hematology, Oncology and Palliative Medicine | Treatment-related pneumonitis | Non–small-cell lung cancer | 3D-CRT | IMRT | Chemoradiation | Non-small-cell lung cancer | VOLUME HISTOGRAM ANALYSIS | PREDICTING RADIATION PNEUMONITIS | DOSIMETRIC FACTORS | DOSE-ESCALATION | THERAPY | REDUCTION | ONCOLOGY | TARGET VOLUME | 3-DIMENSIONAL CONFORMAL RADIOTHERAPY | chemoradiation | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | non-small-cell lung cancer | treatment-related pneumonitis | ORGAN MOTION | Carcinoma, Non-Small-Cell Lung - radiotherapy | Lung Neoplasms - drug therapy | Confidence Intervals | Radiation Pneumonitis - etiology | Follow-Up Studies | Radiation Pneumonitis - pathology | Humans | Middle Aged | Lung Neoplasms - radiotherapy | Male | Radiotherapy, Intensity-Modulated - adverse effects | Aged, 80 and over | Adult | Female | Retrospective Studies | Carcinoma, Non-Small-Cell Lung - pathology | Radiotherapy Dosage | Radiotherapy, Intensity-Modulated - methods | Radiation Pneumonitis - epidemiology | Disease-Free Survival | Radiotherapy, Conformal - adverse effects | Aged | Combined Modality Therapy - methods | Carcinoma, Non-Small-Cell Lung - drug therapy | Radiotherapy, Conformal - methods | Chemotherapy | Care and treatment | Pneumonia | Cancer patients | Analysis | Bacterial pneumonia | Diagnosis | Lung cancer, Non-small cell | Radiotherapy | Cancer | Index Medicus | CHEST | SURGERY | PATIENTS | LUNGS | CARCINOMAS | RADIOLOGY AND NUCLEAR MEDICINE | PNEUMONITIS | RADIATION DOSES | TOXICITY | RADIOTHERAPY | CHEMOTHERAPY
Journal Article
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2012, Volume 84, Issue 1, pp. 238 - 243
Purpose Angiotensin-converting enzyme (ACE) inhibitors have been shown to mitigate radiation-induced lung injury in preclinical models. The aim of this study... 
Radiology | Hematology, Oncology and Palliative Medicine | Radiation-induced lung injury | ACE inhibitors | Pulmonary toxicity | Lung cancer | Radiation pneumonitis | FIBROSIS | INDUCED PNEUMONOPATHY | PREVENTION | INJURY | MODEL | COMPUTED-TOMOGRAPHY | RAT LUNG | CELL LUNG-CANCER | RECEPTOR BLOCKER | ONCOLOGY | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Carcinoma, Non-Small-Cell Lung - pathology | Carcinoma, Non-Small-Cell Lung - radiotherapy | Lung Neoplasms - drug therapy | Radiation Pneumonitis - etiology | Radiation Pneumonitis - pathology | Humans | Middle Aged | Lung Neoplasms - radiotherapy | Lung Neoplasms - pathology | Male | Tumor Burden | Radiation Pneumonitis - epidemiology | Radiation Pneumonitis - prevention & control | Small Cell Lung Carcinoma - drug therapy | Incidence | Captopril - therapeutic use | Small Cell Lung Carcinoma - pathology | Lisinopril - therapeutic use | Small Cell Lung Carcinoma - radiotherapy | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Lung - radiation effects | Aged | Retrospective Studies | Carcinoma, Non-Small-Cell Lung - drug therapy | Enzymes | Medical colleges | Pneumonia | Nuclear radiation | Oncology, Experimental | Bacterial pneumonia | Research | Radiotherapy | Cancer | Index Medicus | Angiotensin-converting enzyme inhibitors | Corticoids | Antiinflammatory agents | Toxicity | Radiation | Thorax | Angiotensin receptors | Chemotherapy | Pneumonitis | Peptidyl-dipeptidase A | statins | Models | Injuries | PATIENTS | NEOPLASMS | ELDERLY PEOPLE | ENZYME INHIBITORS | LUNGS | RADIATION DOSES | TOXICITY | ANGIOTENSIN | CHEMOTHERAPY | RADIATION INJURIES | IRRADIATION | HEALTH HAZARDS | ENZYMES | INFLAMMATION | RADIOLOGY AND NUCLEAR MEDICINE | PNEUMONITIS | RADIOTHERAPY | RECEPTORS
Journal Article
NEUROLOGY, ISSN 0028-3878, 03/2019, Volume 92, Issue 12, pp. 585 - 585
Journal Article
Neurology, ISSN 0028-3878, 03/2019, Volume 92, Issue 12, pp. 586 - 586
Journal Article
Chest, ISSN 0012-3692, 12/2018, Volume 154, Issue 6, pp. 1416 - 1423
Immune checkpoint inhibitors (ICIs) are newer, immunotherapy-based drugs that have been shown to improve survival in advanced non-small cell lung cancer... 
NSCLC | pneumonitis | immunotherapy
Journal Article
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2011, Volume 80, Issue 5, pp. 1365 - 1371
Purpose To study the relationship between fluorodeoxyglucose (FDG) uptake in pulmonary tissue after radical radiation therapy (RT) and the presence and... 
Radiology | Hematology, Oncology and Palliative Medicine | Fluorodeoxyglucose | radiotherapy | Positron emission tomography | Response assessment | Lung cancer | Radiation pneumonitis | DIAGNOSIS | COMPUTED-TOMOGRAPHY | RADICAL RADIOTHERAPY | DISEASE-ACTIVITY | F-18-FDG UPTAKE | ONCOLOGY | DRUG-INDUCED PNEUMONITIS | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PET | Carcinoma, Non-Small-Cell Lung - radiotherapy | Fluorodeoxyglucose F18 - pharmacokinetics | Lung Neoplasms - drug therapy | Prospective Studies | Radiation Pneumonitis - pathology | Humans | Lung Neoplasms - radiotherapy | Lung - diagnostic imaging | Radiation Pneumonitis - metabolism | Cisplatin - administration & dosage | Fluorodeoxyglucose F18 - adverse effects | Fluorouracil - administration & dosage | Time Factors | Lung - radiation effects | Lung - metabolism | Paclitaxel - administration & dosage | Radiotherapy Dosage | Positron-Emission Tomography - adverse effects | Radiopharmaceuticals - pharmacokinetics | Carboplatin - administration & dosage | Radiation Pneumonitis - diagnostic imaging | Positron-Emission Tomography - methods | Pulmonary Disease, Chronic Obstructive - complications | Lymphatic Irradiation | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Lung Neoplasms - diagnostic imaging | Carcinoma, Non-Small-Cell Lung - diagnostic imaging | Radiopharmaceuticals - adverse effects | Carcinoma, Non-Small-Cell Lung - drug therapy | Medical colleges | Care and treatment | Pneumonia | PET imaging | Bacterial pneumonia | Radiation | Radiotherapy | Lung cancer, Non-small cell | Health aspects | Cancer | Chemotherapy | Pneumonitis | Scanning | Toxicity | Oncology | Inflammation | Risk factors | Index Medicus | EMISSION COMPUTED TOMOGRAPHY | TRANSITION ELEMENTS | FLUORODEOXYGLUCOSE | ANTIMATTER | FLUORINE ISOTOPES | THERAPY | METALS | POSITRON COMPUTED TOMOGRAPHY | ANTILEPTONS | BETA DECAY RADIOISOTOPES | RADIOLOGY AND NUCLEAR MEDICINE | PNEUMONITIS | DIAGNOSTIC TECHNIQUES | NEOPLASMS | COMPUTERIZED TOMOGRAPHY | ISOTOPES | RESPIRATORY SYSTEM | INFLAMMATION | ODD-ODD NUCLEI | BODY | PATHOLOGICAL CHANGES | FLUORINE 18 | HAZARDS | TOMOGRAPHY | ANTIPARTICLES | HOURS LIVING RADIOISOTOPES | LUNGS | PLATINUM | FERMIONS | MEDICINE | ANTIMETABOLITES | ELEMENTS | LEPTONS | NANOSECONDS LIVING RADIOISOTOPES | DRUGS | RADIOTHERAPY | LIGHT NUCLEI | RADIOLOGY | MATTER | BETA-PLUS DECAY RADIOISOTOPES | PLATINUM METALS | ISOMERIC TRANSITION ISOTOPES | RADIOISOTOPES | SYMPTOMS | ELEMENTARY PARTICLES | CHEMOTHERAPY | NUCLEAR MEDICINE | ORGANS | DISEASES | NUCLEI | POSITRONS
Journal Article
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2017, Volume 99, Issue 2, pp. 353 - 361
Purpose Ionizing radiation (IR)–induced pulmonary fibrosis (PF) is an irreversible and severe late effect of thoracic radiation therapy. The goal of this study... 
Radiology | Hematology, Oncology and Palliative Medicine | LUNG | STEM-CELLS | TOTAL-BODY | TGF-BETA | EPITHELIAL-CELLS | ONCOLOGY | INJURY | PNEUMONITIS | CELLULAR SENESCENCE | SUPEROXIDE-DISMUTASE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | CANCER-THERAPY | Radiation Pneumonitis - pathology | Cytokines - analysis | Lung - chemistry | RNA, Messenger - analysis | Hydroxyproline - analysis | Male | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | beta-Galactosidase - analysis | Lung - enzymology | Cyclin-Dependent Kinase Inhibitor p16 - analysis | Alveolar Epithelial Cells - pathology | Cellular Senescence | Proto-Oncogene Proteins c-bcl-2 - analysis | Inflammation Mediators - metabolism | Polymerase Chain Reaction | Lung - radiation effects | Radiation, Ionizing | Mice, Inbred C57BL | bcl-2-Associated X Protein - metabolism | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Alveolar Epithelial Cells - drug effects | bcl-2-Associated X Protein - antagonists & inhibitors | Animals | Sulfonamides - therapeutic use | Radiation Pneumonitis - genetics | Mice | Aniline Compounds - therapeutic use | Proto-Oncogene Proteins c-bcl-2 - genetics | Radiation Pneumonitis - drug therapy | Medical colleges | Ionizing radiation | Pulmonary fibrosis | Radiotherapy | Analysis | Index Medicus | FIBROSIS | IRRADIATION | INHIBITION | GY RANGE | RADIOLOGY AND NUCLEAR MEDICINE | MICE | RADIATION DOSES | IONIZING RADIATIONS
Journal Article
Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 12/2017, Volume 21, Issue 12, pp. 3264 - 3276
Radiation‐induced lung injury ( RILI ) is one of the most common and fatal complications of thoracic radiotherapy. It is characterized with two main features... 
radiation‐induced lung injury | epithelial–mesenchymal transition | free radicals | polydatin | EMT | radiation-induced lung injury | epithelial–mesenchymal transition (EMT) | polydatin (PD) | MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | SMAD3 | INDUCED FIBROSIS | CANCER CELLS | IRRADIATED MICE | DAMAGE | IMPAIRMENT | CELL BIOLOGY | epithelial-mesenchymal transition (EMT) | TH2-LIKE IMMUNE-RESPONSE | GROWTH | EXPRESSION | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics | Epithelial Cells - metabolism | Epithelial-Mesenchymal Transition - radiation effects | Radiation Pneumonitis - pathology | Epithelial Cells - drug effects | Humans | Acute Lung Injury - genetics | Epithelial-Mesenchymal Transition - drug effects | Smad3 Protein - immunology | Stilbenes - pharmacology | Radiation Pneumonitis - prevention & control | NF-E2-Related Factor 2 - immunology | Smad3 Protein - genetics | Transforming Growth Factor beta1 - immunology | Acute Lung Injury - prevention & control | Radiation-Protective Agents - pharmacology | Female | Lung - radiation effects | NF-E2-Related Factor 2 - genetics | Lung - metabolism | Th1-Th2 Balance - drug effects | Disease Models, Animal | Cell Line | Epithelial Cells - radiation effects | Glucosides - pharmacology | Lung - pathology | Sirtuin 3 - genetics | Signal Transduction | Mice, Inbred C57BL | Gene Expression Regulation | Epithelial Cells - pathology | Transforming Growth Factor beta1 - genetics | Acute Lung Injury - pathology | Radiation Pneumonitis - immunology | Sirtuin 3 - immunology | Animals | Th1-Th2 Balance - radiation effects | Lung - drug effects | Radiation Pneumonitis - genetics | Acute Lung Injury - immunology | Mice | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - immunology | Transforming growth factors | Lung diseases | Stem cells | Radiation | Cell culture | Radiation effects | Mesenchyme | Complications | Lung | Lymphocytes T | Smad3 protein | Thorax | Radiation therapy | Tissues | Signal transduction | Signaling | Pneumonitis | Beta irradiation | Fibrosis | Radiation injuries | Irradiation | Inhibition | Injuries | Index Medicus | Original
Journal Article
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2006, Volume 66, Issue 5, pp. 1399 - 1407
To investigate factors associated with treatment-related pneumonitis in non–small-cell lung cancer patients treated with concurrent chemoradiotherapy. We... 
Non–small-cell lung cancer | Treatment related pneumonitis | Three-dimensional conformal radiotherapy | Concurrent chemoradiotherapy | Non-small-cell lung cancer | PREDICTING RADIATION PNEUMONITIS | treatment related pneumonitis | RISK | CHEMORADIOTHERAPY | PARAMETERS | EARLY DNA-DAMAGE | IRRADIATION | THERAPY | DOSE-VOLUME HISTOGRAM | ONCOLOGY | concurrent chemoradiotherapy | three-dimensional conformal radiotherapy | CHEMORADIATION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | MOUSE LUNG | non-small-cell lung cancer | Radiotherapy Dosage | Carcinoma, Non-Small-Cell Lung - radiotherapy | Lung Neoplasms - drug therapy | Radiation Pneumonitis - etiology | Humans | Middle Aged | Lung Neoplasms - radiotherapy | Male | Antineoplastic Agents - therapeutic use | Analysis of Variance | Aged, 80 and over | Radiotherapy, Conformal | Adult | Female | Aged | Combined Modality Therapy - methods | Retrospective Studies | Carcinoma, Non-Small-Cell Lung - drug therapy | Complications and side effects | Medical colleges | Care and treatment | Pneumonia | Cancer patients | Chemotherapy | Bacterial pneumonia | Radiation | Lung cancer, Non-small cell | Radiotherapy | Cancer | Index Medicus | MULTIVARIATE ANALYSIS | PATIENTS | LUNGS | CARCINOMAS | RADIOLOGY AND NUCLEAR MEDICINE | PNEUMONITIS | RADIATION DOSES | TOXICITY | RADIOTHERAPY | CHEMOTHERAPY | COMBINED THERAPY | PLANNING
Journal Article
Chest, ISSN 0012-3692, 04/2019, Volume 155, Issue 4, pp. e79 - e82
Immune checkpoint inhibitors have revolutionized cancer therapy. As the use of checkpoint inhibitors becomes widespread, the early recognition and treatment of... 
pembrolizumab pneumonitis | hypersensitivity pneumonitis | checkpoint inhibitors | Bird fancier‘s lung | immune-related adverse event | Bird fancier's lung | MANAGEMENT | RESPIRATORY SYSTEM | PNEUMONITIS | DEATH | CANCER | CRITICAL CARE MEDICINE | Drug therapy | Hypersensitivity pneumonitis | Diagnosis
Journal Article
Journal Article
Radiotherapy and Oncology, ISSN 0167-8140, 2011, Volume 101, Issue 1, pp. 86 - 92
Journal Article
Medical Physics, ISSN 0094-2405, 05/2015, Volume 42, Issue 5, pp. 2421 - 2430
Purpose: Prediction of radiation pneumonitis (RP) has been shown to be challenging due to the involvement of a variety of factors including dose-volume metrics... 
Magnetohydrodynamics | dosimetry | Conformal radiation treatment | regression analysis | enzymes | Entropy | Scintigraphy | Tissues | Digital computing or data processing equipment or methods, specially adapted for specific applications | Monte Carlo methods | NTCP | Graphical methods | belief networks | Bayesian network | Probability theory | diseases | biomarker | cardiology | Dose‐volume analysis | Inference methods or devices | ensemble learning | Lungs | radiation therapy | Markov processes | In which a programme is changed according to experience gained by the computer itself during a complete run; Learning machines | Philosophy of science | molecular biophysics | medical computing | radiation pneumonitis | Cancer | DISTRIBUTIONS | IRRADIATION | THERAPY | MODELS | RADIOTHERAPY | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Radiotherapy Dosage | Transforming Growth Factors - blood | Carcinoma, Non-Small-Cell Lung - radiotherapy | Multivariate Analysis | Markov Chains | Radiation Pneumonitis - etiology | Area Under Curve | Humans | Logistic Models | Biomarkers - blood | Machine Learning | Radiation Pneumonitis - diagnosis | alpha-Macroglobulins - metabolism | Peptidyl-Dipeptidase A - blood | Heart - radiation effects | Interleukin-6 - blood | Radiation Pneumonitis - blood | Bayes Theorem | Carcinoma, Non-Small-Cell Lung - blood | ROC Curve | Radiotherapy, Conformal - adverse effects | Carcinoma, Non-Small-Cell Lung - drug therapy | Monte Carlo Method | Cohort Studies | Index Medicus | MARKOV PROCESS | MONTE CARLO METHOD | NEOPLASMS | LUNGS | 60 APPLIED LIFE SCIENCES | ANGIOTENSIN | HEART | MULTIVARIATE ANALYSIS | FORECASTING | BIOLOGICAL MARKERS | ENZYMES | PROBABILISTIC ESTIMATION | PNEUMONITIS | RADIOSENSITIVITY
Journal Article