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Kidney International, ISSN 0085-2538, 01/2015, Volume 87, Issue 1, pp. 74 - 84
Journal Article
Kidney International, ISSN 0085-2538, 10/2012, Volume 82, Issue 7, pp. 771 - 789
Glomerular podocytes are highly specialized epithelial cells whose injury in glomerular diseases causes proteinuria. Since mitochondrial dysfunction is an... 
mitochondrial dysfunction | podocytes | SIRT1 | aldosterone | PGC-1a | OXIDATIVE STRESS | PGC-1 alpha | INDUCED APOPTOSIS | PGC-1-ALPHA | TRANSCRIPTIONAL COACTIVATOR | CELL APOPTOSIS | METABOLIC REGULATOR | UROLOGY & NEPHROLOGY | RAT PODOCYTES | FOCAL SEGMENTAL GLOMERULOSCLEROSIS | CALORIE RESTRICTION | Sirtuin 1 - metabolism | Apoptosis - drug effects | Receptors, Mineralocorticoid - metabolism | Podocytes - virology | Respiratory Syncytial Virus Infections - metabolism | Stilbenes - pharmacology | Aldosterone | Sirtuin 1 - genetics | Kidney Diseases - genetics | Receptors, Mineralocorticoid - drug effects | Transfection | RNA Interference | Time Factors | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Kidney Diseases - chemically induced | Mineralocorticoid Receptor Antagonists - pharmacology | Trans-Activators - genetics | Respiratory Syncytial Virus Infections - virology | Genes, Reporter | Cytoprotection | Disease Models, Animal | Kidney Diseases - metabolism | Cell Line | Promoter Regions, Genetic | Podocytes - metabolism | Kidney Diseases - pathology | Kidney Diseases - prevention & control | Mice, Inbred C57BL | Gene Expression Regulation | Respiratory Syncytial Virus Infections - genetics | Mitochondria - metabolism | Mitochondria - drug effects | Mitochondria - pathology | Podocytes - pathology | Animals | Podocytes - drug effects | Mitochondria - virology | Trans-Activators - metabolism | Mice | Transcription Factors | Enzyme Activation | Respiratory Syncytial Viruses - pathogenicity
Journal Article
Kidney International, ISSN 0085-2538, 12/2018, Volume 94, Issue 6, pp. 1099 - 1110
Development of physiologically relevant cellular models with strong translatability to human pathophysiology is critical for identification and validation of... 
kidney development | stem cell | proximal tubule | glomerulus | podocyte | SPECIFICITY | MOUSE | INJURY | MECHANISMS | INDUCTION | PODOCYTES | RNA-SEQ | UROLOGY & NEPHROLOGY | DIFFERENTIATION | CAS9 | EFFICIENT | Kidney - physiology | Organoids - physiology | Homeodomain Proteins - metabolism | Humans | Transcriptome | Drug Discovery - methods | Kidney - metabolism | Time Factors | Organoids - metabolism | Organoids - ultrastructure | Cell Differentiation | Membrane Proteins - metabolism | Induced Pluripotent Stem Cells - metabolism | Biomarkers - metabolism | Cell Line | Kidney - drug effects | Podocytes - metabolism | Induced Pluripotent Stem Cells - drug effects | Induced Pluripotent Stem Cells - physiology | Membrane Proteins - genetics | Gene Expression Regulation | Genotype | Induced Pluripotent Stem Cells - ultrastructure | Nerve Tissue Proteins - genetics | Homeodomain Proteins - genetics | Kidney - ultrastructure | Nerve Tissue Proteins - metabolism | Cell Lineage | Phenotype | Podocytes - ultrastructure | High-Throughput Screening Assays | Podocytes - drug effects | Podocytes - physiology | CRISPR-Cas Systems | Organoids - drug effects | Gene Editing - methods | differentiation | proteinuria | cas9 | epithelial-cells | Klinisk medicin | Urology & Nephrology | Clinical Medicine | crosstalk | podocytes | specificity | injury | mechanisms | rna-seq
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2010, Volume 285, Issue 30, pp. 23457 - 23465
Vascular endothelial growth factor (VEGF) is a dimeric glycoprotein that plays a crucial role in microvascular complications of diabetes, including diabetic... 
KIDNEY GLOMERULI | INHIBITION | REPRESSION | VEGF | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | HIGH GLUCOSE | DIABETIC-NEPHROPATHY | MICE | MOUSE PODOCYTES | CELL-LINES | Diabetes Mellitus - pathology | Diabetes Mellitus - genetics | Humans | 3' Untranslated Regions - genetics | Molecular Sequence Data | MicroRNAs - metabolism | Minichromosome Maintenance Complex Component 7 | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Promoter Regions, Genetic - genetics | Hyperglycemia - genetics | Dose-Response Relationship, Drug | Base Sequence | Hyperglycemia - pathology | Cell Cycle Proteins - genetics | Transcription, Genetic | Hyperglycemia - physiopathology | Nuclear Proteins - genetics | Microvessels - cytology | Reproducibility of Results | Podocytes - metabolism | Endothelial Cells - metabolism | Diabetes Mellitus - metabolism | Morpholines - pharmacology | Glucose - pharmacology | Podocytes - pathology | DNA-Binding Proteins - genetics | Down-Regulation - drug effects | Morpholines - chemistry | Hyperglycemia - metabolism | Podocytes - cytology | Animals | Podocytes - drug effects | Diabetes Mellitus - physiopathology | Polymers - chemistry | Mice | MicroRNAs - genetics | HeLa Cells | Endothelial Cells - drug effects | Molecular Bases of Disease | MicroRNA | Signal Transduction | Gene regulation | Diabetes | Growth factors | Kidney
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 08/2017, Volume 273, pp. 56 - 72
Journal Article
Kidney International, ISSN 0085-2538, 06/2018, Volume 93, Issue 6, pp. 1298 - 1307
Proteinuria encompasses diverse causes including both genetic diseases and acquired forms such as diabetic and hypertensive nephropathy. The basis of... 
Bis-T-23 | actin | podocytes | dynamin | GLOMERULOSCLEROSIS | ACTIVATION | A PROTECTS PODOCYTES | SLIT DIAPHRAGM | MICROTUBULES | KINASE | MOUSE | INJURY | RECEPTOR | CYTOSKELETAL CHANGES | UROLOGY & NEPHROLOGY | Humans | Actins - metabolism | Proteinuria - pathology | Focal Adhesions - pathology | Molecular Targeted Therapy | Renal Insufficiency, Chronic - drug therapy | Renal Insufficiency, Chronic - metabolism | Actin Cytoskeleton - drug effects | Glomerular Basement Membrane - pathology | Renal Insufficiency, Chronic - genetics | Glomerular Basement Membrane - physiopathology | Glomerular Basement Membrane - metabolism | Actin Cytoskeleton - metabolism | Glomerular Filtration Rate | Podocytes - metabolism | Signal Transduction | Proteinuria - metabolism | Podocytes - pathology | Proteinuria - genetics | Renal Agents - therapeutic use | Renal Insufficiency, Chronic - pathology | Focal Adhesions - drug effects | Glomerular Basement Membrane - drug effects | Animals | Proteinuria - drug therapy | Podocytes - drug effects | Focal Adhesions - metabolism | Actin Cytoskeleton - pathology | Patents | Cell culture | Antigens | Animal models | Phenotypes | Filtration | Kidneys | Epithelial cells | Therapeutic applications | Diabetes mellitus | Polymerization | Feet | Nephropathy | Microscopy | Actin | Glomerulus | Cytoskeleton | Kidney diseases | Diaphragm | Regulatory proteins | Proteinuria | Integrins
Journal Article