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Chemistry – A European Journal, ISSN 0947-6539, 04/2017, Volume 23, Issue 19, pp. 4467 - 4526
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 11/2013, Volume 21, Issue 22, pp. 6981 - 6995
A novel class of podophyllotoxin derivatives have been designed and synthesized based on the synergistic antitumor effects of topoisomerase II and histone... 
Hybrid | Synergistic effect | Podophyllotoxin | Topoisomerase II | HDAC | Cancer | CANCER-CELLS | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | PHARMACOLOGICAL PROFILES | T-CELL LYMPHOMA | POTENT INHIBITORS | ANTITUMOR AGENTS | GROWTH-FACTOR RECEPTOR | DNA | IN-VIVO | BIOLOGICAL EVALUATION | DERIVATIVES | Phenylenediamines - chemical synthesis | Podophyllotoxin - pharmacology | Humans | Hydroxamic Acids - chemistry | Structure-Activity Relationship | Recombinant Proteins - biosynthesis | Histone Deacetylase Inhibitors - chemical synthesis | Topoisomerase II Inhibitors - chemistry | DNA Topoisomerases, Type II - chemistry | Topoisomerase II Inhibitors - chemical synthesis | Drug Evaluation, Preclinical | Podophyllotoxin - chemistry | DNA Topoisomerases, Type II - metabolism | Hydroxamic Acids - toxicity | Podophyllotoxin - chemical synthesis | Histone Deacetylases - genetics | HCT116 Cells | Histone Deacetylases - chemistry | Recombinant Proteins - chemistry | Histone Deacetylases - metabolism | Recombinant Proteins - genetics | Topoisomerase II Inhibitors - pharmacology | Enzyme Activation - drug effects | Histone Deacetylase Inhibitors - chemistry | Histone Deacetylase Inhibitors - pharmacology | Phenylenediamines - pharmacology | Phenylenediamines - chemistry | Podophyllotoxin - analogs & derivatives
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 10/2015, Volume 25, Issue 19, pp. 4239 - 4244
Journal Article
MOLECULES, ISSN 1420-3049, 06/2019, Volume 24, Issue 12, p. 2224
Molecular hybridization has proven to be a successful multi-target strategy in the design and development of new antitumor agents. Based on this rational... 
docking calculation | 3,4,5-trimethoxyphenyl group | antitumor activity | BIOCHEMISTRY & MOLECULAR BIOLOGY | quinolinequinones | hybrid molecules | DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | cytotoxicity | naphtoquinones | VITRO CYTOTOXICITY EVALUATION | Podophyllotoxin - pharmacology | Tubulin Modulators - pharmacology | Antineoplastic Agents - chemical synthesis | Humans | Tubulin - genetics | Structure-Activity Relationship | Stilbenes - pharmacology | rho-Associated Kinases - antagonists & inhibitors | Dose-Response Relationship, Drug | Tubulin Modulators - chemical synthesis | Neoplasms - genetics | Topoisomerase II Inhibitors - chemistry | DNA Topoisomerases, Type II - chemistry | Antineoplastic Agents - pharmacology | Molecular Structure | Topoisomerase II Inhibitors - chemical synthesis | Tubulin - chemistry | Amides - pharmacology | rho-Associated Kinases - chemistry | Tubulin Modulators - chemistry | Quinolines - chemistry | rho-Associated Kinases - genetics | Topoisomerase II Inhibitors - pharmacology | Antineoplastic Agents - chemistry | Naphthoquinones - chemical synthesis | Neoplasms - drug therapy | Quinolines - chemical synthesis | Cell Line, Tumor | DNA Topoisomerases, Type II - genetics | Naphthoquinones - chemistry | Cell Proliferation - drug effects | Molecular Docking Simulation | Pyridines - pharmacology | Drug Screening Assays, Antitumor | Enzymes | Biotechnology | Quinone | Clinical trials | Polymerization | Hybridization | Tumor cell lines | Kinases | Cancer therapies | Chromatography | Cell adhesion & migration | Anticancer properties | Design | Proteins | Quinones | Antitumor agents | Cell cycle | Inhibition | Drug dosages | Deoxyribonucleic acid--DNA | Apoptosis | Cancer
Journal Article
Planta Medica, ISSN 0032-0943, 04/2017, Volume 234, Issue 6, pp. 574 - 581
Journal Article