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science & technology (381) 381
life sciences & biomedicine (340) 340
animals (250) 250
humans (250) 250
transcription, genetic (205) 205
biochemistry & molecular biology (200) 200
pol1 transcription initiation complex proteins (198) 198
pol1 transcription initiation complex proteins - metabolism (190) 190
rna polymerase i - metabolism (185) 185
cell biology (184) 184
transcription factors - metabolism (167) 167
dna-binding proteins - metabolism (146) 146
mice (125) 125
pol1 transcription initiation complex proteins - genetics (125) 125
dna, ribosomal - genetics (95) 95
molecular sequence data (94) 94
promoter regions, genetic (87) 87
protein binding (87) 87
transcription factors - genetics (83) 83
cell nucleolus - metabolism (77) 77
cell line (76) 76
rna, ribosomal - genetics (76) 76
dna, ribosomal - metabolism (75) 75
rna, ribosomal - biosynthesis (73) 73
hela cells (72) 72
phosphorylation (72) 72
rna polymerase i - genetics (68) 68
dna-binding proteins - genetics (65) 65
rna (65) 65
base sequence (64) 64
amino acid sequence (62) 62
biological and medical sciences (62) 62
research article (62) 62
genetics & heredity (61) 61
rna polymerase i (58) 58
proteins (56) 56
nucleolus (54) 54
fundamental and applied biological sciences. psychology (53) 53
research (51) 51
gene expression regulation (50) 50
nuclear proteins - metabolism (49) 49
transcription (49) 49
mutation (46) 46
ribonucleic acid--rna (45) 45
genetic transcription (44) 44
molecular and cellular biology (44) 44
transcription factors (44) 44
ubf (44) 44
molecular genetics (43) 43
ribosomal rna (41) 41
cell cycle (40) 40
multidisciplinary sciences (40) 40
science & technology - other topics (40) 40
rna, ribosomal - metabolism (39) 39
cell nucleus - metabolism (38) 38
genes (38) 38
cells, cultured (37) 37
gene expression (37) 37
binding sites (36) 36
rats (36) 36
saccharomyces cerevisiae - genetics (36) 36
ribonucleic acid (35) 35
rna polymerases (35) 35
transcription. transcription factor. splicing. rna processing (35) 35
dna (33) 33
genetic aspects (30) 30
rna polymerase (30) 30
rrna (30) 30
tata-box binding protein (30) 30
female (29) 29
nuclear proteins - genetics (29) 29
recombinant fusion proteins - metabolism (29) 29
transcription factors - chemistry (29) 29
ribosomal dna (28) 28
developmental biology (27) 27
phosphoproteins - metabolism (27) 27
physiological aspects (27) 27
chromatin - metabolism (26) 26
male (26) 26
molecular biology (26) 26
oncology (26) 26
promoter regions, genetic - genetics (25) 25
recombinant proteins - metabolism (25) 25
saccharomyces cerevisiae proteins (25) 25
transfection (25) 25
3t3 cells (24) 24
blotting, western (24) 24
cell line, tumor (24) 24
chromatin (24) 24
cloning, molecular (24) 24
deoxyribonucleic acid--dna (24) 24
dna-binding proteins - isolation & purification (24) 24
histones - metabolism (24) 24
transcription factors - isolation & purification (24) 24
analysis (23) 23
cell nucleolus - ultrastructure (23) 23
nucleoli (23) 23
transcription, genetic - drug effects (23) 23
biochemistry (22) 22
dna-binding proteins - chemistry (22) 22
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1. Full Text Molecular basis of Rrn3-regulated RNA polymerase I initiation and cell growth
by Blattner, Claudia and Jennebach, Stefan and Herzog, Franz and Mayer, Andreas and Cheung, Alan C.M and Witte, Gregor and Lorenzen, Kristina and Hopfner, Karl-Peter and Heck, Albert J.R and Aebersold, Ruedi and Cramer, Patrick
Genes & development, ISSN 0890-9369, 10/2011, Volume 25, Issue 19, pp. 2093 - 2105
Gene class-specific RNA synthesis | Ribosome biogenesis | Promoter specificity | rRNA production | Gene transcription | Genetics & Heredity | Life Sciences & Biomedicine | Developmental Biology | Science & Technology | Cell Biology | Protein Structure, Tertiary | Amino Acid Sequence | Promoter Regions, Genetic | Cell Proliferation | Saccharomyces cerevisiae - genetics | Humans | Protein Multimerization | Models, Molecular | Molecular Sequence Data | Saccharomyces cerevisiae Proteins - genetics | Serine - metabolism | Saccharomyces cerevisiae - cytology | Saccharomyces cerevisiae - metabolism | Sequence Alignment | Pol1 Transcription Initiation Complex Proteins - genetics | Pol1 Transcription Initiation Complex Proteins - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Pol1 Transcription Initiation Complex Proteins - chemistry | Mutation | DNA Polymerase I - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Synthesis | Cell development (Biology) | RNA | Crystals | Research | Structure | RNA polymerases | Index Medicus | gene class-specific RNA synthesis | Research Paper | promoter specificity | ribosome biogenesis
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2. Full Text Structural Insights into the Eukaryotic Transcription Initiation Machinery
by Nogales, Eva and Louder, Robert K and He, Yuan
Annual review of biophysics, ISSN 1936-122X, 5/2017, Volume 46, Issue 1, pp. 59 - 83
TFIID | TFIIE | TFIIF | TFIIH | PIC | cryo-EM | general transcription factors | Cryo-EM | General transcription factors | Multiprotein Complexes - metabolism | Promoter Regions, Genetic | Transcription Factors, TFII - genetics | Animals | Eukaryota | Humans | Transcription Factors, TFII - metabolism | Multiprotein Complexes - genetics | RNA Polymerase II - genetics | Transcription, Genetic | RNA Polymerase II - metabolism | Pol1 Transcription Initiation Complex Proteins | Eukaryotes | Genetic aspects | Genetic transcription | Observations | Index Medicus
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3. Full Text Conserved architecture of the core RNA polymerase II initiation complex
by Mühlbacher, Wolfgang and Sainsbury, Sarah and Hemann, Matthias and Hantsche, Merle and Neyer, Simon and Herzog, Franz and Cramer, Patrick
Nature communications, ISSN 2041-1723, 07/2014, Volume 5, Issue 1, pp. 4310 - 4310
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Eukaryotic Initiation Factors - chemistry | Eukaryotic Initiation Factors - genetics | Saccharomyces cerevisiae - genetics | Molecular Sequence Data | Protein Structure, Tertiary - genetics | Saccharomyces cerevisiae Proteins - genetics | Promoter Regions, Genetic - genetics | Transcription Factors, TFII - chemistry | Transcription Factors, TFII - genetics | Pol1 Transcription Initiation Complex Proteins - genetics | Base Sequence | Mass Spectrometry | Pol1 Transcription Initiation Complex Proteins - chemistry | RNA Polymerase II - genetics | Transcription Initiation, Genetic - physiology | RNA Polymerase II - chemistry | Saccharomyces cerevisiae Proteins - chemistry | Index Medicus
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4. Full Text RNA polymerase II components and Rrn7 form a preinitiation complex on the HomolD box to promote ribosomal protein gene expression in Schizosaccharomyces pombe
by Montes, Matías and Moreira‐Ramos, Sandra and Rojas, Diego A and Urbina, Fabiola and Käufer, Norbert F and Maldonado, Edio
The FEBS journal, ISSN 1742-464X, 02/2017, Volume 284, Issue 4, pp. 615 - 633
Schizosaccharomyces pombe | ribosomal protein | general transcription factor | HomolD | RNA polymerase II | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Transcription Factor TFIIB - metabolism | Mediator Complex - metabolism | Transcription Factor TFIIB - genetics | RNA Polymerase II - metabolism | Ribosomal Proteins - metabolism | TATA-Box Binding Protein - metabolism | Schizosaccharomyces - genetics | Pol1 Transcription Initiation Complex Proteins - genetics | TATA-Box Binding Protein - genetics | Pol1 Transcription Initiation Complex Proteins - metabolism | Cloning, Molecular | Escherichia coli - metabolism | Transcription, Genetic | Binding Sites | Transcription Factor TFIIA - metabolism | Gene Expression Regulation, Fungal | Recombinant Proteins - metabolism | Promoter Regions, Genetic | Gene Expression | Ribosomal Proteins - genetics | Mediator Complex - genetics | Recombinant Proteins - genetics | Fungal Proteins - genetics | Schizosaccharomyces - metabolism | Transcription Factors, TFII - genetics | Escherichia coli - genetics | TATA Box | Protein Binding | Transcription Factor TFIIA - genetics | Transcription Factors, TFII - metabolism | RNA Polymerase II - genetics | Fungal Proteins - metabolism | Genetic research | Genetic transcription | DNA binding proteins | RNA | Genes | Protein binding | Proteins | Yeast | RNA polymerase | Gene expression | Index Medicus
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5. Full Text Structure of the initiation-competent RNA polymerase i and its implication for transcription
by Pilsl, Michael and Crucifix, Corinne and Papai, Gabor and Krupp, Ferdinand and Steinbauer, Robert and Griesenbeck, Joachim and Milkereit, Philipp and Tschochner, Herbert and Schultz, Patrick
Nature communications, ISSN 2041-1723, 07/2016, Volume 7, Issue 1, pp. 12126 - 12126
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Promoter Regions, Genetic | Protein Multimerization | RNA Polymerase I - metabolism | RNA Polymerase I - chemistry | Saccharomyces cerevisiae Proteins - genetics | Pol1 Transcription Initiation Complex Proteins - genetics | Pol1 Transcription Initiation Complex Proteins - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Protein Domains | Transcription, Genetic | Cryoelectron Microscopy - methods | RNA Polymerase I - genetics | Saccharomyces cerevisiae Proteins - chemistry | Index Medicus
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6. Full Text AF4 uses the SL1 components of RNAP1 machinery to initiate MLL fusion- and AEP-dependent transcription
by Okuda, Hiroshi and Kanai, Akinori and Ito, Shinji and Matsui, Hirotaka and Yokoyama, Akihiko
Nature communications, ISSN 2041-1723, 11/2015, Volume 6, Issue 1, pp. 8869 - 8869
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Promoter Regions, Genetic | Histone-Lysine N-Methyltransferase - genetics | Myeloid-Lymphoid Leukemia Protein - metabolism | Oncogene Proteins, Fusion - metabolism | Humans | Mice, Inbred C57BL | Nuclear Proteins - metabolism | RNA Polymerase I - metabolism | RNA Polymerase II - metabolism | DNA-Binding Proteins - genetics | DNA-Binding Proteins - metabolism | Transcriptional Elongation Factors | Animals | Pol1 Transcription Initiation Complex Proteins - genetics | Histone-Lysine N-Methyltransferase - metabolism | Myeloid-Lymphoid Leukemia Protein - genetics | Oncogene Proteins, Fusion - genetics | Pol1 Transcription Initiation Complex Proteins - metabolism | Female | RNA Polymerase II - genetics | Transcription, Genetic | Mice | Nuclear Proteins - genetics | RNA Polymerase I - genetics | Proteins | Initiation complex | Chromatin | TATA-binding protein | Leukemia | Genes | Selectivity | RNA polymerase | Ribonucleic acid--RNA | DNA-directed RNA polymerase | Gene fusion | RNA polymerase II | Index Medicus
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7. Full Text DNA replication initiator Cdc6 also regulates ribosomal DNA transcription initiation
by Huang, Shijiao and Xu, Xiaowei and Wang, Guopeng and Lu, Guoliang and Xie, Wenbing and Tao, Wei and Zhang, Hongyin and Jiang, Qing and Zhang, Chuanmao
Journal of cell science, ISSN 0021-9533, 04/2016, Volume 129, Issue 7, pp. 1429 - 1440
rDNA transcription | Nucleophosmin | RRN3 | Cdc6 | RNA polymerase I | Cell cycle | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Protein Structure, Tertiary | Humans | Cell Cycle Proteins - metabolism | Nuclear Proteins - metabolism | Nucleolus Organizer Region - genetics | RNA Polymerase I - metabolism | Promoter Regions, Genetic - genetics | Pol1 Transcription Initiation Complex Proteins - metabolism | HEK293 Cells | Cell Cycle Proteins - genetics | Cell Line, Tumor | DNA Replication - genetics | Protein Binding | Transcription Initiation, Genetic - physiology | G1 Phase - genetics | HeLa Cells | Nuclear Proteins - genetics | DNA, Ribosomal - genetics | Index Medicus
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8. Full Text Yeast Rrn7 and Human TAF1B Are TFIIB-Related RNA Polymerase I General Transcription Factors
by Bruce A. Knutson and Steven Hahn
Science (American Association for the Advancement of Science), ISSN 0036-8075, 9/2011, Volume 333, Issue 6049, pp. 1637 - 1640
Proteins | Yeasts | Docks | RNA | Active sites | DNA | REPORTS | General transcription factors | Genetic mutation | Cyclins | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Transcription. Transcription factor. Splicing. Rna processing | Molecular and cellular biology | Molecular genetics | Protein Structure, Tertiary | Amino Acid Sequence | Protein Structure, Secondary | Transcription Factor TFIIB - metabolism | Transcription Factor TFIIB - chemistry | Humans | Transcription Factor TFIIIB - chemistry | Transcription Factor TFIIIB - genetics | Molecular Sequence Data | RNA Polymerase I - metabolism | Saccharomyces cerevisiae Proteins - genetics | Protein Folding | TATA-Box Binding Protein - metabolism | Transcription Factor TFIIIB - metabolism | Sequence Alignment | Pol1 Transcription Initiation Complex Proteins - genetics | Pol1 Transcription Initiation Complex Proteins - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Pol1 Transcription Initiation Complex Proteins - chemistry | Transcription, Genetic | Protein Interaction Domains and Motifs | Amino Acid Substitution | Saccharomyces cerevisiae Proteins - chemistry | Physiological aspects | Transcription factors | Genetic aspects | Yeast fungi | RNA polymerases | Enzymes | Eukaryotes | Biosynthesis | Yeast | RNA polymerase | Index Medicus | Brf1 protein
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9. Full Text Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population
by Hein, Nadine and Cameron, Donald P and Hannan, Katherine M and Nguyen, Nhu-Y.N and Fong, Chun Yew and Sornkom, Jirawas and Wall, Meaghan and Pavy, Megan and Cullinane, Carleen and Diesch, Jeannine and Devlin, Jennifer R and George, Amee J and Sanij, Elaine and Quin, Jaclyn and Poortinga, Gretchen and Verbrugge, Inge and Baker, Adele and Drygin, Denis and Harrison, Simon J and Rozario, James D and Powell, Jason A and Pitson, Stuart M and Zuber, Johannes and Johnstone, Ricky W and Dawson, Mark A and Guthridge, Mark A and Wei, Andrew and McArthur, Grant A and Pearson, Richard B and Hannan, Ross D
Blood, ISSN 0006-4971, 05/2017, Volume 129, Issue 21, pp. 2882 - 2895
Life Sciences & Biomedicine | Hematology | Science & Technology | Transcription, Genetic - drug effects | G2 Phase - genetics | Humans | Leukemia, Myeloid, Acute - epidemiology | G2 Phase - drug effects | Tumor Suppressor Protein p53 - genetics | Checkpoint Kinase 2 - metabolism | Checkpoint Kinase 2 - genetics | Pol1 Transcription Initiation Complex Proteins - genetics | Mice, Mutant Strains | Pol1 Transcription Initiation Complex Proteins - metabolism | Leukemia, Myeloid, Acute - drug therapy | Neoplastic Stem Cells - pathology | Cell Division - genetics | Benzothiazoles - pharmacology | Leukemia, Myeloid, Acute - pathology | Tumor Suppressor Protein p53 - metabolism | Pol1 Transcription Initiation Complex Proteins - antagonists & inhibitors | Cell Division - drug effects | Checkpoint Kinase 1 - metabolism | Animals | Cell Line, Tumor | Mice, Inbred NOD | Mice | Neoplastic Stem Cells - enzymology | Checkpoint Kinase 1 - genetics | Naphthyridines - pharmacology | Leukemia, Myeloid, Acute - genetics | Index Medicus | Abridged Index Medicus | Myeloid Neoplasia
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