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Journal Article
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 07/2017, Volume 23, Issue 14, pp. 3711 - 3720
Purpose: To explore whether a cross-talk exists between PARP inhibition and PD-L1/PD-1 immune checkpoint axis, and determine whether blockade of PD-L1/PD-1... 
CELL LUNG-CANCER | BREAST-CANCER | OVEREXPRESSION | ACTIVATION | THERAPY | PEMBROLIZUMAB | ONCOLOGY | OVARIAN-CANCER | PROVIDES | COMBINATION | CHEMOTHERAPY | Tumor Microenvironment - drug effects | Poly (ADP-Ribose) Polymerase-1 - immunology | Breast Neoplasms - immunology | Humans | Poly(ADP-ribose) Polymerase Inhibitors - immunology | Lymphocytes, Tumor-Infiltrating - drug effects | B7-H1 Antigen - genetics | B7-H1 Antigen - immunology | Breast Neoplasms - drug therapy | Poly (ADP-Ribose) Polymerase-1 - antagonists & inhibitors | Poly(ADP-ribose) Polymerase Inhibitors - administration & dosage | Tumor Microenvironment - immunology | Xenograft Model Antitumor Assays | Immunosuppression | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Cell Line, Tumor | Female | Mice | Gene Expression Regulation, Neoplastic - drug effects | Programmed Cell Death 1 Receptor - immunology | Programmed Cell Death 1 Receptor - genetics | Lymphocytes, Tumor-Infiltrating - immunology | Cell culture | Flow cytometry | Biotechnology | Animal models | PD-1 protein | Immunoblotting | Lymphocytes T | Immunity | Anticancer properties | Lymphocytes | Xenografts | Tumor-infiltrating lymphocytes | Tumor cells | Poly(ADP-ribose) polymerase | Breast cancer | Tumor cell lines | Inhibitors | Immune checkpoint | Experimental design | PD-L1 protein | Cell lines | Breast | In vivo methods and tests | Tumors | Cancer
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 06/2017, Volume 24, Issue 20, pp. 2156 - 2173
Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme that plays a critical role in diverse cellular functions, such as DNA damage detection and repair,... 
Biomarker | Synthetic lethality | Gastrointestinal cancer | Carcinogenesis | PARP inhibitors | Poly (ADP-ribose) polymerase-1 (PARP-1) | POLY(ADP-RIBOSE) POLYMERASE | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | synthetic lethality | EXCISION-REPAIR GENES | PARP INHIBITOR ABT-888 | HEPATOCELLULAR-CARCINOMA | IN-VITRO | carcinogenesis | GASTRIC-CANCER | gastrointestinal cancer | COLORECTAL-CANCER | PHARMACOLOGY & PHARMACY | NF-KAPPA-B | PHASE-I | poly (ADP-ribose) polymerase-1 (PARP-1) | PANCREATIC-CANCER CELLS | Poly (ADP-Ribose) Polymerase-1 - analysis | Gastrointestinal Neoplasms - genetics | Gastrointestinal Neoplasms - drug therapy | Humans | Gastrointestinal Tract - drug effects | Antineoplastic Agents - therapeutic use | Molecular Targeted Therapy | Drug Discovery | Gastrointestinal Tract - metabolism | Gastrointestinal Tract - pathology | Poly (ADP-Ribose) Polymerase-1 - antagonists & inhibitors | Poly(ADP-ribose) Polymerase Inhibitors - therapeutic use | Gastrointestinal Neoplasms - pathology | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Animals | Antineoplastic Agents - pharmacology | Polymorphism, Single Nucleotide | Poly (ADP-Ribose) Polymerase-1 - genetics | Transcription | Gastrointestinal tract diseases | Pathogenesis | Liver | Gene regulation | DNA damage | Poly(ADP-ribose) | Disorders | Clinical trials | Single-nucleotide polymorphism | ADP | DNA repair | Inflammatory diseases | Enzymatic activity | Ribose | Pancreas | Deoxyribonucleic acid--DNA | Medical research | Neurodegenerative diseases | Medical treatment | Poly(ADP-ribose) polymerase | Esophagus | Neurological diseases | Polymerase | Poly(ADP-ribose) Polymerase 1 | Damage detection | Cell death | Tumors | Cancer | Polymorphism
Journal Article
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 1203 - 12
Vascular calcification is highly prevalent in end-stage renal diseases and is predictive of cardiovascular events and mortality. Poly(ADP-ribose) polymerase 1... 
PHOSPHATE | ARTERIAL MEDIAL CALCIFICATION | OXIDATIVE-STRESS | ACTIVATION | INHIBITION | MULTIDISCIPLINARY SCIENCES | SMOOTH-MUSCLE-CELLS | PROMOTER | PARP-1 | EXPRESSION | MODULATION | Up-Regulation | Rats, Wistar | Humans | Male | MicroRNAs - metabolism | Core Binding Factor Alpha 1 Subunit - antagonists & inhibitors | Core Binding Factor Alpha 1 Subunit - metabolism | Gene Knockdown Techniques | Uremia - chemically induced | Vascular Calcification - etiology | Radial Artery - pathology | Interleukin-6 - metabolism | STAT3 Transcription Factor - metabolism | Disease Models, Animal | Tissue Culture Techniques | Cells, Cultured | Rats | Poly (ADP-Ribose) Polymerase-1 - metabolism | Uremia - complications | Muscle, Smooth, Vascular - cytology | Vascular Calcification - pathology | Adenine - toxicity | Poly (ADP-Ribose) Polymerase-1 - antagonists & inhibitors | Animals | Myocytes, Smooth Muscle | Kidney Failure, Chronic - complications | Primary Cell Culture | Core Binding Factor Alpha 1 Subunit - genetics | Poly (ADP-Ribose) Polymerase-1 - genetics | RNA, Small Interfering - metabolism | Calcification (ectopic) | End-stage renal disease | Calcium | Poly(ADP-ribose) | Smooth muscle | ADP | Offsets | Arteries | Interleukin 6 | Proteins | Biomedical materials | Clonal deletion | Ribose | Mineralization | Deletion | Biocompatibility | Cbfa-1 protein | Phenotypes | Contractility | MiRNA | Stat3 protein | Muscles | Poly(ADP-ribose) polymerase | Pharmacology | Chemical compounds | Muscle contraction | Polymerase | Poly(ADP-ribose) Polymerase 1 | Renal failure | Calcification | Kidney diseases | Cardiovascular diseases
Journal Article
Journal of Vascular Surgery, ISSN 0741-5214, 2016, Volume 65, Issue 4, pp. 1161 - 1169
Objective Chronic nonhealing wounds are a major health problem for patients in the United States and worldwide. Diabetes and ischemia are two major risk... 
Surgery | SURGERY | CRITICAL LIMB ISCHEMIA | ENDOTHELIAL PROGENITOR CELLS | POLY(ADP-RIBOSE) POLYMERASE | CONTROLLED TRIAL | THERAPY | MOBILIZATION | DOUBLE-BLIND | FOOT ULCERS | PERIPHERAL VASCULAR DISEASE | NEOVASCULARIZATION | HYPEROXIA | Neovascularization, Physiologic - drug effects | Antigens, CD34 - metabolism | Diabetes Mellitus, Experimental - enzymology | Humans | Ischemia - enzymology | Diabetic Angiopathies - etiology | Male | Skin Ulcer - etiology | Endothelial Progenitor Cells - enzymology | Cell Hypoxia | Diabetic Angiopathies - pathology | Time Factors | Ischemia - complications | Poly (ADP-Ribose) Polymerase-1 - deficiency | Diabetic Angiopathies - enzymology | Diabetes Mellitus, Experimental - complications | Angiogenesis Inducing Agents - pharmacology | Nitric Oxide Synthase Type III - metabolism | Skin Ulcer - enzymology | Wound Healing - drug effects | Ischemia - pathology | Diabetes Mellitus, Experimental - physiopathology | Human Umbilical Vein Endothelial Cells - drug effects | Endothelial Progenitor Cells - drug effects | Cells, Cultured | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Poly (ADP-Ribose) Polymerase-1 - metabolism | Diabetic Angiopathies - drug therapy | Poly (ADP-Ribose) Polymerase-1 - antagonists & inhibitors | Mice, Knockout | Cell Movement - drug effects | Phenanthrenes - pharmacology | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Skin Ulcer - pathology | Animals | Human Umbilical Vein Endothelial Cells - enzymology | Skin Ulcer - drug therapy | AC133 Antigen - metabolism | Diabetes Mellitus, Experimental - pathology | Glucose - metabolism | Poly (ADP-Ribose) Polymerase-1 - genetics | Medical colleges | Care and treatment | Wound healing | Wounds and injuries | Sugars | Monosaccharides | Endothelial growth factors | Analysis
Journal Article
BioMed Research International, ISSN 2314-6133, 2017, Volume 2017, pp. 2924848 - 11
Journal Article