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Current medicinal chemistry, ISSN 0929-8673, 06/2017, Volume 24, Issue 20, pp. 2156 - 2173
Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme that plays a critical role in diverse cellular functions, such as DNA damage detection and repair, transcriptional regulation and cell death... 
Biomarker | Synthetic lethality | Gastrointestinal cancer | Carcinogenesis | PARP inhibitors | Poly (ADP-ribose) polymerase-1 (PARP-1) | Pharmacology & Pharmacy | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Poly (ADP-Ribose) Polymerase-1 - analysis | Gastrointestinal Neoplasms - genetics | Gastrointestinal Neoplasms - drug therapy | Humans | Gastrointestinal Tract - drug effects | Antineoplastic Agents - therapeutic use | Molecular Targeted Therapy | Drug Discovery | Gastrointestinal Tract - metabolism | Gastrointestinal Tract - pathology | Poly (ADP-Ribose) Polymerase-1 - antagonists & inhibitors | Poly(ADP-ribose) Polymerase Inhibitors - therapeutic use | Gastrointestinal Neoplasms - pathology | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Animals | Antineoplastic Agents - pharmacology | Polymorphism, Single Nucleotide | Poly (ADP-Ribose) Polymerase-1 - genetics | Transcription | Gastrointestinal tract diseases | Pathogenesis | Liver | Gene regulation | DNA damage | Poly(ADP-ribose) | Disorders | Clinical trials | Single-nucleotide polymorphism | DNA repair | Inflammatory diseases | Enzymatic activity | Ribose | Pancreas | Deoxyribonucleic acid--DNA | Medical research | Neurodegenerative diseases | Medical treatment | Poly(ADP-ribose) polymerase | Adenosine diphosphate | Esophagus | Neurological diseases | Poly(ADP-ribose) Polymerase 1 | Damage detection | Cell death | Tumors | Cancer | Polymorphism
Journal Article
Journal Article
Frontiers in immunology, ISSN 1664-3224, 09/2017, Volume 8, pp. 1172 - 1172
...; thus, alternative therapies are needed. Poly(ADP-ribose) polymerases (PARPs) are the post-translational modifying enzymes with a primary role in DNA repair... 
Acute lung injury | NF-κB | Poly(ADP-ribose)polymerase | Chronic obstructive pulmonary disease | Lung inflammation | STAT-6 | Asthma | Life Sciences & Biomedicine | Immunology | Science & Technology | asthma | acute lung injury | chronic obstructive pulmonary disease | lung inflammation | poly(ADP-ribose)polymerase
Journal Article
Cancer research (Chicago, Ill.), ISSN 0008-5472, 12/2004, Volume 64, Issue 24, pp. 8960 - 8967
Journal Article
Head & neck, ISSN 1043-3074, 03/2018, Volume 40, Issue 8, pp. 1676 - 1684
Background Patients with metastatic Merkel cell carcinoma are treated similarly to small cell lung cancer (SCLC). Poly ADP‐ribose polymerase‐1 (PARP1... 
targeted therapy | genomics | poly ADP‐ribose polymerase (PARP) | Merkel cell carcinoma | Merkel cell polyomavirus | poly ADP-ribose polymerase (PARP) | Otorhinolaryngology | Life Sciences & Biomedicine | Surgery | Science & Technology | Immunohistochemistry | Skin Neoplasms - drug therapy | Humans | Middle Aged | Male | Carcinoma, Merkel Cell - drug therapy | Head and Neck Neoplasms - metabolism | Tumor Suppressor Protein p53 - genetics | Aged, 80 and over | Female | Retinoblastoma Binding Proteins - genetics | Head and Neck Neoplasms - drug therapy | Poly (ADP-Ribose) Polymerase-1 - metabolism | Piperazines - pharmacology | Poly (ADP-Ribose) Polymerase-1 - antagonists & inhibitors | Skin Neoplasms - metabolism | Whole Exome Sequencing | Phthalazines - pharmacology | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | DNA Repair | Carcinoma, Merkel Cell - metabolism | Cell Line, Tumor | Aged | Mutation | Ubiquitin-Protein Ligases - genetics | Medical research | Carcinoma | Gene mutations | Lung cancer | Medicine, Experimental | Metastasis | Health aspects | Sugars | Monosaccharides | Cancer | Small cell lung carcinoma | Therapeutic applications | p53 Protein | DNA damage | Clinical trials | Poly(ADP-ribose) polymerase | Tumor cell lines | DNA repair | Metastases | Poly(ADP-ribose) Polymerase 1 | Ribose | Platinum | Neck | Tumors | Index Medicus
Journal Article