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1. Full Text The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells
by Marçais, Antoine and Cherfils-Vicini, Julien and Viant, Charlotte and Degouve, Sophie and Viel, Sébastien and Fenis, Aurore and Rabilloud, Jessica and Mayol, Katia and Tavares, Armelle and Bienvenu, Jacques and Gangloff, Yann-Gaël and Gilson, Eric and Vivier, Eric and Walzer, Thierry
Nature immunology, ISSN 1529-2908, 2014, Volume 15, Issue 8, pp. 749 - 757
Life Sciences & Biomedicine | Immunology | Science & Technology | Influenza A Virus, H1N1 Subtype - immunology | Cell Proliferation | Humans | Multiprotein Complexes - genetics | Mechanistic Target of Rapamycin Complex 2 | Interleukin-15 - immunology | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - antagonists & inhibitors | TOR Serine-Threonine Kinases - antagonists & inhibitors | STAT5 Transcription Factor - metabolism | Signal Transduction - immunology | Lymphocyte Activation - immunology | TOR Serine-Threonine Kinases - genetics | Killer Cells, Natural - immunology | Poly I-C - immunology | Immunosuppressive Agents - pharmacology | Mice, Inbred C57BL | Cells, Cultured | Inflammation - immunology | Sirolimus - pharmacology | Mice, Knockout | Muromegalovirus - immunology | TOR Serine-Threonine Kinases - immunology | Animals | Mice | Killer Cells, Natural - metabolism | Orthomyxoviridae Infections - immunology | Herpesviridae Infections - immunology | Multiprotein Complexes - immunology | Interleukin-15 | Killer cells | Genetic aspects | Immune response | Properties | Protein kinases | Index Medicus | Life Sciences | Microbiology and Parasitology | Bacteriology | Virology
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2. Full Text Astrocyte Indoleamine 2,3-Dioxygenase Is Induced by the TLR3 Ligand Poly(I:C): Mechanism of Induction and Role in Antiviral Response
by Hyeon-Sook Suh and Meng-Liang Zhao and Mark Rivieccio and Shinyeop Choi and Erin Connolly and Yongmei Zhao and Osamu Takikawa and Celia F. Brosnan and Sunhee C. Lee
Journal of Virology, ISSN 0022-538X, 09/2007, Volume 81, Issue 18, pp. 9838 - 9850
Life Sciences & Biomedicine | Science & Technology | Virology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Miscellaneous | Microbiology | Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics | Encephalitis, Viral - genetics | Membrane Glycoproteins - metabolism | Virus Replication - genetics | Humans | NF-kappa B - metabolism | Cytomegalovirus Infections - immunology | Astrocytes - enzymology | Cytomegalovirus Infections - genetics | Indoleamine-Pyrrole 2,3,-Dioxygenase - immunology | Tryptophan - metabolism | HIV Infections - immunology | Cytomegalovirus - genetics | Virus Replication - drug effects | Poly I-C - pharmacology | Viral Envelope Proteins - genetics | Microglia - enzymology | Toll-Like Receptor 3 - immunology | Toll-Like Receptor 3 - agonists | Toll-Like Receptor 3 - metabolism | Macrophages - enzymology | Gene Expression Regulation, Enzymologic - genetics | Tryptophan - immunology | Ligands | Encephalitis, Viral - immunology | Gene Expression Regulation, Enzymologic - drug effects | NF-kappa B - immunology | Kynurenine - genetics | HIV Infections - enzymology | Encephalitis, Viral - enzymology | Macrophages - virology | Microglia - immunology | Astrocytes - immunology | Viral Envelope Proteins - metabolism | Kynurenine - metabolism | Membrane Glycoproteins - immunology | Astrocytes - virology | Macrophages - immunology | Cytokines - immunology | Interferon Regulatory Factor-3 - immunology | Indoleamine-Pyrrole 2,3,-Dioxygenase - biosynthesis | Nitric Oxide - immunology | HIV Infections - genetics | Cells, Cultured | Virus Replication - immunology | HIV-1 - genetics | Proteins - immunology | Membrane Glycoproteins - genetics | Cytomegalovirus - immunology | Cytomegalovirus Infections - enzymology | HIV-1 - immunology | Proteins - metabolism | Microglia - virology | Interferon Regulatory Factor-3 - metabolism | Viral Envelope Proteins - immunology | Gene Expression Regulation, Enzymologic - immunology | Nitric Oxide - metabolism | Kynurenine - immunology | Cytokines - pharmacology | Interferon Inducers - pharmacology | Index Medicus | Cellular Response to Infection
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3. Full Text The DHX33 RNA Helicase Senses Cytosolic RNA and Activates the NLRP3 Inflammasome
by Mitoma, Hiroki and Hanabuchi, Shino and Kim, Taeil and Bao, Musheng and Zhang, Zhiqiang and Sugimoto, Naoshi and Liu, Yong-Jun
Immunity (Cambridge, Mass.), ISSN 1074-7613, 07/2013, Volume 39, Issue 1, pp. 123 - 135
Life Sciences & Biomedicine | Immunology | Science & Technology | Interleukin-18 - immunology | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Cytosol - immunology | Humans | Caspase 1 - metabolism | Immunoblotting | Caspase 1 - immunology | RNA - genetics | RNA Interference | Interleukin-1beta - metabolism | Gene Expression - immunology | HEK293 Cells | Poly I-C - immunology | RNA, Double-Stranded - metabolism | DEAD-box RNA Helicases - metabolism | Carrier Proteins - immunology | Macrophages - immunology | RNA - metabolism | Cell Line | RNA - immunology | Macrophage Activation - immunology | Interleukin-1beta - immunology | Protein Binding - immunology | Reverse Transcriptase Polymerase Chain Reaction | Inflammasomes - genetics | Carrier Proteins - genetics | DEAD-box RNA Helicases - genetics | Microscopy, Confocal | Macrophages - metabolism | Carrier Proteins - metabolism | Inflammasomes - immunology | RNA, Double-Stranded - genetics | RNA, Double-Stranded - immunology | DEAD-box RNA Helicases - immunology | RNA, Bacterial - immunology | Cytosol - metabolism | RNA, Viral - immunology | Interleukin-18 - metabolism | RNA | Biological response modifiers | Proteins | Laboratories | Glycerol | Infections | Sensors | Viral infections | Deoxyribonucleic acid--DNA | Immune system | Index Medicus
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4. Full Text Nutritional Wheat Amylase-Trypsin Inhibitors Promote Intestinal Inflammation via Activation of Myeloid Cells
by Zevallos, Victor F and Raker, Verena and Tenzer, Stefan and Jimenez-Calvente, Carolina and Ashfaq-Khan, Muhammad and Rüssel, Nina and Pickert, Geethanjali and Schild, Hansjörg and Steinbrink, Kerstin and Schuppan, Detlef
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 2017, Volume 152, Issue 5, pp. 1100 - 1113.e12
Gastroenterology and Hepatology | Celiac Disease | Digestion | Gluten | Wheat Sensitivity | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Glutens - immunology | Triticum - immunology | Humans | Colon - immunology | Ileum - immunology | Intestines - immunology | Celiac Disease - immunology | Myeloid Cells - immunology | Colitis - chemically induced | Interferon Inducers - toxicity | Colitis - immunology | Diet, Gluten-Free | Adaptive Immunity | Duodenum - immunology | Cell Line | Trypsin Inhibitors - immunology | Mice, Inbred C57BL | Plant Proteins - immunology | Inflammation | Mesentery | Toll-Like Receptor 4 - immunology | Lymph Nodes - immunology | Poly I-C - toxicity | Dextran Sulfate - toxicity | Immunity, Innate - immunology | Amylases - antagonists & inhibitors | Animals | Mice | Trypsin inhibitors | Medical colleges | Amylases | Trypsin | Immunotherapy | Wheat | Dextran | Enzymes | Dendritic cells | Proteolysis | Gluten-free diet | Hydrolases | Sulfates | Index Medicus | Abridged Index Medicus
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5. Full Text NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions
by Ludigs, Kristina and Jandus, Camilla and Utzschneider, Daniel T and Staehli, Francesco and Bessoles, Stéphanie and Dang, Anh Thu and Rota, Giorgia and Castro, Wilson and Zehn, Dietmar and Vivier, Eric and Held, Werner and Romero, Pedro and Guarda, Greta
Nature communications, ISSN 2041-1723, 02/2016, Volume 7, Issue 1, pp. 10554 - 10554
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Inflammation - chemically induced | Spleen - immunology | Self Tolerance - immunology | Humans | Cercopithecus aethiops | Intracellular Signaling Peptides and Proteins - immunology | Flow Cytometry | T-Lymphocytes - drug effects | Killer Cells, Natural - immunology | Interferon Inducers - toxicity | Animals, Congenic | Arenaviridae Infections - immunology | Intracellular Signaling Peptides and Proteins - genetics | Vero Cells | Gene Expression Regulation - immunology | Mice, Inbred C57BL | Histocompatibility Antigens Class I - immunology | Mice, Transgenic | Histocompatibility Antigens Class I - genetics | Inflammation - immunology | Spleen - cytology | Reverse Transcriptase Polymerase Chain Reaction | Poly I-C - toxicity | Mice, Knockout | Animals | Lymphocytic choriomeningitis virus | T-Lymphocytes - immunology | Mice | Index Medicus | Life Sciences | Immunology
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6. Full Text TRIM38 negatively regulates TLR3/4-mediated innate immune and inflammatory responses by two sequential and distinct mechanisms
by Hu, Ming-Ming and Xie, Xue-Qin and Yang, Qing and Liao, Chen-Yang and Ye, Wen and Lin, Heng and Shu, Hong-Bing
The Journal of immunology (1950), ISSN 0022-1767, 11/2015, Volume 195, Issue 9, pp. 4415 - 4425
Life Sciences & Biomedicine | Immunology | Science & Technology | Interferon-beta - immunology | Gene Expression - drug effects | Dendritic Cells - immunology | Humans | Immunity, Innate - genetics | Immunoblotting | Male | Lipopolysaccharides - immunology | Signal Transduction - immunology | Bone Marrow Cells - immunology | Gene Expression - immunology | HEK293 Cells | Inflammation Mediators - metabolism | Tumor Necrosis Factor-alpha - immunology | Female | Poly I-C - immunology | Cytokines - genetics | Carrier Proteins - immunology | Dendritic Cells - metabolism | Macrophages - immunology | Macrophages - microbiology | Cytokines - immunology | Inflammation Mediators - immunology | Salmonella typhimurium - physiology | Poly I-C - pharmacology | Cytokines - metabolism | Salmonella typhimurium - immunology | Cells, Cultured | Toll-Like Receptor 3 - immunology | Signal Transduction - genetics | Toll-Like Receptor 4 - immunology | Reverse Transcriptase Polymerase Chain Reaction | Toll-Like Receptor 3 - metabolism | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Carrier Proteins - genetics | Immunity, Innate - immunology | Tumor Necrosis Factor-alpha - pharmacology | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Interferon-beta - pharmacology | Signal Transduction - drug effects | Lipopolysaccharides - pharmacology | Bone Marrow Cells - microbiology | Dendritic Cells - microbiology | Bone Marrow Cells - metabolism | Index Medicus | Abridged Index Medicus
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7. Full Text Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant
by Longhi, M. Paula and Trumpfheller, Christine and Idoyaga, Juliana and Caskey, Marina and Matos, Ines and Kluger, Courtney and Salazar, Andres M and Colonna, Marco and Steinman, Ralph M
The Journal of experimental medicine, ISSN 0022-1007, 07/2009, Volume 206, Issue 7, pp. 1589 - 1602
Immunology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | T-Lymphocyte Subsets - immunology | Spleen - immunology | T-Lymphocyte Subsets - cytology | Dendritic Cells - immunology | Interferon Type I - immunology | Th1 Cells - immunology | CD4-Positive T-Lymphocytes - immunology | Chimera - immunology | Lymphocyte Activation - immunology | Bone Marrow Cells - immunology | Poly I-C - immunology | Receptor, Interferon alpha-beta - genetics | Cytokines - immunology | Adjuvants, Immunologic | CD4-Positive T-Lymphocytes - cytology | Spleen - cytology | Mice, Inbred Strains | Mice, Knockout | Immunity, Innate - immunology | Animals | Receptor, Interferon alpha-beta - immunology | Lymphocyte Activation - drug effects | Interleukin-12 - immunology | Signal Transduction - physiology | Dendritic Cells - cytology | Mice | Th1 Cells - cytology | Index Medicus
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8. Full Text Cutting edge: RIPK1 kinase inactive mice are viable and protected from TNF-Induced necroptosis in vivo
by Polykratis, Apostolos and Hermance, Nicole and Zelic, Matija and Roderick, Justine and Kim, Chun and Van, Trieu-My and Lee, Thomas H and Chan, Francis K.M and Pasparakis, Manolis and Kelliher, Michelle A
The Journal of immunology (1950), ISSN 0022-1767, 08/2014, Volume 193, Issue 4, pp. 1539 - 1543
Life Sciences & Biomedicine | Immunology | Science & Technology | Apoptosis - drug effects | Receptors, Tumor Necrosis Factor, Type I - immunology | Vaccinia virus - growth & development | NF-kappa B - immunology | Hypothermia - chemically induced | MAP Kinase Signaling System - immunology | Vaccinia virus - immunology | Necrosis - immunology | Tumor Necrosis Factor-alpha - immunology | Hypothermia - mortality | Receptor-Interacting Protein Serine-Threonine Kinases - immunology | Macrophages - immunology | Poly I-C - pharmacology | Mice, Inbred C57BL | Cells, Cultured | Virus Replication - immunology | Inflammation - immunology | Adaptor Proteins, Vesicular Transport - immunology | Gene Knock-In Techniques | Necrosis - chemically induced | Tumor Necrosis Factor-alpha - pharmacology | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | Apoptosis - immunology | Inflammation - genetics | Vaccinia - immunology | Mice | Index Medicus | Abridged Index Medicus
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9. Full Text Cutting edge: A dual role for type I IFNs during polyinosinic-polycytidylic acid-induced NK cell activation
by Beuneu, Hélène and Deguine, Jacques and Bouvier, Isabelle and Di Santo, James P and Albert, Matthew L and Bousso, Philippe
The Journal of immunology (1950), ISSN 0022-1767, 09/2011, Volume 187, Issue 5, pp. 2084 - 2088
Life Sciences & Biomedicine | Immunology | Science & Technology | Cell Separation | Mice, Inbred C57BL | Adoptive Transfer | Interferon Type I - immunology | Interleukin-15 - immunology | Signal Transduction - immunology | Lymphocyte Activation - immunology | Animals | Flow Cytometry | Killer Cells, Natural - immunology | Mice | Poly I-C - immunology | Interferon Inducers - immunology | Index Medicus | Abridged Index Medicus | Killer Cells, Natural/immunology | Poly I-C/immunology | Life Sciences | Interleukin-15/immunology | Lymphocyte Activation/immunology | Signal Transduction/immunology | Interferon Type I/immunology | Interferon Inducers/immunology
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10. Full Text Human CD141 + (BDCA-3) + dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens
by Jongbloed, Sarah L and Kassianos, Andrew J and McDonald, Kylie J and Clark, Georgina J and Ju, Xinsheng and Angel, Catherine E and Chen, Chun-Jen J and Dunbar, P. Rod and Wadley, Robert B and Jeet, Varinder and Vulink, Annelie J. E and Hart, Derek N. J and Radford, Kristen J
The Journal of experimental medicine, ISSN 0022-1007, 06/2010, Volume 207, Issue 6, pp. 1247 - 1260
Immunology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Myeloid Cells - cytology | Phosphoproteins - immunology | CD8-Positive T-Lymphocytes - cytology | Dendritic Cells - immunology | Humans | Th1 Cells - immunology | Necrosis - pathology | Lymphoid Tissue - immunology | Necrosis - immunology | CD4-Positive T-Lymphocytes - immunology | Cross-Priming - drug effects | Thrombomodulin - metabolism | Myeloid Cells - immunology | Antigens, Surface - metabolism | Dendritic Cells - drug effects | Myeloid Cells - drug effects | Lymphoid Tissue - drug effects | Interleukin-12 - biosynthesis | Antigens, CD1 - immunology | Cell Line | Th1 Cells - drug effects | Poly I-C - pharmacology | CD4-Positive T-Lymphocytes - cytology | Interferon-beta - biosynthesis | Toll-Like Receptor 3 - metabolism | Lymphoid Tissue - cytology | Cross-Priming - immunology | Recombinant Proteins - immunology | CD8-Positive T-Lymphocytes - drug effects | Antigens - immunology | Dendritic Cells - cytology | Th1 Cells - cytology | Viral Matrix Proteins - immunology | CD8-Positive T-Lymphocytes - immunology | CD4-Positive T-Lymphocytes - drug effects | Index Medicus
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