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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2010, Volume 107, Issue 28, pp. 12611 - 12616
Asbestos carcinogenesis has been linked to the release of cytokines and mutagenic reactive oxygen species (ROS) from inflammatory cells. Asbestos is cytotoxic... 
Actinomycin | Asbestos | Cell death | Secretion | Plasma cells | Inflammation | Macrophages | Carcinogenesis | Necrosis | Apoptosis | Mesothelioma | Biomarker | Tumor necrosis factor-alpha | Chemoprevention | TRANSFORMATION | POLY(ADP-RIBOSE) POLYMERASE | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | CROCIDOLITE ASBESTOS | HMGB1 | biomarker | MAMMALIAN-CELLS | tumor necrosis factor-alpha | PATHOGENESIS | chemoprevention | NECROTIC CELLS | carcinogenesis | TNF-ALPHA | INHIBITORS | mesothelioma | Tumor Necrosis Factor-alpha - metabolism | Asbestos - metabolism | Epithelial Cells - metabolism | Reactive Oxygen Species - metabolism | Humans | Reactive Oxygen Species - pharmacology | Adenosine Diphosphate Ribose - metabolism | Adenosine Diphosphate Ribose - pharmacology | Carcinogens - metabolism | Asbestos - pharmacology | Pleural Neoplasms - metabolism | Inflammation - metabolism | Carcinogens - pharmacology | Cell Nucleus - metabolism | HMGB Proteins - pharmacology | HMGB1 Protein - pharmacology | HMGB1 Protein - metabolism | Cell Death | Mesocricetus | Female | HMGB Proteins - metabolism | Poly Adenosine Diphosphate Ribose - pharmacology | Epithelium - drug effects | Cricetinae | Cytokines - metabolism | Epithelium - metabolism | Hydrogen Peroxide - pharmacology | Necrosis - metabolism | Hydrogen Peroxide - metabolism | Tumor Necrosis Factor-alpha - pharmacology | Macrophages - metabolism | Poly(ADP-ribose) Polymerases - metabolism | Animals | Mesothelioma - metabolism | Poly(ADP-ribose) Polymerases - pharmacology | Cells - metabolism | Mice | Mice, Inbred BALB C | Cytokines - pharmacology | Prevention | Mesothelium | Chromosomal proteins | Research | Chemical properties | Health aspects | Reactive oxygen species | Transformation | Deposits | Hydrogen peroxide | Cytokines | Cytotoxicity | HMGB1 protein | Nuclei | Carcinogens | Tumor necrosis factor-a | ATP | Cytoplasm | Biological Sciences
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 4, p. e19194
The cofactor nicotinamide adenine dinucleotide (NAD+) has emerged as a key regulator of metabolism, stress resistance and longevity. Apart from its role as an... 
Biomarkers - metabolism | Sirtuin 1 - metabolism | Protein Carbonylation | Electron Transport | Oxidative Stress | Rats, Wistar | Antioxidants - metabolism | Tumor Suppressor Protein p53 - metabolism | Rats | Mitochondria - metabolism | Aldehydes - metabolism | Organ Specificity | Brain - metabolism | Poly Adenosine Diphosphate Ribose - metabolism | Poly(ADP-ribose) Polymerases - metabolism | Animals | Intracellular Space - metabolism | Female | Acetylation | DNA Damage | Enzyme Activation | Lipid Peroxidation | NAD - metabolism | Aging - metabolism | Antioxidants | Tyrosine | Niacinamide | Purines | Enzymes | Ionizing radiation | DNA damage | Tumor proteins | Sugars | Monosaccharides | Apoptosis | Dehydrogenases | Syngeneic grafts | Oxidative metabolism | Liver | p53 Protein | Neurobiology | Poly(ADP-ribose) | Lipid peroxidation | ADP | Proteins | Electron transport chain | Signal transduction | Mitochondria | Animal tissues | Aging | Physiology | Chronic obstructive pulmonary disease | Deoxyribonucleic acid--DNA | Peroxidation | Liver diseases | Longevity | Metabolism | Gene expression | Overexpression | Nicotinamide adenine dinucleotide | Nicotinamide | NADPH | Oxidative stress | Carbonyl compounds | Neurosciences | Senescence | Biosynthesis | DNA repair | NADH | Ribose | Rodents | Cell cycle | Age | Carbonyls | Kidneys | Organs | Poly(ADP-ribose) polymerase | Adenine | Histology | Pharmacology | Polymerase | NAD | Lungs | Intracellular | Deoxyribonucleic acid | DNA
Journal Article
Biomaterials, ISSN 0142-9612, 2011, Volume 32, Issue 23, pp. 5438 - 5458
Abstract Oxidative stress is a major component of harmful cascades activated in neurodegenerative disorders. We sought to elucidate possible effects of... 
Advanced Basic Science | Dentistry | Oxidative stress | Mitochondria | Caspase-dependent apoptosis | Endoplasmic reticulum | Alginate oligosaccharide | PC12 cells | LOCALIZATION | ACTIVATION | MATERIALS SCIENCE, BIOMATERIALS | ENGINEERING, BIOMEDICAL | STABILIZATION | CHAPERONE | APOPTOSOME | CA2 | BAX | CYTOCHROME-C RELEASE | PROTEINS | MEMBRANE PERMEABILIZATION | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Calcium - metabolism | Glutathione - metabolism | Amyloid beta-Peptides - pharmacology | Oxidative Stress - physiology | Caspase 3 - metabolism | Endoplasmic Reticulum - metabolism | NF-kappa B - metabolism | Neurons - cytology | Peptide Fragments - pharmacology | Extracellular Signal-Regulated MAP Kinases - metabolism | PC12 Cells | Oligosaccharides - pharmacology | Proto-Oncogene Proteins c-bcl-2 - metabolism | Apoptosis Inducing Factor - pharmacology | Cell Nucleus - metabolism | Endoplasmic Reticulum - drug effects | Oxidation-Reduction - drug effects | Neurons - metabolism | Phosphorylation - drug effects | Glucuronic Acid - chemistry | Neurons - drug effects | Polysaccharide-Lyases - chemistry | Apoptosis Inducing Factor - metabolism | Cell Survival - drug effects | Cytochromes c - metabolism | Hydrogen Peroxide - pharmacology | Tumor Suppressor Protein p53 - metabolism | bcl-2-Associated X Protein - metabolism | Rats | Mitochondria - metabolism | Caspase 12 - metabolism | Hexuronic Acids - chemistry | Mitochondria - drug effects | HSP70 Heat-Shock Proteins - metabolism | Cell Shape - drug effects | Poly(ADP-ribose) Polymerases - metabolism | Animals | Models, Biological | Alginates - chemistry | NF-E2-Related Factor 2 - metabolism | HSP90 Heat-Shock Proteins - metabolism | Apoptosis - physiology | Oxidative Stress - drug effects | Cell Nucleus - drug effects | Neurosciences | Nervous system diseases | Biological products | Hydrogen peroxide | Heat shock proteins | Nerve growth factor | Superoxide | Mitochondrial DNA | Biochemistry | Antioxidants | Tumor proteins | Protein kinases | Alzheimer's disease | Apoptosis | Stresses | Surgical implants | Biomedical materials | Cell death | Cascades | Blocking | Activation | Kinases
Journal Article
Molecular Cell, ISSN 1097-2765, 10/2010, Volume 40, Issue 1, pp. 63 - 74
As part of the genotoxic stress response, cells activate the transcription factor NF-κB. The DNA strand break sensor poly(ADP-ribose)-polymerase-1 (PARP-1) and... 
MOLECULAR-MECHANISM | POLY(ADP-RIBOSYL)ATION | GENOTOXIC STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPLEXES | DOUBLE-STRAND BREAKS | POLYUBIQUITIN CHAINS | ATM | BINDING | NEMO | PROTEIN-KINASES | CELL BIOLOGY | Tumor Necrosis Factor-alpha - metabolism | Phosphorylation | Calcium - metabolism | Inhibitor of Apoptosis Proteins - genetics | Humans | Ubiquitin - metabolism | NF-kappa B - metabolism | DNA Breaks, Double-Stranded | Cell Nucleus - enzymology | DNA-Binding Proteins - metabolism | Cytosol - enzymology | Ubiquitination | Transfection | I-kappa B Kinase - metabolism | RNA Interference | Time Factors | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Inhibitor of Apoptosis Proteins - metabolism | TNF Receptor-Associated Factor 6 - genetics | Protein-Serine-Threonine Kinases - metabolism | Recombinant Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Signal Transduction | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | MAP Kinase Kinase Kinases - metabolism | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Hep G2 Cells | Protein Transport | Ubiquitin-Protein Ligases | Poly(ADP-ribose) Polymerases - metabolism | NF-kappa B - genetics | Ubiquitin-Conjugating Enzymes - metabolism | TNF Receptor-Associated Factor 6 - metabolism | Protein Binding | DNA Damage | HeLa Cells | Mutation | Poly (ADP-Ribose) Polymerase-1 | Adaptor Proteins, Signal Transducing - metabolism
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2012, Volume 7, Issue 4, p. e36019
Yersinia outer protein J (YopJ) is a type III secretion system (T3SS) effector of pathogenic Yersinia (Yersinia pestis, Yersinia enterocolitica and Yersinia... 
INDUCED CELL-DEATH | PROINFLAMMATORY CYTOKINE | LEGIONELLA-PNEUMOPHILA | DENDRITIC CELLS | BACTERIA-FACED MACROPHAGES | CHROMATIN PROTEIN HMGB1 | MULTIDISCIPLINARY SCIENCES | NLRP3 INFLAMMASOME | NF-KAPPA-B | III SECRETION SYSTEM | NALP3 INFLAMMASOME | Caspase 7 - metabolism | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Caspase 3 - metabolism | Caspase 1 - metabolism | Yersinia - pathogenicity | Interleukin-1beta - metabolism | HMGB1 Protein - metabolism | bcl-2-Associated X Protein - deficiency | Macrophages - microbiology | Yersinia pestis - metabolism | Yersinia Infections - pathology | Yersinia enterocolitica - pathogenicity | Yersinia Infections - microbiology | bcl-2-Associated X Protein - metabolism | Cathepsin B - metabolism | Caspase Inhibitors | Mice, Knockout | Macrophages - metabolism | Yersinia pseudotuberculosis - metabolism | Caspase 1 - deficiency | Yersinia enterocolitica - metabolism | Mice | Enzyme Activation | Yersinia pseudotuberculosis - pathogenicity | bcl-2 Homologous Antagonist-Killer Protein - deficiency | Caspase 8 - metabolism | bcl-2 Homologous Antagonist-Killer Protein - genetics | GTPase-Activating Proteins - metabolism | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Necrosis - pathology | Yersinia Infections - metabolism | Protease Inhibitors - pharmacology | Protein Isoforms - metabolism | Female | Yersinia pestis - pathogenicity | bcl-2-Associated X Protein - genetics | GTPase-Activating Proteins - antagonists & inhibitors | Mice, Inbred C57BL | Bacterial Proteins - genetics | Cells, Cultured | Yersinia - metabolism | Cathepsin B - antagonists & inhibitors | Necrosis - metabolism | Mitochondria - metabolism | Immunity, Innate | Animals | Caspase 1 - genetics | Protein Binding | Bacterial Proteins - metabolism | Protein Isoforms - genetics | Cathepsins | Disease susceptibility | Interleukins | Macrophages | Necrosis | Apoptosis | Salmonella | Oxidative stress | Reactive oxygen species | Microscopic analysis | Bax protein | Bcl-2 protein | Toxicity | Downstream effects | Interleukin | Cytotoxicity | Homology | Infections | Activation | Kinases | ADP | HMGB1 protein | Caspase-3 | Caspase-1 | Pseudotuberculosis | Signal transduction | Mitochondria | Cell activation | Ribose | Cathepsin B | Stress response | Pathogens | Cell survival | Cytokines | Mortality | Poly(ADP-ribose) polymerase | Caspase | IL-1β | Metabolism | Gene expression | Lymphoma | Polymerase | Caspase-8 | High mobility group proteins | Infectious diseases | Inhibitors | Lymphocytes B | Cell death | Isoforms | B-cell lymphoma
Journal Article
The EMBO Journal, ISSN 0261-4189, 12/2007, Volume 26, Issue 24, pp. 5020 - 5032
The signaling lipid molecule 15‐deoxy‐delta 12,14‐prostaglandin J2 (15d‐PGJ2) has multiple cellular functions, including anti‐inflammatory and antineoplastic... 
15d‐PGJ2 | translation | proliferation | inflammation | eIF4A | Translation | Inflammation | Proliferation | 15d-PGJ2 | TRANSFORMATION SUPPRESSOR PDCD4 | KAPPA-B ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | 15-DEOXY-DELTA(12,14)-PROSTAGLANDIN J | BINDING-PROTEIN | INITIATION CODON | CELL BIOLOGY | HEPATITIS-C VIRUS | PATHWAY | STRESS GRANULE FORMATION | PRODUCT PATEAMINE-A | RNA HELICASE EIF4A | Tumor Necrosis Factor-alpha - metabolism | Arachidonic Acid - metabolism | Protein Biosynthesis | Sodium Compounds - metabolism | Hypoglycemic Agents - metabolism | Humans | TNF Receptor-Associated Factor 2 - genetics | Cytoplasmic Granules - chemistry | PPAR gamma - metabolism | Anti-Inflammatory Agents - metabolism | Chromans - metabolism | Poly(A)-Binding Proteins - metabolism | Prostaglandin D2 - metabolism | Cytoplasmic Granules - metabolism | Eukaryotic Initiation Factor-2 - metabolism | Prostaglandin D2 - analogs & derivatives | T-Cell Intracellular Antigen-1 | Eukaryotic Initiation Factor-4A - genetics | Emetine - metabolism | Enzyme Inhibitors - metabolism | Poly(A)-Binding Proteins - genetics | Gene Expression Regulation | TNF Receptor-Associated Factor 2 - metabolism | Protein Synthesis Inhibitors - metabolism | Thiazolidinediones - metabolism | Arsenites - metabolism | Dinoprostone - metabolism | Eukaryotic Initiation Factor-2 - genetics | Inflammation - genetics | Cyclopentanes - metabolism | Signal Transduction - physiology | Prostaglandins A - metabolism | HeLa Cells | Eukaryotic Initiation Factor-4A - metabolism | Lipids | Cellular biology | Molecular biology | Binding sites | Inflammatory diseases
Journal Article