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Nature Reviews Cancer, ISSN 1474-175X, 02/2016, Volume 16, Issue 2, pp. 110 - 120
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2008, Volume 283, Issue 48, pp. 33394 - 33405
Micro-RNAs are similar to 21-25-nucleotide-long noncoding RNAs that regulate gene expression primarily at the post-transcriptional level in animals. Here, we... 
SURVIVAL | C/EBP-ALPHA | MICRORNA FUNCTION | THERAPY | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | TUMOR-SUPPRESSOR | TARGETS | DEGRADATION | HUMAN HEPATOCELLULAR CARCINOMAS | EXPRESSION | Lung Neoplasms - drug therapy | Histone Deacetylases - biosynthesis | Antibiotics, Antineoplastic - pharmacology | Caspase 7 - biosynthesis | Apoptosis - drug effects | Humans | Lung Neoplasms - metabolism | Apoptosis - genetics | MicroRNAs - metabolism | Proto-Oncogene Proteins - biosynthesis | RNA, Neoplasm - metabolism | Receptors, Growth Factor - genetics | Caspase 3 - genetics | Caspase 3 - biosynthesis | Gene Expression Regulation, Neoplastic - drug effects | Gene Expression Regulation, Neoplastic - genetics | Lung Neoplasms - genetics | Forkhead Transcription Factors - biosynthesis | Histone Deacetylases - genetics | Caspase 7 - genetics | Cell Survival | Proto-Oncogene Proteins c-met | Repressor Proteins - genetics | Proto-Oncogene Proteins - genetics | Poly(ADP-ribose) Polymerases - biosynthesis | Down-Regulation - drug effects | Forkhead Transcription Factors - genetics | Proto-Oncogene Proteins c-bcl-2 - biosynthesis | Down-Regulation - genetics | Animals | Poly(ADP-ribose) Polymerases - genetics | Repressor Proteins - biosynthesis | Mice, Nude | Myeloid Cell Leukemia Sequence 1 Protein | Receptors, Growth Factor - biosynthesis | Cell Line, Tumor | Proto-Oncogene Proteins c-pim-1 - genetics | RNA, Neoplasm - genetics | Mice | MicroRNAs - genetics | Poly (ADP-Ribose) Polymerase-1 | Proto-Oncogene Proteins c-bcl-2 - genetics | Proto-Oncogene Proteins c-pim-1 - biosynthesis | Doxorubicin - pharmacology | Cell Movement | RNA-Mediated Regulation and Noncoding Rnas
Journal Article
Cancer Research, ISSN 0008-5472, 06/2013, Volume 73, Issue 12, pp. 3683 - 3691
Replication stress and DNA damage activate the ATR-Chk1 checkpoint signaling pathway that licenses repair and cell survival processes. In this study, we... 
CHECKPOINT KINASE 1 | IN-VITRO | ONCOLOGY | XANTHINE DERIVATIVES | DNA-DAMAGE RESPONSE | PROTEIN-KINASE | TUMOR-CELLS | MYELOGENOUS LEUKEMIA-CELLS | RADIOSENSITIZING AGENT | MAMMALIAN-CELLS | CHK1 INHIBITOR | Protein Kinases - metabolism | Protein Kinases - genetics | Humans | Ovarian Neoplasms - pathology | Cell Survival - genetics | Deoxycytidine - pharmacology | Immunoblotting | Sulfones - pharmacology | Cell Cycle Proteins - antagonists & inhibitors | Dose-Response Relationship, Drug | Ovarian Neoplasms - genetics | RNA Interference | BRCA1 Protein - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Female | Antineoplastic Agents - pharmacology | Ovarian Neoplasms - metabolism | Phosphorylation - drug effects | cdc25 Phosphatases - metabolism | Protein-Serine-Threonine Kinases - metabolism | Pyrazoles - pharmacology | Cell Survival - drug effects | Topotecan - pharmacology | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Signal Transduction - genetics | cdc25 Phosphatases - genetics | Ataxia Telangiectasia Mutated Proteins | Cisplatin - pharmacology | Pyrimidines - pharmacology | Poly(ADP-ribose) Polymerase Inhibitors | BRCA1 Protein - genetics | Poly(ADP-ribose) Polymerases - metabolism | BRCA2 Protein - metabolism | Signal Transduction - drug effects | Cell Line, Tumor | Benzimidazoles - pharmacology | Checkpoint Kinase 1 | Pyrazines - pharmacology | BRCA2 Protein - genetics | Deoxycytidine - analogs & derivatives | homologous recombination | ovarian cancer | Poly(ADP-ribose) polymerase | veliparib | gemcitabine | BRCA1 | cisplatin | BRCA2 | topotecan
Journal Article
Science, ISSN 0036-8075, 03/2017, Volume 355, Issue 6330, pp. 1152 - 1158
Journal Article
Nature medicine, ISSN 1078-8956, 2017, Volume 23, Issue 4, pp. 517 - +
Journal Article
Science Signaling, ISSN 1945-0877, 03/2011, Volume 4, Issue 166, pp. ra19 - ra19
Cancer cells acquire resistance to DNA-damaging therapeutic agents, such as cisplatin, but the genetic mechanisms through which this occurs remain unclear. We... 
BREAST-CANCER | APOPTOSIS | PROTEIN | EPITHELIAL-CELLS | TELOMERASE | DNA-DAMAGE | TUMOR-SUPPRESSOR | DEATH | TARGET GENE | EXPRESSION | CELL BIOLOGY | Neoplasms - metabolism | G2 Phase - genetics | Transcriptional Activation - genetics | Humans | Transcriptional Activation - drug effects | Protein Inhibitors of Activated STAT - metabolism | DNA Repair - genetics | G2 Phase - drug effects | Neoplasms - genetics | Tumor Suppressor Proteins - genetics | Protein Inhibitors of Activated STAT - genetics | DNA Damage - genetics | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Nuclear Proteins - genetics | Gene Expression Regulation, Neoplastic - genetics | Cell Division - genetics | DNA Repair - drug effects | Tumor Suppressor Proteins - metabolism | Nuclear Proteins - metabolism | Cisplatin - pharmacology | Nerve Tissue Proteins - genetics | Proto-Oncogene Proteins c-myc - metabolism | Cell Division - drug effects | Neoplasms - drug therapy | Nerve Tissue Proteins - metabolism | Drug Resistance, Neoplasm - genetics | Poly(ADP-ribose) Polymerases - metabolism | Animals | Poly(ADP-ribose) Polymerases - genetics | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Mice | Proto-Oncogene Proteins c-myc - genetics | Poly (ADP-Ribose) Polymerase-1 | Adaptor Proteins, Signal Transducing - metabolism | Drug Resistance, Neoplasm - drug effects
Journal Article
Lancet Oncology, The, ISSN 1470-2045, 2017, Volume 18, Issue 1, pp. 75 - 87
Summary Background Poly(ADP-ribose) polymerase (PARP) inhibitors have activity in ovarian carcinomas with homologous recombination deficiency. Along with BRCA1... 
Hematology, Oncology and Palliative Medicine | POLY(ADP-RIBOSE) POLYMERASE | OLAPARIB | ONCOLOGY | HOMOLOGOUS RECOMBINATION DEFICIENCY | MUTANT-CELLS | DNA-REPAIR | CANCER | HETEROZYGOSITY | TUMORS | BREAST | GENOMIC LOSS | Prognosis | Prospective Studies | Follow-Up Studies | Humans | Middle Aged | Ovarian Neoplasms - pathology | Salvage Therapy | Neoplasm Recurrence, Local - drug therapy | Germ-Line Mutation - genetics | Neoplasm Recurrence, Local - pathology | Ovarian Neoplasms - genetics | Neoplasms, Glandular and Epithelial - genetics | Peritoneal Neoplasms - drug therapy | Fallopian Tube Neoplasms - genetics | Female | Antineoplastic Agents - pharmacology | Poly(ADP-ribose) Polymerases - chemistry | Ovarian Neoplasms - drug therapy | Platinum - pharmacology | Fallopian Tube Neoplasms - drug therapy | Peritoneal Neoplasms - pathology | Neoplasms, Glandular and Epithelial - pathology | Fallopian Tube Neoplasms - pathology | Survival Rate | Poly(ADP-ribose) Polymerase Inhibitors - therapeutic use | BRCA1 Protein - genetics | International Agencies | Peritoneal Neoplasms - genetics | Neoplasms, Glandular and Epithelial - drug therapy | Carcinoma, Ovarian Epithelial | Indoles - therapeutic use | Neoplasm Recurrence, Local - genetics | Aged | Neoplasm Staging | BRCA2 Protein - genetics | Drug Resistance, Neoplasm - drug effects | Sugars | Monosaccharides | Ovarian cancer | Analysis | Carcinoma | Cancer
Journal Article
Lancet Oncology, The, ISSN 1470-2045, 2013, Volume 14, Issue 9, pp. 882 - 892
Journal Article
Journal of Immunology, ISSN 0022-1767, 12/2012, Volume 189, Issue 11, pp. 5304 - 5313
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 01/2015, Volume 33, Issue 3, pp. 244 - 250
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 06/2015, Volume 35, Issue 23, pp. 8882 - 95
Journal Article