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PLoS ONE, ISSN 1932-6203, 07/2014, Volume 9, Issue 7, p. e102148
Spontaneously hypertensive rat (SHR) is a suitable model for studies of the complications of hypertension. It is known that activation of poly(ADP-ribose)... 
APOPTOSIS | SIGNALING PATHWAYS | OXIDATIVE STRESS | ACTIVATION | ENDOTHELIAL DYSFUNCTION | MULTIDISCIPLINARY SCIENCES | RATS | ANGIOTENSIN-II | ISCHEMIA-REPERFUSION | FAILURE | LEFT-VENTRICULAR HYPERTROPHY | Protein Kinase C - genetics | Phosphorylation | Natriuretic Peptide, Brain - metabolism | Heart Failure - physiopathology | Rats, Inbred WKY | Glycogen Synthase Kinase 3 beta | Hypertension - drug therapy | Male | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Proto-Oncogene Proteins c-akt - genetics | Heart Failure - prevention & control | Hypertrophy, Left Ventricular - genetics | Piperidines - pharmacology | Forkhead Transcription Factors - metabolism | Isoenzymes - metabolism | Protein Kinase C - metabolism | Blood Pressure - drug effects | HSP90 Heat-Shock Proteins - genetics | Hypertension - genetics | Hypertrophy, Left Ventricular - drug therapy | Proto-Oncogene Proteins c-akt - metabolism | Heart Failure - etiology | Rats, Inbred SHR | Natriuretic Peptide, Brain - genetics | Signal Transduction | Isoenzymes - genetics | Hypertrophy, Left Ventricular - etiology | Rats | Heart Failure - genetics | Forkhead Transcription Factors - genetics | Glycogen Synthase Kinase 3 - metabolism | Nerve Tissue Proteins - genetics | Poly(ADP-ribose) Polymerase Inhibitors | Hypertension - physiopathology | Gene Expression Regulation - drug effects | Nerve Tissue Proteins - metabolism | Poly(ADP-ribose) Polymerases - metabolism | Animals | Poly(ADP-ribose) Polymerases - genetics | Glycogen Synthase Kinase 3 - genetics | HSP90 Heat-Shock Proteins - metabolism | Hypertension - complications | Hypertrophy, Left Ventricular - physiopathology | Quinazolines - pharmacology | Heart | Brain | Protein kinase C | Poly(ADP-ribose) | AKT protein | Biochemistry | ADP | Blood | Proteins | Signal transduction | Ischemia | Forkhead protein | Blood pressure | Heart failure | Enzymes | Echocardiography | Chemistry | Inhibitors | Isoforms | Fibrosis | Hypertrophy | Hsp90 protein | Congestive heart failure | Kinases | Remodeling | Medical schools | Ribose | Rodents | Cardiology | Pharmaceutical sciences | Hypertension | Brain natriuretic peptide | AKT1 protein | Isoenzymes | Complications | Glycogen | Heat shock proteins | Extracellular signal-regulated kinase | Glycogen synthase kinase 3 | Poly(ADP-ribose) polymerase | Cardiomyocytes | Medicine | Polymerase | Collagen | Ventricle | Laboratory animals | Heat shock | Apoptosis
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 08/2017, Volume 23, Issue 15, pp. 4095 - 4106
Journal Article
Journal of Immunology, ISSN 0022-1767, 12/2013, Volume 191, Issue 12, pp. 5959 - 5972
TNF-α is a cytokine involved in systemic inflammation and regulation of immune cells. It is produced chiefly by activated macrophages as a membrane or secreted... 
Recombinant Fusion Proteins - pharmacology | Species Specificity | Tumor Necrosis Factor-alpha - genetics | Antimicrobial Cationic Peptides - biosynthesis | Molecular Sequence Data | Phylogeny | Protein Isoforms - isolation & purification | Recombinant Fusion Proteins - metabolism | Fishes - immunology | Yersinia Infections - metabolism | Yersinia Infections - veterinary | Protein Isoforms - chemistry | Yersinia ruckeri | Base Sequence | Phytohemagglutinins - pharmacology | Fish Diseases - immunology | Novirhabdovirus | Antimicrobial Cationic Peptides - genetics | Oncorhynchus mykiss - immunology | Cytokines - genetics | Oncorhynchus mykiss - metabolism | Amino Acid Sequence | Cell Line | Fishes - genetics | Poly I-C - pharmacology | Rhabdoviridae Infections - veterinary | Rhabdoviridae Infections - metabolism | Oncorhynchus mykiss - genetics | Organ Specificity | Tumor Necrosis Factor-alpha - isolation & purification | Protein Isoforms - physiology | Gene Expression Regulation - drug effects | Sequence Homology, Amino Acid | Macrophages - metabolism | Sequence Alignment | Animals | Tumor Necrosis Factor-alpha - chemistry | Rhabdoviridae Infections - immunology | Lipopolysaccharides - pharmacology | Tumor Necrosis Factor-alpha - physiology | Tumor Necrosis Factor-alpha - classification | Peptidoglycan - pharmacology | Yersinia Infections - immunology | Cytokines - biosynthesis | Interferon-gamma - pharmacology | Fish Diseases - metabolism
Journal Article
Nature Reviews Clinical Oncology, ISSN 1759-4774, 12/2010, Volume 7, Issue 12, pp. 683 - 692
This Review outlines the understanding and management of triple-negative breast cancer (TNBC). TNBC shares morphological and genetic abnormalities with... 
EPITHELIAL-MESENCHYMAL TRANSITION | EXPRESSION PATTERNS | MOLECULAR SUBTYPES | POLY(ADP-RIBOSE) POLYMERASE | ONCOLOGY | BASAL-LIKE SUBTYPE | PHASE-II | GENE AMPLIFICATION | ESTROGEN-RECEPTOR STATUS | PROGESTERONE-RECEPTOR | PROGNOSTIC MARKERS | Carcinoma, Ductal, Breast - genetics | Prognosis | Humans | Gene Expression Regulation, Neoplastic | Drug Resistance, Neoplasm | Antineoplastic Agents - therapeutic use | Gene Expression Profiling | Receptors, Estrogen - analysis | Receptors, Progesterone - genetics | Carcinoma, Ductal, Breast - chemistry | Breast Neoplasms - therapy | Carcinoma, Ductal, Breast - classification | Receptors, Progesterone - analysis | Breast Neoplasms - chemistry | Neoplasm Metastasis | Carcinoma, Ductal, Breast - pathology | Female | Antineoplastic Agents - pharmacology | Genes, BRCA1 | Antineoplastic Agents - classification | BRCA1 Protein - deficiency | Neoplasm Proteins - genetics | Breast Neoplasms - classification | Receptors, Estrogen - genetics | Neoplasm Invasiveness | Neoplasm Proteins - biosynthesis | Neoplasm Recurrence, Local | BRCA1 Protein - physiology | Combined Modality Therapy | Carcinoma, Ductal, Breast - therapy | Mitotic Index | Breast Neoplasms - genetics | Case Management | Breast Neoplasms - pathology | Genes, erbB-2 | Receptors, Estrogen - biosynthesis | Neoplasm Proteins - analysis | Receptor, ErbB-2 - analysis | Receptors, Progesterone - biosynthesis | Chemotherapy | BRCA mutations | Breast cancer | Genetic aspects | Diagnosis | Research | Drug therapy | Health aspects | Risk factors | Cancer
Journal Article
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 06/2015, Volume 33, Issue 17, pp. 1895 - 1901
Journal Article
Genes and Development, ISSN 0890-9369, 04/2003, Volume 17, Issue 8, pp. 1030 - 1042
Transcription and processing of pre-mRNA are coupled events. By using a combination of biochemical, molecular, and genetic methods, we have found that the... 
Transcription termination | 3′ end processing | Cleavage/polyadenylation | RNAP II | Transcription initiation | RNA-POLYMERASE-II | EM VISUALIZATION | transcription initiation | PROTEIN | transcription termination | cleavage/polyadenylation | AFFINITY PURIFICATION | DEVELOPMENTAL BIOLOGY | SACCHAROMYCES-CEREVISIAE | PRE-MESSENGER-RNA | YEAST | POLY(A) SIGNAL | GENETICS & HEREDITY | GENE-EXPRESSION | 3 ' end processing | COACTIVATOR PC4 | RNA Precursors - chemistry | Transcription Factor TFIIB - metabolism | Saccharomyces cerevisiae - genetics | mRNA Cleavage and Polyadenylation Factors - metabolism | Transcriptional Activation | mRNA Cleavage and Polyadenylation Factors - chemistry | 3' Untranslated Regions - genetics | 3' Untranslated Regions - metabolism | Transcription Factor TFIIB - genetics | RNA Polymerase II - metabolism | DNA Primers - chemistry | Recombinant Fusion Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Polymerase Chain Reaction | RNA Precursors - metabolism | Transcription, Genetic | Phosphoprotein Phosphatases | Poly A | Mutagenesis, Site-Directed | RNA Processing, Post-Transcriptional | RNA Precursors - genetics | Terminator Regions, Genetic | Saccharomyces cerevisiae Proteins - genetics | Mutation - genetics | Precipitin Tests | Carrier Proteins - genetics | Carrier Proteins - metabolism | Chromatography, Affinity | Escherichia coli - genetics | Saccharomyces cerevisiae Proteins - metabolism | Trans-Activators - metabolism | In Vitro Techniques | Saccharomyces cerevisiae Proteins - chemistry | Suppression, Genetic | Messenger RNA | Analysis | Genetic research | Physiological aspects | Genetic aspects | Biochemistry | Genetic transcription | Research | Phylogeny | Gene expression | Brewer's yeast | polyadenylation | cleavage | Research Paper
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2016, Volume 291, Issue 29, pp. 15093 - 15107
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 02/2014, Volume 208, Issue 1, pp. 47 - 57
HIMOXOL (methyl 3-hydroxyimino-11-oxoolean-12-en-28-oate) is a synthetic derivative of oleanolic acid (OA). HIMOXOL revealed the highest cytotoxic effect among... 
Breast cancer | Autophagy | HIMOXOL | Apoptosis | SIGNALING PATHWAYS | ACTIVATED PROTEIN-KINASE | TRITERPENOIDS | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | SUPPRESSES MIGRATION | DEATH | PROSTATE-CANCER | PHARMACOLOGY & PHARMACY | TOXICOLOGY | MULTIDRUG-RESISTANCE | NF-KAPPA-B | Cell Cycle - genetics | Microtubule-Associated Proteins - genetics | Apoptosis - drug effects | Microtubule-Associated Proteins - metabolism | Humans | Oleanolic Acid - analogs & derivatives | Caspase 3 - metabolism | Caspase 8 - metabolism | Cell Survival - genetics | Oleanolic Acid - pharmacology | Apoptosis - genetics | NF-kappa B - metabolism | Autophagy - drug effects | Breast Neoplasms - metabolism | Caspase 8 - genetics | Proto-Oncogene Proteins c-bcl-2 - metabolism | Cell Death - genetics | Caspase 3 - genetics | Apoptosis Regulatory Proteins - genetics | Female | Antineoplastic Agents - pharmacology | Membrane Proteins - metabolism | Autophagy - genetics | Cell Death - drug effects | bcl-2-Associated X Protein - genetics | Beclin-1 | Cell Survival - drug effects | Membrane Proteins - genetics | bcl-2-Associated X Protein - metabolism | Up-Regulation - genetics | Signal Transduction - genetics | Breast Neoplasms - drug therapy | Apoptosis Regulatory Proteins - metabolism | Up-Regulation - drug effects | Poly(ADP-ribose) Polymerases - metabolism | Breast Neoplasms - genetics | Poly(ADP-ribose) Polymerases - genetics | NF-kappa B - genetics | Signal Transduction - drug effects | Cell Line, Tumor | Mitogen-Activated Protein Kinases - genetics | Poly (ADP-Ribose) Polymerase-1 | Cell Cycle - drug effects | Proto-Oncogene Proteins c-bcl-2 - genetics | Mitogen-Activated Protein Kinases - metabolism | Tumor proteins | Cancer cells
Journal Article