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Genes and Development, ISSN 0890-9369, 06/2004, Volume 18, Issue 11, pp. 1272 - 1282
Necrosis has been considered a passive form of cell death in which the cell dies as a result of a bioenergetic catastrophe imposed by external conditions.... 
Alkylating DNA damage | Bax | PARP | Metabolism | Bak | Necrosis | p53 | APOPTOSIS | POLY(ADP-RIBOSE) POLYMERASE GENE | DEVELOPMENTAL BIOLOGY | RELEASE | alkylating DNA damage | BCL-2 | CHROMATIN PROTEIN | MICE RESISTANT | necrosis | GLUCOSE-METABOLISM | DISEASE | GENETICS & HEREDITY | metabolism | ENDOPLASMIC-RETICULUM | Tumor Necrosis Factor-alpha - metabolism | Inflammation - pathology | Alkylating Agents - pharmacology | Molecular Sequence Data | Tumor Suppressor Protein p53 - genetics | Poly(ADP-ribose) Polymerases - drug effects | Inflammation - metabolism | DNA Damage - physiology | Mice, Mutant Strains | Adenosine Triphosphate - metabolism | Base Sequence | HMGB1 Protein - metabolism | Membrane Proteins - metabolism | NAD - metabolism | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - drug effects | Macrophages - pathology | Membrane Proteins - genetics | Cells, Cultured | Tumor Suppressor Protein p53 - metabolism | Proto-Oncogene Proteins - genetics | bcl-2-Associated X Protein | Enzyme Activation - drug effects | Fibroblasts - pathology | Tumor Suppressor Protein p53 - drug effects | Macrophages - metabolism | Poly(ADP-ribose) Polymerases - metabolism | Animals | bcl-2 Homologous Antagonist-Killer Protein | Membrane Proteins - drug effects | Macrophages - drug effects | Mice | Proto-Oncogene Proteins c-bcl-2 | Proteins | Research | Cell death | DNA repair | DNA damage | Index Medicus | Research Papers
Journal Article
Journal of Investigative Dermatology, ISSN 0022-202X, 02/2007, Volume 127, Issue 2, pp. 331 - 341
Keratinocytes are continuously in contact with external stimuli and have the capacity to produce several soluble mediators. Pathogen-associated molecular... 
TOLL-LIKE-RECEPTORS | DOUBLE-STRANDED-RNA | DENDRITIC CELLS | SKIN-ASSOCIATED CHEMOKINE | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | INNATE IMMUNE-RESPONSE | INFLAMMATORY PROTEIN 3-ALPHA | NECROSIS-FACTOR-ALPHA | FACTOR-KAPPA-B | HUMAN EPIDERMAL-KERATINOCYTES | DERMATOLOGY | Oligonucleotides - genetics | Phosphorylation | Toll-Like Receptor 5 - genetics | Humans | Toll-Like Receptor 9 - genetics | I-kappa B Proteins - metabolism | RNA, Messenger - metabolism | Flagellin - pharmacology | Tissue Distribution | Cell Nucleus - metabolism | Protein Isoforms - metabolism | Biological Transport | Oligonucleotides - pharmacology | Toll-Like Receptor 3 - genetics | Toll-Like Receptors - metabolism | Chemokine CXCL9 | Toll-Like Receptor 5 - metabolism | Poly I-C - pharmacology | Cytokines - metabolism | Cells, Cultured | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 3 - metabolism | Toll-Like Receptor 4 - metabolism | Chemokine CXCL10 | Transcription Factor RelA - metabolism | Keratinocytes - metabolism | Toll-Like Receptors - genetics | Chemokines, CXC - metabolism | Lipopolysaccharides - pharmacology | CpG Islands | Ligands | Chemokines - metabolism | Toll-Like Receptor 9 - metabolism | CD40 antigen | Oligonucleotides | Flagellin | mRNA | intercellular adhesion molecule 1 | Immunity | Lipopolysaccharides | CXC chemokines | CCL20 protein | Toll-like receptors | CpG islands | TLR7 protein | Dermatology | Keratinocytes | Nuclear transport | Stress | TLR3 protein | TLR9 protein | TLR1 protein | External stimuli | CXCL10 protein | Histocompatibility antigen HLA | Interferon | Internet | Monocyte chemoattractant protein 1 | Tumor necrosis factor- alpha | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2010, Volume 107, Issue 28, pp. 12611 - 12616
Asbestos carcinogenesis has been linked to the release of cytokines and mutagenic reactive oxygen species (ROS) from inflammatory cells. Asbestos is cytotoxic... 
Actinomycin | Asbestos | Cell death | Secretion | Plasma cells | Inflammation | Macrophages | Carcinogenesis | Necrosis | Apoptosis | Mesothelioma | Biomarker | Tumor necrosis factor-alpha | Chemoprevention | TRANSFORMATION | POLY(ADP-RIBOSE) POLYMERASE | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | CROCIDOLITE ASBESTOS | HMGB1 | biomarker | MAMMALIAN-CELLS | tumor necrosis factor-alpha | PATHOGENESIS | chemoprevention | NECROTIC CELLS | carcinogenesis | TNF-ALPHA | INHIBITORS | mesothelioma | Tumor Necrosis Factor-alpha - metabolism | Asbestos - metabolism | Epithelial Cells - metabolism | Reactive Oxygen Species - metabolism | Humans | Reactive Oxygen Species - pharmacology | Adenosine Diphosphate Ribose - metabolism | Adenosine Diphosphate Ribose - pharmacology | Carcinogens - metabolism | Asbestos - pharmacology | Pleural Neoplasms - metabolism | Inflammation - metabolism | Carcinogens - pharmacology | Cell Nucleus - metabolism | HMGB Proteins - pharmacology | HMGB1 Protein - pharmacology | HMGB1 Protein - metabolism | Cell Death | Mesocricetus | Female | HMGB Proteins - metabolism | Poly Adenosine Diphosphate Ribose - pharmacology | Epithelium - drug effects | Cricetinae | Cytokines - metabolism | Epithelium - metabolism | Hydrogen Peroxide - pharmacology | Necrosis - metabolism | Hydrogen Peroxide - metabolism | Tumor Necrosis Factor-alpha - pharmacology | Macrophages - metabolism | Poly(ADP-ribose) Polymerases - metabolism | Animals | Mesothelioma - metabolism | Poly(ADP-ribose) Polymerases - pharmacology | Cells - metabolism | Mice | Mice, Inbred BALB C | Cytokines - pharmacology | Prevention | Mesothelium | Chromosomal proteins | Research | Chemical properties | Health aspects | Proteins | Carcinogens | Cytokines | Oncology | Biochemistry | Cells | Index Medicus | Reactive oxygen species | Transformation | Deposits | Hydrogen peroxide | Cytotoxicity | HMGB1 protein | Nuclei | Tumor necrosis factor-a | ATP | Cytoplasm | Biological Sciences
Journal Article
Advanced Materials, ISSN 0935-9648, 11/2013, Volume 25, Issue 42, pp. 6123 - 6127
Journal Article
Journal Article
Biological Psychiatry, ISSN 0006-3223, 2010, Volume 68, Issue 12, pp. 1172 - 1181
Background Gene-environment interactions (GEI) are involved in the pathogenesis of mental diseases. We evaluated interaction between mutant human... 
Psychiatry | mouse models | Tet-off system | schizophrenia | DISC1 | gene-environment interactions | mood disorders | PSYCHIATRY | BEHAVIORAL PHENOTYPES | BIPOLAR DISORDER | NEUROSCIENCES | PREFRONTAL CORTEX | GENOMIC STRUCTURE | DENDRITIC SPINE DENSITY | INFECTION | SCHIZOPHRENIA RISK | INDUCIBLE EXPRESSION | Mood Disorders - genetics | Prenatal Exposure Delayed Effects - psychology | Microtubule-Associated Proteins - metabolism | Glycogen Synthase Kinase 3 beta | Male | Brain - metabolism | Mice, Mutant Strains | Stress, Psychological - metabolism | Atrophy - genetics | Behavior, Animal - drug effects | Female | Corticosterone - blood | Disease Models, Animal | Animals, Newborn | Poly I-C - pharmacology | Cytokine Receptor gp130 - metabolism | Cytokines - metabolism | Mice, Transgenic | Glycogen Synthase Kinase 3 - metabolism | Nerve Tissue Proteins - genetics | Prenatal Exposure Delayed Effects - metabolism | Pregnancy | Prenatal Exposure Delayed Effects - genetics | 1-Alkyl-2-acetylglycerophosphocholine Esterase - metabolism | Animals | Carrier Proteins - metabolism | Prenatal Exposure Delayed Effects - immunology | Mood Disorders - pathology | Dendritic Spines - pathology | Brain - pathology | Mice | Biogenic Monoamines - metabolism | GRB2 Adaptor Protein - metabolism | Atrophy - metabolism | Brain - immunology | Mood Disorders - metabolism | Psychological aspects | Schizophrenia | Neurosciences | Universities and colleges | Pregnant women | Analysis | Index Medicus
Journal Article
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 2014, Volume 350, Issue 1, pp. 22 - 35
Identification of therapeutic strategies that might enhance the efficacy of B-cell lymphoma-2 (Bcl-2) inhibitor ABT-737 [N-{4-[4(... 
MALIGNANT GLIOMA-CELLS | APOPTOSIS-INDUCING LIGAND | LYMPHOMA-CELLS | BAX ACTIVATION | SOLID TUMORS | MIMETIC ABT-737 TARGETS | BCL-2 FAMILY PROTEINS | PHARMACOLOGY & PHARMACY | MCL-1 DOWN-REGULATION | MEMBRANE PERMEABILIZATION | BRAIN-TUMORS | Glioblastoma - enzymology | Phosphatidylinositol 3-Kinase - antagonists & inhibitors | Humans | Caspase 3 - metabolism | Caspase 8 - metabolism | Piperazines - toxicity | Intracellular Signaling Peptides and Proteins - metabolism | Chromosome Segregation - drug effects | Membrane Potential, Mitochondrial - drug effects | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Biphenyl Compounds - toxicity | Proto-Oncogene Proteins c-bcl-2 - metabolism | Caspases - metabolism | Bcl-2-Like Protein 11 | Glioblastoma - genetics | Mitochondrial Proteins - metabolism | Glioblastoma - metabolism | Antineoplastic Agents - pharmacology | Proto-Oncogene Proteins | Cell Death - drug effects | Apoptosis Inducing Factor - metabolism | DNA Damage - drug effects | Cytochromes c - metabolism | bcl-2-Associated X Protein - metabolism | Morpholines - pharmacology | Mitochondria - metabolism | Mitochondria - drug effects | Mitochondria - pathology | Nitrophenols - toxicity | Drug Synergism | Membrane Proteins | Poly(ADP-ribose) Polymerases - metabolism | Apoptosis Regulatory Proteins | Signal Transduction - drug effects | Aminopyridines - pharmacology | Glioblastoma - pathology | Cell Line, Tumor | Sulfonamides - toxicity | Primary Cell Culture | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Index Medicus | Cellular and Molecular
Journal Article
Diabetes, ISSN 0012-1797, 01/2012, Volume 61, Issue 1, pp. 217 - 228
Cellular metabolic memory occurs in diabetic microvascular and macrovascular complications, but the underlying mechanisms remain unclear. Here, we investigate... 
INTIMA-MEDIA THICKNESS | IN-VITRO | ACTIVATED PROTEIN-KINASE | OXYGEN SPECIES PATHWAY | INHIBITION | TYPE-1 DIABETES-MELLITUS | INSULIN-RESISTANCE | ENDOTHELIAL-CELLS | ENDOCRINOLOGY & METABOLISM | UP-REGULATION | HYPERGLYCEMIC DAMAGE | Retina - drug effects | Sirtuin 1 - metabolism | Gene Expression Regulation, Enzymologic - drug effects | Diabetes Mellitus, Experimental - drug therapy | Retina - metabolism | Metformin - therapeutic use | Reactive Oxygen Species - metabolism | Reactive Oxygen Species - pharmacology | NF-kappa B - metabolism | Sirtuin 1 - genetics | Diabetes Mellitus, Experimental - blood | Osmolar Concentration | Cattle | Adenylate Kinase - metabolism | Adenylate Kinase - physiology | Diabetes Mellitus, Experimental - metabolism | Endothelial Cells - physiology | Protein-Serine-Threonine Kinases - metabolism | Hypoglycemic Agents - therapeutic use | Endothelial Cells - metabolism | Protein-Serine-Threonine Kinases - physiology | Metformin - pharmacology | Cells, Cultured | bcl-2-Associated X Protein - metabolism | Rats | Hypoglycemic Agents - pharmacology | Metabolic Networks and Pathways - genetics | Animals | Sirtuin 1 - physiology | Diabetes Mellitus, Experimental - pathology | Metabolic Networks and Pathways - drug effects | Blood Glucose - metabolism | Retina - pathology | Endothelial Cells - drug effects | Hyperglycemia | Physiological aspects | Development and progression | Research | Diabetes | Glucose | Adenylic acid | Dextrose | Sirtuins | Oxygen | Bax protein | Diabetes mellitus | Memory | Poly(ADP-ribose) polymerase | Retina | AMP-activated protein kinase | SIRT1 protein | Endothelial cells | Stress | LKB1 protein | Mitochondria | NF- Kappa B protein | Glyceraldehyde-3-phosphate dehydrogenase | Metformin | Apoptosis | Index Medicus | Abridged Index Medicus | Complications
Journal Article