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Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity
Cancer cell, ISSN 1535-6108, 12/2004, Volume 6, Issue 6, pp. 611 - 623
Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Gene Expression - genetics | Virus Replication - genetics | Humans | Viral Proteins - metabolism | Cytopathogenic Effect, Viral - genetics | Caspase 3 | RNA Transport | Capsid Proteins - metabolism | HCT116 Cells | Cell Cycle Proteins - metabolism | In Situ Hybridization, Fluorescence | Caspase Inhibitors | Blotting, Western | Proto-Oncogene Proteins c-mdm2 | Models, Biological | Adenovirus E1A Proteins - genetics | Epithelial Cells - virology | Viral Nonstructural Proteins - metabolism | Adenoviruses, Human - genetics | Adenoviridae - metabolism | Mutation | Adenoviruses, Human - metabolism | Capsid Proteins - genetics | Neoplasms - metabolism | Epithelial Cells - metabolism | DNA, Viral - biosynthesis | Neoplasms - virology | Caspases - metabolism | Neoplasms - genetics | Adenovirus E1A Proteins - metabolism | Polymerase Chain Reaction | Adenoviridae - genetics | Cell Cycle Proteins - genetics | Protein Biosynthesis - genetics | RNA, Viral - metabolism | Adenovirus E1B Proteins - metabolism | Nuclear Proteins - genetics | Adenovirus E1B Proteins - genetics | Proto-Oncogene Proteins - metabolism | Epithelial Cells - radiation effects | Cyclin-Dependent Kinase Inhibitor p21 | Cells, Cultured | Tumor Suppressor Protein p53 - metabolism | Viral Nonstructural Proteins - genetics | Viral Plaque Assay | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | bcl-2-Associated X Protein | Poly(ADP-ribose) Polymerases - metabolism | Viral Vaccines | Tumor Suppressor Protein p14ARF - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Apoptosis | Index Medicus
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Loading RightsBiomaterials, ISSN 0142-9612, 2011, Volume 32, Issue 23, pp. 5438 - 5458
Advanced Basic Science | Dentistry | Oxidative stress | Mitochondria | Caspase-dependent apoptosis | Endoplasmic reticulum | Alginate oligosaccharide | PC12 cells | Engineering | Materials Science | Technology | Engineering, Biomedical | Materials Science, Biomaterials | Science & Technology | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Calcium - metabolism | Glutathione - metabolism | Amyloid beta-Peptides - pharmacology | Oxidative Stress - physiology | Caspase 3 - metabolism | Endoplasmic Reticulum - metabolism | NF-kappa B - metabolism | Neurons - cytology | Peptide Fragments - pharmacology | Extracellular Signal-Regulated MAP Kinases - metabolism | PC12 Cells | Oligosaccharides - pharmacology | Proto-Oncogene Proteins c-bcl-2 - metabolism | Apoptosis Inducing Factor - pharmacology | Cell Nucleus - metabolism | Endoplasmic Reticulum - drug effects | Oxidation-Reduction - drug effects | Neurons - metabolism | Phosphorylation - drug effects | Glucuronic Acid - chemistry | Neurons - drug effects | Polysaccharide-Lyases - chemistry | Apoptosis Inducing Factor - metabolism | Cell Survival - drug effects | Cytochromes c - metabolism | Hydrogen Peroxide - pharmacology | Tumor Suppressor Protein p53 - metabolism | bcl-2-Associated X Protein - metabolism | Rats | Mitochondria - metabolism | Caspase 12 - metabolism | Hexuronic Acids - chemistry | Mitochondria - drug effects | HSP70 Heat-Shock Proteins - metabolism | Cell Shape - drug effects | Poly(ADP-ribose) Polymerases - metabolism | Animals | Models, Biological | Alginates - chemistry | NF-E2-Related Factor 2 - metabolism | HSP90 Heat-Shock Proteins - metabolism | Apoptosis - physiology | Oxidative Stress - drug effects | Cell Nucleus - drug effects | Neurosciences | Nervous system diseases | Biological products | Hydrogen peroxide | Heat shock proteins | Nerve growth factor | Superoxide | Mitochondrial DNA | Biochemistry | Antioxidants | Tumor proteins | Protein kinases | Alzheimer's disease | Apoptosis | Stresses | Surgical implants | Biomedical materials | Cell death | Cascades | Blocking | Activation | Kinases | Index Medicus
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Loading RightsGenes & development, ISSN 0890-9369, 06/2004, Volume 18, Issue 11, pp. 1272 - 1282
Alkylating DNA damage | Bax | PARP | Metabolism | Bak | Necrosis | p53 | Genetics & Heredity | Life Sciences & Biomedicine | Developmental Biology | Science & Technology | Cell Biology | Tumor Necrosis Factor-alpha - metabolism | Inflammation - pathology | Alkylating Agents - pharmacology | Molecular Sequence Data | Tumor Suppressor Protein p53 - genetics | Poly(ADP-ribose) Polymerases - drug effects | Inflammation - metabolism | DNA Damage - physiology | Mice, Mutant Strains | Adenosine Triphosphate - metabolism | Base Sequence | HMGB1 Protein - metabolism | Membrane Proteins - metabolism | NAD - metabolism | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - drug effects | Macrophages - pathology | Membrane Proteins - genetics | Cells, Cultured | Tumor Suppressor Protein p53 - metabolism | Proto-Oncogene Proteins - genetics | bcl-2-Associated X Protein | Enzyme Activation - drug effects | Fibroblasts - pathology | Tumor Suppressor Protein p53 - drug effects | Macrophages - metabolism | Poly(ADP-ribose) Polymerases - metabolism | Animals | bcl-2 Homologous Antagonist-Killer Protein | Membrane Proteins - drug effects | Macrophages - drug effects | Mice | Proto-Oncogene Proteins c-bcl-2 | Proteins | Research | Cell death | DNA repair | DNA damage | Index Medicus | Research Papers | necrosis | metabolism
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Loading RightsMolecular cell, ISSN 1097-2765, 04/2008, Volume 30, Issue 1, pp. 11 - 25
SYSBIO | CELLCYCLE | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Mathematics | Mitochondrial Proteins - genetics | Recombinant Fusion Proteins - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | Caspases - metabolism | RNA Interference | Mitochondrial Proteins - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Models, Theoretical | Mitochondria - metabolism | Membrane Potentials - physiology | TNF-Related Apoptosis-Inducing Ligand - metabolism | X-Linked Inhibitor of Apoptosis Protein - genetics | Poly(ADP-ribose) Polymerases - metabolism | Poly(ADP-ribose) Polymerases - genetics | X-Linked Inhibitor of Apoptosis Protein - metabolism | Recombinant Fusion Proteins - genetics | Luminescent Proteins - genetics | Signal Transduction - physiology | Apoptosis - physiology | Enzyme Activation | HeLa Cells | Proto-Oncogene Proteins c-bcl-2 - genetics | TNF-Related Apoptosis-Inducing Ligand - genetics | Luminescent Proteins - metabolism | Analysis | Apoptosis | Index Medicus | Bcl-2 | proteasome | TRAIL | biological modeling | FRET reporter | apoptosis | XIAP | TNF | caspase | computational
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Loading RightsCancer cell, ISSN 1535-6108, 2008, Volume 14, Issue 3, pp. 250 - 262
CHEMBIO | CELLCYCLE | Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Neoplasms - metabolism | RNA, Small Interfering - genetics | Apoptosis - drug effects | HSC70 Heat-Shock Proteins - metabolism | Humans | HSP72 Heat-Shock Proteins - genetics | Protease Inhibitors - pharmacology | Ubiquitination | Protein Isoforms - metabolism | Transfection | Neoplasms - genetics | Cell Line | HSC70 Heat-Shock Proteins - genetics | Bortezomib | HCT116 Cells | HSP72 Heat-Shock Proteins - metabolism | Cyclin-Dependent Kinase 4 - metabolism | Lactams, Macrocyclic - pharmacology | Proto-Oncogene Proteins c-raf - metabolism | HSP70 Heat-Shock Proteins - metabolism | Benzoquinones - pharmacology | Poly(ADP-ribose) Polymerases - metabolism | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Cell Line, Tumor | HSP90 Heat-Shock Proteins - metabolism | Cell Proliferation - drug effects | Apoptosis - physiology | Kinetics | Proteasome Endopeptidase Complex - metabolism | Cell Cycle - drug effects | Neoplasms - pathology | Proteasome Inhibitors | Pyrazines - pharmacology | Boronic Acids - pharmacology | Protein Isoforms - genetics | Proteins | Oncology, Experimental | Heat shock proteins | Research | Cancer | Tumors | Apoptosis | Index Medicus
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Loading RightsAmerican Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, 05/2009, Volume 296, Issue 5, pp. 1060 - 1068
Caspase | Fas | Permeability of mitochondrial membrane | Bcl-2 family proteins | Caspase inhibitor | Gastroenterology & Hepatology | Physiology | Life Sciences & Biomedicine | Science & Technology | Up-Regulation | Colonic Neoplasms - genetics | Apoptosis - drug effects | Humans | Intracellular Signaling Peptides and Proteins - metabolism | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Colonic Neoplasms - metabolism | Tumor Suppressor Protein p53 - genetics | Dose-Response Relationship, Drug | Mitochondrial Membranes - drug effects | Proto-Oncogene Proteins c-bcl-2 - metabolism | Caspases - metabolism | Bcl-2-Like Protein 11 | RNA Interference | Time Factors | Mitochondrial Proteins - metabolism | Flavonoids - pharmacology | Membrane Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Cytochromes c - metabolism | HCT116 Cells | Tumor Suppressor Protein p53 - metabolism | Mitochondria - metabolism | Mitochondria - drug effects | Mitochondria - pathology | Permeability | Caspase Inhibitors | Apoptosis Regulatory Proteins - metabolism | Mitochondrial Membranes - metabolism | Poly(ADP-ribose) Polymerases - metabolism | Colonic Neoplasms - pathology | Cysteine Proteinase Inhibitors - pharmacology | Antineoplastic Agents, Phytogenic - pharmacology | bcl-X Protein - metabolism | RNA, Small Interfering - metabolism | Proteins | Molecules | Diet | Cyclin-dependent kinases | Colorectal cancer | Cells | Apoptosis | Index Medicus
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Loading RightsThe FEBS journal, ISSN 1742-464X, 09/2013, Volume 280, Issue 18, pp. 4522 - 4530
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | RNA, Small Interfering - genetics | Phosphorylation | Shc Signaling Adaptor Proteins - metabolism | Adenocarcinoma - pathology | Adenocarcinoma of Lung | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Sequestosome-1 Protein | Humans | Lung Neoplasms - metabolism | Gene Expression Regulation, Neoplastic | Apoptosis - genetics | Lung Neoplasms - pathology | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Proto-Oncogene Proteins c-akt - genetics | Shc Signaling Adaptor Proteins - antagonists & inhibitors | Adenocarcinoma - metabolism | Caspases - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Adenocarcinoma - genetics | Autophagy - genetics | Culture Media - chemistry | Neoplasm Proteins - genetics | Proto-Oncogene Proteins c-akt - metabolism | Lung Neoplasms - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Caspases - genetics | Amino Acids - deficiency | Poly(ADP-ribose) Polymerases - metabolism | Poly(ADP-ribose) Polymerases - genetics | Shc Signaling Adaptor Proteins - genetics | Src Homology 2 Domain-Containing, Transforming Protein 1 | Mitogen-Activated Protein Kinase 3 - metabolism | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Adaptor Proteins, Signal Transducing - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | RNA, Small Interfering - metabolism | Index Medicus
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Loading RightsCancer research (Chicago, Ill.), ISSN 0008-5472, 06/2013, Volume 73, Issue 12, pp. 3683 - 3691
Life Sciences & Biomedicine | Oncology | Science & Technology | Gynecology. Andrology. Obstetrics | Pharmacology. Drug treatments | Biological and medical sciences | Multiple tumors. Solid tumors. Tumors in childhood (general aspects) | Medical sciences | Antineoplastic agents | Tumors | Female genital diseases | Protein Kinases - metabolism | Protein Kinases - genetics | Humans | Ovarian Neoplasms - pathology | Cell Survival - genetics | Deoxycytidine - pharmacology | Immunoblotting | Sulfones - pharmacology | Cell Cycle Proteins - antagonists & inhibitors | Dose-Response Relationship, Drug | Ovarian Neoplasms - genetics | RNA Interference | BRCA1 Protein - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Female | Antineoplastic Agents - pharmacology | Ovarian Neoplasms - metabolism | Phosphorylation - drug effects | cdc25 Phosphatases - metabolism | Protein-Serine-Threonine Kinases - metabolism | Pyrazoles - pharmacology | Cell Survival - drug effects | Topotecan - pharmacology | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Signal Transduction - genetics | cdc25 Phosphatases - genetics | Ataxia Telangiectasia Mutated Proteins | Cisplatin - pharmacology | Pyrimidines - pharmacology | Poly(ADP-ribose) Polymerase Inhibitors | BRCA1 Protein - genetics | Poly(ADP-ribose) Polymerases - metabolism | BRCA2 Protein - metabolism | Signal Transduction - drug effects | Cell Line, Tumor | Benzimidazoles - pharmacology | Checkpoint Kinase 1 | Pyrazines - pharmacology | BRCA2 Protein - genetics | Deoxycytidine - analogs & derivatives | Index Medicus | homologous recombination | ovarian cancer | Poly(ADP-ribose) polymerase | veliparib | gemcitabine | BRCA1 | cisplatin | BRCA2 | topotecan
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Loading RightsCellular physiology and biochemistry, ISSN 1015-8987, 01/2018, Volume 44, Issue 5, pp. 1842 - 1855
Original Paper | Senescence | Glp-1 | Ghrelin | Microvascular endothelial cells | Apoptosis | Physiology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Reactive Oxygen Species - metabolism | Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors | Apoptosis - drug effects | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Caspase 3 - metabolism | Cellular Senescence - drug effects | Lipids - pharmacology | p38 Mitogen-Activated Protein Kinases - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Microvessels - cytology | Endothelial Cells - metabolism | Mitogen-Activated Protein Kinase 9 - metabolism | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 8 - metabolism | Cells, Cultured | Glucagon-Like Peptide 1 - pharmacology | Ghrelin - pharmacology | Glucose - pharmacology | Mitochondria - metabolism | Mitochondria - drug effects | Poly(ADP-ribose) Polymerases - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Endothelial Cells - cytology | Mitogen-Activated Protein Kinase 9 - antagonists & inhibitors | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Mitogen-Activated Protein Kinase 1 - metabolism | Diabetic retinopathy | Neurosciences | Cardiomyocytes | Lipids | Metabolism | Kinases | Experiments | Angiogenesis | Cell growth | Nitric oxide | Rodents | Atherosclerosis | Diabetes | Index Medicus
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Loading RightsNutrition and cancer, ISSN 0163-5581, 08/2017, Volume 69, Issue 6, pp. 932 - 942
Oncology | Life Sciences & Biomedicine | Nutrition & Dietetics | Science & Technology | Caspase 7 - metabolism | Cyclin D1 - metabolism | Oncogene Proteins - genetics | Phosphorylation | Epithelial Cells - metabolism | Apoptosis - drug effects | Phenylethyl Alcohol - analogs & derivatives | Epithelial Cells - drug effects | Humans | Receptors, Androgen - metabolism | Caspase 3 - metabolism | Male | NF-kappa B - metabolism | Cyclin E - genetics | Proto-Oncogene Proteins c-akt - genetics | Prostatic Neoplasms | Cyclin D1 - antagonists & inhibitors | Caspase 3 - genetics | Prostate-Specific Antigen - metabolism | Epithelial Cells - cytology | Proto-Oncogene Proteins c-akt - metabolism | Cyclin E - antagonists & inhibitors | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | bcl-2-Associated X Protein - genetics | Prostate-Specific Antigen - genetics | Cell Survival - drug effects | Signal Transduction | Caspase 7 - genetics | Oncogene Proteins - metabolism | bcl-2-Associated X Protein - metabolism | Antioxidants - pharmacology | Oncogene Proteins - antagonists & inhibitors | Phenylethyl Alcohol - pharmacology | Receptors, Androgen - genetics | Cyclin D1 - genetics | NF-kappa B - genetics | Cell Cycle Checkpoints - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Cyclin E - metabolism | Cell proliferation | Flow cytometry | Bax protein | Bcl-2 protein | Prostate-specific antigen | Epithelial cells | Androgen receptors | AKT protein | Anticancer properties | Signal transduction | Pathways | Castration | Cell cycle | Inhibition | Secretion | Stat3 protein | Caspase | Poly(ADP-ribose) polymerase | Olives | Cyclins | Cyclin-dependent kinase 2 | Cytometry | Androgens | Antitumor activity | Prostate cancer | Prostate | Cancer | Apoptosis | Index Medicus | NF-κB | apoptosis | androgen receptor | hydroxytyrosol | cell proliferation
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