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The Journal of pharmacology and experimental therapeutics, ISSN 1521-0103, 2015, Volume 353, Issue 3, pp. 446 - 457
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2018, Volume 362, Issue 6414, pp. eaat8407 - 557
The pathologic accumulation and aggregation of α-synuclein (α-syn) underlies Parkinson’s disease (PD). The molecular mechanisms by which pathologic α-syn... 
STRAINS | MECHANISMS | PROTEIN | MULTIDISCIPLINARY SCIENCES | AGGREGATION | CELL-DEATH | Recombinant Proteins - metabolism | Parkinson Disease - pathology | Dopaminergic Neurons - pathology | Mice, Inbred C57BL | Poly (ADP-Ribose) Polymerase-1 - metabolism | Recombinant Proteins - genetics | Gene Knockout Techniques | Poly (ADP-Ribose) Polymerase-1 - antagonists & inhibitors | Mice, Knockout | Brain - metabolism | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Poly Adenosine Diphosphate Ribose - metabolism | Animals | Dopaminergic Neurons - metabolism | Cell Death | Brain - pathology | Benzimidazoles - pharmacology | Mice | Parkinson Disease - metabolism | alpha-Synuclein - genetics | Enzyme Activation | Nitric Oxide - metabolism | alpha-Synuclein - metabolism | Poly (ADP-Ribose) Polymerase-1 - genetics | Therapy | Parkinson's disease | Pathogenesis | Disorders | Cognitive ability | Nervous system | Cerebrospinal fluid | Rigidity | Mental depression | Proteins | Fibrillogenesis | Cell activation | Neurodegeneration | Autonomic nervous system | Neostriatum | Biocompatibility | Anxiety | Inhibition | Toxic diseases | Constipation | Movement disorders | Deoxyribonucleic acid--DNA | Neurodegenerative diseases | Mortality | Adenosine diphosphate | Pathology | Cell injury | Molecular modelling | Inhibitors | Nitric oxide | Biomarkers | Toxicity | DNA damage | Activation | Accumulation | Neurotoxicity | Clonal deletion | Feedforward | Phenotypes | Adenosine | Dopamine | Neurons | Poly(ADP-ribose) polymerase | Caspase | Axons | Sleep | Cell death | In vivo methods and tests | Apoptosis | Index Medicus
Journal Article
Journal Article
The Lancet (British edition), ISSN 0140-6736, 2010, Volume 376, Issue 9737, pp. 245 - 251
Journal Article
Journal of clinical oncology, ISSN 1527-7755, 2017, Volume 35, Issue 19, pp. 2193 - 2202
Purpose Data suggest that DNA damage by poly (ADP-ribose) polymerase inhibition and/or reduced vascular endothelial growth factor signaling by vascular... 
SENSITIVE OVARIAN-CANCER | MULTICENTER | ANTI-PD-1 | ONCOLOGY | ANTITUMOR-ACTIVITY | NIVOLUMAB | Piperazines - administration & dosage | Vascular Endothelial Growth Factor Receptor-1 - antagonists & inhibitors | Phthalazines - pharmacokinetics | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Quinazolines - pharmacokinetics | Protein Kinase Inhibitors - adverse effects | Dose-Response Relationship, Drug | Genital Neoplasms, Female - drug therapy | Adult | Female | Quinazolines - administration & dosage | Piperazines - pharmacokinetics | Phthalazines - administration & dosage | Antibodies, Monoclonal - pharmacokinetics | Genital Neoplasms, Female - immunology | B7-H1 Antigen - immunology | Piperazines - adverse effects | Poly(ADP-ribose) Polymerase Inhibitors - administration & dosage | Genital Neoplasms, Female - metabolism | Protein Kinase Inhibitors - administration & dosage | B7-H1 Antigen - antagonists & inhibitors | Antibodies, Monoclonal - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | B7-H1 Antigen - biosynthesis | Quinazolines - adverse effects | Aged | Genital Neoplasms, Female - pathology | Phthalazines - adverse effects | Lymphocytes, Tumor-Infiltrating - immunology | Index Medicus | Phase I and Clinical Pharmacology | Combined Modality | Breast Cancer | ORIGINAL REPORTS
Journal Article