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Journal of clinical oncology, ISSN 1527-7755, 04/2015, Volume 33, Issue 12, pp. 1397 - 1406
Journal Article
Journal Article
Journal Article
Journal of clinical oncology, ISSN 1527-7755, 07/2017, Volume 35, Issue 19, pp. 2193 - 2202
Purpose Data suggest that DNA damage by poly (ADP-ribose) polymerase inhibition and/or reduced vascular endothelial growth factor signaling by vascular... 
Life Sciences & Biomedicine | Oncology | Science & Technology | Piperazines - administration & dosage | Vascular Endothelial Growth Factor Receptor-1 - antagonists & inhibitors | Phthalazines - pharmacokinetics | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Quinazolines - pharmacokinetics | Protein Kinase Inhibitors - adverse effects | Dose-Response Relationship, Drug | Genital Neoplasms, Female - drug therapy | Adult | Female | Quinazolines - administration & dosage | Piperazines - pharmacokinetics | Phthalazines - administration & dosage | Antibodies, Monoclonal - pharmacokinetics | Genital Neoplasms, Female - immunology | B7-H1 Antigen - immunology | Piperazines - adverse effects | Poly(ADP-ribose) Polymerase Inhibitors - administration & dosage | Genital Neoplasms, Female - metabolism | Protein Kinase Inhibitors - administration & dosage | B7-H1 Antigen - antagonists & inhibitors | Antibodies, Monoclonal - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | B7-H1 Antigen - biosynthesis | Quinazolines - adverse effects | Aged | Genital Neoplasms, Female - pathology | Phthalazines - adverse effects | Lymphocytes, Tumor-Infiltrating - immunology | Index Medicus | Phase I and Clinical Pharmacology | Combined Modality | Breast Cancer | ORIGINAL REPORTS
Journal Article
The Journal of pharmacology and experimental therapeutics, ISSN 1521-0103, 06/2015, Volume 353, Issue 3, pp. 446 - 457
Recent findings indicate that a major mechanism by which poly (ADP-ribose) polymerase (PARP) inhibitors kill cancer cells is by trapping PARP1 and PARP2 to the sites of DNA damage... 
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Poly(ADP-ribose) Polymerases - metabolism | Antineoplastic Agents - pharmacology | Animals | Poly(ADP-ribose) Polymerase Inhibitors | Humans | Enzyme Inhibitors - pharmacology
Journal Article
Cancer science, ISSN 1347-9032, 11/2018, Volume 109, Issue 11, pp. 3383 - 3392
...‐directed therapies for other solid organ malignancies. Poly (ADP‐ribose) polymerase inhibitors (PARPi... 
lysine‐specific histone demethylase‐1A | poly (ADP‐ribose) polymerase inhibitor | immune checkpoint inhibitor | cancer stem cell | triple‐negative breast cancer | triple-negative breast cancer | lysine-specific histone demethylase-1A | poly (ADP-ribose) polymerase inhibitor | Life Sciences & Biomedicine | Oncology | Science & Technology | Homologous Recombination - drug effects | Neoplastic Stem Cells - drug effects | Humans | Clinical Trials as Topic | Triple Negative Breast Neoplasms - drug therapy | B7-H1 Antigen - genetics | Poly(ADP-ribose) Polymerase Inhibitors - therapeutic use | Up-Regulation - drug effects | Triple Negative Breast Neoplasms - genetics | Neoplastic Stem Cells - metabolism | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Triple Negative Breast Neoplasms - metabolism | Immunotherapy | Female | Histone Deacetylase Inhibitors - pharmacology | Epigenesis, Genetic - drug effects | Histone Deacetylase Inhibitors - therapeutic use | Gene Expression Regulation, Neoplastic - drug effects | Drug Resistance, Neoplasm - drug effects | Epigenetic inheritance | Lysine | Cell death | Stem cells | Sugars | Monosaccharides | Drugs | Histone deacetylase | Transcription factors | DNA damage | Homologous recombination | Cytotoxicity | Cancer therapies | DNA repair | Immunosuppressive agents | Ovarian cancer | Proteins | Epidermal growth factor | Antitumor agents | Ribose | Cell cycle | Deoxyribonucleic acid--DNA | Phenotypes | Breast cancer | Chemotherapy | Immunogenicity | Response rates | Epigenetics | Ligands | Tumors | Apoptosis | Review
Journal Article
Nature reviews. Drug discovery, ISSN 1474-1784, 05/2005, Volume 4, Issue 5, pp. 421 - 440
Journal Article