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Clinical Cancer Research, ISSN 1078-0432, 05/2007, Volume 13, Issue 9, pp. 2728 - 2737
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 06/2009, Volume 27, Issue 16, pp. 2705 - 2711
Journal Article
Journal Article
Lancet, The, ISSN 0140-6736, 2010, Volume 376, Issue 9737, pp. 235 - 244
Journal Article
Lancet Oncology, The, ISSN 1470-2045, 2013, Volume 14, Issue 9, pp. 882 - 892
Journal Article
Lancet, The, ISSN 0140-6736, 2010, Volume 376, Issue 9737, pp. 245 - 251
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 03/2007, Volume 6, Issue 3, pp. 945 - 956
Poly(ADP-ribose) polymerase (PARP)-1 (EC 2.4.2.30) is a nuclear enzyme that promotes the base excision repair of DNA breaks. Inhibition of PARP-1 enhances the... 
structure-activity relationship studies | screening | screening strategies (assays) | DNA damage and repair mechanisms | xenograft models | poly(ADP-ribose) polymerase | PARP inhibitors | colon cancer | modulation of DNA repair | TUMOR-CELL LINES | DESIGN | BASE EXCISION-REPAIR | POTENTIATION | METABOLISM | ONCOLOGY | MICE | CYTOTOXICITY | RADIATION | DAMAGE | TEMOZOLOMIDE | Gamma Rays | Gene Expression Regulation, Enzymologic - drug effects | Heterocyclic Compounds, 3-Ring - pharmacology | Humans | Colorectal Neoplasms - radiotherapy | Topoisomerase I Inhibitors | DNA Repair - radiation effects | Drug Resistance, Neoplasm | Cell Line, Tumor - drug effects | Structure-Activity Relationship | Dacarbazine - pharmacology | Colorectal Neoplasms - drug therapy | Dacarbazine - analogs & derivatives | Female | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Drug Evaluation, Preclinical | Cell Line, Tumor - radiation effects | DNA Repair - drug effects | Benzodiazepines - pharmacology | Topotecan - pharmacology | Enzyme Inhibitors - pharmacology | Poly(ADP-ribose) Polymerase Inhibitors | Maximum Tolerated Dose | Poly(ADP-ribose) Polymerases - metabolism | Animals | Mice, Nude | Heterocyclic Compounds, 3-Ring - chemistry | Benzodiazepines - chemistry | Mice | Drug Screening Assays, Antitumor
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 02/2011, Volume 103, Issue 4, pp. 334 - 346
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 07/2017, Volume 35, Issue 19, pp. 2193 - 2202
Purpose Data suggest that DNA damage by poly (ADP-ribose) polymerase inhibition and/or reduced vascular endothelial growth factor signaling by vascular... 
SENSITIVE OVARIAN-CANCER | MULTICENTER | ANTI-PD-1 | ONCOLOGY | ANTITUMOR-ACTIVITY | NIVOLUMAB | Piperazines - administration & dosage | Vascular Endothelial Growth Factor Receptor-1 - antagonists & inhibitors | Phthalazines - pharmacokinetics | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Quinazolines - pharmacokinetics | Protein Kinase Inhibitors - adverse effects | Dose-Response Relationship, Drug | Genital Neoplasms, Female - drug therapy | Adult | Female | Quinazolines - administration & dosage | Piperazines - pharmacokinetics | Phthalazines - administration & dosage | Antibodies, Monoclonal - pharmacokinetics | Genital Neoplasms, Female - immunology | B7-H1 Antigen - immunology | Piperazines - adverse effects | Poly(ADP-ribose) Polymerase Inhibitors - administration & dosage | Genital Neoplasms, Female - metabolism | Protein Kinase Inhibitors - administration & dosage | B7-H1 Antigen - antagonists & inhibitors | Antibodies, Monoclonal - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | B7-H1 Antigen - biosynthesis | Quinazolines - adverse effects | Aged | Genital Neoplasms, Female - pathology | Phthalazines - adverse effects | Lymphocytes, Tumor-Infiltrating - immunology | <