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Science (American Association for the Advancement of Science), ISSN 1095-9203, 2012, Volume 336, Issue 6081, pp. 593 - 597
.... The data reveal two DNA damage response pathways not previously observed upon deletion of individual shelterin proteins... 
Telomeres | Yeasts | Quantification | Lymphocytes | DNA | DNA damage | REPORTS | Cell cycle | Ataxia telangiectasia | Repression | Chromosomes | JOINING PATHWAY | POT1 PROTEINS | MAMMALIAN TELOMERES | SGS1 | MULTIDISCIPLINARY SCIENCES | DYSFUNCTIONAL TELOMERES | DOUBLE-STRAND BREAKS | HOMOLOGOUS RECOMBINATION | NHEJ | YEAST KU | Telomere - ultrastructure | Antigens, Nuclear - metabolism | Telomeric Repeat Binding Protein 1 - genetics | Telomeric Repeat Binding Protein 1 - metabolism | Homologous Recombination | DNA Breaks, Double-Stranded | DNA Ligases - metabolism | DNA-Binding Proteins - metabolism | Poly-ADP-Ribose Binding Proteins | Telomere-Binding Proteins - genetics | DNA End-Joining Repair | Telomere - metabolism | Telomere-Binding Proteins - metabolism | Protein-Serine-Threonine Kinases - metabolism | Tumor Suppressor Proteins - metabolism | Chromosomal Proteins, Non-Histone - metabolism | Signal Transduction | Cell Cycle Proteins - metabolism | Cells, Cultured | Ataxia Telangiectasia Mutated Proteins | Xenopus Proteins | DNA-Binding Proteins - genetics | Telomere Homeostasis | Mice, Knockout | Poly(ADP-ribose) Polymerases - metabolism | Animals | Antigens, Nuclear - genetics | Cell Cycle | Ku Autoantigen | DNA Repair | DNA Ligase ATP | Telomeric Repeat Binding Protein 2 - metabolism | Mice | Poly (ADP-Ribose) Polymerase-1 | Telomeric Repeat Binding Protein 2 - genetics | Tumor Suppressor p53-Binding Protein 1 | Proteins | Physiological aspects | Research | Health aspects | DNA repair | Telomerase
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2017, Volume 355, Issue 6331, pp. 1312 - 1317
Journal Article
Nature cell biology, ISSN 1476-4679, 2018, Volume 20, Issue 8, pp. 954 - 965
.... We identified two previously uncharacterized proteins, C2Oorf196 and FAM35A, whose inactivation confers strong PARP-inhibitor resistance... 
PATHWAY CHOICE | STRAND BREAK REPAIR | RESECTION | DAMAGE-RESPONSE | 53BP1 | CLASS-SWITCH RECOMBINATION | FANCONI-ANEMIA | DIFFERENTIAL EXPRESSION ANALYSIS | POLYMERASE-ZETA | TELOMERES | CELL BIOLOGY | Osteosarcoma - drug therapy | Mad2 Proteins - metabolism | Humans | Multiprotein Complexes | Ovarian Neoplasms - pathology | Bone Neoplasms - pathology | DNA Breaks, Double-Stranded | Bone Neoplasms - metabolism | Breast Neoplasms - metabolism | Dose-Response Relationship, Drug | Ovarian Neoplasms - genetics | Telomere-Binding Proteins - genetics | DNA End-Joining Repair | HEK293 Cells | Female | Bone Neoplasms - genetics | Ovarian Neoplasms - metabolism | Bone Neoplasms - drug therapy | BRCA1 Protein - deficiency | Telomere-Binding Proteins - metabolism | Ovarian Neoplasms - drug therapy | Osteosarcoma - metabolism | DNA-Binding Proteins | Tumor Suppressor p53-Binding Protein 1 - metabolism | Recombinational DNA Repair | Tumor Suppressor p53-Binding Protein 1 - genetics | Cisplatin - pharmacology | Breast Neoplasms - drug therapy | Proteins - genetics | Xenograft Model Antitumor Assays | BRCA1 Protein - genetics | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Breast Neoplasms - genetics | Proteins - metabolism | Breast Neoplasms - pathology | Mad2 Proteins - genetics | Cell Line, Tumor | Mice | Osteosarcoma - genetics | Cell Cycle Proteins | Osteosarcoma - pathology | Care and treatment | DNA | Cancer cells | Breast cancer | Genetic aspects | Research | Gene expression | Single-stranded DNA | DNA damage | Homologous recombination | Poly(ADP-ribose) | Homology | Genomes | Inactivation | Proteins | Ribose | Null cells | Deoxyribonucleic acid--DNA | BRCA2 protein | CRISPR | Deactivation | BRCA1 protein | Poly(ADP-ribose) polymerase | Adenosine diphosphate | Oligosaccharides | Double-strand break repair | Screens | Cisplatin | Inhibitors | Prostate | Viability | Tumors | Telomere-Binding Proteins / metabolism | Osteosarcoma / genetics | Telomere-Binding Proteins / genetics | BRCA1 Protein / genetics | Cellular Biology | Genetics | Proteins / genetics | Osteosarcoma / drug therapy | Ovarian Neoplasms / genetics | Mad2 Proteins / genetics | Proteins / metabolism | Breast Neoplasms / drug therapy | Breast Neoplasms / metabolism | Tumor Suppressor p53-Binding Protein 1 / genetics | BRCA1 Protein / deficiency | Ovarian Neoplasms / metabolism | Mad2 Proteins / metabolism | Breast Neoplasms / pathology | Bone Neoplasms / genetics | Ovarian Neoplasms / pathology | Bone Neoplasms / pathology | Life Sciences | Bone Neoplasms / drug therapy | Ovarian Neoplasms / drug therapy | Osteosarcoma / metabolism | Biochemistry, Molecular Biology | Breast Neoplasms / genetics | Drug Resistance, Neoplasm / genetics | Osteosarcoma / pathology | Bone Neoplasms / metabolism | Poly(ADP-ribose) Polymerase Inhibitors / pharmacology | Cisplatin / pharmacology | Molecular biology | Tumor Suppressor p53-Binding Protein 1 / metabolism | Cancer
Journal Article
Nature cell biology, ISSN 1476-4679, 2012, Volume 14, Issue 3, pp. 318 - 328
.... We carried out a genome-wide siRNA-based screen in human cells. Among positive regulators of HR we identified networks of DNA-damage-response and pre-mRNA-processing proteins, and among negative regulators we identified a phosphatase network... 
TARGET | SPINDLE-CHECKPOINT | REPAIR | TAO1 | ATM | PARALOG | PROMOTES | EXPRESSION | P53 | CELL BIOLOGY | RNA, Small Interfering - genetics | RNA-Binding Proteins - genetics | Histone Chaperones - genetics | Humans | Histone Chaperones - metabolism | Homologous Recombination | Immunoblotting | Green Fluorescent Proteins - genetics | Gene Regulatory Networks | Nuclear Pore Complex Proteins - genetics | RNA Interference | Cell Cycle Proteins - genetics | RNA Precursors - metabolism | Nuclear Proteins - genetics | Rad51 Recombinase - metabolism | Green Fluorescent Proteins - metabolism | Rad51 Recombinase - genetics | Nuclear Pore Complex Proteins - metabolism | Cell Cycle Proteins - metabolism | Heterogeneous-Nuclear Ribonucleoproteins - metabolism | Nuclear Proteins - metabolism | RNA Precursors - genetics | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Genome, Human - genetics | Heterogeneous-Nuclear Ribonucleoproteins - genetics | Transcription Factors - metabolism | Poly(ADP-ribose) Polymerases - metabolism | BRCA2 Protein - metabolism | Poly(ADP-ribose) Polymerases - genetics | DNA Repair | Cell Line, Tumor | Models, Genetic | DNA Damage | BRCA2 Protein - genetics | Microscopy, Fluorescence | RNA-Binding Proteins - metabolism | Proteins | Physiological aspects | Research | Binding proteins | DNA damage | Ribonucleoproteins
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2018, Volume 293, Issue 21, pp. 7942 - 7968
... (G3BP is Ras-GAP SH3 domain-binding protein) methylation is inhibited by LRP6 and that G3BP1 stimulates NFATc4 transcription... 
atherosclerosis | Type 2 diabetes | BONE BIOLOGY | cardiovascular disease | TRANSCRIPTION FACTOR RUNX2 | SINGLETON-MERTEN SYNDROME | CARDIOVASCULAR CALCIFICATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | INHIBITS VASCULAR CALCIFICATION | vascular biology | metabolic syndrome | DIABETES-MELLITUS | Wnt signaling | arteriosclerosis | protein methylation | ATHEROSCLEROTIC CALCIFICATION | IN-VIVO | calcification | ARGININE METHYLATION | vascular smooth muscle cells | CORONARY-ARTERY-DISEASE | Calcinosis - genetics | RNA Helicases - metabolism | Poly-ADP-Ribose Binding Proteins - metabolism | Calcium - metabolism | Humans | Myocytes, Smooth Muscle - pathology | Antiviral Agents - metabolism | Aorta - metabolism | Arteriosclerosis - genetics | Wnt Proteins - metabolism | Wnt Proteins - genetics | RNA Helicases - genetics | Calcinosis - metabolism | RNA Recognition Motif Proteins - metabolism | DNA Helicases - genetics | Myocytes, Smooth Muscle - metabolism | Low Density Lipoprotein Receptor-Related Protein-6 | Signal Transduction | Mice, Inbred C57BL | Cells, Cultured | Poly-ADP-Ribose Binding Proteins - genetics | beta Catenin - metabolism | beta Catenin - genetics | Mice, Knockout | Aorta - pathology | DNA Helicases - metabolism | Adaptor Proteins, Signal Transducing - physiology | Animals | Arteriosclerosis - metabolism | Mice | RNA Recognition Motif Proteins - genetics | Receptors, LDL - physiology | Calcinosis - pathology | Arteriosclerosis - pathology | Molecular Bases of Disease
Journal Article
Nature communications, ISSN 2041-1723, 02/2017, Volume 8, Issue 1, p. 14252
.... Aptamers are single-stranded RNA or DNA molecules that have recently shown utility in a clinical setting, as they can specifically neutralize biomedically relevant proteins, particularly cell surface... 
AUTOANTIBODIES | NEUTROPHIL EXTRACELLULAR TRAPS | SYSTEMIC-LUPUS-ERYTHEMATOSUS | THERAPY | MACROPHAGES | PEGAPTANIB | MULTIDISCIPLINARY SCIENCES | JUVENILE RHEUMATOID-ARTHRITIS | DISEASE | ANTI-VEGF APTAMER | ONCOPROTEIN DEK | Oncogene Proteins - genetics | Chemotactic Factors - antagonists & inhibitors | Poly-ADP-Ribose Binding Proteins - metabolism | Extracellular Traps - metabolism | Humans | Poly-ADP-Ribose Binding Proteins - antagonists & inhibitors | Male | Healthy Volunteers | Synovial Fluid - chemistry | Chromosomal Proteins, Non-Histone - antagonists & inhibitors | DNA-Binding Proteins - metabolism | Extracellular Traps - immunology | Chemotactic Factors - metabolism | Arthritis, Juvenile - therapy | Chemotactic Factors - genetics | Adult | Female | Synovial Fluid - cytology | Oncogene Proteins - immunology | Disease Models, Animal | Chemotactic Factors - immunology | DNA-Binding Proteins - antagonists & inhibitors | Chromosomal Proteins, Non-Histone - metabolism | Mice, Inbred C57BL | Neutrophils - immunology | Oncogene Proteins - metabolism | Poly-ADP-Ribose Binding Proteins - genetics | Aptamers, Nucleotide - therapeutic use | DNA-Binding Proteins - genetics | Chromosomal Proteins, Non-Histone - genetics | Mice, Knockout | Oncogene Proteins - antagonists & inhibitors | Zymosan - immunology | Chromosomal Proteins, Non-Histone - immunology | Synovial Fluid - immunology | Animals | Arthritis, Juvenile - immunology | Poly-ADP-Ribose Binding Proteins - immunology | Mice | Primary Cell Culture
Journal Article
The EMBO Journal, ISSN 1460-2075, 2005, Volume 24, Issue 11, pp. 1911 - 1920
The ADP‐ribosylation of proteins is an important post‐translational modification that occurs in a variety of biological processes, including DNA repair, transcription, chromatin biology and long... 
NAD | protein module | PARP | metabolites | ligand | Metabolites | Ligand | Protein module | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESOLUTION | ACTIVE CENTROMERES | IDENTIFICATION | HUMAN POLY(ADP-RIBOSE) POLYMERASE | HISTONE | CELL BIOLOGY | RIBOSYLATION | DNA | GLYCOHYDROLASE | Poly(ADP-ribose) Polymerases | Species Specificity | Histones - chemistry | Humans | Adenosine Diphosphate Ribose - metabolism | Archaeal Proteins - chemistry | Molecular Sequence Data | Crystallography, X-Ray | Structure-Activity Relationship | Neoplasm Proteins - metabolism | Recombinant Fusion Proteins - metabolism | Archaeoglobus fulgidus - chemistry | Carrier Proteins - chemistry | Catalysis | Binding Sites | Archaeal Proteins - metabolism | Protein Structure, Tertiary | Amino Acid Sequence | Protein Structure, Secondary | Models, Molecular | Neoplasm Proteins - chemistry | Recombinant Fusion Proteins - chemistry | Hydrolysis | Sequence Homology, Amino Acid | Poly Adenosine Diphosphate Ribose - metabolism | Sequence Alignment | Carrier Proteins - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Calorimetry, Differential Scanning | Ligands | Protein Conformation | Adenosine Diphosphate - metabolism | Histones - metabolism | Phosphoric Monoester Hydrolases - metabolism | Phosphoric Monoester Hydrolases - chemistry | Saccharomyces cerevisiae Proteins - chemistry
Journal Article
Developmental cell, ISSN 1534-5807, 01/2009, Volume 16, Issue 1, pp. 105 - 117
Journal Article