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Nature Cell Biology, ISSN 1465-7392, 03/2012, Volume 14, Issue 3, pp. 318 - 328
Repair of DNA double-strand breaks is critical to genomic stability and the prevention of developmental disorders and cancer. A central pathway for this repair... 
TARGET | SPINDLE-CHECKPOINT | NUCLEAR RIBONUCLEOPROTEIN-G | REPAIR | STABILIZATION | TAO1 | DOUBLE-STRAND BREAKS | MAMMALIAN-CELLS | PROMOTES | EXPRESSION | CELL BIOLOGY | RNA, Small Interfering - genetics | RNA-Binding Proteins - genetics | Histone Chaperones - genetics | Humans | Histone Chaperones - metabolism | Homologous Recombination | Immunoblotting | Green Fluorescent Proteins - genetics | Gene Regulatory Networks | Nuclear Pore Complex Proteins - genetics | RNA Interference | Cell Cycle Proteins - genetics | RNA Precursors - metabolism | Nuclear Proteins - genetics | Rad51 Recombinase - metabolism | Green Fluorescent Proteins - metabolism | Rad51 Recombinase - genetics | Nuclear Pore Complex Proteins - metabolism | Cell Cycle Proteins - metabolism | Heterogeneous-Nuclear Ribonucleoproteins - metabolism | Nuclear Proteins - metabolism | RNA Precursors - genetics | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Genome, Human - genetics | Heterogeneous-Nuclear Ribonucleoproteins - genetics | Transcription Factors - metabolism | Poly(ADP-ribose) Polymerases - metabolism | BRCA2 Protein - metabolism | Poly(ADP-ribose) Polymerases - genetics | DNA Repair | Cell Line, Tumor | Models, Genetic | DNA Damage | BRCA2 Protein - genetics | Microscopy, Fluorescence | RNA-Binding Proteins - metabolism | Proteins | Physiological aspects | Research | Binding proteins | DNA damage | Ribonucleoproteins | Index Medicus
Journal Article
Science, ISSN 0036-8075, 5/2012, Volume 336, Issue 6081, pp. 593 - 597
The telomere end-protection problem is defined by the aggregate of DNA damage signaling and repair pathways that require repression at telomeres. To define the... 
Telomeres | Yeasts | Quantification | Lymphocytes | DNA | DNA damage | REPORTS | Cell cycle | Ataxia telangiectasia | Repression | Chromosomes | JOINING PATHWAY | POT1 PROTEINS | MAMMALIAN TELOMERES | SGS1 | MULTIDISCIPLINARY SCIENCES | DYSFUNCTIONAL TELOMERES | DOUBLE-STRAND BREAKS | HOMOLOGOUS RECOMBINATION | NHEJ | YEAST KU | Telomere - ultrastructure | Antigens, Nuclear - metabolism | Telomeric Repeat Binding Protein 1 - genetics | Telomeric Repeat Binding Protein 1 - metabolism | Homologous Recombination | DNA Breaks, Double-Stranded | DNA Ligases - metabolism | DNA-Binding Proteins - metabolism | Poly-ADP-Ribose Binding Proteins | Telomere-Binding Proteins - genetics | DNA End-Joining Repair | Telomere - metabolism | Telomere-Binding Proteins - metabolism | Protein-Serine-Threonine Kinases - metabolism | Tumor Suppressor Proteins - metabolism | Chromosomal Proteins, Non-Histone - metabolism | Signal Transduction | Cell Cycle Proteins - metabolism | Cells, Cultured | Ataxia Telangiectasia Mutated Proteins | Xenopus Proteins | DNA-Binding Proteins - genetics | Telomere Homeostasis | Mice, Knockout | Poly(ADP-ribose) Polymerases - metabolism | Animals | Antigens, Nuclear - genetics | Cell Cycle | Ku Autoantigen | DNA Repair | DNA Ligase ATP | Telomeric Repeat Binding Protein 2 - metabolism | Mice | Poly (ADP-Ribose) Polymerase-1 | Telomeric Repeat Binding Protein 2 - genetics | Tumor Suppressor p53-Binding Protein 1 | Proteins | Physiological aspects | Research | Health aspects | DNA repair | Telomerase | Index Medicus | Ataxia telangiectasia mutated protein
Journal Article
Nature, ISSN 0028-0836, 2015, Volume 521, Issue 7553, pp. 541 - U308
Journal Article
Developmental Cell, ISSN 1534-5807, 01/2009, Volume 16, Issue 1, pp. 105 - 117
Journal Article
Molecular Cell, ISSN 1097-2765, 10/2010, Volume 40, Issue 1, pp. 63 - 74
As part of the genotoxic stress response, cells activate the transcription factor NF-κB. The DNA strand break sensor poly(ADP-ribose)-polymerase-1 (PARP-1) and... 
MOLECULAR-MECHANISM | POLY(ADP-RIBOSYL)ATION | GENOTOXIC STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPLEXES | DOUBLE-STRAND BREAKS | POLYUBIQUITIN CHAINS | ATM | BINDING | NEMO | PROTEIN-KINASES | CELL BIOLOGY | Tumor Necrosis Factor-alpha - metabolism | Phosphorylation | Calcium - metabolism | Inhibitor of Apoptosis Proteins - genetics | Humans | Ubiquitin - metabolism | NF-kappa B - metabolism | DNA Breaks, Double-Stranded | Cell Nucleus - enzymology | DNA-Binding Proteins - metabolism | Cytosol - enzymology | Ubiquitination | Transfection | I-kappa B Kinase - metabolism | RNA Interference | Time Factors | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Inhibitor of Apoptosis Proteins - metabolism | TNF Receptor-Associated Factor 6 - genetics | Protein-Serine-Threonine Kinases - metabolism | Recombinant Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Signal Transduction | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | MAP Kinase Kinase Kinases - metabolism | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Hep G2 Cells | Protein Transport | Ubiquitin-Protein Ligases | Poly(ADP-ribose) Polymerases - metabolism | NF-kappa B - genetics | Ubiquitin-Conjugating Enzymes - metabolism | TNF Receptor-Associated Factor 6 - metabolism | Protein Binding | DNA Damage | HeLa Cells | Mutation | Poly (ADP-Ribose) Polymerase-1 | Adaptor Proteins, Signal Transducing - metabolism | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 21, pp. 7942 - 7968
In aortic vascular smooth muscle (VSM), the canonical Wnt receptor LRP6 inhibits protein arginine (Arg) methylation, a new component of noncanonical Wnt... 
atherosclerosis | Type 2 diabetes | BONE BIOLOGY | cardiovascular disease | TRANSCRIPTION FACTOR RUNX2 | SINGLETON-MERTEN SYNDROME | CARDIOVASCULAR CALCIFICATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | INHIBITS VASCULAR CALCIFICATION | vascular biology | metabolic syndrome | DIABETES-MELLITUS | Wnt signaling | arteriosclerosis | protein methylation | ATHEROSCLEROTIC CALCIFICATION | IN-VIVO | calcification | ARGININE METHYLATION | vascular smooth muscle cells | CORONARY-ARTERY-DISEASE | Calcinosis - genetics | RNA Helicases - metabolism | Poly-ADP-Ribose Binding Proteins - metabolism | Calcium - metabolism | Humans | Myocytes, Smooth Muscle - pathology | Antiviral Agents - metabolism | Aorta - metabolism | Arteriosclerosis - genetics | Wnt Proteins - metabolism | Wnt Proteins - genetics | RNA Helicases - genetics | Calcinosis - metabolism | RNA Recognition Motif Proteins - metabolism | DNA Helicases - genetics | Myocytes, Smooth Muscle - metabolism | Low Density Lipoprotein Receptor-Related Protein-6 | Signal Transduction | Mice, Inbred C57BL | Cells, Cultured | Poly-ADP-Ribose Binding Proteins - genetics | beta Catenin - metabolism | beta Catenin - genetics | Mice, Knockout | Aorta - pathology | DNA Helicases - metabolism | Adaptor Proteins, Signal Transducing - physiology | Animals | Arteriosclerosis - metabolism | Mice | RNA Recognition Motif Proteins - genetics | Receptors, LDL - physiology | Calcinosis - pathology | Arteriosclerosis - pathology | Index Medicus | Molecular Bases of Disease
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 03/2013, Volume 20, Issue 3, pp. 317 - 325
The pathogenic sequelae of BRCA1 mutation in human and mouse cells are mitigated by concomitant deletion of 538P1, which binds histone H4 dimethylated at Lys20... 
POLY(ADP-RIBOSE) POLYMERASE | METHYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | DOUBLE-STRAND BREAKS | HISTONE ACETYLTRANSFERASE ACTIVITY | BRCA1 | CELL BIOLOGY | REPAIR PROTEINS | BIOPHYSICS | SITES | CLASS-SWITCH RECOMBINATION | CELL-CYCLE | Chromatin - metabolism | Humans | Histone Acetyltransferases - genetics | Molecular Sequence Data | Homologous Recombination | Intracellular Signaling Peptides and Proteins - metabolism | DNA Breaks, Double-Stranded | Gene Knockdown Techniques | DNA-Binding Proteins - metabolism | BRCA1 Protein - metabolism | Histone Acetyltransferases - metabolism | Acetylation | Lysine Acetyltransferase 5 | DNA Helicases - genetics | Intracellular Signaling Peptides and Proteins - genetics | Amino Acid Sequence | ATPases Associated with Diverse Cellular Activities | Chromosomal Proteins, Non-Histone - metabolism | Magnetic Resonance Spectroscopy | Cells, Cultured | Histone Deacetylases - metabolism | DNA-Binding Proteins - genetics | Chromosomal Proteins, Non-Histone - genetics | BRCA1 Protein - genetics | Carrier Proteins - genetics | DNA Helicases - metabolism | Carrier Proteins - metabolism | Intracellular Signaling Peptides and Proteins - chemistry | Protein Conformation | Histones - metabolism | Tumor Suppressor p53-Binding Protein 1 | Chromatin - genetics | Care and treatment | Chromatin | BRCA mutations | Physiological aspects | Breast cancer | Genetic aspects | Research | Structure | Health aspects | Risk factors | Mutation | Molecular biology | DNA repair | DNA damage | Index Medicus | 53BP1 | Homologous recombination | PARP inhibitors | TIP60
Journal Article
Journal Article
Science, ISSN 0036-8075, 9/2009, Volume 325, Issue 5945, pp. 1240 - 1243
Journal Article
Journal Article