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Journal Article
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 07/2014, Volume 371, Issue 4, pp. 303 - 312
This study shows that the mTORC pathway is central to the antiphospholipid syndrome. Among patients with kidney transplants and antiphospholipid syndrome, 70%... 
RAPAMYCIN | BETA-GLYCOPROTEIN-I | MEDICINE, GENERAL & INTERNAL | SYSTEMIC-LUPUS-ERYTHEMATOSUS | ANGIOPLASTY | ANTIBODY-MEDIATED REJECTION | POLYCYSTIC KIDNEY-DISEASE | SMOOTH-MUSCLE-CELLS | ANTI-BETA-GLYCOPROTEIN-I ANTIBODIES | SYNDROME NEPHROPATHY | VASCULOPATHY | Endothelium, Vascular - cytology | Cell Proliferation | Kidney - blood supply | Kidney - pathology | TOR Serine-Threonine Kinases - metabolism | Humans | Immunoglobulin G | Immunosuppressive Agents - therapeutic use | Middle Aged | Male | Antiphospholipid Syndrome - complications | TOR Serine-Threonine Kinases - antagonists & inhibitors | Autopsy | Adult | Female | Antiphospholipid Syndrome - metabolism | Immunosuppressive Agents - pharmacology | Kidney Diseases - metabolism | Sirolimus - therapeutic use | Antiphospholipid Syndrome - drug therapy | Kidney Transplantation | Sirolimus - pharmacology | Antibodies, Antiphospholipid - metabolism | Analysis of Variance | Endothelium, Vascular - metabolism | Endothelium, Vascular - pathology | Kidney Diseases - etiology | Metabolic Networks and Pathways - drug effects | Care and treatment | Rapamycin | Health aspects | Antiphospholipid syndrome | TOR protein | Cell proliferation | Lupus | Heart attacks | Kidneys | Transplants & implants | Sirolimus | AKT protein | Antiphospholipid antibodies | Kinases | Thrombosis | Endothelial cells | Endothelium | 1-Phosphatidylinositol 3-kinase | Vascular diseases | Nephropathy | Biopsy | Autoimmune diseases | Kidney transplantation
Journal Article
American Journal of Kidney Diseases, ISSN 0272-6386, 2016, Volume 69, Issue 2, pp. 210 - 219
Journal Article