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autosomal dominant polycystic kidney disease (52) 52
development and progression (51) 51
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polycystic kidney diseases - drug therapy (49) 49
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physiology (48) 48
rodents (48) 48
progression (47) 47
analysis (46) 46
polycystic kidney, autosomal dominant - drug therapy (46) 46
polycystic kidney, autosomal dominant - pathology (46) 46
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article (45) 45
genetic aspects (45) 45
polycystic kidney diseases - pathology (45) 45
expression (44) 44
kidney - drug effects (44) 44
cell biology (43) 43
child (43) 43
health aspects (43) 43
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abridged index medicus (41) 41
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risk factors (40) 40
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cell proliferation (38) 38
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protein (35) 35
kidney transplantation (34) 34
polycystic kidney diseases - metabolism (34) 34
apoptosis (33) 33
inhibition (33) 33
transplantation (33) 33
treatment outcome (33) 33
urologic and male genital diseases (33) 33
cell proliferation - drug effects (32) 32
trpp cation channels - genetics (32) 32
growth (31) 31
liver (31) 31
middle aged (31) 31
polycystic kidney, autosomal dominant - physiopathology (31) 31
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liver diseases (27) 27
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polycystic kidney, autosomal dominant - metabolism (27) 27
signal transduction - drug effects (27) 27
cyst formation (26) 26
genetics (26) 26
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activation (25) 25
autosomal recessive polycystic kidney disease (25) 25
cyst growth (25) 25
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Journal Article
PLoS ONE, ISSN 1932-6203, 05/2017, Volume 12, Issue 5, pp. e0177934 - e0177934
Increased intracellular cyclic AMP (cAMP) in renal tubular epithelia accelerates the progression of polycystic kidney disease (PKD). Thus, decreasing cAMP... 
SOM230 | SOMATOSTATIN ANALOGS | ACTIVATION | INHIBITION | CYSTOGENESIS | MULTIDISCIPLINARY SCIENCES | GROWTH | KINASE | CONGENITAL HEPATIC-FIBROSIS | LIVER-DISEASE | PROGRESSION | Liver - pathology | Kidney - pathology | Ribosomal Protein S6 Kinases - metabolism | Somatostatin - adverse effects | Heart - physiology | Humans | Body Weight - drug effects | Polycystic Kidney, Autosomal Recessive - physiopathology | Ki-67 Antigen - metabolism | Male | Extracellular Signal-Regulated MAP Kinases - metabolism | Insulin - blood | Phosphoproteins - metabolism | Glucagon - blood | Somatostatin - pharmacology | Polycystic Kidney, Autosomal Recessive - pathology | Kidney - metabolism | Drug Interactions | Hyperglycemia - chemically induced | Liver - drug effects | Polycystic Kidney, Autosomal Recessive - drug therapy | Hydrocortisone - blood | Cyclic AMP - metabolism | Kidney - physiopathology | Disease Models, Animal | Somatostatin - analogs & derivatives | Kidney - drug effects | Liver - metabolism | Octreotide - adverse effects | Rats | Octreotide - therapeutic use | Octreotide - pharmacology | Animals | Receptor, IGF Type 1 - blood | Heart - drug effects | Somatostatin - therapeutic use | Blood Glucose - metabolism | Polycystic Kidney, Autosomal Recessive - metabolism | Insulin-Like Growth Factor I - metabolism | Care and treatment | Patient outcomes | Body weight | Analysis | Cyclic adenylic acid | G proteins | Health aspects | Polycystic kidney disease | Disorders | Colleges & universities | Hormones | Incidence | Anticancer properties | Proteins | Adenylate cyclase | Hyperglycemia | Medical science | Cell growth | Education | Inhibition | Liver diseases | AMP | Splicing | Ducts | Cyclic AMP | Metabolism | Gene expression | Insulin | Bile duct | Nephropathy | Cysts | Fibrosis | Mutation | Endocrinology | Clear cell-type renal cell carcinoma | Kidney transplantation | Bile | Cell proliferation | Animal models | Medical services | Homeostasis | Clinical trials | Stimulation | Insulin-like growth factors | Kinases | Urology | Analogs | Rodents | Primates | Safety | Age | Congenital diseases | Argipressin | Nutrition | Secretion | Health | Risk reduction | Pharmacology | Rivers | Chemical compounds | Vasopressin | Medicine | Antitumor activity | Kidney diseases | Tumors | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2013, Volume 8, Issue 12, pp. e81480 - e81480
Human autosomal recessive polycystic kidney disease (ARPKD) produces kidneys which are massively enlarged due to multiple cysts, hypertension, and congenital... 
CONGENITAL HEPATIC-FIBROSIS | PPAR-GAMMA | RECEPTOR | GENE | MULTIDISCIPLINARY SCIENCES | THERAPEUTIC TARGET | Cysts - drug therapy | Liver - pathology | Benzoates - therapeutic use | Liver - enzymology | Humans | Liver Diseases - pathology | Polycystic Kidney, Autosomal Recessive - physiopathology | Hepatocytes - pathology | Male | Extracellular Signal-Regulated MAP Kinases - metabolism | Kidney Function Tests | Polycystic Kidney, Autosomal Recessive - pathology | Liver - drug effects | Polycystic Kidney, Autosomal Recessive - drug therapy | Female | Blood Pressure - drug effects | Hepatocytes - drug effects | Benzimidazoles - therapeutic use | Cysts - physiopathology | Disease Models, Animal | Liver Function Tests | Angiotensin II - metabolism | Rats | Cysts - pathology | Rats, Sprague-Dawley | Organ Size - drug effects | Animals | Signal Transduction - drug effects | Receptor, Angiotensin, Type 1 - metabolism | Benzoates - pharmacology | Benzimidazoles - pharmacology | Cell Proliferation - drug effects | Liver Diseases - drug therapy | Liver Diseases - physiopathology | Transforming Growth Factor beta - metabolism | Hypertension | Liver diseases | Body weight | Angiotensin | Antihypertensive drugs | Aspartate | Bone morphogenetic proteins | Transforming growth factors | Polycystic kidney disease | Syngeneic grafts | Liver | Interstitial cells | Fuel consumption | Renal tubules | Blood | Education | Rodents | Cascades | Blood pressure | Hepatotoxicity | Alanine | Kidneys | Congenital diseases | Polycystic kidney | Ducts | Medical treatment | Diabetes mellitus | Oral administration | Bile duct | Blood levels | Urea | Signaling | Injury prevention | Cysts | Hepatocytes | Fibrosis | Kidney diseases | Peroxisome proliferator-activated receptors | Mutation | Kidney transplantation | Index Medicus
Journal Article
Gastroenterology, ISSN 0016-5085, 2007, Volume 132, Issue 3, pp. 1104 - 1116
Background & Aims: In polycystic liver diseases (PCLDs), increased cholangiocyte proliferation and fluid secretion are key features and cholangiocyte adenosine... 
Gastroenterology and Hepatology | KIDNEY-DISEASE | MOLECULAR CHARACTERIZATION | CYST FORMATION | CYCLIC ADENOSINE | TYROSINE KINASE INHIBITION | SOMATOSTATIN RECEPTORS | CELL-PROLIFERATION | HAN-SPRD RATS | ORTHOLOGOUS MODEL | GASTROENTEROLOGY & HEPATOLOGY | BILIARY EPITHELIUM | Cysts - etiology | Bile Ducts - metabolism | Bile Duct Diseases - etiology | Liver Diseases - pathology | Dose-Response Relationship, Drug | Polycystic Kidney, Autosomal Recessive - pathology | Cysts - metabolism | Liver - drug effects | Time Factors | Bile Duct Diseases - metabolism | Polycystic Kidney, Autosomal Recessive - complications | Liver Diseases - etiology | Liver Cirrhosis - metabolism | Polycystic Kidney, Autosomal Recessive - drug therapy | Receptors, Somatostatin - metabolism | Cyclic AMP - metabolism | Organ Culture Techniques | Disease Models, Animal | Liver Cirrhosis - etiology | Cysts - prevention & control | Kidney - drug effects | Liver Cirrhosis - prevention & control | Bile Ducts - drug effects | Liver - metabolism | Liver Diseases - prevention & control | Rats | Octreotide - therapeutic use | Cysts - pathology | Octreotide - pharmacology | Rats, Sprague-Dawley | Disease Progression | Gastrointestinal Agents - pharmacology | Animals | Bile Duct Diseases - prevention & control | Gastrointestinal Agents - therapeutic use | Receptors, Somatostatin - drug effects | Cell Proliferation - drug effects | Liver Diseases - metabolism | Polycystic Kidney, Autosomal Recessive - metabolism | Bile Duct Diseases - pathology | Adenosine | Analysis | Index Medicus | Abridged Index Medicus
Journal Article
Nephrology Dialysis Transplantation, ISSN 0931-0509, 2/2009, Volume 24, Issue 2, pp. 526 - 534
Background. Antagonists of relevant Gs protein-coupled and agonists of relevant Gi protein-coupled receptors lower renal cAMP and inhibit growth of renal cysts... 
Cyclic AMP | Calcimimetic | mouse | Pkd2 | PCK rat | Polycystic kidney disease | VASOPRESSIN-ELICITED WATER | INHIBITION | EPITHELIAL-CELLS | MEDULLARY COLLECTING DUCTS | RAT-KIDNEY | CA2 | PHENOTYPE | UROLOGY & NEPHROLOGY | PROLIFERATION | LIVER-DISEASE | CAMP | TRANSPLANTATION | Protein-Serine-Threonine Kinases - deficiency | Kidney - pathology | Humans | Polycystic Kidney, Autosomal Dominant - pathology | Male | RNA, Messenger - metabolism | Receptors, Calcium-Sensing - metabolism | Phenethylamines | Polycystic Kidney, Autosomal Recessive - genetics | Polycystic Kidney, Autosomal Recessive - pathology | Kidney - metabolism | Polycystic Kidney, Autosomal Dominant - genetics | Mice, Mutant Strains | Rats, Mutant Strains | Polycystic Kidney, Autosomal Recessive - drug therapy | Female | Cyclic AMP - metabolism | Polycystic Kidney, Autosomal Dominant - drug therapy | Disease Models, Animal | Aniline Compounds - pharmacology | Calcium - agonists | Kidney - drug effects | RNA, Messenger - genetics | Protein-Serine-Threonine Kinases - genetics | Rats | Receptors, Calcium-Sensing - agonists | Mice, Knockout | Polycystic Kidney, Autosomal Dominant - metabolism | Animals | Receptors, Vasopressin - genetics | Mice | Aquaporin 2 - genetics | Polycystic Kidney, Autosomal Recessive - metabolism | Propylamines | Index Medicus | polycystic kidney disease | cyclic AMP | calcimimetic | Original | WS25 mouse
Journal Article
Journal of the American Society of Nephrology, ISSN 1046-6673, 07/2008, Volume 19, Issue 7, pp. 1331 - 1341
Despite identification of the genes responsible for autosomal dominant polycystic kidney disease (PKD) and autosomal recessive PKD (ARPKD), the precise... 
ACTIVATION | PROTEIN | PATHWAY | PHOSPHORYLATION | CYST EPITHELIAL-CELLS | EPIDERMAL-GROWTH-FACTOR | CAROLIS-DISEASE | UROLOGY & NEPHROLOGY | PCK | PROLIFERATION | RAT MODEL | Nitriles - toxicity | Kidney - pathology | Nitriles - pharmacology | Glycoproteins - metabolism | Male | Quinolines - pharmacology | Kidney Function Tests | Polycystic Kidney, Autosomal Recessive - pathology | Receptor, Epidermal Growth Factor - metabolism | Polycystic Kidney, Autosomal Recessive - drug therapy | Quinolines - toxicity | Cyclic AMP - metabolism | Aniline Compounds - pharmacology | Glycoproteins - antagonists & inhibitors | Rats | Proto-Oncogene Proteins pp60(c-src) - antagonists & inhibitors | Aniline Compounds - toxicity | Rats, Sprague-Dawley | Disease Progression | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Organ Size - drug effects | Animals | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Proto-Oncogene Proteins pp60(c-src) - metabolism | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Mice | Mice, Inbred BALB C | Quinolines - therapeutic use | Receptor, ErbB-2 | Aniline Compounds - therapeutic use | Polycystic Kidney, Autosomal Recessive - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Nitriles - therapeutic use | Index Medicus | Basic Research
Journal Article
Gastroenterology, ISSN 0016-5085, 2012, Volume 142, Issue 3, pp. 622 - 633.e4
Background & Aims In polycystic kidney disease and polycystic liver disease (PLD), the normally nonproliferative hepato-renal epithelia acquire a... 
Gastroenterology and Hepatology | Therapeutic Strategy | Animal Model | Phosphatase | Cell Division | CANCER-CELLS | ACTIVATION | ANTICANCER AGENTS | IN-VITRO | VITAMIN-K3 | GROWTH | HEPATIC CYSTOGENESIS | LONG-ACTING SOMATOSTATIN | ANIMAL-MODEL | GASTROENTEROLOGY & HEPATOLOGY | PHOSPHATASES | Cysts - drug therapy | Up-Regulation | Liver - pathology | Liver - enzymology | Kidney - pathology | Humans | Kidney - enzymology | Liver Diseases - pathology | Bile Ducts, Intrahepatic - drug effects | Polycystic Kidney, Autosomal Recessive - genetics | Polycystic Kidney, Autosomal Recessive - pathology | cdc25 Phosphatases - deficiency | cdc25 Phosphatases - antagonists & inhibitors | Liver - drug effects | Polycystic Kidney, Autosomal Recessive - enzymology | Time Factors | Liver Diseases - enzymology | Polycystic Kidney, Autosomal Recessive - drug therapy | Cysts - enzymology | cdc25 Phosphatases - metabolism | Disease Models, Animal | TRPP Cation Channels - metabolism | Bile Ducts, Intrahepatic - pathology | Liver Diseases - genetics | Kidney - drug effects | Cells, Cultured | Enzyme Inhibitors - pharmacology | Rats | Receptors, Cell Surface - metabolism | cdc25 Phosphatases - genetics | Cysts - pathology | Bile Ducts, Intrahepatic - enzymology | TRPP Cation Channels - genetics | Mice, Knockout | Vitamin K 3 - pharmacology | Organ Size - drug effects | Animals | Cysts - genetics | Cell Proliferation - drug effects | Liver Diseases - drug therapy | Mice | Cell Cycle - drug effects | Receptors, Cell Surface - genetics | Hypertension | Antigen-antibody reactions | Medical colleges | Phosphatases | Liver diseases | Molecular genetics | Analysis | Models | Kidney diseases | Index Medicus | Abridged Index Medicus | cell division | phosphatase | therapeutic strategy | animal model
Journal Article
Journal of Pediatric Gastroenterology and Nutrition, ISSN 0277-2116, 04/2015, Volume 60, Issue 4, pp. 467 - 473
Journal Article
Kidney International, ISSN 0085-2538, 09/2011, Volume 80, Issue 6, pp. 612 - 619
Journal Article
Journal Article
Kidney International, ISSN 0085-2538, 10/2003, Volume 64, Issue 4, pp. 1310 - 1319
Combination treatment of PKD utilizing dual inhibition of EGF-receptor activity and ligand bioavailability. We have previously demonstrated an essential role... 
tyrosine kinase inhibition | bpk mice | collecting tubule cysts | autosomal-recessive polycystic kidney disease | epidermal growth factor receptor | Autosomal-recessive polycystic kidney disease | Collecting tubule cysts | Tyrosine kinase inhibition | Epidermal growth factor receptor | PROTEIN | POLYCYSTIC KIDNEY-DISEASE | FACTOR-ALPHA | EPITHELIAL-CELLS | GENE | CYST FORMATION | EPIDERMAL-GROWTH-FACTOR | UROLOGY & NEPHROLOGY | TYROSINE KINASE INHIBITOR | AUTOSOMAL-DOMINANT | MICE | Kidney - pathology | Aniline Compounds | Hydroxamic Acids - adverse effects | Organic Chemicals - toxicity | Biological Availability | Dose-Response Relationship, Drug | Polycystic Kidney, Autosomal Recessive - pathology | Kidney - diagnostic imaging | Ultrasonography | Hydroxamic Acids - administration & dosage | Polycystic Kidney, Autosomal Recessive - drug therapy | Drug Therapy, Combination | Organic Chemicals - administration & dosage | Hydroxamic Acids - toxicity | Kidney - drug effects | Drug Administration Schedule | Organic Chemicals - adverse effects | Organic Chemicals - therapeutic use | Polycystic Kidney, Autosomal Recessive - diagnostic imaging | Animals | Sulfonamides - therapeutic use | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Sulfonamides - adverse effects | Hydroxamic Acids - therapeutic use | Ligands | Sulfonamides - toxicity | Mice | Mice, Inbred BALB C | Sulfonamides - administration & dosage | Aminoquinolines | Index Medicus
Journal Article