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Kidney International, ISSN 0085-2538, 05/2013, Volume 83, Issue 5, pp. 855 - 864
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2016, Volume 11, Issue 10, pp. e0163063 - e0163063
Autosomal recessive polycystic kidney disease (ARPKD) is associated with progressive enlargement of the kidneys fuelled by the formation and expansion of... 
MULTIDISCIPLINARY SCIENCES | EXPERIENCE | Biomarkers - urine | Cystatin C - blood | Blood Urea Nitrogen | Humans | Polycystic Kidney, Autosomal Recessive - pathology | Kidney - metabolism | Kidney - diagnostic imaging | Ultrasonography | Renal Insufficiency - blood | Child | Kidney - physiopathology | Severity of Illness Index | Interleukin-18 - blood | Polycystic Kidney, Autosomal Recessive - urine | Rats | Kidney Transplantation | Renal Insufficiency - urine | Biomarkers - blood | Hepatitis A Virus Cellular Receptor 1 - blood | Cysts - pathology | Polycystic Kidney, Autosomal Recessive - diagnostic imaging | Magnetic Resonance Imaging | Animals | Renal Insufficiency - pathology | Creatinine - blood | Polycystic Kidney, Autosomal Recessive - blood | Mice | Lipocalin-2 - blood | CT imaging | Big data | Diagnostic imaging | Genetic disorders | Chronic kidney failure | Polycystic kidney disease | Neonates | Pediatrics | End-stage renal disease | Nuclear magnetic resonance--NMR | Renal function | Transplants & implants | Clinical trials | Drug development | Renal insufficiency | Pain | Data management | Computed tomography | Nephrectomy | Mathematical models | Bioindicators | Children | Ultrasound | Age | Enlargement | Urine | Medical research | Kidneys | Medical imaging | Polycystic kidney | Empirical equations | Health risks | Data processing | Signal averaging | Patients | Disease control | Cysts | Magnetic resonance imaging | Biomarkers | Kidney diseases | Mutation | Formulas (mathematics) | Kidney transplantation | Index Medicus | Nuclear magnetic resonance | NMR
Journal Article
Journal Article
Nature Reviews Nephrology, ISSN 1759-5061, 09/2017, Volume 13, Issue 9, pp. 519 - 520
Journal Article
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 12/2017, Volume 313, Issue 6, pp. F1223 - F1231
Cystic epithelia acquire mesenchymal-like features in polycystic kidney disease (PKD). In this phenotypic alteration, it is well known that transforming growth... 
C-Myc | Smad3 | Phosphoisoform | Autosomal dominant polycystic kidney disease | Cyclin-dependent kinase 4 | phosphoisoform | PROTOONCOGENE EXPRESSION | PHYSIOLOGY | TGF-BETA | c-Myc | MICROSATELLITE INSTABILITY | RECEPTOR | autosomal dominant polycystic kidney disease | HUMAN COLORECTAL-CANCER | COLON-CARCINOMA CELLS | GROWTH-FACTOR-BETA | GENE | MESENCHYMAL TRANSITIONS | cyclin-dependent kinase 4 | UROLOGY & NEPHROLOGY | CELLULAR PATHOPHYSIOLOGY | Genetic Predisposition to Disease | Phosphorylation | Epithelial Cells - metabolism | Kidney - pathology | Signal Transduction | Mice, Inbred C57BL | Epithelial Cells - pathology | JNK Mitogen-Activated Protein Kinases - metabolism | Smad3 Protein - metabolism | Cyclin-Dependent Kinase 4 - metabolism | Proto-Oncogene Proteins c-myc - metabolism | Polycystic Kidney, Autosomal Recessive - genetics | Mice, Knockout | Polycystic Kidney, Autosomal Recessive - pathology | Smad3 Protein - deficiency | Smad3 Protein - genetics | Kidney - metabolism | Phenotype | Animals | Polycystic Kidney, Autosomal Recessive - metabolism | Disease Models, Animal | Immunoprecipitation | Carcinoma | Mesenchyme | Polycystic kidney | Syngeneic grafts | Epithelial cells | Transforming growth factor | Colorectal carcinoma | Colorectal cancer | c-Myc protein | Smooth muscle | JNK protein | Smad3 protein | Myc protein | Nuclei | Western blotting | Cyclin-dependent kinase | Genotype & phenotype | Cysts | Actin | Rodents | Kidney diseases | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2017, Volume 12, Issue 5, pp. e0177934 - e0177934
Increased intracellular cyclic AMP (cAMP) in renal tubular epithelia accelerates the progression of polycystic kidney disease (PKD). Thus, decreasing cAMP... 
SOM230 | SOMATOSTATIN ANALOGS | ACTIVATION | INHIBITION | CYSTOGENESIS | MULTIDISCIPLINARY SCIENCES | GROWTH | KINASE | CONGENITAL HEPATIC-FIBROSIS | LIVER-DISEASE | PROGRESSION | Liver - pathology | Kidney - pathology | Ribosomal Protein S6 Kinases - metabolism | Somatostatin - adverse effects | Heart - physiology | Humans | Body Weight - drug effects | Polycystic Kidney, Autosomal Recessive - physiopathology | Ki-67 Antigen - metabolism | Male | Extracellular Signal-Regulated MAP Kinases - metabolism | Insulin - blood | Phosphoproteins - metabolism | Glucagon - blood | Somatostatin - pharmacology | Polycystic Kidney, Autosomal Recessive - pathology | Kidney - metabolism | Drug Interactions | Hyperglycemia - chemically induced | Liver - drug effects | Polycystic Kidney, Autosomal Recessive - drug therapy | Hydrocortisone - blood | Cyclic AMP - metabolism | Kidney - physiopathology | Disease Models, Animal | Somatostatin - analogs & derivatives | Kidney - drug effects | Liver - metabolism | Octreotide - adverse effects | Rats | Octreotide - therapeutic use | Octreotide - pharmacology | Animals | Receptor, IGF Type 1 - blood | Heart - drug effects | Somatostatin - therapeutic use | Blood Glucose - metabolism | Polycystic Kidney, Autosomal Recessive - metabolism | Insulin-Like Growth Factor I - metabolism | Care and treatment | Patient outcomes | Body weight | Analysis | Cyclic adenylic acid | G proteins | Health aspects | Polycystic kidney disease | Disorders | Colleges & universities | Hormones | Incidence | Anticancer properties | Proteins | Adenylate cyclase | Hyperglycemia | Medical science | Cell growth | Education | Inhibition | Liver diseases | AMP | Splicing | Ducts | Cyclic AMP | Metabolism | Gene expression | Insulin | Bile duct | Nephropathy | Cysts | Fibrosis | Mutation | Endocrinology | Clear cell-type renal cell carcinoma | Kidney transplantation | Bile | Cell proliferation | Animal models | Medical services | Homeostasis | Clinical trials | Stimulation | Insulin-like growth factors | Kinases | Urology | Analogs | Rodents | Primates | Safety | Age | Congenital diseases | Argipressin | Nutrition | Secretion | Health | Risk reduction | Pharmacology | Rivers | Chemical compounds | Vasopressin | Medicine | Antitumor activity | Kidney diseases | Tumors | Index Medicus
Journal Article
Gastroenterology, ISSN 0016-5085, 2007, Volume 132, Issue 3, pp. 1104 - 1116
Background & Aims: In polycystic liver diseases (PCLDs), increased cholangiocyte proliferation and fluid secretion are key features and cholangiocyte adenosine... 
Gastroenterology and Hepatology | KIDNEY-DISEASE | MOLECULAR CHARACTERIZATION | CYST FORMATION | CYCLIC ADENOSINE | TYROSINE KINASE INHIBITION | SOMATOSTATIN RECEPTORS | CELL-PROLIFERATION | HAN-SPRD RATS | ORTHOLOGOUS MODEL | GASTROENTEROLOGY & HEPATOLOGY | BILIARY EPITHELIUM | Cysts - etiology | Bile Ducts - metabolism | Bile Duct Diseases - etiology | Liver Diseases - pathology | Dose-Response Relationship, Drug | Polycystic Kidney, Autosomal Recessive - pathology | Cysts - metabolism | Liver - drug effects | Time Factors | Bile Duct Diseases - metabolism | Polycystic Kidney, Autosomal Recessive - complications | Liver Diseases - etiology | Liver Cirrhosis - metabolism | Polycystic Kidney, Autosomal Recessive - drug therapy | Receptors, Somatostatin - metabolism | Cyclic AMP - metabolism | Organ Culture Techniques | Disease Models, Animal | Liver Cirrhosis - etiology | Cysts - prevention & control | Kidney - drug effects | Liver Cirrhosis - prevention & control | Bile Ducts - drug effects | Liver - metabolism | Liver Diseases - prevention & control | Rats | Octreotide - therapeutic use | Cysts - pathology | Octreotide - pharmacology | Rats, Sprague-Dawley | Disease Progression | Gastrointestinal Agents - pharmacology | Animals | Bile Duct Diseases - prevention & control | Gastrointestinal Agents - therapeutic use | Receptors, Somatostatin - drug effects | Cell Proliferation - drug effects | Liver Diseases - metabolism | Polycystic Kidney, Autosomal Recessive - metabolism | Bile Duct Diseases - pathology | Adenosine | Analysis | Index Medicus | Abridged Index Medicus
Journal Article