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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/1996, Volume 93, Issue 4, pp. 1524 - 1528
Polycystic kidney disease 1 (PKD1) is the major locus of the common genetic disorder autosomal dominant polycystic kidney disease. We have studied PKD1 mRNA,... 
Proteins | COS cells | TRPP cation channels | Kidneys | Messenger RNA | Capsules | Cysts | Autosomal dominant polycystic kidney | Antibodies | Polycystic kidney diseases | antibody | autosomal dominant polycystic kidney disease | RENAL-DISEASE | MULTIDISCIPLINARY SCIENCES | Physiological aspects | Research | Observations | Epithelial cells | Polycystic kidney disease
Journal Article
The EMBO Journal, ISSN 0261-4189, 08/2018, Volume 37, Issue 15, p. n/a
Polycystic kidney disease (PKD) and other renal ciliopathies are characterized by cysts, inflammation, and fibrosis. Cilia function as signaling centers, but a... 
macrophages | cilia | nephronophthisis | polycystic kidney disease | MIGRATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | PLANAR CELL POLARITY | CELL BIOLOGY | NEPHROCYSTIN-4 | GENE | DISEASE | MUTATIONS | CYST GROWTH | Protein Kinase C - genetics | Epithelial Cells - metabolism | Humans | Polycystic Kidney, Autosomal Dominant - pathology | Male | Polycystic Kidney, Autosomal Dominant - genetics | Protein Kinase C - metabolism | HEK293 Cells | Madin Darby Canine Kidney Cells | Female | Chemokine CCL2 - metabolism | Kidney Tubules - pathology | Protein-Serine-Threonine Kinases - metabolism | Cell Line | Cilia - pathology | Mice, Inbred C57BL | Phagocytosis - physiology | Protein-Serine-Threonine Kinases - genetics | Zebrafish | Kidney Diseases, Cystic - pathology | Mice, Knockout | Kidney Tubules - cytology | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Dogs | Mice | Kidney Diseases, Cystic - congenital | CC chemokine receptors | Phenotypes | Kidneys | Polycystic kidney | Epithelial cells | Homeostasis | Polycystic kidney disease 1 protein | Leukocytes (mononuclear) | Inflammation | Macrophages | Renal tubules | Proteins | LKB1 protein | Phagocytes | Signaling | Clonal deletion | CCR2 protein | Cysts | Fibrosis | Deletion | Chemokines | Monocyte chemoattractant protein 1 | Cilia | Immune system | Immunology | Cell Adhesion, Polarity & Cytoskeleton | Molecular Biology of Disease
Journal Article
Science, ISSN 0036-8075, 09/2018, Volume 361, Issue 6406, pp. 992 - 992
Mutations in two genes, PKD1 and PKD2, account for most cases of autosomal dominant polycystic kidney disease, one of the most common monogenetic disorders.... 
DOMAIN | PROTEIN | CHANNEL | GENE | POLYCYSTIC KIDNEY-DISEASE | MULTIDISCIPLINARY SCIENCES | IDENTIFICATION | EXPRESSION | PKD2 MUTATIONS | PRIMARY CILIA | INSIGHTS | Humans | Crystallography, X-Ray | Multiprotein Complexes - genetics | Protein Folding | TRPP Cation Channels - genetics | Polycystic Kidney, Autosomal Dominant - metabolism | Cryoelectron Microscopy | Multiprotein Complexes - ultrastructure | TRPP Cation Channels - chemistry | Multiprotein Complexes - chemistry | Polycystic Kidney, Autosomal Dominant - genetics | Protein Domains | TRPP Cation Channels - ultrastructure | Mutation | TRPP Cation Channels - metabolism | Genetic research | Human genetics | Research | Stoichiometry | Electric potential | Residues | Size exclusion chromatography | Calcium | Pathogenesis | Genes | Trafficking | Disorders | Mapping | Helices | Proteins | Transient receptor potential proteins | Voltage | Ion channels | Assembly | Cilia | Calcium release channels | Calcium (intracellular) | Kidneys | Architecture | Polycystic kidney | Channel gating | Polycystic kidney disease 1 protein | Electron microscopy | Epithelium | Calcium permeability | Domains | Organic chemistry | Polycystin-2 | Microscopy | Computer applications | Renal failure | Kidney diseases | Disruption | Lipoxygenase | Gene mapping | Endoplasmic reticulum | Cellular structure | Calcium (reticular) | Calcium ions | Stimuli
Journal Article
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, ISSN 1931-857X, 08/2019, Volume 317, Issue 2, pp. F221 - F228
Autosomal dominant polycystic kidney disease (ADPKD) is associated with increased chemokines, cytokines, and growth factors in the diseased kidney. We found... 
PATHWAYS | APOPTOSIS | PHYSIOLOGY | interleukin-1 | MECHANISM | DOMAIN-LIKE PROTEIN | DEATH | autosomal dominant polycystic kidney disease | tumor necrosis factor-alpha | INHIBITION | INFLAMMATION | UROLOGY & NEPHROLOGY | EXPRESSION | necroptosis
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2010, Volume 5, Issue 2, p. e9239
Autosomal dominant polycystic kidney disease (ADPKD) is a commonly inherited renal disorder caused by defects in the PKD1 or PKD2 genes. ADPKD is associated... 
KIDNEY-DISEASE | PATHOGENESIS | SLOWS DISEASE PROGRESSION | PROTEIN | MULTIDISCIPLINARY SCIENCES | PKD1 GENE | TUBEROUS SCLEROSIS | CELL-GROWTH | C-JUN | GENE-PRODUCT | MEMBRANE LOCALIZATION | Immunohistochemistry | Cell Line | Tumor Suppressor Proteins - metabolism | Signal Transduction | Humans | Middle Aged | Polycystic Kidney, Autosomal Dominant - pathology | Immunoblotting | Intracellular Signaling Peptides and Proteins - metabolism | Serine - metabolism | TRPP Cation Channels - genetics | Polycystic Kidney, Autosomal Dominant - metabolism | 14-3-3 Proteins - metabolism | TRPP Cation Channels - chemistry | Polycystic Kidney, Autosomal Dominant - genetics | RNA Interference | TRPP Cation Channels - physiology | Protein Binding | Adult | TOR Serine-Threonine Kinases | Proto-Oncogene Proteins c-akt - metabolism | Protein-Serine-Threonine Kinases - metabolism | Hypertension | Proteins | Tuberous sclerosis | Genetic aspects | Kidney diseases | Protein binding | TOR protein | End-stage renal disease | Phosphorylation | Transplants & implants | Syngeneic grafts | Pathogenesis | Intracellular signalling | AKT protein | Hamartin | Transplantation | Kinases | Cytosol | Risk factors | Sclerosis | Cell adhesion & migration | Signal transduction | Localization | Cilia | Binding | Polycystic kidney | Health risks | Polycystic kidney disease 1 protein | Tethering | Rapamycin | Pharmacology | Risk analysis | Gene expression | Morbidity | 1-Phosphatidylinositol 3-kinase | 14-3-3 protein | Cysts | Protein synthesis | Renal failure | Tumor suppressor genes | Dialysis | Mutation | Risk management | Position (location) | Cardiovascular diseases | Kidney transplantation | Cancer
Journal Article