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Journal of Controlled Release, ISSN 0168-3659, 06/2016, Volume 232, pp. 20 - 28
Low efficacy of cationic polymer-based formulations (polyplexes) for systemic gene delivery to tumors remains the crucial concern for their clinical... 
Gene delivery | Polyplexes | Nanoparticle extravasation | Tumor uptake | Tumor vasculature | VASCULAR-PERMEABILITY | MALIGNANT-MELANOMA | CHEMISTRY, MULTIDISCIPLINARY | TRANSFECTION EFFICACY | INDUCED HYPERTENSION | ENHANCED PERMEABILITY | TRANSPORT | PLASMID DNA | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | SOLID TUMOR | NONVIRAL VECTORS | Angiotensin II - administration & dosage | Vasodilator Agents - pharmacokinetics | Gene Expression Regulation, Neoplastic | Melanoma, Experimental - metabolism | Green Fluorescent Proteins - genetics | Receptor, Melanocortin, Type 1 - metabolism | Nitroglycerin - pharmacology | Drug Delivery Systems | Polyethyleneimine - pharmacokinetics | Melanoma, Experimental - physiopathology | Regional Blood Flow - drug effects | Nitroglycerin - pharmacokinetics | Nitroglycerin - administration & dosage | Female | Mice, Inbred DBA | Losartan - pharmacokinetics | Polyethylene Glycols - pharmacology | Vasoconstrictor Agents - pharmacology | Gene Transfer Techniques | Angiotensin II - pharmacology | Vasoconstrictor Agents - administration & dosage | Vasoconstrictor Agents - pharmacokinetics | Collagen Type I - metabolism | Vasodilator Agents - pharmacology | Melanoma, Experimental - therapy | Mice, Inbred C57BL | Oligopeptides - pharmacokinetics | Losartan - pharmacology | DNA - administration & dosage | Polyethylene Glycols - pharmacokinetics | Polyethyleneimine - pharmacology | Angiotensin II - pharmacokinetics | Polyethylene Glycols - administration & dosage | Polyethyleneimine - analogs & derivatives | Administration, Intravenous | Animals | Melanoma, Experimental - genetics | Polyethyleneimine - administration & dosage | Cell Line, Tumor | Luciferases, Firefly - genetics | Nanoparticles - administration & dosage | Oligopeptides - administration & dosage | Losartan - administration & dosage | Vasodilator Agents - administration & dosage | Nitrates | Drug therapy | Nitroglycerin | Tumors | Molecular genetics | Melanoma | Angiotensin | Research institutes
Journal Article
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 10/2012, Volume 163, Issue 1, pp. 82 - 92
Gene therapy is a promising therapeutic approach for treating disease, but the efficient delivery of genes to desired locations with minimal side effects... 
Magnetic resonance imaging (MRI) | Gene delivery | Super paramagnetic iron oxide nanoparticles (SPIONs) | Chitosan and PEI coated magnetic micelles (CP–mag-micelles) | Theranostics | Chitosan and PEI coated magnetic micelles (CP-mag-micelles) | STEM-CELLS | CONTRAST AGENTS | DRUG-DELIVERY | CHITOSAN-GRAFT-POLYETHYLENIMINE | POLYMERIC MICELLE | SIRNA DELIVERY | CHEMISTRY, MULTIDISCIPLINARY | CARRIER | IN-VITRO | THERAPY | NANOPARTICLE-BOUND DNA | PHARMACOLOGY & PHARMACY | Fluorescent Dyes - pharmacokinetics | Carbocyanines - pharmacokinetics | Carbocyanines - administration & dosage | Humans | Magnetic Resonance Imaging - methods | Magnetite Nanoparticles - administration & dosage | Polyethylene Glycols - chemistry | Tissue Distribution | Transfection - methods | Magnetic Phenomena | Micelles | Polyesters - administration & dosage | Polyethyleneimine - chemistry | HEK293 Cells | Fluorescent Dyes - administration & dosage | Gene Expression | Mice, Inbred C57BL | Chitosan - administration & dosage | DNA - administration & dosage | Polyethylene Glycols - administration & dosage | Polyesters - chemistry | Magnetite Nanoparticles - chemistry | Animals | Chitosan - chemistry | Polyethyleneimine - administration & dosage | Cell Line, Tumor | Mice | 3T3 Cells | Iron compounds | Magnetic resonance imaging | Ferric oxide | Genes | Nucleic acids | Gene therapy | Polyols | magnetic resonance imaging (MRI) | gene delivery | theranostics | super paramagnetic iron oxide nanoparticles (SPIONs)
Journal Article
Journal Article
Journal Article
International Journal of Pharmaceutics, ISSN 0378-5173, 03/2016, Volume 500, Issue 1-2, pp. 196 - 209
Targeted delivery of carmustine (BCNU), an efficient brain tumor therapeutic, has been challenged with bioavailability issues due to the Blood Brain Barrier... 
Brain tumor | Polyplex | Magnetite | Iron oxide nanoparticles | Carmustine | Superparamagnetic | Chemotherapeutics | Core-shell | Blood brain barrier | Nano-co-Plex | IRON-OXIDE NANOPARTICLES | GLIOMAS | CELLS | DRUG-DELIVERY | TRANSFECTION | MEMS DEVICE | POLYETHYLENIMINE | BCNU | SILICA NANOPARTICLES | PHARMACOLOGY & PHARMACY | AGENTS | Polyvinyl Alcohol - chemistry | Polyvinyl Alcohol - pharmacology | Humans | Antineoplastic Agents, Alkylating - pharmacology | Magnetite Nanoparticles - administration & dosage | Antineoplastic Agents, Alkylating - administration & dosage | Drug Delivery Systems | Brain - metabolism | Fluorescein-5-isothiocyanate - chemistry | Polyethyleneimine - chemistry | Fluorescent Dyes - pharmacology | Antineoplastic Agents, Alkylating - chemistry | Fluorescent Dyes - administration & dosage | Cell Survival - drug effects | Fluorescent Dyes - chemistry | Fluorescein-5-isothiocyanate - pharmacology | Fluorescein-5-isothiocyanate - administration & dosage | Carmustine - chemistry | Polyethyleneimine - pharmacology | Polyvinyl Alcohol - administration & dosage | Carmustine - pharmacology | Administration, Intranasal | Particle Size | Magnetite Nanoparticles - chemistry | Polyethyleneimine - administration & dosage | Cell Line, Tumor | Drug Liberation | Carmustine - administration & dosage | Antimitotic agents | Drugs | Drug delivery systems | Antineoplastic agents | Analysis | Vehicles | Brain tumors | Superconductors | Iron compounds | Ferric oxide | Precipitation (Meteorology) | Magnetic fields
Journal Article
Anticancer Research, ISSN 0250-7005, 05/2017, Volume 37, Issue 5, pp. 2195 - 2200
Background: Chemotherapy is an effective option to treat recurrent or metastatic cancer but its debilitating side-effects limit the dose and time of exposure.... 
Metastasis | Cytosine deaminase | Prodrug enzyme therapy | Imaging | Lung cancer | prodrug enzyme therapy | MOLECULAR CHEMOTHERAPY | THERANOSTIC NANOPLEX | INTRATUMORAL CONVERSION | cytosine deaminase | RETROVIRAL REPLICATING VECTOR | imaging | lung cancer | BREAST-CANCER | IN-VITRO | ONCOLOGY | PROSTATE-CANCER | CYTOSINE DEAMINASE GENE | ENZYME/PRODRUG CANCER-THERAPY | TUMOR-GROWTH | Prodrugs - administration & dosage | Lung Neoplasms - drug therapy | Drug Carriers - therapeutic use | Humans | Polylysine - administration & dosage | Drug Carriers - administration & dosage | Lung Neoplasms - pathology | Polylysine - chemistry | Antineoplastic Agents - therapeutic use | Prodrugs - chemistry | Antineoplastic Agents - administration & dosage | Drug Carriers - chemistry | Fluorouracil - therapeutic use | Fluorouracil - administration & dosage | Cytosine Deaminase - therapeutic use | Escherichia coli Proteins - administration & dosage | Cytosine Deaminase - administration & dosage | Polyethyleneimine - chemistry | Cytosine Deaminase - chemistry | Female | Nanostructures - therapeutic use | Polyethyleneimine - therapeutic use | Antineoplastic Agents - chemistry | Mice, SCID | Polylysine - therapeutic use | Disease Progression | Animals | Escherichia coli Proteins - therapeutic use | Fluorouracil - chemistry | Nanostructures - administration & dosage | Polyethyleneimine - administration & dosage | Cell Line, Tumor | Nanostructures - chemistry | Prodrugs - therapeutic use | Escherichia coli Proteins - chemistry
Journal Article
Vaccine, ISSN 0264-410X, 2009, Volume 27, Issue 30, pp. 4010 - 4017
Abstract During persistent infection and hypoxic-stress, Mycobacterium tuberculosis ( Mtb ) expresses a series of Mtb latency antigens. The aim of this study... 
Allergy and Immunology | DNA vaccine | Tuberculosis latency antigens | Pulmonary immunization | PLGA–PEI nanoparticles | T cell response | PLGA-PEI nanoparticles | CATIONIC MICROPARTICLES | MEDICINE, RESEARCH & EXPERIMENTAL | PROTEIN | DENDRITIC CELLS | GENE DELIVERY | HYPOXIC RESPONSE | IMMUNOLOGY | PROTECTIVE EFFICACY | IMPROVED IMMUNOGENICITY | BOVINE TUBERCULOSIS | DORMANCY REGULON | VACCINES | Vaccines, DNA - genetics | Adjuvants, Immunologic - administration & dosage | Adjuvants, Immunologic - pharmacology | Dendritic Cells - immunology | Humans | Antigens, Bacterial - immunology | Mycobacterium tuberculosis - immunology | Vaccines, DNA - immunology | Polyglycolic Acid - pharmacology | Antigens, Bacterial - genetics | Vaccines, DNA - administration & dosage | Immunization, Secondary | Female | Tuberculosis Vaccines - immunology | Lactic Acid - pharmacology | Interleukin-12 - secretion | Lactic Acid - administration & dosage | Polyglycolic Acid - administration & dosage | Tuberculosis Vaccines - genetics | Interferon-gamma - secretion | Tuberculosis Vaccines - administration & dosage | Tumor Necrosis Factor-alpha - secretion | Cells, Cultured | Administration, Inhalation | Polyethyleneimine - pharmacology | Vaccines, Subunit - immunology | Animals | Polyethyleneimine - administration & dosage | Vaccines, Subunit - administration & dosage | T-Lymphocytes - immunology | Mice | Mice, Inbred BALB C | Nanoparticles - administration & dosage | Mycobacterium tuberculosis - genetics | Drugs | Antigens | Tuberculosis vaccines | Drug delivery systems | Dendritic cells | Vaccination | T cells | Vehicles | Nanoparticles | Tuberculosis | DNA | Genetic research | Health aspects | Mitogens | Public health | Cell proliferation
Journal Article
European Journal of Pharmaceutics and Biopharmaceutics, ISSN 0939-6411, 07/2017, Volume 116, pp. 4 - 11
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 06/2013, Volume 168, Issue 3, pp. 271 - 279
Journal Article