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Pharmaceutical Research, ISSN 0724-8741, 2007, Volume 24, Issue 8, pp. 1590 - 1598
Knowledge about the uptake mechanism and subsequent intracellular routing of non-viral gene delivery systems is important for the development of more efficient... 
Biomedical Engineering | Biochemistry, general | gene delivery | Biomedicine | Pharmacy | cationic polymers | Medical Law | endocytosis | Pharmacology/Toxicology | caveolae | Gene delivery | Endocytosis | Cationic polymers | Caveolae | PATHWAYS | POLYPLEXES | INTRACELLULAR FATE | CHOLESTEROL | POLYETHYLENIMINE | CHEMISTRY, MULTIDISCIPLINARY | DELIVERY | INTERNALIZATION | MEDIATED ENDOCYTOSIS | MACROPINOCYTOSIS | PHARMACOLOGY & PHARMACY | EFFICIENCY | Luciferases - metabolism | Nocodazole - pharmacology | Cercopithecus aethiops | Caveolae - drug effects | Methacrylates - chemistry | beta-Cyclodextrins - pharmacology | Clathrin-Coated Vesicles - metabolism | Luciferases - genetics | Flow Cytometry | Macromolecular Substances - chemistry | Transfection - methods | Polyethyleneimine - chemistry | Biological Transport - drug effects | Fluorescent Dyes - chemistry | Polyamines - chemistry | Caveolae - metabolism | Cholera Toxin - metabolism | Endocytosis - drug effects | Enzyme Inhibitors - pharmacology | Nylons - chemistry | Chlorpromazine - pharmacology | Clathrin-Coated Vesicles - drug effects | DNA - chemistry | Animals | Androstadienes - pharmacology | Genistein - pharmacology | Macromolecular Substances - pharmacokinetics | Cholera Toxin - pharmacokinetics | Transferrin - pharmacokinetics | Transferrin - metabolism | COS Cells | Macromolecular Substances - metabolism | Microscopy, Fluorescence | Gene expression | Cholera toxin | Cellular biology | Deoxyribonucleic acid | DNA | Pharmacology | Gene therapy | Polymers | Research Paper
Journal Article
Biomacromolecules, ISSN 1525-7797, 08/2017, Volume 18, Issue 8, pp. 2231 - 2246
After more than 20 years of intensive investigations, gene therapy has become one of the most promising strategies for treating genetic diseases. However, the... 
Gene Transfer Techniques | Polylysine - pharmacology | DNA - chemistry | Animals | DNA - pharmacology | Humans | Polyethyleneimine - chemistry | Polyethyleneimine - pharmacology | Polylysine - chemistry | Drug Carriers - chemistry | Drug Carriers - pharmacology
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 02/2015, Volume 200, pp. 1 - 12
Neutral particles 20–45 nm in diameter showed potential as tumor antigen vectors because they targeted the draining lymph nodes after subcutaneous injection.... 
Cationic micelle | Polyethylenimine | Draining lymph node | Cytotoxic T lymphocytes | Trp2 antigen peptide | T lymphocytes | Cytotoxic | ACTIVATION | METASTASIS | DENDRITIC CELLS | VACCINE | MATURATION | CANCER | CHEMISTRY, MULTIDISCIPLINARY | NANOPARTICLES | MELANOMA | IMMUNE-RESPONSES | IN-VIVO | PHARMACOLOGY & PHARMACY | Adjuvants, Immunologic - administration & dosage | Adjuvants, Immunologic - pharmacology | Dendritic Cells - immunology | Peptide Fragments - pharmacology | Antineoplastic Agents - therapeutic use | Membrane Proteins - pharmacology | Antineoplastic Agents - administration & dosage | Membrane Proteins - therapeutic use | Antigens - administration & dosage | T-Lymphocytes, Cytotoxic - drug effects | Adjuvants, Immunologic - chemistry | Micelles | Polyethyleneimine - chemistry | Dendritic Cells - drug effects | Female | Lymph Nodes - drug effects | Antineoplastic Agents - pharmacology | Adjuvants, Immunologic - therapeutic use | Polyethyleneimine - therapeutic use | Skin Neoplasms - pathology | T-Lymphocytes, Cytotoxic - immunology | Skin Neoplasms - therapy | Melanoma, Experimental - therapy | Mice, Inbred C57BL | Peptide Fragments - administration & dosage | Melanoma, Experimental - pathology | Polyethyleneimine - pharmacology | Lymph Nodes - immunology | Antineoplastic Agents - chemistry | Stearic Acids - chemistry | Antigens - chemistry | Membrane Proteins - administration & dosage | Peptide Fragments - chemistry | Animals | Membrane Proteins - chemistry | Tumor Burden - drug effects | Cell Differentiation - drug effects | Polyethyleneimine - administration & dosage | Cell Line, Tumor | Dendritic Cells - cytology | Peptide Fragments - therapeutic use | Antigens - pharmacology | Peptides | Dendritic cells | Lymphocytes | Analysis | Melanoma | Index Medicus
Journal Article
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 06/2016, Volume 232, pp. 20 - 28
Low efficacy of cationic polymer-based formulations (polyplexes) for systemic gene delivery to tumors remains the crucial concern for their clinical... 
Gene delivery | Polyplexes | Nanoparticle extravasation | Tumor uptake | Tumor vasculature | VASCULAR-PERMEABILITY | MALIGNANT-MELANOMA | CHEMISTRY, MULTIDISCIPLINARY | TRANSFECTION EFFICACY | INDUCED HYPERTENSION | ENHANCED PERMEABILITY | TRANSPORT | PLASMID DNA | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | SOLID TUMOR | NONVIRAL VECTORS | Angiotensin II - administration & dosage | Vasodilator Agents - pharmacokinetics | Gene Expression Regulation, Neoplastic | Melanoma, Experimental - metabolism | Green Fluorescent Proteins - genetics | Receptor, Melanocortin, Type 1 - metabolism | Nitroglycerin - pharmacology | Drug Delivery Systems | Polyethyleneimine - pharmacokinetics | Melanoma, Experimental - physiopathology | Regional Blood Flow - drug effects | Nitroglycerin - pharmacokinetics | Nitroglycerin - administration & dosage | Female | Mice, Inbred DBA | Losartan - pharmacokinetics | Polyethylene Glycols - pharmacology | Vasoconstrictor Agents - pharmacology | Gene Transfer Techniques | Angiotensin II - pharmacology | Vasoconstrictor Agents - administration & dosage | Vasoconstrictor Agents - pharmacokinetics | Collagen Type I - metabolism | Vasodilator Agents - pharmacology | Melanoma, Experimental - therapy | Mice, Inbred C57BL | Oligopeptides - pharmacokinetics | Losartan - pharmacology | DNA - administration & dosage | Polyethylene Glycols - pharmacokinetics | Polyethyleneimine - pharmacology | Angiotensin II - pharmacokinetics | Polyethylene Glycols - administration & dosage | Polyethyleneimine - analogs & derivatives | Administration, Intravenous | Animals | Melanoma, Experimental - genetics | Polyethyleneimine - administration & dosage | Cell Line, Tumor | Luciferases, Firefly - genetics | Nanoparticles - administration & dosage | Oligopeptides - administration & dosage | Losartan - administration & dosage | Vasodilator Agents - administration & dosage | Nitrates | Drug therapy | Nitroglycerin | Tumors | Molecular genetics | Melanoma | Angiotensin | Research institutes
Journal Article
Biomaterials, ISSN 0142-9612, 2011, Volume 32, Issue 31, pp. 7774 - 7784
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 2017, Volume 61, Issue 10
Journal Article
International Journal of Pharmaceutics, ISSN 0378-5173, 03/2016, Volume 500, Issue 1-2, pp. 196 - 209
Targeted delivery of carmustine (BCNU), an efficient brain tumor therapeutic, has been challenged with bioavailability issues due to the Blood Brain Barrier... 
Brain tumor | Polyplex | Magnetite | Iron oxide nanoparticles | Carmustine | Superparamagnetic | Chemotherapeutics | Core-shell | Blood brain barrier | Nano-co-Plex | IRON-OXIDE NANOPARTICLES | GLIOMAS | CELLS | DRUG-DELIVERY | TRANSFECTION | MEMS DEVICE | POLYETHYLENIMINE | BCNU | SILICA NANOPARTICLES | PHARMACOLOGY & PHARMACY | AGENTS | Polyvinyl Alcohol - chemistry | Polyvinyl Alcohol - pharmacology | Humans | Antineoplastic Agents, Alkylating - pharmacology | Magnetite Nanoparticles - administration & dosage | Antineoplastic Agents, Alkylating - administration & dosage | Drug Delivery Systems | Brain - metabolism | Fluorescein-5-isothiocyanate - chemistry | Polyethyleneimine - chemistry | Fluorescent Dyes - pharmacology | Antineoplastic Agents, Alkylating - chemistry | Fluorescent Dyes - administration & dosage | Cell Survival - drug effects | Fluorescent Dyes - chemistry | Fluorescein-5-isothiocyanate - pharmacology | Fluorescein-5-isothiocyanate - administration & dosage | Carmustine - chemistry | Polyethyleneimine - pharmacology | Polyvinyl Alcohol - administration & dosage | Carmustine - pharmacology | Administration, Intranasal | Particle Size | Magnetite Nanoparticles - chemistry | Polyethyleneimine - administration & dosage | Cell Line, Tumor | Drug Liberation | Carmustine - administration & dosage | Antimitotic agents | Drugs | Drug delivery systems | Antineoplastic agents | Analysis | Vehicles | Brain tumors | Superconductors | Iron compounds | Ferric oxide | Precipitation (Meteorology) | Magnetic fields
Journal Article
Journal Article
International Journal of Nanomedicine, ISSN 1176-9114, 06/2013, Volume 8, pp. 2101 - 2117
Background: Targeted delivery of small interfering RNA (siRNA) has been regarded as one of the most important technologies for the development of siRNA... 
Polyethyleneimine | 2-hydroxypropyl-β-cyclodextrin | Gene silencing | SiRNA carrier | Vascular endothelial growth factor | Folic acid | POLYMERS | RNA | COMPLEXES | gene silencing | NANOSCIENCE & NANOTECHNOLOGY | siRNA carrier | DELIVERY | vascular endothelial growth factor | 2-hydroxypropyl-beta-cyclodextrin | PHARMACOLOGY & PHARMACY | polyethyleneimine | folic acid | VECTORS | 2-Hydroxypropyl-beta-cyclodextrin | RNA, Small Interfering - genetics | Folic Acid - pharmacology | Molecular Weight | Humans | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | beta-Cyclodextrins - pharmacokinetics | beta-Cyclodextrins - pharmacology | Drug Carriers - chemistry | Polyethyleneimine - pharmacokinetics | RNA, Small Interfering - chemistry | Flow Cytometry | Transfection | Polyethyleneimine - chemistry | Neoplasms, Experimental | Female | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Cell Survival - drug effects | RNA, Small Interfering - pharmacokinetics | RNA, Small Interfering - pharmacology | Folic Acid - chemistry | Gene Silencing | Polyethyleneimine - pharmacology | Antineoplastic Agents - chemistry | Folic Acid - pharmacokinetics | Drug Carriers - pharmacology | Xenograft Model Antitumor Assays | Animals | beta-Cyclodextrins - chemistry | Mice, Nude | Drug Carriers - pharmacokinetics | Mice | HeLa Cells | Original Research
Journal Article
Journal Article
Biomaterials, ISSN 0142-9612, 2005, Volume 26, Issue 5, pp. 545 - 554
Journal Article