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Science Translational Medicine, ISSN 1946-6234, 11/2015, Volume 7, Issue 314, pp. 314ra183 - 314ra183
Journal Article
International Journal of Pharmaceutics, ISSN 0378-5173, 09/2018, Volume 548, Issue 2, pp. 747 - 758
Journal Article
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 12/2015, Volume 220, Issue Pt A, pp. 180 - 188
Journal Article
Nature Biotechnology, ISSN 1087-0156, 01/2000, Volume 18, Issue 1, pp. 52 - 57
Controlled release from biodegradable polymers is a novel approach to replace daily painful injections of protein drugs. A major obstacle to development of... 
Aggregation | Protein delivery | Bovine serum albumin | Poly(DL-lactide-co- glycolide | Stabilization | stabilization | BIODEGRADABLE MICROSPHERES | BONE MORPHOGENETIC PROTEIN-2 | aggregation | MOISTURE-INDUCED AGGREGATION | poly(DL-lactide-co-glycolide) | DELIVERY | protein delivery | FORMULATIONS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | DEGRADATION | FIBROBLAST GROWTH-FACTOR | MICROENCAPSULATION | ALBUMIN | SUSTAINED-RELEASE | bovine serum albumin | Disulfides - metabolism | Solubility - drug effects | Protein Denaturation - drug effects | Molecular Weight | Hydrolysis - drug effects | Protein Conformation - drug effects | Serum Albumin - administration & dosage | Polyglactin 910 - metabolism | Microspheres | Bone Morphogenetic Proteins - metabolism | Osmolar Concentration | Computer Simulation | Isoelectric Point | Proteins - administration & dosage | Fibroblast Growth Factor 2 - metabolism | Polyglactin 910 - chemistry | Antacids - pharmacology | Serum Albumin - chemistry | Polyglactin 910 - administration & dosage | Transforming Growth Factor beta | Peptide Fragments - metabolism | Bone Morphogenetic Proteins - administration & dosage | Bone Morphogenetic Protein 2 | Drug Stability | Water - metabolism | Fibroblast Growth Factor 2 - administration & dosage | Peptide Fragments - chemistry | Animals | Proteins - metabolism | Mice | Proteins - chemistry | Delayed-Action Preparations | 3T3 Cells | Hydrogen-Ion Concentration | Serum Albumin - metabolism | fibroblast growth factor | bone morphogenetic protein 2 | microspheres | polylactide-co-glycolide
Journal Article
International Journal of Molecular Sciences, ISSN 1422-0067, 2012, Volume 13, Issue 1, pp. 516 - 533
Journal Article
Molecular Therapy, ISSN 1525-0016, 07/2017, Volume 25, Issue 7, pp. 1655 - 1664
Polymeric nanoparticles (NPs) have demonstrated their potential to induce antigen (Ag)-specific immunological tolerance in multiple immune models and are at... 
bioconjugation | immune tolerance | regulatory T cells | multiple sclerosis | nanoparticle | drug delivery | autoimmune disease | MEDICINE, RESEARCH & EXPERIMENTAL | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | BONE-MARROW | INDUCTION | IMMUNOLOGICAL-TOLERANCE | TRANSPLANTATION | PLATFORM | CODELIVERY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | DISEASE | GENETICS & HEREDITY | REGULATORY T-CELLS | IMMUNE TOLERANCE | Forkhead Transcription Factors - immunology | Myelin Proteolipid Protein - immunology | Spleen - immunology | Nanoparticles - chemistry | Ovalbumin - immunology | Encephalomyelitis, Autoimmune, Experimental - immunology | Delayed-Action Preparations - chemistry | Spleen - drug effects | Polyglactin 910 - metabolism | T-Lymphocytes, Regulatory - pathology | Delayed-Action Preparations - administration & dosage | Myelin Proteolipid Protein - pharmacology | T-Lymphocytes, Regulatory - immunology | Immunoconjugates - pharmacology | Interleukin-2 Receptor alpha Subunit - genetics | Female | Encephalomyelitis, Autoimmune, Experimental - genetics | Polyglactin 910 - chemistry | Myelin Proteolipid Protein - chemistry | Spleen - pathology | Ovalbumin - chemistry | CD4 Antigens - genetics | Immune Tolerance - drug effects | Interleukin-2 Receptor alpha Subunit - immunology | Biomarkers - metabolism | CD4 Antigens - immunology | Gene Expression | Encephalomyelitis, Autoimmune, Experimental - pathology | Immunoconjugates - metabolism | Mice, Inbred C57BL | Forkhead Transcription Factors - genetics | Ovalbumin - pharmacology | Immunoconjugates - chemistry | Antigens - chemistry | Particle Size | Encephalomyelitis, Autoimmune, Experimental - therapy | T-Lymphocytes, Regulatory - drug effects | Animals | Antigens - immunology | Mice | Nanoparticles - administration & dosage | Primary Cell Culture | Antigens - pharmacology | Animal models | Multiple sclerosis | Nuclear magnetic resonance--NMR | Encephalomyelitis | Transplants & implants | Disease | Peptides | Lymphocytes T | Nanoparticles | Developmental stages | Lymphocytes | CD25 antigen | Foxp3 protein | Polymers | Antigens | T cell receptors | Immunological tolerance | Experimental allergic encephalomyelitis | Investigations | CD4 antigen | Immunogenicity | Poly(lactide-co-glycolide) | Autoimmune diseases | Physicochemical properties | Methods | Original
Journal Article
Molecular Therapy, ISSN 1525-0016, 07/2017, Volume 25, Issue 7, pp. 1676 - 1685
Targeted approaches to treat autoimmune diseases would improve upon current therapies that broadly suppress the immune system and lead to detrimental side... 
tolerance induction mechanism | antigen-specific tolerance | immune tolerance | PLGA | PLG nanoparticles | MEDICINE, RESEARCH & EXPERIMENTAL | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | DENDRITIC CELLS | ANTIGENS | IL-10 | IMMUNOLOGICAL-TOLERANCE | DELIVERY | RESPONSES | MULTIPLE-SCLEROSIS | PATHWAY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | CROSS-PRESENTATION | B7-2 Antigen - genetics | Myelin Proteolipid Protein - immunology | B7-1 Antigen - genetics | Spleen - immunology | Nanoparticles - chemistry | Ovalbumin - immunology | Encephalomyelitis, Autoimmune, Experimental - immunology | Delayed-Action Preparations - chemistry | Spleen - drug effects | Polyglactin 910 - metabolism | T-Lymphocytes, Regulatory - pathology | Delayed-Action Preparations - administration & dosage | Myelin Proteolipid Protein - pharmacology | T-Lymphocytes, Regulatory - immunology | Antigen-Presenting Cells - pathology | Immunoconjugates - pharmacology | Female | CD40 Antigens - genetics | Encephalomyelitis, Autoimmune, Experimental - genetics | Polyglactin 910 - chemistry | B7-2 Antigen - immunology | Myelin Proteolipid Protein - chemistry | Spleen - pathology | Ovalbumin - chemistry | Immune Tolerance - drug effects | Gene Expression | Encephalomyelitis, Autoimmune, Experimental - pathology | B7-1 Antigen - immunology | Immunoconjugates - metabolism | Antigen-Presenting Cells - drug effects | Mice, Inbred C57BL | Ovalbumin - pharmacology | Antigen-Presenting Cells - immunology | Immunoconjugates - chemistry | Antigens - chemistry | Particle Size | Encephalomyelitis, Autoimmune, Experimental - therapy | T-Lymphocytes, Regulatory - drug effects | Animals | Antigens - immunology | Mice | Nanoparticles - administration & dosage | Primary Cell Culture | Antigens - pharmacology | CD40 Antigens - immunology | Cell proliferation | Multiple sclerosis | Transcription factors | CD40 antigen | Disease | Peptides | CD86 antigen | Lymphocytes T | Nanoparticles | Myelin proteolipid protein | Lymphocytes | Localization | Immune system | Antigen presentation | Cytokines | Dendritic cells | Myelin | CD80 antigen | Inflammation | T cell receptors | Immunological tolerance | Studies | Major histocompatibility complex | Antigen-presenting cells | Internalization | PD-L1 protein | Proteolipid protein | Poly(lactide-co-glycolide) | Autoimmune diseases | Apoptosis | Original
Journal Article
Journal Article