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1. Full Text Predicting therapeutic nanomedicine efficacy using a companion magnetic resonance imaging nanoparticle
by Miller, Miles A and Gadde, Suresh and Pfirschke, Christina and Engblom, Camilla and Sprachman, Melissa M and Kohler, Rainer H and Yang, Katherine S and Laughney, Ashley M and Wojtkiewicz, Gregory and Kamaly, Nazila and Bhonagiri, Sushma and Pittet, Mikael J and Farokhzad, Omid C and Weissleder, Ralph
Science translational medicine, ISSN 1946-6234, 11/2015, Volume 7, Issue 314, pp. 314ra183 - 314ra183
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Paclitaxel - metabolism | Predictive Value of Tests | Humans | Ovarian Neoplasms - pathology | Magnetic Resonance Imaging - methods | Tumor Microenvironment | Polyethylene Glycols - chemistry | Ferrosoferric Oxide - metabolism | Fibrosarcoma - metabolism | Polyglactin 910 - metabolism | Nanoparticles | Ovarian Neoplasms - genetics | Tissue Distribution | Paclitaxel - chemistry | Antineoplastic Agents, Phytogenic - administration & dosage | Fibrosarcoma - pathology | Time Factors | Female | Antineoplastic Agents, Phytogenic - metabolism | Ovarian Neoplasms - metabolism | Polyglactin 910 - chemistry | Paclitaxel - administration & dosage | Ovarian Neoplasms - drug therapy | Polyethylene Glycols - metabolism | Mice, Inbred C57BL | Antineoplastic Agents, Phytogenic - chemistry | Mice, Transgenic | Ferrosoferric Oxide - chemistry | Chemistry, Pharmaceutical | Disease Progression | Particle Size | Xenograft Model Antitumor Assays | Fibrosarcoma - genetics | Macrophages - metabolism | Animals | Mice, Nude | Magnetics - methods | Nanomedicine - methods | Cell Line, Tumor | Mice, Inbred BALB C | DNA Damage | Fibrosarcoma - drug therapy | Index Medicus
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2. Full Text Nanoparticle penetration of human cervicovaginal mucus: The effect of polyvinyl alcohol
by Yang, Ming and Lai, Samuel K and Yu, Tao and Wang, Ying-Ying and Happe, Christina and Zhong, Weixi and Zhang, Michael and Anonuevo, Abraham and Fridley, Colleen and Hung, Amy and Fu, Jie and Hanes, Justin
Journal of controlled release, ISSN 0168-3659, 10/2014, Volume 192, pp. 202 - 208
Drug delivery | Mucoadhesion | Mucus-penetrating particles | Surfactant | Biodegradable polymers | Pharmacology & Pharmacy | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Polyethylene Glycols - metabolism | Polyvinyl Alcohol - chemistry | Drug Carriers - metabolism | Nanoparticles - chemistry | Adhesiveness | Humans | Coated Materials, Biocompatible - chemistry | Coated Materials, Biocompatible - metabolism | Polyethylene Glycols - chemistry | Polyglactin 910 - metabolism | Polyvinyl Alcohol - metabolism | Drug Carriers - chemistry | Polyesters - chemistry | Polyesters - metabolism | Cervix Mucus - metabolism | Nanoparticles - metabolism | Polyglactin 910 - chemistry | Surface active agents | Polyols | Index Medicus | mucus-penetrating particles | mucoadhesion | biodegradable polymers | surfactant
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3. Full Text PEG–PLGA based large porous particles for pulmonary delivery of a highly soluble drug, low molecular weight heparin
by Patel, Brijeshkumar and Gupta, Vivek and Ahsan, Fakhrul
Journal of controlled release, ISSN 0168-3659, 09/2012, Volume 162, Issue 2, pp. 310 - 320
Low molecular weight heparin | PEG–PLGA | Highly water-soluble drugs | Microparticles | Pulmonary delivery | PEG-PLGA | Pharmacology & Pharmacy | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Pharmaceutical technology. Pharmaceutical industry | Biological and medical sciences | Medical sciences | General pharmacology | Pharmacology. Drug treatments | L-Lactate Dehydrogenase - metabolism | Alkaline Phosphatase - metabolism | Drug Carriers - administration & dosage | Male | Polyethylene Glycols - chemistry | Drug Carriers - chemistry | Polyglactin 910 - pharmacokinetics | Bronchoalveolar Lavage Fluid - cytology | Lung - metabolism | Polyglactin 910 - chemistry | Polyglactin 910 - administration & dosage | Solubility | Administration, Inhalation | Heparin, Low-Molecular-Weight - chemistry | Polyethylene Glycols - pharmacokinetics | Rats | Rats, Sprague-Dawley | Polyethylene Glycols - administration & dosage | Particle Size | Heparin, Low-Molecular-Weight - pharmacokinetics | Animals | Drug Carriers - pharmacokinetics | Bronchoalveolar Lavage Fluid - chemistry | Heparin, Low-Molecular-Weight - administration & dosage | Macrophages, Alveolar - metabolism | Porosity | Analysis | Block copolymers | Index Medicus
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4. Full Text PLGA-PEG nanoparticles for targeted delivery of the mTOR/PI3kinase inhibitor dactolisib to inflamed endothelium
by Gholizadeh, Shima and Kamps, Jan. A.A.M and Hennink, Wim E and Kok, Robbert J
International journal of pharmaceutics, ISSN 0378-5173, 09/2018, Volume 548, Issue 2, pp. 747 - 758
Nanoparticles | NVP-BEZ235 | Inflammation | PLGA | Targeted delivery | DRUG-DELIVERY | PHOSPHATIDYLINOSITOL 3-KINASE/MAMMALIAN TARGET | CANCER | IN-VITRO DEGRADATION | SAINT-O-SOMES | CELL-MIGRATION | SELECTIVE DELIVERY | RAPAMYCIN INHIBITOR | PI3K/AKT/MTOR PATHWAY | Polyethylene Glycols - metabolism | Human Umbilical Vein Endothelial Cells - drug effects | Enzyme Inhibitors - metabolism | Human Umbilical Vein Endothelial Cells - metabolism | Humans | Imidazoles - administration & dosage | Endothelium, Vascular - drug effects | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Polyglactin 910 - metabolism | Quinolines - administration & dosage | Polyethylene Glycols - administration & dosage | Enzyme Inhibitors - administration & dosage | Quinolines - metabolism | Inflammation - metabolism | Endothelium, Vascular - metabolism | Inflammation - drug therapy | Nanoparticles - metabolism | Nanoparticles - administration & dosage | X-Ray Diffraction - methods | Drug Delivery Systems - methods | Polyglactin 910 - administration & dosage | Imidazoles - metabolism | Index Medicus
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5. Full Text Biodegradable Thermosensitive PLGA-PEG-PLGA Polymer for Non-irritating and Sustained Ophthalmic Drug Delivery
by Chan, Pui Shan and Xian, Jia Wen and Li, Qingqing and Chan, Chun Wai and Leung, Sharon S. Y and To, Kenneth K. W
The AAPS journal, ISSN 1550-7416, 7/2019, Volume 21, Issue 4, pp. 1 - 13
Biochemistry, general | Biotechnology | ocular delivery | Biomedicine | in situ thermosensitive hydrogel | biocompatibility | PLGA-PEG-PLGA | subconjunctival injection | Pharmacy | Pharmacology/Toxicology | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Retina - drug effects | Retina - metabolism | Temperature | Hydrogels | Polyglactin 910 - toxicity | Drug Carriers - administration & dosage | Drug Carriers - toxicity | Polyglactin 910 - metabolism | Biocompatible Materials - toxicity | Tissue Distribution | Cornea - drug effects | Female | Cornea - pathology | Irritants - pharmacokinetics | Polyglactin 910 - administration & dosage | Polyethylene Glycols - metabolism | Drug Carriers - metabolism | Irritants - toxicity | Polyethylene Glycols - toxicity | Rats, Sprague-Dawley | Polyethylene Glycols - administration & dosage | Irritants - administration & dosage | Cornea - metabolism | Animals | Drug Liberation | Hydrophobic and Hydrophilic Interactions | Biocompatible Materials - administration & dosage | Biocompatible Materials - pharmacokinetics | Retina - pathology | Injections, Intraocular | Drugs | Ethylene glycol | Drug delivery systems | Ophthalmic drugs | Therapeutics | Permeability | Polymer industry | Polymers | Patient compliance | Homeopathy | Materia medica and therapeutics | Vehicles | Index Medicus
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6. Full Text Mucoadhesive microparticles with a nanostructured surface for enhanced bioavailability of glaucoma drug
by Park, Chun Gwon and Kim, Young Kook and Kim, Mi Jeung and Park, Min and Kim, Myung Hun and Lee, Seung Ho and Choi, Sung Yoon and Lee, Won Seok and Chung, You Jung and Jung, Young Eun and Park, Ki Ho and Choy, Young Bin
Journal of controlled release, ISSN 0168-3659, 12/2015, Volume 220, Issue Pt A, pp. 180 - 188
Glaucoma | Drug delivery | Mucosal adhesion | Ophthalmology | Microparticles | Nanostructured surface | Pharmacology & Pharmacy | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Administration, Ophthalmic | Adrenergic alpha-2 Receptor Agonists - chemistry | Adrenergic alpha-2 Receptor Agonists - pharmacokinetics | Polyglactin 910 - toxicity | Biological Availability | Male | Polyethylene Glycols - chemistry | Polyglactin 910 - metabolism | Drug Carriers | Aqueous Humor - metabolism | Nanoparticles | Adrenergic alpha-2 Receptor Agonists - administration & dosage | Drug Compounding | Ophthalmic Solutions | Mucus - metabolism | Polyglactin 910 - chemistry | Polyethylene Glycols - metabolism | Rabbits | Adhesiveness | Solubility | Glaucoma - drug therapy | Technology, Pharmaceutical - methods | Polyethylene Glycols - toxicity | Animals | Brimonidine Tartrate - chemistry | Brimonidine Tartrate - pharmacokinetics | Brimonidine Tartrate - administration & dosage | Nanotechnology | Drugs | Drug delivery systems | Ophthalmic drugs | Drug therapy | Polyols | Vehicles | Medical colleges | Polyethylene glycol | Brimonidine | Patient compliance | Biomedical engineering | Index Medicus
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7. Full Text Stabilization of proteins encapsulated in injectable poly (lactide- co -glycolide)
by Mallery, Susan R and Zhu, Gaozhong and Schwendeman, Steven P
Nature biotechnology, ISSN 1087-0156, 01/2000, Volume 18, Issue 1, pp. 52 - 57
Aggregation | Protein delivery | Bovine serum albumin | Poly(DL-lactide-co- glycolide | Stabilization | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Fundamental and applied biological sciences. Psychology | Biotechnology | Biological and medical sciences | Miscellaneous | Health. Pharmaceutical industry | Industrial applications and implications. Economical aspects | Disulfides - metabolism | Solubility - drug effects | Protein Denaturation - drug effects | Molecular Weight | Hydrolysis - drug effects | Protein Conformation - drug effects | Serum Albumin - administration & dosage | Polyglactin 910 - metabolism | Microspheres | Bone Morphogenetic Proteins - metabolism | Osmolar Concentration | Computer Simulation | Isoelectric Point | Proteins - administration & dosage | Fibroblast Growth Factor 2 - metabolism | Polyglactin 910 - chemistry | Antacids - pharmacology | Serum Albumin - chemistry | Polyglactin 910 - administration & dosage | Transforming Growth Factor beta | Peptide Fragments - metabolism | Bone Morphogenetic Proteins - administration & dosage | Bone Morphogenetic Protein 2 | Drug Stability | Water - metabolism | Fibroblast Growth Factor 2 - administration & dosage | Peptide Fragments - chemistry | Animals | Proteins - metabolism | Mice | Proteins - chemistry | Delayed-Action Preparations | 3T3 Cells | Hydrogen-Ion Concentration | Serum Albumin - metabolism | fibroblast growth factor | bone morphogenetic protein 2 | microspheres | polylactide-co-glycolide | Index Medicus
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8. Full Text In vivo distribution of surface-modified PLGA nanoparticles following intravaginal delivery
by Cu, Yen and Booth, Carmen J and Saltzman, W. Mark
Journal of controlled release, ISSN 0168-3659, 2011, Volume 156, Issue 2, pp. 258 - 264
Fluorescence | Surface modification | Intravaginal delivery | Mucosal | Nanoparticle | Pharmacology & Pharmacy | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Pharmaceutical technology. Pharmaceutical industry | Biological and medical sciences | Medical sciences | General pharmacology | Pharmacology. Drug treatments | Polyethylene Glycols - metabolism | Drug Carriers - metabolism | Nanoparticles - chemistry | Mice, Inbred C57BL | Coumarins - administration & dosage | Nanoparticles - ultrastructure | Administration, Intravaginal | Polyethylene Glycols - chemistry | Thiazoles - administration & dosage | Polyglactin 910 - metabolism | Vagina - ultrastructure | Drug Carriers - chemistry | Animals | Avidin - chemistry | Female | Vagina - metabolism | Mice | Polyglactin 910 - chemistry | Nanoparticles | Index Medicus | nanoparticle | intravaginal delivery | fluorescence | surface modification | mucosal
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9. Full Text Preparation and in vitro evaluation of doxorubicin-loaded Fe3O4 magnetic nanoparticles modified with biocompatible copolymers (Retracted article. See vol. 15, pg. 5573, 2020)
by Akbarzadeh, Abolfazl and Mikaeili, Haleh and Zarghami, Nosratollah and Mohammad, Rahmati and Barkhordari, Amin and Davaran, Soodabeh
International journal of nanomedicine, ISSN 1178-2013, 01/2012, Volume 7, Issue default, pp. 511 - 526
Pharmacology & Pharmacy | Science & Technology - Other Topics | Nanoscience & Nanotechnology | Life Sciences & Biomedicine | Science & Technology | Lung Neoplasms - drug therapy | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Polyethylene Glycols - chemistry | Doxorubicin - chemistry | Drug Carriers - chemistry | Dose-Response Relationship, Drug | Polyglactin 910 - pharmacokinetics | Antibiotics, Antineoplastic - chemistry | X-Ray Diffraction | Polyglactin 910 - chemistry | Polyglactin 910 - pharmacology | Antibiotics, Antineoplastic - pharmacokinetics | Doxorubicin - administration & dosage | Polyethylene Glycols - pharmacology | Cell Survival - drug effects | Polyethylene Glycols - pharmacokinetics | Doxorubicin - pharmacokinetics | Drug Carriers - pharmacology | Antibiotics, Antineoplastic - administration & dosage | Cell Shape - drug effects | Magnetite Nanoparticles - chemistry | Cell Line, Tumor | Drug Carriers - pharmacokinetics | Nanoparticles | Cytotoxicity | Copolymers | Polyethylene glycol | Spectrum analysis | Index Medicus | drug encapsulation efficiency | doxorubicin encapsulation | water uptake | superparamagnetic iron oxide nanoparticles | triblock copolymer | Original Research
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10. Full Text Resveratrol Delivery from Porous Poly(lactide-co-glycolide) Scaffolds Promotes an Anti-Inflammatory Environment within Visceral Adipose Tissue
by Murphy, Kendall P and Hendley, Michael A and Isely, Christopher and Annamalai, Prakasam and Peña, Edsel and Gower, R. Michael
ACS applied materials & interfaces, ISSN 1944-8244, 12/2018, Volume 10, Issue 50, pp. 43363 - 43374
Research | immune response to biomaterials | scaffold | poly(lactide- co-glyocolide) | resveratrol | adipose tissue engineering | Science & Technology - Other Topics | Materials Science | Nanoscience & Nanotechnology | Technology | Materials Science, Multidisciplinary | Science & Technology | Inflammation - pathology | Cytokines - metabolism | Resveratrol - pharmacology | Arginase - metabolism | Male | 3T3-L1 Cells | Intra-Abdominal Fat - metabolism | Drug Implants - pharmacology | Resveratrol - chemistry | Inflammation - metabolism | Animals | Drug Implants - chemistry | Inflammation - drug therapy | Panniculitis - drug therapy | Mice | Intra-Abdominal Fat - pathology | Panniculitis - pathology | Polyglactin 910 - chemistry | Polyglactin 910 - pharmacology | Porosity | Panniculitis - metabolism | Index Medicus | poly(lactide-co-glyocolide)
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