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Biotechnology Advances, ISSN 0734-9750, 11/2015, Volume 33, Issue 6, pp. 1342 - 1354
Diabetes is a high prevalence and one of the most severe and lethal diseases in the world. Insulin is commonly used to treat diabetes in order to give patients... 
Polymeric nanoparticles | Oral delivery | Intestinal uptake | Diabetes | Chitosan | Insulin | Poly(lactic-co-glycolic acid) | PERORAL DELIVERY | LOADED PLGA NANOPARTICLES | CHITOSAN NANOPARTICLES | ALGINATE/CHITOSAN NANOPARTICLES | BETA-CYCLODEXTRIN POLYMERS | PROTEIN DRUG-DELIVERY | DIABETIC-RATS | INTESTINAL-ABSORPTION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | EX-VIVO | IN-VIVO EVALUATION | Polyamines - administration & dosage | Polymers - administration & dosage | Nanoparticles - chemistry | Humans | Drug Carriers - administration & dosage | Dextrans - chemistry | Polyglutamic Acid - administration & dosage | Drug Carriers - chemistry | Polyglutamic Acid - analogs & derivatives | Polyesters | Lactic Acid - administration & dosage | Hyaluronic Acid - administration & dosage | Lactic Acid - chemistry | Polyamines - chemistry | Administration, Oral | Chitosan - administration & dosage | Hyaluronic Acid - chemistry | Insulin - administration & dosage | Polyglutamic Acid - chemistry | Alginates - administration & dosage | Chitosan - chemistry | Insulin - chemistry | Alginates - chemistry | Polymers - chemistry | Nanoparticles - administration & dosage | Dextrans - administration & dosage | Drug Delivery Systems - methods | Nanoparticles | Dextran | Gastrointestinal system | Polymer industry | Hyaluronic acid | Diabetes therapy | Index Medicus | Encapsulation | Toxicity | Strategy | Bioavailability | Patients
Journal Article
Nanomedicine: Nanotechnology, Biology, and Medicine, ISSN 1549-9634, 2012, Volume 8, Issue 1, pp. 71 - 80
Abstract The in vivo efficacy of doxorubicin (DOX)-loaded poly(γ-benzyl l -glutamate)- block -hyaluronan (PBLG23 - b -HYA10 )-based polymersomes (PolyDOX) was... 
Internal Medicine | Hyaluronan | Ehrlich ascites tumor (EAT) | Antitumor activity | Doxorubicin | Polymersomes | MEDICINE, RESEARCH & EXPERIMENTAL | BLOCK-COPOLYMERS | SOLID TUMORS | DRUG-DELIVERY | RECEPTOR | NANOSCIENCE & NANOTECHNOLOGY | VASCULAR-PERMEABILITY | CANCER | CARRIERS | PACLITAXEL | LIPOSOMAL DOXORUBICIN | ENDOCYTOSIS HARE | Doxorubicin - blood | Doxorubicin - therapeutic use | Drug Carriers - adverse effects | Hyaluronic Acid - therapeutic use | Nanoparticles - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Drug Carriers - administration & dosage | Polyglutamic Acid - administration & dosage | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Nanoparticles - adverse effects | Drug Carriers - chemistry | Polyglutamic Acid - analogs & derivatives | Antineoplastic Agents - adverse effects | Female | Hyaluronic Acid - blood | Hyaluronic Acid - adverse effects | Doxorubicin - administration & dosage | Endocytosis - immunology | Technetium - chemistry | Rabbits | Hyaluronic Acid - administration & dosage | Hyaluronic Acid - chemistry | Carcinoma, Ehrlich Tumor - drug therapy | Doxorubicin - chemical synthesis | Polyglutamic Acid - blood | Polyglutamic Acid - chemistry | Animals | Hyaluronic Acid - analogs & derivatives | Antineoplastic Agents - blood | Hyaluronan Receptors - immunology | Mice | Mice, Inbred BALB C | Nanoparticles - administration & dosage | Polyglutamic Acid - therapeutic use | Neoplasms, Experimental - drug therapy | Doxorubicin - adverse effects | Polyglutamic Acid - adverse effects | Anthracyclines | Ascites | Hyaluronic acid | Tumors | Polymers | Chemical Sciences
Journal Article
European Journal of Pharmaceutics and Biopharmaceutics, ISSN 0939-6411, 08/2014, Volume 87, Issue 3, pp. 472 - 479
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 04/2018, Volume 276, pp. 125 - 139
Journal Article
Biomaterials, ISSN 0142-9612, 2011, Volume 32, Issue 15, pp. 3862 - 3874
Abstract Angiogenesis plays a prominent role in cancer progression. Anti-angiogenic therapy therefore, either alone or in combination with conventional... 
Advanced Basic Science | Dentistry | Angiogenesis | Integrin | Polyglutamic acid | Polymer therapeutics | Paclitaxel | RGD peptidomimetic | MATERIALS SCIENCE, BIOMATERIALS | RGD PEPTIDES | ENGINEERING, BIOMEDICAL | PS 2 PATIENTS | BRAIN-TUMORS | CELL LUNG-CANCER | BREAST-CANCER | CONJUGATE | POLIGLUMEX CT-2103 | INHIBITORS | CATHEPSIN-B | Paclitaxel - metabolism | Rats, Wistar | Humans | Polyglutamic Acid - administration & dosage | Integrins - metabolism | Drug Delivery Systems | Polyglutamic Acid - analogs & derivatives | Paclitaxel - chemistry | Antineoplastic Agents, Phytogenic - administration & dosage | Antineoplastic Agents, Phytogenic - metabolism | Antineoplastic Agents, Phytogenic - therapeutic use | Paclitaxel - administration & dosage | Oligopeptides - chemistry | Polyglutamic Acid - metabolism | Paclitaxel - analogs & derivatives | Rats | Antineoplastic Agents, Phytogenic - chemistry | Cathepsin B - metabolism | Oligopeptides - metabolism | Paclitaxel - therapeutic use | Neoplasms - drug therapy | Polyglutamic Acid - chemistry | Animals | Neovascularization, Pathologic - drug therapy | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Polyglutamic Acid - therapeutic use | Drugs | Drug delivery systems | Biological products | Endothelial growth factors | Development and progression | Permeability | Antineoplastic agents | Cells | Endothelium | Vehicles | Antimitotic agents | Fibrin | Fibrinogen | Physiological aspects | Polymer industry | Polymers | Vascular endothelial growth factor | Tumors | Integrins | Index Medicus | paclitaxel | polymer therapeutics | integrin
Journal Article
Journal Article
Journal Article
The Chemical Record, ISSN 1527-8999, 2005, Volume 5, Issue 6, pp. 352 - 366
Journal Article
Journal of Biomedical Materials Research Part A, ISSN 1549-3296, 11/2017, Volume 105, Issue 11, pp. 3006 - 3016
A novel hyaluronan (HA) derivative, poly(L‐glutamic acid)‐grafted hyaluronan (PGA‐g‐HA), was synthesized to improve the durability of conventional HA products... 
poly(L‐glutamic acid) | intra‐articular injection | hyaluronan | cartilage | intra-articular injection | poly(L-glutamic acid) | RHEUMATOID-ARTHRITIS | MATERIALS SCIENCE, BIOMATERIALS | MOLECULAR-WEIGHT | CARTILAGE DEGENERATION | SYNOVIAL-FLUID | ENGINEERING, BIOMEDICAL | CROSS-LINKED HYALURONATE | SODIUM HYALURONATE | TERTIARY STRUCTURES | AQUEOUS-SOLUTION | HYLAN G-F-20 | KNEE OSTEOARTHRITIS | Viscosity | Hyaluronic Acid - therapeutic use | Hyaluronic Acid - administration & dosage | Chondrocytes - immunology | Cells, Cultured | Hyaluronic Acid - chemistry | Elasticity | Male | Polyglutamic Acid - administration & dosage | Rats, Sprague-Dawley | Chondrocytes - drug effects | Polyglutamic Acid - chemistry | Animals | Anti-Inflammatory Agents - chemistry | Injections, Intra-Articular | Anti-Inflammatory Agents - therapeutic use | Anti-Inflammatory Agents - administration & dosage | Osteoarthritis, Knee - immunology | Polyglutamic Acid - therapeutic use | Osteoarthritis, Knee - drug therapy | Glutamate | Hyaluronic acid | Amino acids | Viscoelasticity | Knee | Glutamic acid | Syngeneic grafts | Grafting | Hyaluronan | Biomedical materials | Interleukin 1 | Bone marrow | Biocompatibility | Storage modulus | Dendritic cells | Durability | Knee (anatomy) | Inflammation | Loss modulus | Injection | Anti-inflammatory agents | Biological activity | Medicine | Acids | Immunogenicity | Chondrocytes | Osteoarthritis
Journal Article