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1. Full Text Poly-γ-glutamic acid: Production, properties and applications
by Ogunleye, Adetoro and Bhat, Aditya and Irorere, Victor U and Hill, David and Williams, Craig and Radecka, Iza
Microbiology (United Kingdom), ISSN 1350-0872, 01/2015, Volume 161, Issue 1, pp. 1 - 17
Poly-gamma-glutamic acid (gamma-PGA) is a naturally occurring biopolymer made up of repeating units of L-glutamic acid, D-glutamic acid or both. gamma-PGA can... 
ENHANCED PRODUCTION | BACILLUS-SUBTILIS NATTO | POLY(GAMMA-GLUTAMIC ACID) | POLY(GLUTAMIC ACID) | FLOCCULATION PROPERTIES | LICHENIFORMIS NCIM 2324 | MICROBIOLOGY | SYNTHETASE COMPLEX | POLY-(GAMMA-GLUTAMIC ACID) | POLYGLUTAMIC ACID | ANTIFREEZE ACTIVITIES | Polyglutamic Acid - analogs & derivatives | Polyglutamic Acid - chemistry | Polyglutamic Acid - metabolism | Polyglutamic Acid - biosynthesis | Bacillus - metabolism | Molecular Conformation | Polymerization | Bacillus - genetics | Fermentation | Food Microbiology | Drug Delivery Systems
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2. Full Text RGD targeting hyaluronic acid coating system for PEI-PBLG polycation gene carriers
by Tian, Huayu and Lin, Lin and Chen, Jie and Chen, Xuesi and Park, Tae Gwan and Maruyama, Atsushi
Journal of Controlled Release, ISSN 0168-3659, 2011, Volume 155, Issue 1, pp. 47 - 53
Hyaluronic acid (HA), a natural anionic mucopolysaccharide, was used to coat polyethylenimine-poly(γ-benzyl L-glutamate)/DNA (PEI-PBLG/DNA) complexes. HA was... 
Targeting | Hyaluronic acid | Gene carriers | Coating system | RGD peptide | HOLE FORMATION | CELLS | POLYMERS | TRANSFECTION | POLY(ETHYLENIMINE) | CHEMISTRY, MULTIDISCIPLINARY | IN-VITRO | DNA COMPLEXES | SUPPORTED LIPID-BILAYERS | INTRACELLULAR DELIVERY | PHARMACOLOGY & PHARMACY | POLYETHYLENEIMINE | Polyglutamic Acid - analogs & derivatives | Polyethyleneimine - analogs & derivatives | Polyglutamic Acid - chemistry | Transfection | Cell Survival | Humans | Polyethyleneimine - chemistry | Hyaluronic Acid - chemistry | DNA - administration & dosage | HeLa Cells | Oligopeptides - chemistry | Genetic research | Peptides | Coatings | DNA | Integrins | Glutamic acid | Gene transfer | Polycations | Cell surface | Grafting | Controlled release | L-Lactate dehydrogenase
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3. Full Text Polymer-based nanoparticles for oral insulin delivery: Revisited approaches
by Fonte, Pedro and Araújo, Francisca and Silva, Cátia and Pereira, Carla and Reis, Salette and Santos, Hélder A and Sarmento, Bruno
Biotechnology Advances, ISSN 0734-9750, 11/2015, Volume 33, Issue 6, pp. 1342 - 1354
Diabetes is a high prevalence and one of the most severe and lethal diseases in the world. Insulin is commonly used to treat diabetes in order to give patients... 
Polymeric nanoparticles | Oral delivery | Intestinal uptake | Diabetes | Chitosan | Insulin | Poly(lactic-co-glycolic acid) | Polyamines - administration & dosage | Polymers - administration & dosage | Nanoparticles - chemistry | Humans | Drug Carriers - administration & dosage | Dextrans - chemistry | Polyglutamic Acid - administration & dosage | Drug Carriers - chemistry | Polyglutamic Acid - analogs & derivatives | Polyesters | Lactic Acid - administration & dosage | Hyaluronic Acid - administration & dosage | Lactic Acid - chemistry | Polyamines - chemistry | Administration, Oral | Chitosan - administration & dosage | Hyaluronic Acid - chemistry | Insulin - administration & dosage | Polyglutamic Acid - chemistry | Alginates - administration & dosage | Chitosan - chemistry | Insulin - chemistry | Alginates - chemistry | Polymers - chemistry | Nanoparticles - administration & dosage | Dextrans - administration & dosage | Drug Delivery Systems - methods | Nanoparticles | Dextran | Gastrointestinal system | Polymer industry | Hyaluronic acid | Diabetes therapy | Index Medicus | Encapsulation | Toxicity | Strategy | Bioavailability | Patients
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4. Full Text The intracellular drug delivery and anti tumor activity of doxorubicin loaded poly(γ-benzyl l -glutamate)- b -hyaluronan polymersomes
by Upadhyay, Kamal K and Bhatt, Anant N and Mishra, Anil K and Dwarakanath, Bilikere S and Jain, Sanyog and Schatz, Christophe and Le Meins, Jean-François and Farooque, Abdullah and Chandraiah, Godugu and Jain, Amit K and Misra, Ambikanandan and Lecommandoux, Sébastien
Biomaterials, ISSN 0142-9612, 2009, Volume 31, Issue 10, pp. 2882 - 2892
Abstract We have investigated the intracellular delivery of doxorubicin (DOX) loaded poly(γ-benzyl l -glutamate)- block -hyaluronan (PBLG- b -HYA) based... 
Advanced Basic Science | Dentistry | Hyaluronan | Cell uptake | Cytotoxicity | Self-assembly | Doxorubicin | Polymersomes | CELLS | OXIDATIVE STRESS | MATERIALS SCIENCE, BIOMATERIALS | HYALURONIC ACID-PACLITAXEL | BLOCK-COPOLYMERS | VESICLES | ENGINEERING, BIOMEDICAL | CLICK CHEMISTRY | MICELLES | ANTITUMOR-ACTIVITY | CANCER | LIPOSOMES | Reactive Oxygen Species - metabolism | Humans | Hyaluronic Acid - pharmacology | Drug Delivery Systems | Polyglutamic Acid - analogs & derivatives | Flow Cytometry | Polyglutamic Acid - pharmacology | Hydrogen-Ion Concentration - drug effects | Hyaluronan Receptors - metabolism | Female | Antineoplastic Agents - pharmacology | Cell Death - drug effects | Doxorubicin - administration & dosage | Cell Survival - drug effects | Microscopy, Electron, Transmission | Cardiotoxins - pharmacology | Intracellular Space - drug effects | Creatine Kinase - blood | Kaplan-Meier Estimate | Rats | Rats, Sprague-Dawley | Animals | L-Lactate Dehydrogenase - blood | Hyaluronic Acid - analogs & derivatives | Intracellular Space - metabolism | Cell Line, Tumor | Doxorubicin - pharmacology | Microscopy, Fluorescence | Index Medicus | Polymers | Chemical Sciences
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5. Full Text Adsorption of toxic mercury(II) by an extracellular biopolymer poly(γ-glutamic acid)
by Inbaraj, B. Stephen and Wang, J.S and Lu, J.F and Siao, F.Y and Chen, B.H
Bioresource Technology, ISSN 0960-8524, 2009, Volume 100, Issue 1, pp. 200 - 207
Adsorption of mercury(II) by an extracellular biopolymer, poly(γ-glutamic acid) (γ-PGA), was studied as a function of pH, temperature, agitation time, ionic... 
Adsorption isotherms | Adsorption kinetics | Biosorption | Mercury | Poly(γ-glutamic acid) | AQUEOUS-SOLUTIONS | CARBON | ENERGY & FUELS | SORPTION | Poly(gamma-glutamic acid) | REMOVAL | AGRICULTURAL ENGINEERING | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | EQUILIBRIUM | METAL-IONS | EXCHANGE | POWDER | BINDING | Polyglutamic Acid - analogs & derivatives | Biopolymers - chemistry | Polyglutamic Acid - chemistry | Adsorption | Models, Chemical | Mercury - isolation & purification | Computer Simulation | Ultrafiltration - methods | Kinetics | Mercury - chemistry | Amino acids | Oxides | Glutamate | Polymers | Index Medicus
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6. Full Text Reversible Inside−Out Micellization of pH-responsive and Water-Soluble Vesicles Based on Polypeptide Diblock Copolymers
by Rodríguez-Hernández, Juan and Lecommandoux, Sébastien
Journal of the American Chemical Society, ISSN 0002-7863, 02/2005, Volume 127, Issue 7, pp. 2026 - 2027
The synthesis of a new zwitterionic diblock copolymer poly(l-glutamic acid)-b-poly(l-lysine) (PGA-b-PLys) is described, and its self-assembly into... 
MICELLES | BLOCK-COPOLYMERS | DRUG-DELIVERY | CHEMISTRY, MULTIDISCIPLINARY | Lysine - analogs & derivatives | Peptides - chemistry | Solubility | Polyglutamic Acid - chemical synthesis | Polyglutamic Acid - analogs & derivatives | Polyglutamic Acid - chemistry | Peptides - chemical synthesis | Light | Micelles | Water - chemistry | Hydrophobic and Hydrophilic Interactions | Nuclear Magnetic Resonance, Biomolecular | Lysine - chemical synthesis | Scattering, Radiation | Lysine - chemistry | Hydrogen-Ion Concentration | Nuclear magnetic resonance spectroscopy | Polypeptides | Research | Polymers | Chemical Sciences
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7. Full Text Harvesting of microalgae by flocculation with poly (γ-glutamic acid)
by Zheng, Hongli and Gao, Zhen and Yin, Jilong and Tang, Xiaohong and Ji, Xiaojun and Huang, He
Bioresource Technology, ISSN 0960-8524, 05/2012, Volume 112, pp. 212 - 220
► Poly (γ-glutamic acid) is tested for harvesting oleaginous microalgae. ► Application the optimized flocculation methods to microalgae gives higher than 90%... 
Microalgae | Microbial flocculant | Response surface methodology | Biomass harvest | RECOVERY | AGRICULTURAL ENGINEERING | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ENERGY & FUELS | BIOMASS | Flocculation - drug effects | Aquatic Organisms - growth & development | Microalgae - drug effects | Microalgae - growth & development | Species Specificity | Chlorella - drug effects | Biomass | Cell Culture Techniques - methods | Salinity | Aquatic Organisms - cytology | Polyglutamic Acid - analogs & derivatives | Polyglutamic Acid - pharmacology | Analysis of Variance | Aquatic Organisms - drug effects | Chlorella - cytology | Time Factors | Chlorella - growth & development | Hydrogen-Ion Concentration - drug effects | Fresh Water | Microalgae - cytology | Glutamate | Amino acids | Microorganisms | Harvesting | Photomicrographs | Micrographs | Lipids | Flocculating
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8. Full Text Mechanisms of cellular uptake and intracellular trafficking with chitosan/DNA/poly(γ-glutamic acid) complexes as a gene delivery vector
by Peng, Shu-Fen and Tseng, Michael T and Ho, Yi-Cheng and Wei, Ming-Cheng and Liao, Zi-Xian and Sung, Hsing-Wen
Biomaterials, ISSN 0142-9612, 2010, Volume 32, Issue 1, pp. 239 - 248
Abstract Chitosan (CS)-based complexes have been considered as a vector for DNA delivery; nonetheless, their transfection efficiency is relatively low. An... 
Advanced Basic Science | Dentistry | Caveolae-mediated pathway | Cellular uptake | Transfection efficiency | Lysosome | Macropinocytosis | MATERIALS SCIENCE, BIOMATERIALS | ENGINEERING, BIOMEDICAL | CAVEOLAE-MEDIATED ENDOCYTOSIS | CHITOSAN | NANOPARTICLES | INTERNALIZATION | GAMMA-GLUTAMYL-TRANSPEPTIDASE | DNA | IN-VIVO | MEMBRANE-PROTEINS | EXPRESSION | Gene Transfer Techniques | Polyglutamic Acid - metabolism | Luciferases - metabolism | Cell Survival | Humans | DNA - ultrastructure | DNA - metabolism | Molecular Dynamics Simulation | Luciferases - genetics | Protein Transport | Polyglutamic Acid - analogs & derivatives | Endocytosis | Transfection | Models, Biological | Intracellular Space - metabolism | Cell Line, Tumor | Kinetics | Chitosan - metabolism
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9. Full Text High-level exogenous glutamic acid-independent production of poly-(γ-glutamic acid) with organic acid addition in a new isolated Bacillus subtilis C10
by Zhang, Huili and Zhang, Anyi and Zhu, Jianzhong and Zhu, Xiangcheng and Cai, Jin and Hong, Yizhi and Huang, Jin and Huang, Lei and Xu, Zhinan
Bioresource Technology, ISSN 0960-8524, 07/2012, Volume 116, pp. 241 - 246
► A new glutamic acid-independent γ-PGA producing strain was isolated. ► This strain was characterized as C10. ► Citric acid and oxalic acid showed capability... 
Bacillus subtilis C10 | Poly-(γ-glutamic acid) | Organic acids | Glutamic acid-independent biosynthesis | ENZYME-ACTIVITIES | Poly-(gamma-glutamic acid) | POLY(GAMMA-GLUTAMIC ACID) | ENERGY & FUELS | BIOPOLYMER | MICROORGANISMS | AGRICULTURAL ENGINEERING | LICHENIFORMIS | REDISTRIBUTION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | BIOSYNTHESIS | GAMMA-POLYGLUTAMIC ACID | METABOLIC FLUX | CORYNEBACTERIUM-GLUTAMICUM | Fermentation - drug effects | Bacillus subtilis - enzymology | Bacillus subtilis - isolation & purification | Polyglutamic Acid - analogs & derivatives | Ammonium Chloride - pharmacology | Biosynthetic Pathways - drug effects | Polyglutamic Acid - biosynthesis | Bacillus subtilis - growth & development | Time Factors | Bioreactors - microbiology | Glutamic Acid - metabolism | Bacillus subtilis - drug effects | Carboxylic Acids - pharmacology | Enzymes | Oxalic acid | Amino acids | Oxalates | Glutamate | Citric acid | Pyruvates | Glutamic acid | Bacillus subtilis | Biosynthesis | Carbon | Strain
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10. Full Text Polymer-drug conjugates: Recent development in clinical oncology
by Li, Chun and Wallace, Sidney
Advanced Drug Delivery Reviews, ISSN 0169-409X, 2008, Volume 60, Issue 8, pp. 886 - 898
Targeted drug delivery aims to increase the therapeutic index by making more drug molecules available at the diseased sites while reducing systemic drug... 
Anticancer drugs | PG-TXL | Polymer-drug conjugates | Nanocarriers | Paclitaxel | BOUND DOXORUBICIN | paclitaxel | ADVANCED SOLID TUMORS | CARRIER SYSTEM | nanocarriers | ANTITUMOR-ACTIVITY | anticancer drugs | PACLITAXEL POLIGLUMEX XYOTAX | CELL LUNG-CANCER | POLY(L-GLUTAMIC ACID)-PACLITAXEL CONJUGATE | polymer-drug conjugates | METASTATIC BREAST-CANCER | OVARIAN OCA-1 TUMOR | PHARMACOLOGY & PHARMACY | PHASE-I | Polyglutamic Acid - analogs & derivatives | Animals | Humans | Paclitaxel - analogs & derivatives | Polyglutamic Acid - administration & dosage | Polymers - chemistry | Clinical Trials as Topic | Antineoplastic Agents - administration & dosage | Drug Evaluation, Preclinical | Paclitaxel - administration & dosage | Drug Carriers - chemistry | Neoplasms - drug therapy | Drugs | Chemotherapy | Water-soluble polymers | Drug delivery systems | Polymer industry | Glutamate | Patient compliance | Vehicles | Cancer | Polymer-Drug Conjugates | Nanocarreirs | Anticancer Drugs
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11. Full Text Ternary complexes of pDNA, polyethylenimine, and γ-polyglutamic acid for gene delivery systems
by Kurosaki, Tomoaki and Kitahara, Takashi and Fumoto, Shintaro and Nishida, Koyo and Nakamura, Junzo and Niidome, Takuro and Kodama, Yukinobu and Nakagawa, Hiroo and To, Hideto and Sasaki, Hitoshi
Biomaterials, ISSN 0142-9612, 2009, Volume 30, Issue 14, pp. 2846 - 2853
Abstract We discovered a vector coated by γ-polyglutamic acid (γ-PGA) for effective and safe gene delivery. In order to develop a useful non-viral vector, we... 
Advanced Basic Science | Dentistry | Nano particle | Self assembly | Surface modification | γ-Polyglutamic acid | Gene transfer | DNA | MATERIALS SCIENCE, BIOMATERIALS | CIRCULATION | ENGINEERING, BIOMEDICAL | TRANSFECTION | GLUTAMIC ACID | gamma-Polyglutamic acid | VECTOR | THERAPY | IN-VIVO | Cell Line | Cell Survival - drug effects | Gene Transfer Techniques | Photochemical Processes | Polyethyleneimine - toxicity | DNA - genetics | Polyglutamic Acid - analogs & derivatives | Polyglutamic Acid - chemistry | DNA - chemistry | Animals | Intracellular Space - metabolism | Polyethyleneimine - chemistry | Erythrocytes - metabolism | Plasmids - chemistry | Plasmids - genetics | Mice | Polyglutamic Acid - toxicity | Index Medicus
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12. Full Text pH-Responsive Chimaeric Pepsomes Based on Asymmetric Poly(ethylene glycol)-b-Poly(L-leucine)-b-Poly(L-glutamic acid) Triblock Copolymer for Efficient Loading and Active Intracellular Delivery of Doxorubicin Hydrochloride
by Chen, Peipei and Qiu, Min and Deng, Chao and Meng, Fenghua and Zhang, Jian and Cheng, Ru and Zhong, Zhiyuan
Biomacromolecules, ISSN 1525-7797, 04/2015, Volume 16, Issue 4, pp. 1322 - 1330
pH-Responsive chimaeric polypeptide-based polymersomes (refer to as pepsomes) were designed and developed from asymmetric poly(ethylene... 
CANCER-CELLS | MULTIFUNCTIONAL NANOCARRIER | SYNTHETIC POLYPEPTIDES | POLYMER SCIENCE | GENE DELIVERY | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | BIODEGRADABLE POLYMERSOMES | N-CARBOXYANHYDRIDES | POLYMERIC MICELLES | BIOMEDICAL APPLICATIONS | ANTICANCER DRUG-DELIVERY | BLOCK-COPOLYMER | Cell Line | Drug Carriers - adverse effects | Peptides - chemistry | Humans | Polyethylene Glycols - chemistry | Drug Carriers - chemical synthesis | Antineoplastic Agents - administration & dosage | Polyglutamic Acid - chemical synthesis | Drug Carriers - chemistry | Polyethylene Glycols - administration & dosage | Polyglutamic Acid - analogs & derivatives | Polyglutamic Acid - chemistry | Animals | Cell Nucleus - metabolism | MCF-7 Cells | Doxorubicin - analogs & derivatives | Antineoplastic Agents - pharmacology | Mice | Polyethylene Glycols - chemical synthesis | Cell Nucleus - drug effects | Doxorubicin - pharmacology | Doxorubicin - administration & dosage | Polyethylene Glycols - pharmacology
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13. Full Text Permanent Polarity and Piezoelectricity of Electrospun α‐Helical Poly(α‐Amino Acid) Fibers
by Farrar, Dawnielle and Ren, Kailiang and Cheng, Derek and Kim, Sungjoo and Moon, Wonkyu and Wilson, William L and West, James E and Yu, S. Michael
Advanced Materials, ISSN 0935-9648, 09/2011, Volume 23, Issue 34, pp. 3954 - 3958
Poly(γ‐benzyl α, L‐glutamate) fibers with high non‐linear optical activity and thermally stable piezoelectricity are fabricated by simple electrospinning... 
energy harvesting | piezoelectricity | piezoelectric polymers | α‐helixes | electrospinning | α-helixes | BENZYL-L-GLUTAMATE | PHYSICS, CONDENSED MATTER | PHYSICS, APPLIED | FILMS | ORIENTATION | MATERIALS SCIENCE, MULTIDISCIPLINARY | CHEMISTRY, PHYSICAL | NANOSCIENCE & NANOTECHNOLOGY | POLY(GAMMA-BENZYL-L-GLUTAMATE) | CHEMISTRY, MULTIDISCIPLINARY | Electrodes | Optical Rotation | Polyglutamic Acid - analogs & derivatives | Polyglutamic Acid - chemistry | Temperature | X-Ray Diffraction | Polyvinyls - chemistry
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14. Full Text Bioreducible Block Copolymers Based on Poly(Ethylene Glycol) and Poly(γ-Benzyl l-Glutamate) for Intracellular Delivery of Camptothecin
by Thambi, Thavasyappan and Yoon, Hong Yeol and Kim, Kwangmeyung and Kwon, Ick Chan and Yoo, Chang Kyoo and Park, Jae Hyung
Bioconjugate Chemistry, ISSN 1043-1802, 10/2011, Volume 22, Issue 10, pp. 1924 - 1931
Poly(ethylene glycol)-b-poly(γ-benzyl l-glutamate)s bearing the disulfide bond (PEG-SS-PBLGs), which is specifically cleavable in intracellular compartments,... 
Camptothecin - pharmacokinetics | Humans | Cell Membrane Permeability | Polyethylene Glycols - chemistry | Antineoplastic Agents - administration & dosage | Drug Carriers - chemistry | Succinimides - chemistry | Polyglutamic Acid - analogs & derivatives | Polyglutamic Acid - chemistry | Micelles | Cell Line, Tumor | Camptothecin - administration & dosage | Antineoplastic Agents - pharmacokinetics | Index Medicus
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