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1. Full Text Polysaccharide‐block‐polypeptide Copolymer Vesicles: Towards Synthetic Viral Capsids
by Schatz, Christophe and Louguet, Stéphanie and Le Meins, Jean‐François and Lecommandoux, Sébastien
Angewandte Chemie International Edition, ISSN 1433-7851, 03/2009, Volume 48, Issue 14, pp. 2572 - 2575
Natural inspiration: Amphiphilic polysaccharide‐block‐polypeptide copolymers were synthesized by click chemistry from dextran end‐functionalized with an alkyne... 
polysaccharides | click chemistry | polymersomes | polypeptides | self‐assembly | Polysaccharides | Self-assembly | Polypeptides | Click chemistry | Polymersomes | DIBLOCK COPOLYMERS | AMYLOSE | DEXTRAN | OLIGOSACCHARIDE | MATERIALS SCIENCE | CHEMISTRY, MULTIDISCIPLINARY | self-assembly | POLYSTYRENE | STIMULI-RESPONSIVE VESICLES | POLYMER VESICLES | WATER | Gene Transfer Techniques | Capsid - chemistry | Peptides - chemistry | Polymers - chemical synthesis | Polysaccharides - chemical synthesis | Dextrans - chemistry | Drug Carriers - chemical synthesis | Azides - chemistry | Polyglutamic Acid - chemical synthesis | Drug Carriers - chemistry | Particle Size | Polyglutamic Acid - analogs & derivatives | Polyglutamic Acid - chemistry | Dextrans - chemical synthesis | Peptides - chemical synthesis | Viruses - chemistry | Polysaccharides - chemistry | Polymers - chemistry | Azides - chemical synthesis | Polymers | Chemical Sciences
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2. Full Text Reversible Inside−Out Micellization of pH-responsive and Water-Soluble Vesicles Based on Polypeptide Diblock Copolymers
by Rodríguez-Hernández, Juan and Lecommandoux, Sébastien
Journal of the American Chemical Society, ISSN 0002-7863, 02/2005, Volume 127, Issue 7, pp. 2026 - 2027
The synthesis of a new zwitterionic diblock copolymer poly(l-glutamic acid)-b-poly(l-lysine) (PGA-b-PLys) is described, and its self-assembly into... 
MICELLES | BLOCK-COPOLYMERS | DRUG-DELIVERY | CHEMISTRY, MULTIDISCIPLINARY | Lysine - analogs & derivatives | Peptides - chemistry | Solubility | Polyglutamic Acid - chemical synthesis | Polyglutamic Acid - analogs & derivatives | Polyglutamic Acid - chemistry | Peptides - chemical synthesis | Light | Micelles | Water - chemistry | Hydrophobic and Hydrophilic Interactions | Nuclear Magnetic Resonance, Biomolecular | Lysine - chemical synthesis | Scattering, Radiation | Lysine - chemistry | Hydrogen-Ion Concentration | Nuclear magnetic resonance spectroscopy | Polypeptides | Research | Polymers | Chemical Sciences
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3. Full Text Injectable glycopolypeptide hydrogels as biomimetic scaffolds for cartilage tissue engineering
by Ren, Kaixuan and He, Chaoliang and Xiao, Chunsheng and Li, Gao and Chen, Xuesi
Biomaterials, ISSN 0142-9612, 2015, Volume 51, pp. 238 - 249
Abstract Glycopolypeptides are an emerging class of bioinspired polymers that mimic naturally occurring glycopeptides or glycoproteins, and therefore are... 
Advanced Basic Science | Dentistry | Cartilage tissue engineering | Glycopolypeptide hydrogel | Biomimic scaffold | Enzymatic crosslinking | Injectable hydrogel | MATERIALS SCIENCE, BIOMATERIALS | DRUG-DELIVERY | ENGINEERING, BIOMEDICAL | MESENCHYMAL STEM-CELLS | POLYPEPTIDES | MICHAEL ADDITION | SITU | REPAIR | BIOMEDICAL APPLICATIONS | REGENERATIVE MEDICINE | BONE | CLICK GLYCOSYLATION | Chondrocytes - cytology | Amides - chemical synthesis | Extracellular Matrix - metabolism | Glycopeptides - chemistry | Cartilage - drug effects | Hydrogels - chemical synthesis | Tissue Scaffolds - chemistry | Chondrocytes - drug effects | Polyglutamic Acid - pharmacology | Proton Magnetic Resonance Spectroscopy | Cartilage - physiology | Cell Death - drug effects | Mannose - chemistry | Amides - pharmacology | Cell Line | Cell Survival - drug effects | Rabbits | Tissue Engineering - methods | Glycosaminoglycans - metabolism | Extracellular Matrix - drug effects | Cells, Cultured | Polyglutamic Acid - chemical synthesis | Rats, Sprague-Dawley | Polyglutamic Acid - chemistry | Injections | Animals | Mice, Nude | Amides - chemistry | Cell Proliferation - drug effects | Mannose - pharmacology | Hydrogels - pharmacology | Glycopeptides - pharmacology | Hydrogels - chemistry | Subcutaneous Tissue - drug effects | Proteins | Crosslinked polymers | Glycosaminoglycans | Hydrogen peroxide | Glutamate | Tissue engineering | Surgical implants | Biomedical materials | Biomimetics | Hydrogels | Biocompatibility | In vitro testing | Scaffolds
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4. Full Text Multiarm‐polyethylene glycol‐polyglutamic acid peptide dendrimer: Design, synthesis, and dissolving thrombus
by Zhang, Shao‐Fei and Lü, Shaoyu and Gao, Chunmei and Yang, Jiandong and Yan, Xiang and Li, Tao and Wen, Na and Huang, Mengjie and Liu, Mingzhu
Journal of Biomedical Materials Research Part A, ISSN 1549-3296, 06/2018, Volume 106, Issue 6, pp. 1687 - 1696
Thrombotic events affect many individuals in a number of ways, all of which can cause significant morbidity and mortality. Nattokinase (NK), as a novel... 
dissolving thrombus | multiarm‐polyethylene glycol | nattokinase | polyglutamic acid | multiarm-polyethylene glycol | DRUG-DELIVERY-SYSTEM | CORES | MATERIALS SCIENCE, BIOMATERIALS | TISSUE-PLASMINOGEN ACTIVATOR | ENGINEERING, BIOMEDICAL | SIZE | NANOPARTICLES | STREPTOKINASE | TARGETED THROMBOLYSIS | AGENTS | Peptides - chemistry | Rats | Male | Polyethylene Glycols - chemistry | Dendrimers - chemical synthesis | Drug Carriers - chemical synthesis | Polyglutamic Acid - chemical synthesis | Drug Carriers - chemistry | Subtilisins - therapeutic use | Polyglutamic Acid - analogs & derivatives | Thrombosis - pathology | Animals | Peptides - chemical synthesis | Fibrinolytic Agents - therapeutic use | Dendrimers - chemistry | Fibrinolytic Agents - administration & dosage | Thrombosis - drug therapy | Subtilisins - administration & dosage | Proteins | Fibrin | Enzymes | Dendrimers | Peptides | Polyethylene glycol | Proteolysis | Denaturation | Mortality | Thrombosis | Blood clot | Therapy | Enzyme activity | Nuclear magnetic resonance--NMR | Fluorescence | Photon correlation spectroscopy | Inactivation | Macrophages | Enzymatic activity | Dichroism | Polyethylene | Deactivation | Light scattering | Spectra | Electron microscopy | Thrombolysis | Morbidity | Catheters | Circular dichroism | Transmission electron microscopy | Acids | Nanocomposites | Zeta potential | Viability
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5. Full Text Synthesis of Poly‐γ‐S‐2‐methylbutyl‐l‐glutamate and Poly‐γ‐S‐2‐methylbutyl‐d‐glutamate and Their Use as Enantiodiscriminating Alignment Media in NMR Spectroscopy
by Hansmann, Stefanie and Schmidts, Volker and Thiele, Christina M
Chemistry – A European Journal, ISSN 0947-6539, 07/2017, Volume 23, Issue 38, pp. 9114 - 9121
Lyotropic liquid crystalline (LLC) phases of polyglutamic acid derivatives, such as poly‐γ‐benzyl‐l‐glutamate, are suitable alignment media for organic... 
alignment medium | enantiodifferentiation | homopolyglutamates | structure elucidation | NMR spectroscopy | ACID-N-CARBOXYANHYDRIDES | RESIDUAL DIPOLAR COUPLINGS | SMALL MOLECULES | CHIRAL LIQUID-CRYSTALS | CHEMISTRY, MULTIDISCIPLINARY | GAMMA-BENZYL | NCA POLYMERIZATION | FACILE SYNTHESIS | POLAR ORGANIC-SOLVENTS | MULTINUCLEAR NMR | RING-OPENING POLYMERIZATION | Polyglutamic Acid - analogs & derivatives | Polyglutamic Acid - chemistry | Liquid Crystals - chemistry | Magnetic Resonance Spectroscopy - methods | Stereoisomerism | Sesquiterpenes | Molecular Structure | Structure-Activity Relationship | Polyglutamic Acid - chemical synthesis
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6. Full Text N-Trimethylsilyl Amines for Controlled Ring-Opening Polymerization of Amino Acid N-Carboxyanhydrides and Facile End Group Functionalization of Polypeptides
by Lu, Hua and Cheng, Jianjun
Journal of the American Chemical Society, ISSN 0002-7863, 09/2008, Volume 130, Issue 38, pp. 12562 - 12563
We report a new strategy that uses N-trimethylsilyl (N-TMS) amine to mediate controlled ring-opening polymerization of amino acid N-carboxyanhydrides (NCAs).... 
BLOCK COPOLYPEPTIDES | COPOLYMERS | NCA | CHEMISTRY, MULTIDISCIPLINARY | Amines - chemistry | Peptides - chemistry | Amino Acids - chemistry | Polyglutamic Acid - chemical synthesis | Carbamates - chemistry | Glutamates - chemistry | Trimethylsilyl Compounds - chemistry | Polyglutamic Acid - analogs & derivatives | Anhydrides - chemistry | Peptides - chemical synthesis | Cyclization | Polylysine - chemical synthesis | Allylamine - chemistry
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7. Full Text Polypeptide‐b‐Poly(Phenyl Isocyanide) Hybrid Rod‐Rod Copolymers: One‐Pot Synthesis, Self‐Assembly, and Cell Imaging
by Shi, Sheng‐Yu and He, Ya‐Guang and Chen, Wei‐Wei and Liu, Na and Zhu, Yuan‐Yuan and Ding, Yun‐Sheng and Yin, Jun and Wu, Zong‐Quan
Macromolecular Rapid Communications, ISSN 1022-1336, 08/2015, Volume 36, Issue 16, pp. 1511 - 1520
Hybrid rod‐rod diblock copolymers, poly(γ‐benzyl L‐glutamate)‐poly(4‐cyano‐benzoic acid 2‐isopropyl‐5‐methyl‐cyclohexyl ester) (PBLG‐PPI), with determined... 
cell imaging | chirality | helix | poly(phenyl isocyanide) | self‐assembly | self-assembly | DIBLOCK COPOLYMERS | COPOLYPEPTIDES | POLYMER SCIENCE | BLOCK-COPOLYMERS | DRUG-DELIVERY | CONJUGATED POLYMER | PEPTIDE | MECHANISTICALLY DISTINCT | SINGLE CATALYST | HELIX-SENSE | POLYPEPTIDE | Peptides - chemistry | Biocompatible Materials - chemistry | Humans | Molecular Conformation | Anhydrides - chemical synthesis | Molecular Imaging | Polyglutamic Acid - chemical synthesis | Glutamates - chemistry | Cell Tracking | Solutions - chemistry | Polyglutamic Acid - analogs & derivatives | Anhydrides - chemistry | Polyglutamic Acid - chemistry | Glutamates - chemical synthesis | Isothiocyanates - chemistry | Benzoic acid | Amino acids | Nitriles | Glutamate | Block copolymers | Self assembly | Copolymers | Micelles | Esters | Jewelry | Confocal | Helicity
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8. Full Text General Route toward Side-Chain-Functionalized α-Helical Polypeptides
by Tang, Haoyu and Zhang, Donghui
Biomacromolecules, ISSN 1525-7797, 06/2010, Volume 11, Issue 6, pp. 1585 - 1592
A series of poly(γ-chloropropyl-l-glutamate) (PCPLG) with controlled polymer molecular weight (MW = 5−28 kg·mol−1) and molecular weight distribution (PDI =... 
GLYCOPROTEIN MIMICS | POLYMER SCIENCE | ACID N-CARBOXYANHYDRIDES | CLICK CHEMISTRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | COPOLYMERS | COMBINATION | PEPTIDES | 1ST SYNTHESIS | GLYCOPOLYMERS | FOLDAMERS | RING-OPENING POLYMERIZATION | Polyglutamic Acid - analogs & derivatives | Polyglutamic Acid - chemistry | Molecular Weight | Peptides - chemical synthesis | Magnetic Resonance Spectroscopy | Organosilicon Compounds - chemistry | Peptides - chemistry | Solutions | Protein Conformation | Circular Dichroism | Polyglutamic Acid - chemical synthesis | Mannose - chemistry
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9. Full Text Decisive Role of Hydrophobic Side Groups of Polypeptides in Thermosensitive Gelation
by Cheng, Yilong and He, Chaoliang and Xiao, Chunsheng and Ding, Jianxun and Zhuang, Xiuli and Huang, Yubin and Chen, Xuesi
Biomacromolecules, ISSN 1525-7797, 07/2012, Volume 13, Issue 7, pp. 2053 - 2059
Thermosensitive hydrogels based on PEG and poly(l-glutamate)s bearing different hydrophobic side groups were separately synthesized by the ring-opening... 
DRUG | SOL | AQUEOUS-SOLUTIONS | POLYMER SCIENCE | ACID | MULTIBLOCK COPOLYMERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BLOCK-COPOLYMER HYDROGELS | CHEMISTRY, ORGANIC | Temperature | Molecular Weight | Humans | Anhydrides - chemical synthesis | Polyethylene Glycols - chemistry | Hydrogels - chemical synthesis | Spectroscopy, Fourier Transform Infrared | Phase Transition | Polyglutamic Acid - analogs & derivatives | Anhydrides - chemistry | Anhydrides - toxicity | Micelles | Hydrogels - toxicity | Cell Survival - drug effects | Protein Structure, Secondary | Polymerization | Polyethylene Glycols - toxicity | Polyglutamic Acid - chemical synthesis | Particle Size | Polyglutamic Acid - chemistry | Hydrophobic and Hydrophilic Interactions | Polyethylene Glycols - chemical synthesis | Polyglutamic Acid - toxicity | HeLa Cells | Hydrogels - chemistry
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10. Full Text Chemoenzyamtic synthesis and self-assembling gelation behavior of amylose-grafted poly(γ-glutamic acid)
by Shouji, Takuya and Yamamoto, Kazuya and Kadokawa, Jun-ichi
International Journal of Biological Macromolecules, ISSN 0141-8130, 04/2017, Volume 97, pp. 99 - 105
In this study, we investigated chmemoenzymatic synthesis of amylose-grafted poly(γ-glutamic acid) (PGA) as a new artificial saccharide-peptide conjugate... 
Enzymatic polymerization | Amylose | Graft copolymer | Chemoenzymatic | Gelation | Poly(γ-glutamic acid) | POLYMER SCIENCE | ANTIPARALLEL DOUBLE HELIX | BIOCHEMISTRY & MOLECULAR BIOLOGY | Poly(gamma-glutamic acid) | PHOSPHORYLASE | CHEMOENZYMATIC SYNTHESIS | POLYSACCHARIDE MATERIALS | CHEMISTRY, APPLIED | Chemistry Techniques, Synthetic | Gels | Peptides - chemistry | Polymerization | Aquifoliaceae - enzymology | Polyglutamic Acid - chemical synthesis | Maltose - chemistry | Phosphorylases - metabolism | Polyglutamic Acid - analogs & derivatives | Polyglutamic Acid - chemistry | Oligosaccharides - chemistry | Amylose - chemistry | Porosity | Enzymes | Amino acids | Glutamate | Phosphates | Glucose | Catalysis | Dextrose
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11. Full Text pH-Responsive Chimaeric Pepsomes Based on Asymmetric Poly(ethylene glycol)-b-Poly(L-leucine)-b-Poly(L-glutamic acid) Triblock Copolymer for Efficient Loading and Active Intracellular Delivery of Doxorubicin Hydrochloride
by Chen, Peipei and Qiu, Min and Deng, Chao and Meng, Fenghua and Zhang, Jian and Cheng, Ru and Zhong, Zhiyuan
Biomacromolecules, ISSN 1525-7797, 04/2015, Volume 16, Issue 4, pp. 1322 - 1330
pH-Responsive chimaeric polypeptide-based polymersomes (refer to as pepsomes) were designed and developed from asymmetric poly(ethylene... 
CANCER-CELLS | MULTIFUNCTIONAL NANOCARRIER | SYNTHETIC POLYPEPTIDES | POLYMER SCIENCE | GENE DELIVERY | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | BIODEGRADABLE POLYMERSOMES | N-CARBOXYANHYDRIDES | POLYMERIC MICELLES | BIOMEDICAL APPLICATIONS | ANTICANCER DRUG-DELIVERY | BLOCK-COPOLYMER | Cell Line | Drug Carriers - adverse effects | Peptides - chemistry | Humans | Polyethylene Glycols - chemistry | Drug Carriers - chemical synthesis | Antineoplastic Agents - administration & dosage | Polyglutamic Acid - chemical synthesis | Drug Carriers - chemistry | Polyethylene Glycols - administration & dosage | Polyglutamic Acid - analogs & derivatives | Polyglutamic Acid - chemistry | Animals | Cell Nucleus - metabolism | MCF-7 Cells | Doxorubicin - analogs & derivatives | Antineoplastic Agents - pharmacology | Mice | Polyethylene Glycols - chemical synthesis | Cell Nucleus - drug effects | Doxorubicin - pharmacology | Doxorubicin - administration & dosage | Polyethylene Glycols - pharmacology
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12. Full Text Natural and edible biopolymer poly‐γ‐glutamic acid: synthesis, production, and applications
by Sung, Moon‐Hee and Park, Chung and Kim, Chul‐Joong and Poo, Haryoung and Soda, Kenji and Ashiuchi, Makoto
The Chemical Record, ISSN 1527-8999, 2005, Volume 5, Issue 6, pp. 352 - 366
Poly‐γ‐glutamic acid (γ‐PGA) is a very promising biodegradable polymer that is produced by Bacillus subtilis. γ‐PGA is water‐soluble, anionic, biodegradable,... 
Bacillus subtilis (chungkookjang) | poly‐γ‐glutamic acid | high molecular weight | immune‐stimulating agent | anti‐tumor agent | Immune-stimulating agent | Anti-tumor agent | High molecular weight | Poly-γ-glutamic acid | HYDROGELS | poly-gamma-glutamic acid | anti-tumor agent | POLYGLUTAMIC ACID | CHEMISTRY, MULTIDISCIPLINARY | MICROORGANISMS | IRRADIATION | LICHENIFORMIS | BIOSYNTHESIS | MICROBIAL POLY(GAMMA-GLUTAMIC ACID) | BACILLUS-SUBTILIS CHUNGKOOKJANG | AMMONIUM-SULFATE | CITRIC-ACID | immune-stimulating agent | Biopolymers - chemistry | Adjuvants, Immunologic - administration & dosage | Molecular Weight | Administration, Oral | Antineoplastic Agents - chemical synthesis | Biopolymers - administration & dosage | Humans | Adjuvants, Immunologic - chemical synthesis | Polyglutamic Acid - administration & dosage | Antineoplastic Agents - administration & dosage | Antineoplastic Agents - chemistry | Polyglutamic Acid - chemical synthesis | Polyglutamic Acid - analogs & derivatives | Biological Products - chemical synthesis | Polyglutamic Acid - chemistry | Biological Products - chemistry | Animals | Adjuvants, Immunologic - chemistry | Biological Products - administration & dosage
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13. Full Text Robust, active tumor-targeting and fast bioresponsive anticancer nanotherapeutics based on natural endogenous materials
by Sun, Bingfeng and Deng, Chao and Meng, Fenghua and Zhang, Jian and Zhong, Zhiyuan
Acta Biomaterialia, ISSN 1742-7061, 11/2016, Volume 45, pp. 223 - 233
The clinical success of cancer nanomedicines critically depends on availability of simple, safe and highly efficient nanocarriers. Here, we report that robust... 
Hyaluronic acid | Polypeptide | Nanomedicine | Cancer therapy | Redox-responsive | MATERIALS SCIENCE, BIOMATERIALS | ACID | ENGINEERING, BIOMEDICAL | SELF-ASSEMBLED NANOPARTICLES | INTRACELLULAR DRUG-DELIVERY | DOXORUBICIN | POLYMERIC MICELLES | CANCER-THERAPY | IN-VIVO | CLINICAL TRANSLATION | Doxorubicin - therapeutic use | Nanoparticles - chemistry | Biocompatible Materials - chemistry | Humans | Antineoplastic Agents - therapeutic use | Polyethylene Glycols - therapeutic use | Polyglutamic Acid - analogs & derivatives | Peptides - chemical synthesis | MCF-7 Cells | Proton Magnetic Resonance Spectroscopy | Doxorubicin - analogs & derivatives | Female | Antineoplastic Agents - pharmacology | Thioctic Acid - chemistry | Polyethylene Glycols - pharmacology | Tissue Distribution - drug effects | Cross-Linking Reagents - chemistry | Hyaluronic Acid - chemistry | Polyethylene Glycols - pharmacokinetics | Thioctic Acid - chemical synthesis | Breast Neoplasms - drug therapy | Polyglutamic Acid - chemical synthesis | Doxorubicin - pharmacokinetics | Xenograft Model Antitumor Assays | Polyglutamic Acid - chemistry | Animals | Breast Neoplasms - pathology | Mice, Nude | Drug Liberation | Doxorubicin - pharmacology | Care and treatment | Cancer | Tumors | Crosslinked polymers | Anthracyclines | Chemotherapy | Physiological aspects | Glutamate | Doxorubicin | Nanoparticles | Drugs | Breast | Mice | Nanostructure
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14. Full Text Anti-tumor efficacy of c(RGDfK)-decorated polypeptide-based micelles co-loaded with docetaxel and cisplatin
by Song, Wantong and Tang, Zhaohui and Zhang, Dawei and Zhang, Ying and Yu, Haiyang and Li, Mingqiang and Lv, Shixian and Sun, Hai and Deng, Mingxiao and Chen, Xuesi
Biomaterials, ISSN 0142-9612, 2013, Volume 35, Issue 9, pp. 3005 - 3014
Abstract There are two important obstacles for the currently applied anti-cancer drug delivery systems. One is the conflict between long-circulation and... 
Advanced Basic Science | Dentistry | Target | Drug delivery | Anti-tumor | C(RGDfK) | Combination | MATERIALS SCIENCE, BIOMATERIALS | CREMOPHOR-FREE | GENE DELIVERY | DRUG-DELIVERY | ENGINEERING, BIOMEDICAL | COMBINATION THERAPY | TUMOR | PACLITAXEL | CELL LUNG-CANCER | BREAST-CANCER | LIPOSOMAL DOXORUBICIN | MULTIDRUG-RESISTANCE | Taxoids - pharmacology | Cisplatin - pharmacokinetics | Humans | Melanoma, Experimental - drug therapy | Molecular Sequence Data | Polyethylene Glycols - chemistry | Antineoplastic Agents - therapeutic use | Taxoids - therapeutic use | Neoplasm Metastasis | Micelles | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Amino Acid Sequence | Cell Survival - drug effects | Tissue Distribution - drug effects | Magnetic Resonance Spectroscopy | Peptides - chemistry | Endocytosis - drug effects | Mice, Inbred C57BL | Melanoma, Experimental - pathology | Hydrodynamics | Cisplatin - pharmacology | Polyglutamic Acid - chemical synthesis | Taxoids - pharmacokinetics | Polyglutamic Acid - chemistry | Animals | Cisplatin - therapeutic use | Tumor Burden - drug effects | Mice | Polyethylene Glycols - chemical synthesis | HeLa Cells | Drugs | Drug delivery systems | Peptides | Melanoma | Tocopherols | Glutamate | Polyols | Vehicles | Integrins | Tumors | Polyethylene glycol | Metastasis | Cancer
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