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1. Full Text Poly( l-glutamic acid)–anticancer drug conjugates
by Li, Chun
Advanced drug delivery reviews, ISSN 0169-409X, 2002, Volume 54, Issue 5, pp. 695 - 713
Anticancer drugs | Drug targeting | Poly( l-glutamic acid) | Polymer–drug conjugates | Enhanced permeability and retention effect | Poly(L-glutamic acid) | Polymer-drug conjugates | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Camptothecin - therapeutic use | Humans | Antineoplastic Agents - therapeutic use | Clinical Trials as Topic | Antineoplastic Agents - administration & dosage | DNA - metabolism | Antimetabolites - therapeutic use | Paclitaxel - therapeutic use | Polyglutamic Acid - chemical synthesis | Drug Carriers | Drug Delivery Systems | Neoplasms - drug therapy | Antimetabolites - administration & dosage | Antineoplastic Agents - metabolism | Polyglutamic Acid - pharmacokinetics | Anthracyclines - administration & dosage | Camptothecin - administration & dosage | Anthracyclines - therapeutic use | Paclitaxel - administration & dosage | Index Medicus
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2. Full Text Poly-Gamma-Glutamic Acid (-PGA)-based encapsulation of adenovirus to evade neutralizing antibodies
by Khalil, Ibrahim R and Khechara, Martin P and Kurusamy, Sathishkumar and Armesilla, Angel L and Gupta, Abhishek and Mendrek, Barbara and Khalaf, Tamara and Scandola, Mariastella and Focarete, Maria Letizia and Kowalczuk, Marek and Radecka, Iza
Molecules (Basel, Switzerland), ISSN 1420-3049, 10/2018, Volume 23, Issue 10, p. 2565
Chitosan | PGA | Immunogenicity | Adenovirus | Biodegradable polymer | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Drug Carriers - therapeutic use | Nanoparticles - chemistry | Humans | Drug Carriers - chemistry | Polyglutamic Acid - analogs & derivatives | Polymers - therapeutic use | Antibodies, Neutralizing - immunology | Neoplasms - therapy | Immunity, Cellular - drug effects | Nanoparticles - therapeutic use | Chitosan - therapeutic use | Adenoviridae - genetics | Adenoviridae - immunology | Oncolytic Virotherapy - adverse effects | Chitosan - immunology | Oncolytic Viruses - genetics | Polyglutamic Acid - immunology | Antibodies, Neutralizing - drug effects | Polyglutamic Acid - chemistry | Chitosan - chemistry | Neoplasms - immunology | Oncolytic Viruses - immunology | Ligands | Polymers - chemistry | Polyglutamic Acid - therapeutic use | Index Medicus | chitosan | biodegradable polymer | γ-PGA | immunogenicity | adenovirus
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3. Full Text The in vivo behavior and antitumor activity of doxorubicin-loaded poly(γ-benzyl l -glutamate)- block -hyaluronan polymersomes in Ehrlich ascites tumor-bearing BalB/c mice
by Upadhyay, Kamal Kumar, PhD and Mishra, Anil Kumar, PhD and Chuttani, Krishna, MSc and Kaul, Ankur, MSc and Schatz, Christophe, PhD and Le Meins, Jean-François, PhD and Misra, Ambikanandan, PhD and Lecommandoux, Sebastien, PhD
Nanomedicine, ISSN 1549-9634, 2012, Volume 8, Issue 1, pp. 71 - 80
Internal Medicine | Hyaluronan | Ehrlich ascites tumor (EAT) | Antitumor activity | Doxorubicin | Polymersomes | Science & Technology - Other Topics | Nanoscience & Nanotechnology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Doxorubicin - blood | Doxorubicin - therapeutic use | Drug Carriers - adverse effects | Hyaluronic Acid - therapeutic use | Nanoparticles - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Drug Carriers - administration & dosage | Polyglutamic Acid - administration & dosage | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Nanoparticles - adverse effects | Drug Carriers - chemistry | Polyglutamic Acid - analogs & derivatives | Antineoplastic Agents - adverse effects | Female | Hyaluronic Acid - blood | Hyaluronic Acid - adverse effects | Doxorubicin - administration & dosage | Endocytosis - immunology | Technetium - chemistry | Rabbits | Hyaluronic Acid - administration & dosage | Hyaluronic Acid - chemistry | Carcinoma, Ehrlich Tumor - drug therapy | Doxorubicin - chemical synthesis | Polyglutamic Acid - blood | Polyglutamic Acid - chemistry | Animals | Hyaluronic Acid - analogs & derivatives | Antineoplastic Agents - blood | Hyaluronan Receptors - immunology | Mice | Mice, Inbred BALB C | Nanoparticles - administration & dosage | Polyglutamic Acid - therapeutic use | Neoplasms, Experimental - drug therapy | Doxorubicin - adverse effects | Polyglutamic Acid - adverse effects | Anthracyclines | Ascites | Hyaluronic acid | Tumors | Index Medicus | Polymers | Chemical Sciences
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4. Full Text Integrin-assisted drug delivery of nano-scaled polymer therapeutics bearing paclitaxel
by Eldar-Boock, Anat and Miller, Keren and Sanchis, Joaquin and Lupu, Ruth and Vicent, María J and Satchi-Fainaro, Ronit
Biomaterials, ISSN 0142-9612, 2011, Volume 32, Issue 15, pp. 3862 - 3874
Advanced Basic Science | Dentistry | Angiogenesis | Integrin | Polyglutamic acid | Polymer therapeutics | Paclitaxel | RGD peptidomimetic | Engineering | Materials Science | Technology | Engineering, Biomedical | Materials Science, Biomaterials | Science & Technology | Paclitaxel - metabolism | Rats, Wistar | Humans | Polyglutamic Acid - administration & dosage | Integrins - metabolism | Drug Delivery Systems | Polyglutamic Acid - analogs & derivatives | Paclitaxel - chemistry | Antineoplastic Agents, Phytogenic - administration & dosage | Antineoplastic Agents, Phytogenic - metabolism | Antineoplastic Agents, Phytogenic - therapeutic use | Paclitaxel - administration & dosage | Oligopeptides - chemistry | Polyglutamic Acid - metabolism | Paclitaxel - analogs & derivatives | Rats | Antineoplastic Agents, Phytogenic - chemistry | Cathepsin B - metabolism | Oligopeptides - metabolism | Paclitaxel - therapeutic use | Neoplasms - drug therapy | Polyglutamic Acid - chemistry | Animals | Neovascularization, Pathologic - drug therapy | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Mice, Inbred BALB C | Polyglutamic Acid - therapeutic use | Drugs | Drug delivery systems | Biological products | Endothelial growth factors | Development and progression | Permeability | Antineoplastic agents | Cells | Endothelium | Vehicles | Antimitotic agents | Fibrin | Fibrinogen | Physiological aspects | Polymer industry | Polymers | Vascular endothelial growth factor | Tumors | Integrins | Index Medicus | paclitaxel | polymer therapeutics | integrin
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5. Full Text An injectable nanoparticle generator enhances delivery of cancer therapeutics
by Xu, Rong and Zhang, Guodong and Mai, Junhua and Deng, Xiaoyong and Segura-Ibarra, Victor and Wu, Suhong and Shen, Jianliang and Liu, Haoran and Hu, Zhenhua and Chen, Lingxiao and Huang, Yi and Koay, Eugene and Huang, Yu and Liu, Jun and Ensor, Joe E and Blanco, Elvin and Liu, Xuewu and Ferrari, Mauro and Shen, Haifa
Nature biotechnology, ISSN 1087-0156, 04/2016, Volume 34, Issue 4, pp. 414 - 418
Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Doxorubicin - therapeutic use | Humans | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Doxorubicin - pharmacokinetics | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Nanoparticles - therapeutic use | Nanomedicine - methods | Cell Line, Tumor | Female | Polyglutamic Acid | Antineoplastic Agents - pharmacokinetics | Mice | Nanoparticles - administration & dosage | Drug Delivery Systems - methods | Doxorubicin - administration & dosage | Nanoparticles | Cancer therapies | Tumors | Cancer | Index Medicus
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6. Full Text Robust, active tumor-targeting and fast bioresponsive anticancer nanotherapeutics based on natural endogenous materials
by Sun, Bingfeng and Deng, Chao and Meng, Fenghua and Zhang, Jian and Zhong, Zhiyuan
Acta biomaterialia, ISSN 1742-7061, 11/2016, Volume 45, pp. 223 - 233
Hyaluronic acid | Polypeptide | Nanomedicine | Cancer therapy | Redox-responsive | Engineering | Materials Science | Technology | Engineering, Biomedical | Materials Science, Biomaterials | Science & Technology | Doxorubicin - therapeutic use | Nanoparticles - chemistry | Biocompatible Materials - chemistry | Humans | Antineoplastic Agents - therapeutic use | Polyethylene Glycols - therapeutic use | Polyglutamic Acid - analogs & derivatives | Peptides - chemical synthesis | MCF-7 Cells | Proton Magnetic Resonance Spectroscopy | Doxorubicin - analogs & derivatives | Female | Antineoplastic Agents - pharmacology | Thioctic Acid - chemistry | Polyethylene Glycols - pharmacology | Tissue Distribution - drug effects | Cross-Linking Reagents - chemistry | Hyaluronic Acid - chemistry | Polyethylene Glycols - pharmacokinetics | Thioctic Acid - chemical synthesis | Breast Neoplasms - drug therapy | Polyglutamic Acid - chemical synthesis | Doxorubicin - pharmacokinetics | Xenograft Model Antitumor Assays | Polyglutamic Acid - chemistry | Animals | Breast Neoplasms - pathology | Mice, Nude | Drug Liberation | Doxorubicin - pharmacology | Care and treatment | Cancer | Tumors | Crosslinked polymers | Anthracyclines | Chemotherapy | Physiological aspects | Glutamate | Doxorubicin | Self assembly | Glutamic acid | Lipoic acid | Xenotransplantation | Breast cancer | Cancer therapies | Mimicry | Lipopolysaccharides | Anticancer properties | Nanoparticles | Acids | CD44 antigen | Xenografts | Antitumor activity | Mice | In vivo methods and tests | Index Medicus | Drugs | Breast | Nanostructure
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7. Full Text Characterization of poly(L‐glutamic acid)‐grafted hyaluronan as a novel candidate medicine and biomedical device for intra‐articular injection
by Muramatsu, Kazuaki and Tajima, Yuya and Kaneko, Rin and Yanagita, Yuta and Hirai, Hiroyuki and Hiura, Nana
Journal of biomedical materials research. Part A, ISSN 1549-3296, 11/2017, Volume 105, Issue 11, pp. 3006 - 3016
poly(L‐glutamic acid) | intra‐articular injection | hyaluronan | cartilage | intra-articular injection | poly(L-glutamic acid) | Engineering | Materials Science | Technology | Engineering, Biomedical | Materials Science, Biomaterials | Science & Technology | Viscosity | Hyaluronic Acid - therapeutic use | Hyaluronic Acid - administration & dosage | Chondrocytes - immunology | Cells, Cultured | Hyaluronic Acid - chemistry | Elasticity | Male | Polyglutamic Acid - administration & dosage | Rats, Sprague-Dawley | Chondrocytes - drug effects | Polyglutamic Acid - chemistry | Animals | Anti-Inflammatory Agents - chemistry | Injections, Intra-Articular | Anti-Inflammatory Agents - therapeutic use | Anti-Inflammatory Agents - administration & dosage | Osteoarthritis, Knee - immunology | Polyglutamic Acid - therapeutic use | Osteoarthritis, Knee - drug therapy | Glutamate | Hyaluronic acid | Amino acids | Viscoelasticity | Knee | Glutamic acid | Storage modulus | Dendritic cells | Syngeneic grafts | Durability | Inflammation | Loss modulus | Injection | Grafting | Anti-inflammatory agents | Biological activity | Medicine | Hyaluronan | Biomedical materials | Acids | Immunogenicity | Chondrocytes | Interleukin 1 | Bone marrow | Biocompatibility | Osteoarthritis | Index Medicus
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8. Full Text Nanoscaled Poly(l‑glutamic acid)/Doxorubicin-Amphiphile Complex as pH-responsive Drug Delivery System for Effective Treatment of Nonsmall Cell Lung Cancer
by Li, Mingqiang and Song, Wantong and Tang, Zhaohui and Lv, Shixian and Lin, Lin and Sun, Hai and Li, Quanshun and Yang, Yan and Hong, Hua and Chen, Xuesi
ACS applied materials & interfaces, ISSN 1944-8244, 03/2013, Volume 5, Issue 5, pp. 1781 - 1792
electrostatic interaction | antitumor | doxorubicin hydrochloride | nonsmall cell lung cancer | pH-responsive | poly(l -glutamic acid) | Science & Technology - Other Topics | Materials Science | Nanoscience & Nanotechnology | Technology | Materials Science, Multidisciplinary | Science & Technology | Doxorubicin - therapeutic use | Drug Delivery Systems - instrumentation | Antineoplastic Combined Chemotherapy Protocols - chemistry | Humans | Rats | Male | Doxorubicin - chemistry | Rats, Sprague-Dawley | Drug Carriers - chemistry | Polyglutamic Acid - chemistry | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Mice | Mice, Inbred BALB C | Surface-Active Agents - chemistry | Carcinoma, Non-Small-Cell Lung - drug therapy | Drug Delivery Systems - methods | Index Medicus
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9. Full Text Multifunctional Synthetic Poly(l-Glutamic Acid)–Based Cancer Therapeutic and Imaging Agents
by Melancon, Marites P and Li, Chun
Molecular imaging, ISSN 1535-3508, 1/2011, Volume 10, Issue 1, pp. 28 - 42
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Radiology, Nuclear Medicine & Medical Imaging | Biochemical Research Methods | Science & Technology | Polyglutamic Acid - analogs & derivatives | Polyglutamic Acid - chemistry | Humans | Neoplasms - radiotherapy | Antineoplastic Agents - therapeutic use | Neoplasms - diagnosis | Antineoplastic Agents - chemistry | Drug Delivery Systems - methods | Neoplasms - drug therapy | Index Medicus | macromolecular contrast agents | Poly(L-glutamic acid) | polymers | PG-paclitaxel | anticancer drugs
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