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Journal of Molecular Neuroscience, ISSN 0895-8696, 6/2016, Volume 59, Issue 2, pp. 290 - 299
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2014, Volume 111, Issue 8, pp. 3158 - 3163
We have recently found higher circulating levels of pituitary adenylate cyclase-activating polypeptide (PACAP) associated with posttraumatic stress disorder... 
Psychological stress | Post traumatic stress disorder | Reactivity | Amygdala | Connectivity | Military psychiatry | Prefrontal cortex | Behavioral neuroscience | Hippocampus | Genotypes | fMRI | Intermediate phenotype | Emotion | Single nucleotide polymorphism | PSYCHOMETRIC PROPERTIES | POSTTRAUMATIC-STRESS-DISORDER | CHILDHOOD MALTREATMENT | TRAUMA EXPOSURE | single nucleotide polymorphism | MULTIDISCIPLINARY SCIENCES | PTSD SYMPTOMS | FUNCTIONAL CONNECTIVITY | ADCYAP1R1 GENOTYPE | ACTIVATING POLYPEPTIDE PACAP | emotion | intermediate phenotype | MEDIAL PREFRONTAL CORTEX | BRAIN | Amygdala - physiopathology | Humans | Middle Aged | African Americans - genetics | Genotype | Connectome | Stress Disorders, Post-Traumatic - physiopathology | Fear - physiology | Magnetic Resonance Imaging | Pituitary Adenylate Cyclase-Activating Polypeptide - metabolism | Pituitary Adenylate Cyclase-Activating Polypeptide - blood | Sex Factors | Adult | Female | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - metabolism | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - genetics | Stress Disorders, Post-Traumatic - genetics | Hippocampus - physiopathology | Fear | Genetic aspects | Hippocampus (Brain) | Identification and classification | Amygdala (Brain) | Genetic polymorphisms | Genotype & phenotype | Brain | T cell receptors | Rodents | Polymorphism | Index Medicus | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2006, Volume 103, Issue 19, pp. 7488 - 7493
Pituitary adenylate cyclase-activating polypeptide (PACAP) has been reported to decrease ischemic neuronal damage and increase IL-6 secretion in rats. However,... 
Neurologic manifestations | Phosphorylation | Mitochondria | Ischemia | Cell death | Neurons | Cytochromes | Mice | Research universities | Vehicles | Pituitary adenylate cyclase-activating polypeptide-specific receptor | Extracellular signal-regulated kinase | bcl-2 | Signal transducer and activator of transcription 3 | CEREBELLAR GRANULE NEURONS | APOPTOSIS | extracellular signal-regulated kinase | MULTIDISCIPLINARY SCIENCES | RAT CORTICAL-NEURONS | RECEPTOR | INTERLEUKIN-6 | BLOOD-BRAIN-BARRIER | HIPPOCAMPAL-NEURONS | MICE LACKING | ischemia | pituitary adenylate cyclase-activating polypeptide-specific receptor signal transducer and activator of transcription | CEREBRAL-ARTERY OCCLUSION | EXPRESSION | Neurons - pathology | Cytochromes c - secretion | Interleukin-6 - genetics | Pituitary Adenylate Cyclase-Activating Polypeptide - genetics | Signal Transduction | Infarction, Middle Cerebral Artery - pathology | Interleukin-6 - deficiency | Infarction, Middle Cerebral Artery - metabolism | Mice, Knockout | Proto-Oncogene Proteins c-bcl-2 - metabolism | Animals | Pituitary Adenylate Cyclase-Activating Polypeptide - metabolism | Pituitary Adenylate Cyclase-Activating Polypeptide - pharmacology | Infarction, Middle Cerebral Artery - genetics | Neurons - secretion | Neurons - metabolism | Neurons - drug effects | Interleukin-6 - metabolism | Apoptosis | Pituitary Adenylate Cyclase-Activating Polypeptide - deficiency | Transducers, Biomedical | Usage | Research | Protein kinases | Signal transduction | Peptides | Cytokines | Rodents | Index Medicus | pituitary adenylate cyclase-activating polypeptide-specific receptor | Biological Sciences | signal transducer and activator of transcription 3
Journal Article
Journal of Molecular Neuroscience, ISSN 0895-8696, 11/2012, Volume 48, Issue 3, pp. 508 - 517
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuroprotective peptide expressed in the central nervous system. To date, changes in the... 
Neurochemistry | Neurology | Neuroprotective effect | Neurosciences | Biomedicine | PACAP | Proteomics | Knockout mouse | Spinal cord injury | Cell Biology | APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | RATS | NEURONAL CELL-DEATH | RECEPTOR | NEUROSCIENCES | PEPTIDE | TRAUMATIC BRAIN-INJURY | MESSENGER-RNA | REACTIVE ASTROCYTES | EXPRESSION | Neurons - pathology | Up-Regulation | Nerve Tissue Proteins - deficiency | Male | Spinal Cord Injuries - genetics | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - physiology | Recovery of Function | Spinal Cord Injuries - pathology | RNA, Messenger - biosynthesis | Time Factors | Cell Death | Nerve Tissue Proteins - biosynthesis | Drug Evaluation, Preclinical | Real-Time Polymerase Chain Reaction | Nerve Tissue Proteins - physiology | Pituitary Adenylate Cyclase-Activating Polypeptide - genetics | Mice, Inbred C57BL | Pituitary Adenylate Cyclase-Activating Polypeptide - biosynthesis | RNA, Messenger - genetics | Gene Expression Regulation | Genotype | Pituitary Adenylate Cyclase-Activating Polypeptide - physiology | Nerve Tissue Proteins - genetics | Mice, Knockout | Animals | Mice | Spinal Cord Injuries - physiopathology | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - genetics | Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I - biosynthesis | Astrocytes - metabolism | Pituitary Adenylate Cyclase-Activating Polypeptide - deficiency | Index Medicus | Pituitary adenylate cyclase-activating polypeptide | Polymerase chain reaction | Neuroprotection | Astrocytes | Cell death | Central nervous system | Data processing | Nervous system | mRNA | Immunoreactivity
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 10/2015, Volume 54, Issue 44, pp. 13095 - 13100
Journal Article
Journal of Comparative Neurology, ISSN 0021-9967, 12/2016, Volume 524, Issue 18, pp. 3827 - 3848
Pituitary adenylate cyclase‐activating polypeptide (PACAP, gene name Adcyap1 ) regulates a wide variety of neurological and physiological functions, including... 
RRID:AB_2336201 | RRID:SciRes_000137 | RRID:AB_10058149 | neuropeptide | RRID:AB_10680176 | RRID:nlx_143660 | RRID:AB_177621 | facial nerve axotomy | Adcyap1 | central nervous system | pituitary adenylyl cyclase‐activating polypeptide | RRID:IMSR_MMRRC:012011 | RRID:AB_10073917 | RRID:AB_10049744 | reporter mouse | RRID:AB_10563748 | Central nervous system | Reporter mouse | Neuropeptide | Pituitary adenylyl cyclase-activating polypeptide | Facial nerve axotomy | pituitary adenylyl cyclase-activating polypeptide | CYCLASE-ACTIVATING POLYPEPTIDE | DORSAL-ROOT GANGLIA | HYPOTHALAMIC PARAVENTRICULAR NUCLEUS | ZOOLOGY | MESSENGER-RNA | CENTRAL-NERVOUS-SYSTEM | RETINOHYPOTHALAMIC TRACT | NEUROSCIENCES | PEPTIDE GENE-EXPRESSION | VASOACTIVE INTESTINAL POLYPEPTIDE | RAT-BRAIN | ADENYLATE-CYCLASE | Immunohistochemistry | Green Fluorescent Proteins - metabolism | Brain - cytology | Spinal Cord - metabolism | Pituitary Adenylate Cyclase-Activating Polypeptide - genetics | Male | Mice, Transgenic | Facial Nerve Injuries - metabolism | Gene Expression Profiling | Green Fluorescent Proteins - genetics | Brain - metabolism | Axotomy | Animals | Pituitary Adenylate Cyclase-Activating Polypeptide - metabolism | Facial Nerve Injuries - pathology | Models, Animal | Neurons - metabolism | Spinal Cord - cytology | Genetic engineering | Colchicine | Peptides | Neurons | Genetic translation | Analysis | Index Medicus
Journal Article
Biochimie, ISSN 0300-9084, 2011, Volume 93, Issue 4, pp. 669 - 677
Journal Article
Chemical Communications : Chem Comm, ISSN 1359-7345, 01/2018, Volume 54, Issue 98, pp. 13853 - 13856
Mass spectrometry has been applied to determine the deamidation sites and the aggregation region of the deamidated human islet amyloid polypeptide (hIAPP).... 
Polypeptides | Agglomeration | Mutation | Mass spectrometry
Journal Article
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, 01/2016, Volume 310, Issue 1, pp. G43 - G51
Enteropancreatic hormone secretion is thought to include a cephalic phase, but the evidence in humans is ambiguous. We studied vagally induced gut hormone... 
Cephalic phase | Pancreatic polypeptide | Vagus | Glucagon | Ghrelin | Atropine | Hyperglycemic clamp insulin | Efferent vagal signaling | Muscarinic blockade | CHOLINERGIC REGULATION | PHYSIOLOGY | muscarinic blockade | ORAL SENSORY STIMULATION | VAGAL-STIMULATION | RAPID OSCILLATIONS | hyperglycemic clamp insulin | GLUCAGON-RESPONSES | INTRAVENOUS GLUCOSE | ghrelin | vagus | AUTONOMIC NERVOUS CONTROL | glucagon | efferent vagal signaling | GASTROENTEROLOGY & HEPATOLOGY | POLYPEPTIDE RESPONSES | atropine | cephalic phase | pancreatic poly-peptide | PANCREATIC ENDOCRINE SECRETION | Intestinal Mucosa - metabolism | Gastric Inhibitory Polypeptide - metabolism | Humans | Vagus Nerve - drug effects | Glucagon-Like Peptide 1 - blood | Male | Insulin - blood | Glucagon - blood | Young Adult | Heart Rate - drug effects | Time Factors | Muscarinic Antagonists - pharmacology | Postprandial Period | Adult | Insulin Secretion | Eating | Pancreatic Polypeptide - metabolism | Glucagon-Like Peptide 1 - metabolism | Intestines - innervation | Gastric Inhibitory Polypeptide - blood | Biomarkers - blood | Pancreas - metabolism | Ghrelin - metabolism | Vagus Nerve - physiology | Ghrelin - blood | Insulin - metabolism | Pancreatic Polypeptide - blood | Denmark | Glucagon - metabolism | Intestinal Secretions - metabolism | Glucose Clamp Technique | Blood Glucose - metabolism | Glucose | Insulin | Dextrose | Pancreatic hormone | Physiological aspects | Physiological research | Research | Pancreas | Secretions | Hormones | Peptides | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2016, Volume 11, Issue 1, pp. e0146981 - e0146981
Journal Article
Science Translational Medicine, ISSN 1946-6234, 10/2013, Volume 5, Issue 209, pp. 209ra151 - 209ra151
We report the discovery and translational therapeutic efficacy of a peptide with potent, balanced co-agonism at both of the receptors for the incretin hormones... 
MEDICINE, RESEARCH & EXPERIMENTAL | BODY-WEIGHT | GLYCEMIC CONTROL | HIGH-FAT DIET | GLUCOSE-INTOLERANCE | ENTEROINSULAR AXIS | PANCREATIC BETA-CELLS | DEPENDENT INSULINOTROPIC POLYPEPTIDE | GASTRIC-INHIBITORY POLYPEPTIDE | LIPOPROTEIN-LIPASE | PEPTIDE YY3-36 | CELL BIOLOGY | Acylation - drug effects | Glucagon-Like Peptide 1 - administration & dosage | Humans | Middle Aged | Male | Rodentia - metabolism | Weight Loss - drug effects | Hyperglycemia - drug therapy | Young Adult | Incretins - pharmacology | Adult | Female | Gastric Inhibitory Polypeptide - pharmacology | Receptors, Glucagon - agonists | Glucose Tolerance Test | Glucagon-Like Peptide 1 - analogs & derivatives | Glucagon-Like Peptide 1 - pharmacology | Rats | Receptors, Glucagon - metabolism | Treatment Outcome | Haplorhini - metabolism | Gastric Inhibitory Polypeptide - administration & dosage | Peptides - pharmacology | Insulin - metabolism | Animals | Glucagon-Like Peptide-1 Receptor | Adolescent | Aged | Mice | Venoms - pharmacology | Incretins - therapeutic use | Diabetes Mellitus, Type 2 - drug therapy | Receptors, Gastrointestinal Hormone | Incretins - administration & dosage | Liraglutide | Index Medicus | Medicin och hälsovetenskap | Medicinsk bioteknologi (inriktn. mot cellbiologi (inkl. stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci) | Medicinsk bioteknologi
Journal Article