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British Journal of Pharmacology, ISSN 0007-1188, 09/2007, Volume 152, Issue 1, pp. 141 - 150
Background and purpose: ARL 67156, 6‐N,N‐Diethyl‐D‐β‐γ‐dibromomethylene adenosine triphosphate, originally named FPL 67156, is the only commercially available... 
extracellular nucleotide | CD39 | FPL 67156 | ARL 67156 | NTPDase | Ecto‐5′‐nucleotidase | ecto‐ATPase | NPP | Ecto-ATPase | Extracellular nucleotide | Ecto-5′-nucleotidase | ecto-ATPase | PHOSPHODIESTERASE-I | GUINEA-PIG | ecto-5'-nucleotidase | NUCLEOTIDE PYROPHOSPHATASES/PHOSPHODIESTERASES | CLONING | NERVE-STIMULATION | SUPERIOR CERVICAL-GANGLIA | PHARMACOLOGY & PHARMACY | ISOLATED VAS-DEFERENS | AUTOTAXIN NPP2 | DIADENOSINE POLYPHOSPHATES | 5'-Nucleotidase - antagonists & inhibitors | Nucleotidases - genetics | Uridine Triphosphate - metabolism | Humans | Substrate Specificity | Nucleotidases - antagonists & inhibitors | Antigens, CD - metabolism | Adenosine Triphosphate - pharmacology | Pyrophosphatases - antagonists & inhibitors | Adenosine Triphosphate - metabolism | Recombinant Proteins - metabolism | Recombinant Proteins - antagonists & inhibitors | Phosphoric Diester Hydrolases - metabolism | Thymidine Monophosphate - metabolism | Apyrase - antagonists & inhibitors | Adenosine Monophosphate - metabolism | Apyrase - metabolism | Enzyme Inhibitors - pharmacology | Adenosine Triphosphatases - metabolism | Dinucleoside Phosphates - metabolism | Thymidine Monophosphate - analogs & derivatives | Adenosine Triphosphate - analogs & derivatives | Hydrolysis | Pyrophosphatases - metabolism | Adenosine Triphosphatases - antagonists & inhibitors | Nucleotidases - metabolism | Animals | Adenosine Triphosphatases - genetics | Mice | Adenosine Diphosphate - metabolism | Kinetics | 5'-Nucleotidase - metabolism | Research Papers
Journal Article
Journal of Immunology, ISSN 0022-1767, 02/2014, Volume 192, Issue 3, pp. 1034 - 1043
Journal Article
Science, ISSN 0036-8075, 4/2007, Volume 316, Issue 5821, pp. 109 - 112
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 11/2014, Volume 463, Issue 3, pp. 413 - 427
The Vps34 (vacuolar protein sorting 34) class III PI3K (phosphoinositide 3-kinase) phosphorylates PtdIns (phosphatidylinositol) at endosomal membranes to... 
Mammalian target of rapamycin (mTOR) | Phosphoinositide 3-kinase (PI3K) | Protein kinase inhibitor | Signal transduction inhibitor | N-Myc downstream-regulated gene-1 (NDRG1) | Protein Structure, Tertiary | Cell Line | Phosphorylation | Class II Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol Phosphates - metabolism | Class I Phosphatidylinositol 3-Kinases - metabolism | Class II Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Humans | Inositol Polyphosphate 5-Phosphatases | Class III Phosphatidylinositol 3-Kinases - metabolism | Pyrimidines - pharmacology | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Endosomes - metabolism | Amino Acid Motifs | Aminopyridines - pharmacology | Hydrophobic and Hydrophilic Interactions | Protein Binding | Class III Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases | Phosphoric Monoester Hydrolases - metabolism | Protein-Serine-Threonine Kinases - metabolism | SGK3, serum- and glucocorticoid-regulated kinase-3 | signal transduction inhibitor | PI3K, phosphoinositide 3-kinase | ITC, isothermal titration calorimetry | SHIP1 | mTORC, mammalian target of rapamycin complex | EEA1, early endosome antigen 1 | INPP4B, inositol polyphosphate 4-phosphatase type II | TSC2, tuberous sclerosis complex 2 | phosphoinositide 3-kinase (PI3K) | HRP, horseradish peroxidase | PDK1, phosphoinositide-dependent kinase 1 | DMEM, Dulbecco's modified Eagle's medium | NDRG1, N-Myc downstream-regulated gene-1 | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | IP1, inositol phosphate | 4E-BP1, eukaryotic initiation factor 4E-binding protein 1 | PX, Phox homology | mammalian target of rapamycin (mTOR) | Accelerated Publication | PH, pleckstrin homology | PtdIns, phosphatidylinositol | PRAS40, proline-rich Akt substrate 40 kDa | protein kinase inhibitor | 2, Src homology 2-domain-containing inositol phosphatase 1 | Vps34, vacuolar protein sorting 34 | VSV-G, vesicular stomatitis virus glycoprotein
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 12/2013, Volume 33, Issue 12, pp. 2759 - 2770
OBJECTIVE—Polyphosphate and heparin are anionic polymers released by activated mast cells and platelets that are known to stimulate the contact pathway of... 
Factor XI | Blood coagulation factor inhibitors | Bradykinin | Leishmania | Inflammation | Factor XII | Kallikreins | kallikreins | factor XI | LIGAND-BINDING | PROTEIN | leishmania | THROMBUS FORMATION | MAST-CELLS | bradykinin | SAND FLY | KININ SYSTEM INHIBITOR | FLY LUTZOMYIA-LONGIPALPIS | inflammation | FACTOR-XI | IN-VIVO | PERIPHERAL VASCULAR DISEASE | blood coagulation factor inhibitors | HEMATOLOGY | GLAND | factor XII | Factor XIIa - metabolism | Heparin - metabolism | Humans | Factor XIa - antagonists & inhibitors | Capillary Permeability - drug effects | Crystallography, X-Ray | Structure-Activity Relationship | Saliva - chemistry | Dose-Response Relationship, Drug | Kininogen, High-Molecular-Weight - antagonists & inhibitors | Factor XIa - metabolism | Time Factors | Anticoagulants - chemistry | Dextran Sulfate - metabolism | Prekallikrein - antagonists & inhibitors | Insect Proteins - isolation & purification | Insect Proteins - metabolism | Anticoagulants - isolation & purification | Insect Proteins - pharmacology | Anticoagulants - metabolism | Psychodidae - chemistry | Models, Molecular | Kininogen, High-Molecular-Weight - metabolism | Polyphosphates - metabolism | Prekallikrein - metabolism | Animals | Factor XIIa - antagonists & inhibitors | Blood Coagulation - drug effects | Anticoagulants - pharmacology | Insect Proteins - chemistry | Blood Coagulation Tests | Protein Conformation | Mice | Thrombin - metabolism
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 03/2017, Volume 61, Issue 3
Journal Article
Molecular Endocrinology, ISSN 0888-8809, 03/2012, Volume 26, Issue 3, pp. 502 - 520
Vasopressin (AVP) and CRH synergistically regulate adrenocorticotropin and insulin release at the level of the pituitary and pancreas, respectively. Here, we... 
HUMAN OXYTOCIN RECEPTOR | CORTICOTROPIN-RELEASING-FACTOR | MEDULLARY CHROMAFFIN CELLS | PRIMARY CULTURE | ADENOSINE-MONOPHOSPHATE | PHARMACOLOGICAL CHARACTERIZATION | ENDOCRINOLOGY & METABOLISM | RESONANCE ENERGY-TRANSFER | RAT-BRAIN | PITUITARY-ADRENAL AXIS | G-PROTEIN | Receptors, Corticotropin-Releasing Hormone - metabolism | Catecholamines - secretion | Humans | Protein Multimerization | Inositol Polyphosphate 5-Phosphatases | Receptors, Vasopressin - metabolism | Receptors, Corticotropin-Releasing Hormone - agonists | Type C Phospholipases - metabolism | Recombinant Fusion Proteins - metabolism | Type C Phospholipases - antagonists & inhibitors | Chromaffin Cells - secretion | Pyrrolidines - pharmacology | Cattle | Estrenes - pharmacology | Pyrrolidinones - pharmacology | HEK293 Cells | Recombinant Fusion Proteins - agonists | Thiazines - pharmacology | Indoles - pharmacology | Adrenal Glands - cytology | Cyclic AMP - metabolism | Hydrocarbons, Halogenated - pharmacology | Second Messenger Systems | Receptors, Vasopressin - agonists | Receptor Cross-Talk | Cells, Cultured | Vasopressins - pharmacology | Corticotropin-Releasing Hormone - pharmacology | Corticotropin-Releasing Hormone - physiology | Chromaffin Cells - metabolism | Animals | Receptors, Corticotropin-Releasing Hormone - antagonists & inhibitors | Protein Binding | Enzyme Activation | Primary Cell Culture | Vasopressins - physiology | Antidiuretic Hormone Receptor Antagonists | Phosphoric Monoester Hydrolases - metabolism | Original Research
Journal Article
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 06/2016, Volume 25, Issue 11, pp. 2295 - 2313
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 12/2011, Volume 90, Issue 6, pp. 1141 - 1148
Induction of endotoxin tolerance in vivo inhibits IRAK4 and increases negative TLR4 regulators. TLRs mediate host defense against microbial pathogens by... 
monocytes/macrophages | lipopolysaccharide | signal transduction | cell activation | tolerance/suppression/anergy | Lipopolysaccharide | Signal transduction | Cell activation | Monocytes/macrophages | Tolerance/suppression/anergy | ANTIINFLAMMATORY RESPONSE SYNDROME | KINASE-ACTIVITY | NECROSIS-FACTOR RECEPTOR | DENDRITIC CELLS | DOWN-REGULATION | IMMUNOLOGY | CELL BIOLOGY | SIGNAL-TRANSDUCTION | TOLL-LIKE RECEPTORS | GENE-EXPRESSION | HEMATOLOGY | NF-KAPPA-B | INNATE IMMUNITY | Interleukin-1 Receptor-Associated Kinases - metabolism | Interleukin-1 Receptor-Associated Kinases - genetics | Interleukin-1 Receptor-Associated Kinases - biosynthesis | Inositol Polyphosphate 5-Phosphatases | Macrophages, Peritoneal - pathology | Intracellular Signaling Peptides and Proteins - metabolism | Cysteine Endopeptidases - metabolism | Phosphoric Monoester Hydrolases - biosynthesis | Inflammation Mediators - metabolism | Tumor Necrosis Factor alpha-Induced Protein 3 | Inflammation Mediators - antagonists & inhibitors | Phosphorylation - immunology | Intracellular Signaling Peptides and Proteins - genetics | Phosphoric Monoester Hydrolases - genetics | Mice, Inbred C57BL | Cells, Cultured | Immune Tolerance | Macrophages, Peritoneal - immunology | Cysteine Endopeptidases - biosynthesis | Endotoxins - antagonists & inhibitors | Animals | Up-Regulation - immunology | Down-Regulation - immunology | Cysteine Endopeptidases - genetics | Interleukin-1 Receptor-Associated Kinases - antagonists & inhibitors | Endotoxins - administration & dosage | Mice | Macrophages, Peritoneal - metabolism | Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases | Phosphoric Monoester Hydrolases - metabolism | monocytes | macrophages | suppression | Receptors, Signal Transduction, & Genes | tolerance | anergy
Journal Article