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TRENDS IN CELL BIOLOGY, ISSN 0962-8924, 01/2018, Volume 28, Issue 1, pp. 1 - 3
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 06/2011, Volume 50, Issue 27, pp. 6137 - 6141
Journal Article
Molecular Cell, ISSN 1097-2765, 10/2016, Volume 64, Issue 2, pp. 251 - 266
Polyubiquitin chains of different topologies regulate diverse cellular processes. K48- and K63-linked chains, the two most abundant chain types, regulate... 
NF-κB | CYLD | AQUA | proteomics | Lys63 | inflammation | TRAF6 | HUWE1 | Lys48 | ACTIVATION | COMPLEX | INHIBITION | SPECIFICITY | ELONGATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CYLD USP | DEGRADATION | POLYUBIQUITIN CHAIN | MECHANISMS | LIGASE | CELL BIOLOGY | Adaptor Proteins, Signal Transducing - chemistry | Interleukin-1beta - pharmacology | Deubiquitinating Enzyme CYLD | Humans | Ubiquitin - metabolism | Substrate Specificity | NF-kappa B - metabolism | NF-kappa B - chemistry | Polyubiquitin - genetics | Ubiquitination | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Lysine - metabolism | Protein Interaction Domains and Motifs | Osteoblasts - cytology | TNF Receptor-Associated Factor 6 - genetics | Binding Sites | Polyubiquitin - chemistry | Polyubiquitin - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Protein Conformation, alpha-Helical | Gene Expression | Tumor Suppressor Proteins - metabolism | Signal Transduction | Osteoblasts - drug effects | Ubiquitin - chemistry | Ubiquitin-Protein Ligases - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Ubiquitin - genetics | Ubiquitin-Protein Ligases - chemistry | Sequence Alignment | NF-kappa B - genetics | Protein Conformation, beta-Strand | Adaptor Proteins, Signal Transducing - genetics | TNF Receptor-Associated Factor 6 - chemistry | TNF Receptor-Associated Factor 6 - metabolism | Cell Line, Tumor | Protein Binding | Adaptor Proteins, Signal Transducing - metabolism | Lysine - chemistry | Osteoblasts - metabolism | Ubiquitin-Protein Ligases - genetics | Index Medicus
Journal Article
Biochemical Journal, ISSN 0264-6021, 11/2006, Volume 399, Issue 3, pp. 361 - 372
The covalent modification of proteins by ubiquitination is a major regulatory mechanism of protein degradation and quality control, endocytosis, vesicular... 
Endocytosis | Ubiquitination | Vesicle trafficking | Ubiquitin-binding domain | Protein structure | Proteasome | proteasome | LYS48-LINKED POLYUBIQUITIN CHAIN | DAMAGE-INDUCIBLE PROTEINS | GAT DOMAIN | ubiquitin-binding domain | BIOCHEMISTRY & MOLECULAR BIOLOGY | ZINC-FINGER DOMAIN | protein structure | UBA DOMAIN | ubiquitination | STRUCTURAL BASIS | endocytosis | PROTEIN-PROTEIN INTERACTIONS | DNA-REPAIR | INTERACTING MOTIF | GGA PROTEINS | vesicle trafficking | Polyubiquitin - metabolism | Protein Structure, Tertiary | Humans | Ubiquitin - chemistry | Ubiquitin - metabolism | Models, Molecular | Structure-Activity Relationship | Protein Transport | Animals | Ubiquitin-Protein Ligase Complexes - metabolism | Protein Binding | Protein Conformation | Protein Processing, Post-Translational | Kinetics | Proteasome Endopeptidase Complex - metabolism | Polyubiquitin - chemistry | DUIM, double-sided ubiquitin-interacting motif | GAT, GGA and TOM | UEV, ubiquitin-conjugating enzyme E2 variant | GGA, Golgi-localized, gamma-ear-containing, ADP-ribosylation-factor-binding protein | TOM, target of Myb | UBP, ubiquitin-specific processing protease | Review | UBA, ubiquitin-associated | ESCRT, endosomal sorting complexes required for transport | UBM, ubiquitin-binding motif | PFU, PLAA family ubiquitin binding | GLUE, GRAM-like ubiquitin binding in EAP45 | Vps, vacuolar sorting protein | UBZ, ubiquitin-binding zinc finger | Ubc, ubiquitin-conjugating enzyme | CUE, coupling of ubiquitin conjugation to endoplasmic reticulum degradation | ZnF, zinc finger | PAZ, polyubiquitin-associated zinc binding | RIP, receptor-interacting protein | PH, pleckstrin homology | MIU, motif interacting with ubiquitin | UIM, ubiquitin-interacting motif | NZF, Npl4 zinc finger
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 11/2010, Volume 49, Issue 48, pp. 9126 - 9131
Building the chains: A general and effective approach for the total chemical synthesis of all the di‐ubiquitin chains (see picture) is presented. The behavior... 
peptides | ligation | proteins | synthetic methods | ubiquitin | PEPTIDE UBIQUITYLATION | CRYSTAL-STRUCTURE | CHEMISTRY, MULTIDISCIPLINARY | STRUCTURAL BASIS | POLYUBIQUITIN CHAINS | DESULFURIZATION | BINDING | EFFICIENT | ISOPEPTIDASE-T | Models, Molecular | Molecular Sequence Data | Amino Acid Sequence | Polyubiquitin - chemical synthesis | Humans | Polyubiquitin - chemistry
Journal Article
The EMBO Journal, ISSN 0261-4189, 02/2015, Volume 34, Issue 3, pp. 307 - 325
The protein kinase PINK1 was recently shown to phosphorylate ubiquitin (Ub) on Ser65, and phosphoUb activates the E3 ligase Parkin allosterically. Here, we... 
PINK1 | phosphorylation | deubiquitinase | ubiquitin | Parkin | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | 63-LINKED POLYUBIQUITIN CHAINS | DAMAGED MITOCHONDRIA | CELL BIOLOGY | E3 LIGASE | ACTIVATE PARKIN | BINDING PROTEINS | CROSS-REACTIVITY | CONJUGATING ENZYME | REVEALS | Phosphorylation - physiology | Ubiquitin-Specific Proteases - genetics | Humans | Endosomal Sorting Complexes Required for Transport - genetics | Mitochondrial Proteins - genetics | Phosphoproteins - metabolism | Polyubiquitin - genetics | Allosteric Regulation - physiology | Mitochondrial Proteins - metabolism | Protein Multimerization - physiology | Ubiquitin Thiolesterase - metabolism | TNF Receptor-Associated Factor 6 - genetics | Ubiquitination - physiology | Ubiquitin-Specific Proteases - metabolism | Polyubiquitin - metabolism | Protein Structure, Tertiary | Endopeptidases - metabolism | Endosomal Sorting Complexes Required for Transport - metabolism | Ubiquitin-Protein Ligases - metabolism | Serine - genetics | Ubiquitin-Conjugating Enzymes - genetics | Phosphoproteins - genetics | Transcription Factors - genetics | Ubiquitin Thiolesterase - genetics | Serine - metabolism | Hydrolysis | Transcription Factors - metabolism | Endopeptidases - genetics | Ubiquitin-Conjugating Enzymes - metabolism | Adaptor Proteins, Signal Transducing - genetics | TNF Receptor-Associated Factor 6 - metabolism | Thiolester Hydrolases - genetics | Thiolester Hydrolases - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Ubiquitin-Protein Ligases - genetics | Enzymes | Phosphorylation | Kinases | Crystal structure
Journal Article