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The EMBO Journal, ISSN 0261-4189, 02/2015, Volume 34, Issue 3, pp. 307 - 325
The protein kinase PINK1 was recently shown to phosphorylate ubiquitin (Ub) on Ser65, and phosphoUb activates the E3 ligase Parkin allosterically. Here, we... 
PINK1 | phosphorylation | deubiquitinase | ubiquitin | Parkin | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | 63-LINKED POLYUBIQUITIN CHAINS | DAMAGED MITOCHONDRIA | CELL BIOLOGY | E3 LIGASE | ACTIVATE PARKIN | BINDING PROTEINS | CROSS-REACTIVITY | CONJUGATING ENZYME | REVEALS | Phosphorylation - physiology | Ubiquitin-Specific Proteases - genetics | Humans | Endosomal Sorting Complexes Required for Transport - genetics | Mitochondrial Proteins - genetics | Phosphoproteins - metabolism | Polyubiquitin - genetics | Allosteric Regulation - physiology | Mitochondrial Proteins - metabolism | Protein Multimerization - physiology | Ubiquitin Thiolesterase - metabolism | TNF Receptor-Associated Factor 6 - genetics | Ubiquitination - physiology | Ubiquitin-Specific Proteases - metabolism | Polyubiquitin - metabolism | Protein Structure, Tertiary | Endopeptidases - metabolism | Endosomal Sorting Complexes Required for Transport - metabolism | Ubiquitin-Protein Ligases - metabolism | Serine - genetics | Ubiquitin-Conjugating Enzymes - genetics | Phosphoproteins - genetics | Transcription Factors - genetics | Ubiquitin Thiolesterase - genetics | Serine - metabolism | Hydrolysis | Transcription Factors - metabolism | Endopeptidases - genetics | Ubiquitin-Conjugating Enzymes - metabolism | Adaptor Proteins, Signal Transducing - genetics | TNF Receptor-Associated Factor 6 - metabolism | Thiolester Hydrolases - genetics | Thiolester Hydrolases - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Ubiquitin-Protein Ligases - genetics | Enzymes | Phosphorylation | Kinases | Crystal structure
Journal Article
Immunological Reviews, ISSN 0105-2896, 11/2011, Volume 244, Issue 1, pp. 9 - 28
Tumor necrosis factor (TNF) is crucial for innate immunity, but deregulated TNF signaling also plays an eminent role in the pathogenesis of many chronic... 
signaling proteins | cytokines | signal transduction | apoptosis/autophagy | cytotoxicity | Signal transduction | Cytotoxicity | Apoptosis/autophagy | Cytokines | Signaling proteins | DEUBIQUITINATING ENZYME | autophagy | CRYSTAL-STRUCTURE | AFFINITY PURIFICATION | apoptosis | FACTOR RECEPTOR-1 | IMMUNOLOGY | ASSEMBLY COMPLEX | FACTOR-ALPHA | SIGNALING COMPLEX | TUMOR-NECROSIS-FACTOR | UNANCHORED POLYUBIQUITIN CHAINS | NF-KAPPA-B | Neoplasms - metabolism | Tumor Necrosis Factor-alpha - metabolism | Protein Binding - genetics | Receptors, Tumor Necrosis Factor, Type I - immunology | Humans | Tumor Necrosis Factor-alpha - genetics | Ubiquitin - metabolism | Apoptosis - genetics | Receptors, Tumor Necrosis Factor, Type I - metabolism | Receptors, Tumor Necrosis Factor, Type II - immunology | Transcriptional Activation - immunology | Autophagy - immunology | Signal Transduction - immunology | Inflammation - metabolism | Neoplasms - genetics | Receptors, Tumor Necrosis Factor, Type II - metabolism | Tumor Necrosis Factor-alpha - immunology | Autophagy - genetics | Inflammation - immunology | Signal Transduction - genetics | Ubiquitin - genetics | Ubiquitination - immunology | Immunity, Innate | Receptors, Tumor Necrosis Factor, Type I - genetics | Receptors, Tumor Necrosis Factor, Type II - genetics | Apoptosis - immunology | Neoplasms - immunology | Inflammation - genetics | Ubiquitin - immunology | Ubiquitination - genetics | Ubiquitin | Tumor necrosis factor | Cell death | Genes | Physiological aspects | Genetic research | Biochemistry | Inflammation | Genetic aspects | Cancer
Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 11/2011, Volume 44, Issue 4, pp. 559 - 571
Journal Article
EMBO reports, ISSN 1469-221X, 10/2018, Volume 19, Issue 10, p. n/a
Journal Article
Plant Physiology, ISSN 0032-0889, 5/2012, Volume 159, Issue 1, pp. 418 - 432
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2008, Volume 105, Issue 52, pp. 20876 - 20881
Hereditary cases of breast and ovarian cancer are often attributed to germ-line mutations of the BRCA1 tumor suppressor gene. Although BRCA1 is involved in... 
Epithelial cells | Ubiquitins | DNA damage | DNA | Alleles | Stem cells | Genetic loci | Genetic mutation | Viability | Tumors | DNA double-strand break repair | Breast cancer | E3 ubiquitin ligase | Homologous recombination | BRCA1/BARD1 heterodimer | BARD1 | PROTEIN | MULTIDISCIPLINARY SCIENCES | breast cancer | UBIQUITIN-LIGASE | CANCER | CYCLE CHECKPOINT | homologous recombination | GENETIC INSTABILITY | MUTATION | TUMOR-SUPPRESSOR | POLYUBIQUITIN CHAINS | Embryonic Stem Cells - metabolism | Cross-Linking Reagents - pharmacology | Humans | Ovarian Neoplasms - pathology | DNA Repair - radiation effects | DNA Repair - genetics | Breast Neoplasms - metabolism | DNA Breaks, Double-Stranded - radiation effects | Gene Knockdown Techniques | Ovarian Neoplasms - genetics | Chromosome Aberrations - drug effects | DNA Breaks, Double-Stranded - drug effects | BRCA1 Protein - metabolism | Tumor Suppressor Proteins - genetics | Recombination, Genetic - genetics | Female | Ovarian Neoplasms - metabolism | Mammary Neoplasms, Animal - genetics | Radiation, Ionizing | Rad51 Recombinase - metabolism | Cell Line | Chromosome Aberrations - radiation effects | DNA Repair - drug effects | Tumor Suppressor Proteins - metabolism | Rad51 Recombinase - genetics | Ubiquitin-Protein Ligases - metabolism | Mitomycin - pharmacology | BRCA1 Protein - genetics | Mammary Neoplasms, Animal - pathology | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Mammary Neoplasms, Animal - metabolism | Embryonic Stem Cells - pathology | Mice | Recombination, Genetic - radiation effects | Ubiquitin-Protein Ligases - genetics | Chromosome Aberrations - chemically induced | Recombination, Genetic - drug effects | Physiological aspects | Genetic aspects | Mammals | Properties | BRCA mutations | Ligases | Biological Sciences | BARD1 heterodimer | BRCA1
Journal Article
Molecular Cell, ISSN 1097-2765, 10/2010, Volume 40, Issue 1, pp. 75 - 86
Activation of the transcription factor NF-κB by multiple genotoxic stimuli modulates cancer cell survival. This response is mediated by a conserved pathway... 
PROTEIN | POLYUBIQUITIN | ISOFORMS | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | NF-KAPPA-B | BINDING | CELL BIOLOGY | Protein-Serine-Threonine Kinases - deficiency | Humans | Male | NF-kappa B - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Ubiquitination | RNA Interference | Time Factors | Tumor Suppressor Proteins - deficiency | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Tumor Suppressor Proteins - metabolism | MAP Kinase Kinase Kinases - genetics | Cell Cycle Proteins - metabolism | Etoposide - pharmacology | Ubiquitin-Conjugating Enzymes - genetics | MAP Kinase Kinase Kinases - metabolism | Ataxia Telangiectasia Mutated Proteins | Signal Transduction - drug effects | Ubiquitin-Conjugating Enzymes - metabolism | Mice | DNA Damage | Enzyme Activation | Mutation | Tumor Necrosis Factor-alpha - metabolism | Phosphorylation | Pyrones - pharmacology | DNA-Binding Proteins - deficiency | DNA-Binding Proteins - metabolism | Transfection | I-kappa B Kinase - metabolism | MAP Kinase Kinase Kinases - deficiency | Mice, Mutant Strains | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Cell Line | Mice, Inbred C57BL | Protein-Serine-Threonine Kinases - genetics | Morpholines - pharmacology | I-kappa B Kinase - genetics | DNA-Binding Proteins - genetics | Nerve Tissue Proteins - genetics | X-Linked Inhibitor of Apoptosis Protein - genetics | Nerve Tissue Proteins - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Adaptor Proteins, Signal Transducing - genetics | X-Linked Inhibitor of Apoptosis Protein - metabolism | Protein Binding | Adaptor Proteins, Signal Transducing - metabolism | Camptothecin - pharmacology | Ubiquitin | Ligases | Lysine | Oncology, Experimental | Automated teller machines | Research | Glutamate | Cancer
Journal Article
BMC Biotechnology, ISSN 1472-6750, 03/2013, Volume 13, Issue 1, pp. 29 - 29
Background: Techniques that enable high levels of transgene expression in plants are attractive for the commercial production of plant-made recombinant... 
Transgene expression | Copy number | Selectable marker | Promoter activity | Rice | tCUP | TCUP CRYPTIC PROMOTER | T-DNA TRANSFORMANTS | TOBACCO | AGROBACTERIUM | CONSTITUTIVE GENE-EXPRESSION | HIGH-LEVEL EXPRESSION | POLYUBIQUITIN GENES | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PLANT TRANSFORMATION | BETA-GLUCURONIDASE | Recombinant Fusion Proteins - biosynthesis | Green Fluorescent Proteins - metabolism | Promoter Regions, Genetic | DNA, Bacterial - metabolism | Oryza - metabolism | Tobacco - metabolism | Caulimovirus - genetics | Transgenes - genetics | Glucuronidase - metabolism | Genetic Vectors - metabolism | Molecular Sequence Data | Phosphotransferases (Alcohol Group Acceptor) - genetics | Gene Dosage | Green Fluorescent Proteins - genetics | Genetic Vectors - genetics | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Amino Acid Oxidoreductases - genetics | Plant Proteins - genetics | DNA, Bacterial - genetics | Plants, Genetically Modified - metabolism | Glucuronidase - genetics | Base Sequence | Gene Expression Regulation, Plant | Recombinant Fusion Proteins - genetics | Genetic markers | Genetic aspects | Promoters (Genetics) | Research | Biotechnology | Genetically modified plants | Genetically engineered foods | Genes | Fluorescence | Gene expression | Proteins | Genetic research | Genetic engineering | Pharmaceutical industry | Food | Tobacco | Microbiology | Science | Genetics | Experiments
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 2014, Volume 211, Issue 7, pp. 1333 - 1347
Journal Article
Molecular Cell, ISSN 1097-2765, 05/2017, Volume 66, Issue 4, pp. 488 - 502.e7
Ubiquitin-binding domain (UBD) proteins regulate numerous cellular processes, but their specificities toward ubiquitin chain types in cells remain... 
proteasome | autophagy | proteasome inhibitor | ubiquitin-binding domain | endocytosis | mass spectrometry | UBD protein | ubiquitin | MVB sorting | UBIQUITYLATED PROTEINS | SINGLE UBIQUITIN | RECOGNITION | RAD23 | STRUCTURAL BASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEGRADATION | POLYUBIQUITIN CHAIN | QUANTITATIVE-ANALYSIS | BINDING | DOMAINS | CELL BIOLOGY | Saccharomyces cerevisiae - genetics | Ubiquitins - genetics | Valosin Containing Protein | Ubiquitin - metabolism | Endosomal Sorting Complexes Required for Transport - genetics | Saccharomyces cerevisiae - drug effects | DNA-Binding Proteins - metabolism | Endocytosis | Proteasome Endopeptidase Complex - drug effects | Ubiquitination - drug effects | Time Factors | Proteolysis | Cell Cycle Proteins - genetics | Membrane Proteins - metabolism | Protein Interaction Domains and Motifs | Ubiquitins - metabolism | Proteasome Inhibitors - pharmacology | Membrane Proteins - genetics | Cell Cycle Proteins - metabolism | Endosomal Sorting Complexes Required for Transport - metabolism | Adenosine Triphosphatases - metabolism | Saccharomyces cerevisiae Proteins - genetics | DNA-Binding Proteins - genetics | Nucleocytoplasmic Transport Proteins - genetics | Proteasome Endopeptidase Complex - genetics | Carrier Proteins - genetics | Carrier Proteins - metabolism | Nucleocytoplasmic Transport Proteins - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Saccharomyces cerevisiae - enzymology | Adenosine Triphosphatases - genetics | Proteasome Endopeptidase Complex - metabolism | Ubiquitin | Physiological aspects | Analysis | Protein binding | Mass spectrometry
Journal Article