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index medicus (1830) 1830
humans (1189) 1189
biochemistry & molecular biology (891) 891
ubiquitin (891) 891
animals (868) 868
polyubiquitin - metabolism (696) 696
cell biology (654) 654
ubiquitination (652) 652
ubiquitin - metabolism (563) 563
polyubiquitin chains (538) 538
proteins (513) 513
protein binding (459) 459
mice (368) 368
proteasome endopeptidase complex - metabolism (349) 349
ubiquitin-protein ligases - metabolism (335) 335
amino acid sequence (331) 331
signal transduction (328) 328
degradation (327) 327
molecular sequence data (323) 323
article (295) 295
polyubiquitin (283) 283
protein structure, tertiary (263) 263
research (245) 245
proteolysis (239) 239
proteasome (235) 235
enzymes (233) 233
cell line (232) 232
protein (231) 231
models, molecular (229) 229
lysine - metabolism (223) 223
nf-kappa-b (216) 216
ubiquitin - chemistry (208) 208
activation (200) 200
mutation (195) 195
ubiquitins - metabolism (194) 194
physiological aspects (188) 188
binding (184) 184
complex (184) 184
molecular biology (183) 183
saccharomyces-cerevisiae (179) 179
hela cells (178) 178
ubiquitin-conjugating enzymes - metabolism (174) 174
recognition (173) 173
binding sites (172) 172
phosphorylation (170) 170
multidisciplinary sciences (169) 169
structural basis (167) 167
hek293 cells (164) 164
nf-kappa b - metabolism (162) 162
gene expression (160) 160
biophysics (158) 158
ligases (154) 154
analysis (152) 152
protein processing, post-translational (145) 145
ubiquitin-protein ligases - genetics (142) 142
polyubiquitin - chemistry (140) 140
saccharomyces cerevisiae proteins - metabolism (137) 137
polyubiquitin - genetics (135) 135
ubiquitin - genetics (130) 130
apoptosis (129) 129
substrate specificity (129) 129
cells (127) 127
endopeptidases - metabolism (126) 126
models, biological (125) 125
expression (124) 124
biochemistry (123) 123
biology (123) 123
ubiquitin-proteasome system (123) 123
dna-binding proteins - metabolism (122) 122
research article (120) 120
cancer (119) 119
pathway (119) 119
protein conformation (118) 118
26s proteasome (115) 115
cell line, tumor (115) 115
dna-repair (115) 115
dna damage (113) 113
ubiquitins - genetics (113) 113
saccharomyces cerevisiae - metabolism (112) 112
genetic aspects (108) 108
carrier proteins - metabolism (107) 107
identification (107) 107
crystal-structure (105) 105
female (103) 103
lysine (101) 101
male (98) 98
nuclear proteins - metabolism (97) 97
domain (93) 93
yeast (93) 93
deubiquitinating enzyme (92) 92
lysine - chemistry (90) 90
polyubiquitin gene (90) 90
protein-degradation (90) 90
genes (89) 89
base sequence (88) 88
dna repair (88) 88
immunology (88) 88
gene expression regulation (87) 87
recombinant fusion proteins - metabolism (87) 87
mass spectrometry (86) 86
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Nature, ISSN 0028-0836, 04/2011, Volume 472, Issue 7343, pp. 361 - 365
TRIM5 is a RING domain-E3 ubiquitin ligase that restricts infection by human immunodeficiency virus (HIV)-1 and other retroviruses immediately following virus... 
HIV-1 | CYCLOPHILIN-A | UNANCHORED POLYUBIQUITIN CHAINS | TRIM5-ALPHA PROTEIN | RECOGNITION | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | IMMUNODEFICIENCY-VIRUS TYPE-1 | RESISTANCE | INFECTION | RESTRICTION | Capsid - chemistry | Receptors, Pattern Recognition - immunology | Humans | Ubiquitin - metabolism | NF-kappa B - metabolism | Lipopolysaccharides - immunology | Transcription Factor AP-1 - metabolism | Receptors, Pattern Recognition - metabolism | Signal Transduction - immunology | Ubiquitin-Protein Ligases - immunology | HIV-1 - chemistry | HEK293 Cells | Carrier Proteins - immunology | Cell Line | Retroviridae - chemistry | Ubiquitin-Protein Ligases - metabolism | Retroviridae - immunology | MAP Kinase Kinase Kinases - metabolism | Transcription Factors - metabolism | Capsid - immunology | Carrier Proteins - genetics | Immunity, Innate - immunology | HIV-1 - immunology | Carrier Proteins - metabolism | Signal Transduction - drug effects | Ubiquitin-Conjugating Enzymes - metabolism | Lipopolysaccharides - pharmacology | Protein Binding | Enzyme Activation | Ubiquitin-Protein Ligases - genetics | Signal transduction | Efficiency | RNA polymerase | Pattern recognition | Kinases | Evacuations & rescues | Immune system | Index Medicus | HIV-1/immunology | Capsid/immunology | Life Sciences | MAP Kinase Kinase Kinases/metabolism | Carrier Proteins/immunology | Immunology | Transcription Factors/metabolism | Capsid/chemistry | HIV-1/chemistry | Ubiquitin/metabolism | Receptors, Pattern Recognition/immunology | Retroviridae/chemistry | Ubiquitin-Protein Ligases/immunology | Ubiquitin-Conjugating Enzymes/metabolism | HumansImmunity, Innate/immunology | Lipopolysaccharides/pharmacology | Signal Transduction/drug effects | Retroviridae/immunology | Transcription Factor AP-1/metabolism | Lipopolysaccharides/immunology | Ubiquitin-Protein Ligases/metabolism | Carrier Proteins/genetics | Signal Transduction/immunology | NF-kappa B/metabolism | Ubiquitin-Protein Ligases/genetics | Carrier Proteins/metabolism | Receptors, Pattern Recognition/metabolism
Journal Article
Nature, ISSN 0028-0836, 03/2011, Volume 471, Issue 7340, pp. 637 - 641
Journal Article
The EMBO Journal, ISSN 0261-4189, 02/2015, Volume 34, Issue 3, pp. 307 - 325
The protein kinase PINK 1 was recently shown to phosphorylate ubiquitin (Ub) on Ser65, and phosphoUb activates the E3 ligase Parkin allosterically. Here, we... 
PINK1 | phosphorylation | deubiquitinase | ubiquitin | Parkin | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | 63-LINKED POLYUBIQUITIN CHAINS | DAMAGED MITOCHONDRIA | CELL BIOLOGY | E3 LIGASE | ACTIVATE PARKIN | BINDING PROTEINS | CROSS-REACTIVITY | CONJUGATING ENZYME | REVEALS | Phosphorylation - physiology | Ubiquitin-Specific Proteases - genetics | Humans | Endosomal Sorting Complexes Required for Transport - genetics | Mitochondrial Proteins - genetics | Phosphoproteins - metabolism | Polyubiquitin - genetics | Allosteric Regulation - physiology | Mitochondrial Proteins - metabolism | Protein Multimerization - physiology | Ubiquitin Thiolesterase - metabolism | TNF Receptor-Associated Factor 6 - genetics | Ubiquitination - physiology | Ubiquitin-Specific Proteases - metabolism | Polyubiquitin - metabolism | Protein Structure, Tertiary | Endopeptidases - metabolism | Endosomal Sorting Complexes Required for Transport - metabolism | Ubiquitin-Protein Ligases - metabolism | Serine - genetics | Ubiquitin-Conjugating Enzymes - genetics | Phosphoproteins - genetics | Transcription Factors - genetics | Ubiquitin Thiolesterase - genetics | Serine - metabolism | Hydrolysis | Transcription Factors - metabolism | Endopeptidases - genetics | Ubiquitin-Conjugating Enzymes - metabolism | Adaptor Proteins, Signal Transducing - genetics | TNF Receptor-Associated Factor 6 - metabolism | Thiolester Hydrolases - genetics | Thiolester Hydrolases - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Ubiquitin-Protein Ligases - genetics | Enzymes | Phosphorylation | Kinases | Crystal structure | Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 10/2010, Volume 40, Issue 1, pp. 63 - 74
As part of the genotoxic stress response, cells activate the transcription factor NF-κB. The DNA strand break sensor poly(ADP-ribose)-polymerase-1 (PARP-1) and... 
MOLECULAR-MECHANISM | POLY(ADP-RIBOSYL)ATION | GENOTOXIC STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPLEXES | DOUBLE-STRAND BREAKS | POLYUBIQUITIN CHAINS | ATM | BINDING | NEMO | PROTEIN-KINASES | CELL BIOLOGY | Tumor Necrosis Factor-alpha - metabolism | Phosphorylation | Calcium - metabolism | Inhibitor of Apoptosis Proteins - genetics | Humans | Ubiquitin - metabolism | NF-kappa B - metabolism | DNA Breaks, Double-Stranded | Cell Nucleus - enzymology | DNA-Binding Proteins - metabolism | Cytosol - enzymology | Ubiquitination | Transfection | I-kappa B Kinase - metabolism | RNA Interference | Time Factors | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Inhibitor of Apoptosis Proteins - metabolism | TNF Receptor-Associated Factor 6 - genetics | Protein-Serine-Threonine Kinases - metabolism | Recombinant Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Signal Transduction | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | MAP Kinase Kinase Kinases - metabolism | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Hep G2 Cells | Protein Transport | Ubiquitin-Protein Ligases | Poly(ADP-ribose) Polymerases - metabolism | NF-kappa B - genetics | Ubiquitin-Conjugating Enzymes - metabolism | TNF Receptor-Associated Factor 6 - metabolism | Protein Binding | DNA Damage | HeLa Cells | Mutation | Poly (ADP-Ribose) Polymerase-1 | Adaptor Proteins, Signal Transducing - metabolism | Index Medicus
Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 10/2010, Volume 40, Issue 1, pp. 75 - 86
Activation of the transcription factor NF-κB by multiple genotoxic stimuli modulates cancer cell survival. This response is mediated by a conserved pathway... 
PROTEIN | POLYUBIQUITIN | ISOFORMS | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | NF-KAPPA-B | BINDING | CELL BIOLOGY | Protein-Serine-Threonine Kinases - deficiency | Humans | Male | NF-kappa B - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Ubiquitination | RNA Interference | Time Factors | Tumor Suppressor Proteins - deficiency | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Tumor Suppressor Proteins - metabolism | MAP Kinase Kinase Kinases - genetics | Cell Cycle Proteins - metabolism | Etoposide - pharmacology | Ubiquitin-Conjugating Enzymes - genetics | MAP Kinase Kinase Kinases - metabolism | Ataxia Telangiectasia Mutated Proteins | Signal Transduction - drug effects | Ubiquitin-Conjugating Enzymes - metabolism | Mice | DNA Damage | Enzyme Activation | Mutation | Tumor Necrosis Factor-alpha - metabolism | Phosphorylation | Pyrones - pharmacology | DNA-Binding Proteins - deficiency | DNA-Binding Proteins - metabolism | Transfection | I-kappa B Kinase - metabolism | MAP Kinase Kinase Kinases - deficiency | Mice, Mutant Strains | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Cell Line | Mice, Inbred C57BL | Protein-Serine-Threonine Kinases - genetics | Morpholines - pharmacology | I-kappa B Kinase - genetics | DNA-Binding Proteins - genetics | Nerve Tissue Proteins - genetics | X-Linked Inhibitor of Apoptosis Protein - genetics | Nerve Tissue Proteins - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Adaptor Proteins, Signal Transducing - genetics | X-Linked Inhibitor of Apoptosis Protein - metabolism | Protein Binding | Adaptor Proteins, Signal Transducing - metabolism | Camptothecin - pharmacology | Ubiquitin | Ligases | Lysine | Oncology, Experimental | Automated teller machines | Research | Glutamate | Cancer | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 06/2010, Volume 465, Issue 7301, pp. 1084 - 1088
Journal Article
Nature, ISSN 0028-0836, 01/2012, Volume 481, Issue 7380, pp. 204 - 210
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2011, Volume 108, Issue 24, pp. 9933 - 9938
The molecular mechanisms regulating noncanonical protein transport across cellular membranes are poorly understood. Cross-presentation of exogenous antigens on... 
T lymphocytes | Antigens | Cross priming | Receptors | Dendritic cells | Ubiquitins | Antibodies | Ova | Physiological regulation | Endosomes | ACTIVATION | DENDRITIC CELLS | UBIQUITIN | MULTIDISCIPLINARY SCIENCES | RETRO-TRANSLOCATION | PROTEASOME | DEGRADATION | ENDOPLASMIC-RETICULUM | EXOGENOUS ANTIGENS | PROTEIN DISLOCATION | Ovalbumin - immunology | Dendritic Cells - immunology | Endosomal Sorting Complexes Required for Transport - genetics | Green Fluorescent Proteins - genetics | Adenosine Triphosphatases - immunology | Endosomes - metabolism | Endosomal Sorting Complexes Required for Transport - immunology | Lectins, C-Type - metabolism | Protein Transport - immunology | RNA Interference | Bone Marrow Cells - immunology | Transcription Factors - immunology | Endocytosis - immunology | DNA-Binding Proteins - immunology | Adenosine Triphosphatases - metabolism | Receptors, Cell Surface - immunology | Blotting, Western | Mice, Knockout | Mannose-Binding Lectins - immunology | Cytosol - metabolism | Adenosine Triphosphatases - genetics | Mice | Receptors, Cell Surface - genetics | Mannose-Binding Lectins - metabolism | Endosomes - immunology | Cytosol - immunology | Lectins, C-Type - immunology | Lectins, C-Type - genetics | DNA-Binding Proteins - metabolism | Ovalbumin - metabolism | Flow Cytometry | Nuclear Proteins - genetics | Dendritic Cells - metabolism | Polyubiquitin - metabolism | Green Fluorescent Proteins - metabolism | Endosomal Sorting Complexes Required for Transport - metabolism | Receptors, Cell Surface - metabolism | Nuclear Proteins - metabolism | Antigens - metabolism | Ubiquitination - immunology | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Nuclear Proteins - immunology | Transcription Factors - metabolism | Animals | Mannose-Binding Lectins - genetics | Antigens - immunology | Cross-Priming | Bone Marrow Cells - metabolism | Microscopy, Fluorescence | Physiological aspects | Cell receptors | Research | Translocation (Genetics) | Biological transport | Proteins | Membranes | Molecular structure | Cells | Index Medicus | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2008, Volume 105, Issue 22, pp. 7732 - 7737
Journal Article
Journal Article