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1. Full Text Ubiquitin-mediated regulation of autophagy
by Chen, RH and Chen, YH and Huang, TY
JOURNAL OF BIOMEDICAL SCIENCE, ISSN 1021-7770, 10/2019, Volume 26, Issue 1, pp. 1 - 12
Autophagy is a major degradation pathway that utilizes lysosome hydrolases to degrade cellular constituents and is often induced under cellular stress... 
MEDICINE, RESEARCH & EXPERIMENTAL | POLYUBIQUITIN | DAMAGED LYSOSOMES | Ubiquitin E3 ligase | Autophagy | Protein ubiquitination | CELL BIOLOGY | CHAIN | PARKIN | Deubiquitinating enzyme | PINK1/PARKIN-MEDIATED MITOPHAGY | UBIQUITYLATION | ULK1 | Selective autophagy | INHIBITS AUTOPHAGY | PROTEASOME SYSTEM | Ubiquitin | Ligases | Delivery services
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2. Full Text Ubiquitin fusion proteins in algae: implications for cell biology and the spread of photosynthesis
by Sibbald, Shannon J and Hopkins, Julia F and Filloramo, Gina V and Archibald, John M
BMC Genomics, ISSN 1471-2164, 01/2019, Volume 20, Issue 1, pp. 38 - 13
BackgroundThe process of gene fusion involves the formation of a single chimeric gene from multiple complete or partial gene sequences. Gene fusion is... 
Ubiquitin | Ubiquitin fusion proteins | Plastid evolution | Endosymbiosis | Algae | ACTIN | POLYUBIQUITIN GENE | SIGNALP | CONCERTED EVOLUTION | FAMILY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | TREE | FISSION | BIRTH | Symbiosis | Ubiquitins - classification | Cercozoa - genetics | Cryptophyta - genetics | Ubiquitins - genetics | Mutant Chimeric Proteins - genetics | Gene Fusion | Phylogeny | Evolution, Molecular | Physiological aspects | Genetic aspects | Research | Photosynthesis | Trees | Peptides | Genes | Biological evolution | Amino acids | Superoxide dismutase | Superoxide | Genomes | Biology | Gene fusion | Gene sequencing | Proteins | Phylogenetics | Nickel | Fusion protein | Plastids
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3. Full Text Branching via K11 and K48 Bestows Ubiquitin Chains with a Unique Interdomain Interface and Enhanced Affinity for Proteasomal Subunit Rpn1
by Boughton, Andrew J and Krueger, Susan and Fushman, David
Structure, ISSN 0969-2126, 10/2019
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4. Full Text Stepwise multipolyubiquitination of p53 by the E6AP-E6 ubiquitin ligase complex
by Masuda, Yuji and Saeki, Yasushi and Arai, Naoko and Kawai, Hidehiko and Kukimoto, Iwao and Tanaka, Keiji and Masutani, Chikahide
Journal of Biological Chemistry, ISSN 0021-9258, 10/2019, Volume 294, Issue 41, pp. 14860 - 14875
The human papillomavirus (HPV) oncoprotein E6 specifically binds to E6AP (E6-associated protein), a HECT (homologous to the E6AP C terminus)-type ubiquitin... 
Index Medicus | Editors' Picks | E6-associated protein | linkage specificity | polyubiquitin chain | E3 ubiquitin ligase | in vitro reconstitution | human papillomavirus (HPV) oncoprotein E6 | enzyme mechanism | Lys48-linked ubiquitin chain | p53 | mass spectrometry (MS)
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5. Full Text Ubiquitin receptors are required for substrate-mediated activation of the proteasome's unfolding ability
by Cundiff, MD and Hurley, CM and Wong, JD and Boscia, JA and Bashyal, A and Rosenberg, J and Reichard, EL and Nassif, ND and Brodbelt, JS and Kraut, DA
SCIENTIFIC REPORTS, ISSN 2045-2322, 10/2019, Volume 9
The ubiquitin-proteasome system (UPS) is responsible for the bulk of protein degradation in eukaryotic cells, but the factors that cause different substrates... 
PROVIDES INSIGHTS | SITE | RECOGNITION | PROTEIN-DEGRADATION | MULTIDISCIPLINARY SCIENCES | POLYUBIQUITIN CHAIN | RPN13 | 26S PROTEASOME | ATP | BINDING | MASS-SPECTROMETRY
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6. Full Text Acid-sensitive auxiliary assisted atypical diubiquitin synthesis exploiting thiol-ene coupling
by Hua, Xiao and Bai, Jing-Si and Kong, Yi-Fu and Chu, Guo-Chao and Shi, Jing and Li, Yi-Ming
Tetrahedron Letters, ISSN 0040-4039, 10/2019, Volume 60, Issue 41, p. 151123
Atypical ubiquitin (Ub) chains are generally involved in intracellular physiological processes, while the molecular mechanisms underlying their regulation... 
Atypical ubiquitin chains | Acid-sensitive auxiliary handles | Thiol-ene coupling | Protein chemical synthesis | PEPTIDE LIGATION | TOTAL CHEMICAL-SYNTHESIS | UBIQUITIN CHAINS | SEMISYNTHESIS | POLYUBIQUITIN | CHEMISTRY, ORGANIC | CLICK | PROTEINS
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7. Full Text AUTACs: Cargo-Specific Degraders Using Selective Autophagy
by Takahashi, Daiki and Moriyama, Jun and Nakamura, Tomoe and Miki, Erika and Takahashi, Eriko and Sato, Ayami and Akaike, Takaaki and Itto-Nakama, Kaori and Arimoto, Hirokazu
Molecular Cell, ISSN 1097-2765, 10/2019
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8. Full Text A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and -independent mechanisms
by Priem, D and Devos, M and Druwe, S and Martens, A and Slowicka, K and Ting, AT and Pasparakis, M and Declerq, W and Vandenabeele, P and van Loo, G and Bertrand, MJM
CELL DEATH & DISEASE, ISSN 2041-4889, 09/2019, Volume 10, Issue 10, pp. 1 - 16
The cytokine TNF promotes inflammation either directly by activating the MAPK and NF-kappa B signaling pathways, or indirectly by triggering cell death. A20 is... 
CYLD | ACTIVATION | COMPLEX | POLYUBIQUITIN | PHOSPHORYLATION | INFLAMMATION | DEATH | CHAINS | NF-KAPPA-B | BINDING | CELL BIOLOGY | Tumor necrosis factor receptors | Ubiquitin | NF-κB protein | Cytotoxicity | MAP kinase | Inflammation | Molecular modelling | Clonal deletion | Cell death | Tumor necrosis factor | A20 protein | Zinc finger proteins | Ubiquitin-protein ligase | Apoptosis
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9. Full Text Structural basis of generic versus specific E2–RING E3 interactions in protein ubiquitination
by Gundogdu, Mehmet and Walden, Helen
Protein Science, ISSN 0961-8368, 10/2019, Volume 28, Issue 10, pp. 1758 - 1770
Protein ubiquitination is a fundamental regulatory component in eukaryotic cell biology, where a cascade of ubiquitin activating (E1), conjugating (E2), and... 
E2–E3 specificity | RING E3 | structural basis of specificity | ubiquitination | DOMAIN | POLYUBIQUITIN | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPLEX REVEALS | E2-E3 specificity | UBIQUITYLATION | CONJUGATING ENZYME | CHAIN ELONGATION | BINDING | LIGASE | Proteins | Ubiquitin | Ubiquitination | Substrates
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10. Full Text The specificity of ubiquitin binding to ubiquilin-1 is regulated by sequences besides its UBA domain
by Harman, Christine A and Monteiro, Mervyn J
BBA - General Subjects, ISSN 0304-4165, 10/2019, Volume 1863, Issue 10, pp. 1568 - 1574
UBQLN proteins regulate proteostasis by facilitating clearance of misfolded proteins through the proteasome and autophagy degradation pathways. Consistent with... 
Ubiquilin | UBQLN1 | Polyubiquitin | UBA domain | UBL domain | PROTEIN | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHAPERONE | IDENTIFICATION | FAMILY | BIOPHYSICS | MUTATION | PROTEASOME | DEGRADATION | ENDOPLASMIC-RETICULUM | ASSOCIATION | Ubiquitin | Medical colleges | Lysine | Proteolysis | Biomedical engineering | Protein binding
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11. Full Text A TRIM32-AMBRA1-ULK1 complex initiates the autophagy response in atrophic muscle cells
by Di Rienzo, Martina and Piacentini, Mauro and Fimia, Gian Maria
Autophagy, ISSN 1554-8627, 09/2019, Volume 15, Issue 9, pp. 1674 - 1676
The Ser/Thr protein kinase ULK1 is an upstream macroautophagy/autophagy regulator that is rapidly activated to ensure a proper adaptive response to stress... 
muscular dystrophy | unanchored polyubiquitin | ULK1 | AMBRA1 | muscle atrophy | TRIM32 | Tripartite Motif Protein | CELL BIOLOGY
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12. Affinity Tools for Decrypting The Ubiquitin Chains
by Li, Z and Zhao, B
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, ISSN 1000-3282, 09/2019, Volume 46, Issue 9, pp. 845 - 857
Protein ubiquitination is one of the most versatile post-translational modifications, and is widely involved in multiple cellular processes including protein... 
LOCALIZATION | ACTIVATION | POLYUBIQUITIN | SPECIFICITY | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | antibody library technique | ubiquitin | MASS-SPECTROMETRY | ubiquitin chains | BIOPHYSICS | ubiquitination | UBIQUITYLATION | ubiquitin linkage-specific antibodies | DEGRADATION | CHEMICAL-SYNTHESIS | PROTEINS
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13. Full Text Shank3 regulates striatal synaptic abundance of Cyld, a deubiquitinase specific for Lys63‐linked polyubiquitin chains
by Jin, Chunmei and Kim, Shinhyun and Kang, Hyojin and Yun, Ki Na and Lee, Yeunkum and Zhang, Yinhua and Kim, Yoonhee and Kim, Jin Young and Han, Kihoon
Journal of Neurochemistry, ISSN 0022-3042, 09/2019, Volume 150, Issue 6, pp. 776 - 786
The SH3 and multiple ankyrin repeat domains 3 (Shank3) proteins are core organizers of the postsynaptic density in neuronal excitatory synapses, and their... 
Lys63‐linked polyubiquitin chain | Shank3 | striatum | Cyld | deubiquitinase | Proteins | Nervous system diseases | Genetic engineering | Analysis | Mental disorders | Synaptogenesis | Disorders | Transgenic mice | Chains | Neurodevelopmental disorders | Density | Substrates | Domains | Neostriatum | Ankyrin | Postsynaptic density | Synapses
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14. Full Text Branching Out: Improved Signaling by Heterotypic Ubiquitin Chains
by Haakonsen, Diane L and Rape, Michael
Trends in Cell Biology, ISSN 0962-8924, 09/2019, Volume 29, Issue 9, pp. 704 - 716
Ubiquitin chains of distinct topologies control the stability, interactions, or localization of many proteins in eukaryotic cells, and thus play an essential... 
protein quality control | ubiquitin code | ubiquitin | branched ubiquitin chain | ANAPHASE-PROMOTING COMPLEX | ACTIVATION | MULTIUBIQUITIN CHAIN | MECHANISM | SPECIFICITY | RECOGNITION | DEGRADATION | POLYUBIQUITIN CHAIN | BINDING | REVEALS | CELL BIOLOGY | Ubiquitin | Cells | Signaling | Information transfer | Chain branching | Control stability | Topology | Localization
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15. Full Text Roles of ubiquitin in autophagy and cell death
by Gómez-Díaz, Carlos and Ikeda, Fumiyo
Seminars in Cell and Developmental Biology, ISSN 1084-9521, 09/2019, Volume 93, pp. 125 - 135
The balance between cell survival and cell death is often lost in human pathologies such as inflammation and cancer. Autophagy plays a critical role in cell... 
Ubiquitin | Inflammation | E3 ligase | Cell death | Deubiquitinase | Autophagy | APOPTOSIS | SPATA2 LINKS CYLD | POLYUBIQUITIN | PROTEIN | LINEAR UBIQUITINATION | DEVELOPMENTAL BIOLOGY | CELL BIOLOGY | INDUCED GENE ACTIVATION | ULK1 UBIQUITYLATION | NF-KAPPA-B | MOLECULAR-BASIS | LIGASE | Post-translational modification | Biochemistry | Proteases | Ligases | USP, ubiquitin-specific protease | IAP, inhibitors of apoptosis proteins | TRAIL, TNF-related apoptosis inducing ligand | TNF, tumor necrosis factor | 1B-light chain 3 | UPS, ubiquitin-proteasome system | ATG, autophagy-related | PTM, posttranslational modification | DUB, deubiquitinase | CYLD, cylindromatosis | LC3, microtubule-associated protein 1 A | UBD, ubiquitin-binding domain | LUBAC, linear ubiquitin chain assembly complex
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16. Full Text Parsley ubiquitin promoter displays higher activity than the CaMV 35S promoter and the chrysanthemum actin 2 promoter for productive, constitutive, and durable expression of a transgene in Chrysanthemum morifolium
by Kishi-Kaboshi, M and Aida, R and Sasaki, K
BREEDING SCIENCE, ISSN 1344-7610, 2019, Volume 69, Issue 3, pp. 536 - 544
The chrysanthemum (Chrysanthemum morifolium) is one of the most popular ornamental plants in the world. Genetic transformation is a promising tool for... 
promoter activity | parsley | AGRONOMY | POLYUBIQUITIN GENES | BETA-GLUCURONIDASE | ARABIDOPSIS | Chrysanthemum morifolium | gene expression | GENETIC-TRANSFORMATION | PLANT SCIENCES | Ubiquitin | Leaves | Genetic transformation | Plant physiology | Cultivation | Actin | Ornamental plants | Viruses | Durability | Genomes | Promoters | Note
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17. Full Text Insights into ubiquitin chain architecture using Ub-clipping
by Swatek, KN and Usher, JL and Kueck, AF and Gladkova, C and Mevissen, TET and Pruneda, JN and Skern, T and Komander, D
NATURE, ISSN 0028-0836, 08/2019, Volume 572, Issue 7770, pp. 533 - 533
Protein ubiquitination is a multi-functional post-translational modification that affects all cellular processes. Its versatility arises from architecturally... 
PARKIN | COMPLEX | POLYUBIQUITIN | MECHANISM | SPECIFICITY | PHOSPHORYLATION | ACETYLATION | MULTIDISCIPLINARY SCIENCES | SPECTROMETRY ENABLES CHARACTERIZATION | MOLECULAR-BASIS | REVEALS | Ubiquitin | Structure | Analysis | Proteomics | Post-translational modification | Proteases | Mass spectrometry | Residues | Enzymes | Phosphorylation | Peptides | Chain branching | Mass spectroscopy | Mapping | Substrates | Complexity | Depolarization | Proteins | Mitochondria | Ubiquitination | Post-translation | Clipping | Scientific imaging | Parkin protein | Acetylation | Polymers | Endoplasmic reticulum | Combinatorial analysis
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