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1. Full Text Alkamides and a neolignan from Echinacea purpurea roots and the interaction of alkamides with G-protein-coupled cannabinoid receptors
by Hohmann, Judit and Rédei, Dóra and Forgo, Peter and Szabó, Pál and Freund, Tamás F and Haller, József and Bojnik, Engin and Benyhe, Sándor
Phytochemistry (Oxford), ISSN 0031-9422, 2011, Volume 72, Issue 14, pp. 1848 - 1853
Alkamide | Echinacea purpurea | G-protein modulation | Cannabinoid receptor | Asteraceae | GTPγS-binding assay | Sesquiterpene | Neolignan | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Plant physiology and development | Chemical constitution | Plant Extracts - chemistry | Polyunsaturated Alkamides - chemistry | Sesquiterpenes - isolation & purification | Lignans - pharmacology | Brain - metabolism | Receptor, Cannabinoid, CB1 - agonists | Cell Membrane - metabolism | Molecular Structure | Polyunsaturated Alkamides - isolation & purification | Cell Membrane - drug effects | Sesquiterpenes - chemistry | Echinacea - chemistry | Lignans - chemistry | Cannabinoids - chemistry | Rats | Arachidonic Acids - pharmacology | Cannabinoids - pharmacology | Lignans - isolation & purification | Brain - drug effects | Cannabinoids - isolation & purification | Receptor, Cannabinoid, CB1 - metabolism | Animals | Signal Transduction - drug effects | Plant Roots - chemistry | Polyunsaturated Alkamides - pharmacology | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Sesquiterpenes - pharmacology | Index Medicus
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2. Full Text Alkamides from Echinacea disrupt the fungal cell wall-membrane complex
by Cruz, I and Cheetham, J.J and Arnason, J.T and Yack, J.E and Smith, M.L
Phytomedicine (Stuttgart), ISSN 0944-7113, 03/2014, Volume 21, Issue 4, pp. 435 - 442
Natural health product | Liposomes | Alcamides of Echinacea | Antifungal mode-of-action | QSAR | Cell wall disruption assay | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Integrative & Complementary Medicine | Plant Sciences | Science & Technology | Antifungal Agents - pharmacology | Microbial Sensitivity Tests | Polyunsaturated Alkamides - chemistry | Antifungal Agents - analysis | Cell Wall - drug effects | Echinacea - chemistry | Plant Extracts - pharmacology | Polyunsaturated Alkamides - pharmacology | Antifungal Agents - chemistry | Saccharomyces cerevisiae | Cell Membrane - drug effects | Quantitative Structure-Activity Relationship | Medicinal plants | Pharmacology, Experimental | Antifungal agents | Research | Echinacea | Brewer's yeast | Health aspects | Index Medicus
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3. Full Text The Role of Alkamides as an Active Principle of Echinacea
by Woelkart, Karin and Bauer, Rudolf
Planta medica, ISSN 0032-0943, 2007, Volume 73, Issue 7, pp. 615 - 623
Mini Review | Echinacea angustifolia | Alkamides | Echinacea purpurea | Immunomodulation | Herb-drug interactions | Asteraceae | Pharmacokinetics | Cannabinoid receptor binding | Biological and medical sciences | Pharmacognosy. Homeopathy. Health food | Medical sciences | General pharmacology | Pharmacology. Drug treatments | Plant Extracts - chemistry | Polyunsaturated Alkamides - chemistry | Administration, Oral | Humans | Plant Extracts - blood | Plant Extracts - administration & dosage | Polyunsaturated Alkamides - administration & dosage | Polyunsaturated Alkamides - blood | Receptors, Cannabinoid - metabolism | Herb-Drug Interactions | Plant Extracts - pharmacokinetics | Polyunsaturated Alkamides - pharmacokinetics | Echinacea | Phytotherapy | Index Medicus
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4. Full Text Fungistatic and Bacteriostatic Activities of Alkamides from Heliopsis longipes Roots:  Affinin and Reduced Amides
by Molina-Torres, Jorge and Salazar-Cabrera, Carlos Junior and Armenta-Salinas, Concepción and Ramírez-Chávez, Enrique
Journal of agricultural and food chemistry, ISSN 0021-8561, 07/2004, Volume 52, Issue 15, pp. 4700 - 4704
Affinin | Fungistatic | Heliopsis longipes | Alkamides | Bacteriostatic | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Applied | Food Science & Technology | Agriculture, Multidisciplinary | Agriculture | Science & Technology | Biological and medical sciences | Pharmacognosy. Homeopathy. Health food | Medical sciences | General pharmacology | Pharmacology. Drug treatments | Amides - pharmacology | Polyunsaturated Alkamides | Amides - isolation & purification | Asteraceae - chemistry | Magnetic Resonance Spectroscopy | Plant Roots - chemistry | Alkenes - isolation & purification | Anti-Bacterial Agents - pharmacology | Alkenes - pharmacology | Fungicides, Industrial - pharmacology | Index Medicus
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5. Full Text Anti-inflammatory effects of ethanolic extract and alkamides-derived from Heliopsis longipes roots
by Hernández, Ivones and Márquez, Lucía and Martínez, Ioanna and Dieguez, Rodrigo and Delporte, Carla and Prieto, Sylvia and Molina-Torres, Jorge and Garrido, Gabino
Journal of ethnopharmacology, ISSN 0378-8741, 2009, Volume 124, Issue 3, pp. 649 - 652
Affinin | Inflammation | Heliopsis longipes | Alkamide | Isobutyl-decanamide | Mouse ear oedema | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Integrative & Complementary Medicine | Plant Sciences | Science & Technology | Biological and medical sciences | Pharmacognosy. Homeopathy. Health food | Medical sciences | General pharmacology | Pharmacology. Drug treatments | Amides - pharmacology | Inflammation - chemically induced | Solvents | Tetradecanoylphorbol Acetate - pharmacology | Ethanol | Plant Extracts - pharmacology | Ear, External - pathology | Alkanes - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Asteraceae - chemistry | Animals | Plant Roots - chemistry | Polyunsaturated Alkamides - pharmacology | Amides - chemistry | Indicators and Reagents | Inflammation - prevention & control | Mice | Edema - chemically induced | Arachidonic Acid | Edema - pathology | Edema - prevention & control | Analgesics | Anti-inflammatory drugs | Enzymes | Index Medicus
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6. Full Text Effects of synthetic alkamides on Arabidopsis fatty acid amide hydrolase activity and plant development
by Faure, Lionel and Cavazos, Ronaldo and Khan, Bibi Rafeiza and Petros, Robby A and Koulen, Peter and Blancaflor, Elison B and Chapman, Kent D
Phytochemistry (Oxford), ISSN 0031-9422, 02/2015, Volume 110, Issue C, pp. 58 - 71
Arabidopsis thaliana | Fatty acid amide hydrolase | Lipids | Affinin | Alkamide | N-Acylethanolamine | Amides - pharmacology | Amidohydrolases - metabolism | Hydrolases - metabolism | Polyunsaturated Alkamides - chemistry | Arabidopsis - enzymology | Plant Development | Amides - chemical synthesis | Arabidopsis - metabolism | Animals | Ethanolamines - metabolism | Polyunsaturated Alkamides - pharmacology | Amides - chemistry | Molecular Structure | Polyunsaturated Alkamides - chemical synthesis | Seedlings - metabolism | Enzymes | Hydrolases | Fatty acids | Analysis | Oligomers | Plant physiology | Plants | Ethanolamines | Index Medicus
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7. Full Text Analgesic activity of affinin, an alkamide from Heliopsis longipes (Compositae)
by Rios, María Yolanda and Aguilar-Guadarrama, A. Berenice and Gutiérrez, María del Carmen
Journal of ethnopharmacology, ISSN 0378-8741, 2007, Volume 110, Issue 2, pp. 364 - 367
Triterpenes | Heliopsis longipes | Alkamides | GABA | Affinin | Lignanes | Compositae | Analgesic activity | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Integrative & Complementary Medicine | Plant Sciences | Science & Technology | Biological and medical sciences | Pharmacognosy. Homeopathy. Health food | Medical sciences | General pharmacology | Pharmacology. Drug treatments | Analgesics - pharmacology | Plant Extracts - pharmacology | gamma-Aminobutyric Acid - metabolism | 4-Butyrolactone - isolation & purification | Brain - metabolism | Asteraceae - chemistry | Pain - drug therapy | Female | Polyunsaturated Alkamides - isolation & purification | Amides - pharmacology | Analgesics - isolation & purification | Dioxoles - isolation & purification | Alkenes - isolation & purification | gamma-Aminobutyric Acid - drug effects | Lignans - isolation & purification | Brain - drug effects | Amides - isolation & purification | Methylene Chloride | Benzodioxoles | Animals | Polyunsaturated Alkamides - pharmacology | Mexico | Mice | 4-Butyrolactone - analogs & derivatives | In Vitro Techniques | Medicine, Traditional | Alkenes - pharmacology | Plants, Medicinal | Analgesics | Mass spectrometry | Index Medicus
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8. Full Text Antiprotozoal activity of Achillea ptarmica (Asteraceae) and its main alkamide constituents
by Althaus, Julia B and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J
Molecules (Basel, Switzerland), ISSN 1420-3049, 2014, Volume 19, Issue 5, pp. 6428 - 6438
Plasmodium falciparum | Alkamide | Leishmania donovani | Trypanosoma brucei rhodesiense | Antiprotozoal activity | Achillea ptarmica | Trypanosoma cruzi | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Plant Extracts - chemistry | Leishmania donovani - drug effects | Plant Components, Aerial - chemistry | Plant Extracts - pharmacology | Fatty Acids, Unsaturated - pharmacology | Trypanocidal Agents - chemistry | Antiprotozoal Agents - chemistry | Plasmodium falciparum - drug effects | Antiprotozoal Agents - pharmacology | Polyunsaturated Alkamides - analysis | Plant Extracts - analysis | Trypanocidal Agents - pharmacology | Polyunsaturated Alkamides - pharmacology | Achillea | Inhibitory Concentration 50 | Trypanosoma cruzi - drug effects | Molecular Structure | Trypanosoma brucei rhodesiense - drug effects | Fatty Acids, Unsaturated - analysis | Index Medicus | antiprotozoal activity | alkamide
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9. Full Text Intranasal Piperine-Loaded Chitosan Nanoparticles as Brain-Targeted Therapy in Alzheimer's Disease: Optimization, Biological Efficacy, and Potential Toxicity
by Elnaggar, Yosra S.R and Etman, Samar M and Abdelmonsif, Doaa A and Abdallah, Ossama Y
Journal of pharmaceutical sciences, ISSN 0022-3549, 10/2015, Volume 104, Issue 10, pp. 3544 - 3556
drug targeting | nanotechnology | chitosan | polymeric drug delivery systems | Alzheimer's disease | nasal drug delivery | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Chemistry, Multidisciplinary | Science & Technology | Tumor Necrosis Factor-alpha - metabolism | Rats, Wistar | Apoptosis - drug effects | Caspase 3 - metabolism | Polyunsaturated Alkamides - therapeutic use | Male | Polyunsaturated Alkamides - toxicity | Benzodioxoles - administration & dosage | Brain Diseases - chemically induced | Drug Delivery Systems | Nanoparticles | Benzodioxoles - toxicity | Benzodioxoles - therapeutic use | Piperidines - toxicity | Alkaloids - toxicity | Piperidines - administration & dosage | Alzheimer Disease - drug therapy | Rats | Antioxidants - pharmacology | Cognition - drug effects | Administration, Intranasal | Particle Size | Polyunsaturated Alkamides - administration & dosage | Animals | Brain Diseases - pathology | Cholinesterase Inhibitors - pharmacology | Piperidines - therapeutic use | Alkaloids - administration & dosage | Alkaloids - therapeutic use | Chitosan | Drugs | Brain | Drug delivery systems | Drug therapy | Vehicles | Index Medicus
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10. Full Text Macrophage Activating Effects of New Alkamides from the Roots of Echinacea Species
by Chen, Ying and Fu, Tong and Tao and Yang, Jinghua and Chang, Yung and Wang, Meihua and Kim, Linda and Qu, Luping and Cassady, John and Scalzo, Ric and Wang, Xiping
Journal of natural products (Washington, D.C.), ISSN 0163-3864, 05/2005, Volume 68, Issue 5, pp. 773 - 776
Biological and medical sciences | Pharmacognosy. Homeopathy. Health food | Medical sciences | General pharmacology | Pharmacology. Drug treatments | Amides - pharmacology | Diynes | Plants, Medicinal - chemistry | Echinacea - chemistry | Anti-Inflammatory Agents - pharmacology | Stereoisomerism | Lipopolysaccharides - metabolism | Fatty Acids, Unsaturated - pharmacology | Polyunsaturated Alkamides | Amides - isolation & purification | Animals | Anti-Inflammatory Agents - chemistry | Fatty Acids, Unsaturated - chemistry | Fatty Acids, Unsaturated - isolation & purification | Plant Roots - chemistry | Amides - chemistry | Macrophages - drug effects | Anti-Inflammatory Agents - isolation & purification | Mice | Molecular Structure | Index Medicus
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11. Full Text Sensory active piperine analogues from Macropiper excelsum and their effects on intestinal nutrient uptake in Caco-2 cells
by Obst, Katja and Lieder, Barbara and Reichelt, Katharina V and Backes, Michael and Paetz, Susanne and Geißler, Katrin and Krammer, Gerhard and Somoza, Veronika and Ley, Jakob P and Engel, Karl-Heinz
Phytochemistry (Oxford), ISSN 0031-9422, 03/2017, Volume 135, pp. 181 - 190
Macropiper excelsum | Glucose uptake | Fatty acid alkamides | Caco-2 | Lignans | Piperaceae | Piperine analogues | Fatty acid uptake | Kawakawa | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Plant Sciences | Science & Technology | Caco-2 Cells | Intestines - drug effects | Polyunsaturated Alkamides - chemistry | Piperidines - chemistry | Alkaloids - pharmacology | Lignans - chemistry | Fruit - drug effects | Humans | Alkaloids - isolation & purification | Fatty Acids, Unsaturated - pharmacology | Lignans - pharmacology | Lignans - isolation & purification | New Zealand | Fatty Acids, Unsaturated - chemistry | Piperidines - pharmacology | Fatty Acids, Unsaturated - isolation & purification | Polyunsaturated Alkamides - pharmacology | Benzodioxoles - chemistry | Piperidines - isolation & purification | Polyunsaturated Alkamides - isolation & purification | Benzodioxoles - isolation & purification | Alkaloids - chemistry | Benzodioxoles - pharmacology | Glucose metabolism | Analysis | Amides | Nuclear magnetic resonance spectroscopy | Glucose | Fatty acids | Dextrose | Index Medicus
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12. Full Text Piper nigrum and Piperine: An Update
by Meghwal, Murlidhar and Goswami, T. K
Phytotherapy research, ISSN 0951-418X, 08/2013, Volume 27, Issue 8, pp. 1121 - 1130
piperine | bioavailability enhancement | drug metabolizing | Piper nigrum | anti‐oxidant | anti‐carcinogenic | anti-carcinogenic | anti-oxidant | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Polyunsaturated Alkamides - chemistry | Piperidines - chemistry | Alkaloids - pharmacology | Animals | Piper nigrum - chemistry | Piperidines - pharmacology | Humans | Polyunsaturated Alkamides - pharmacology | Benzodioxoles - chemistry | Alkaloids - chemistry | Benzodioxoles - pharmacology | Asthma | Index Medicus
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