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1. Full Text Alkamides and a neolignan from Echinacea purpurea roots and the interaction of alkamides with G-protein-coupled cannabinoid receptors
by Hohmann, Judit and Rédei, Dóra and Forgo, Peter and Szabó, Pál and Freund, Tamás F and Haller, József and Bojnik, Engin and Benyhe, Sándor
Phytochemistry, ISSN 0031-9422, 2011, Volume 72, Issue 14, pp. 1848 - 1853
Three alkamides and nitidanin diisovalerianate were identified, together with 14 known alkamides and one sesquiterpene from the roots of . Their interaction... 
Alkamide | Echinacea purpurea | G-protein modulation | Cannabinoid receptor | Asteraceae | GTPγS-binding assay | Sesquiterpene | Neolignan | L. MOENCH | ANXIETY | BIOCHEMISTRY & MOLECULAR BIOLOGY | PLANT SCIENCES | ANGUSTIFOLIA | GTP gamma S-binding assay | CONSTITUENTS | ALKYLAMIDES | Plant Extracts - chemistry | Polyunsaturated Alkamides - chemistry | Sesquiterpenes - isolation & purification | Lignans - pharmacology | Brain - metabolism | Receptor, Cannabinoid, CB1 - agonists | Cell Membrane - metabolism | Molecular Structure | Polyunsaturated Alkamides - isolation & purification | Cell Membrane - drug effects | Sesquiterpenes - chemistry | Echinacea - chemistry | Lignans - chemistry | Cannabinoids - chemistry | Rats | Arachidonic Acids - pharmacology | Cannabinoids - pharmacology | Lignans - isolation & purification | Brain - drug effects | Cannabinoids - isolation & purification | Receptor, Cannabinoid, CB1 - metabolism | Animals | Signal Transduction - drug effects | Plant Roots - chemistry | Polyunsaturated Alkamides - pharmacology | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Sesquiterpenes - pharmacology | Index Medicus
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2. Full Text Alkamides from Echinacea disrupt the fungal cell wall-membrane complex
by Cruz, I and Cheetham, J.J and Arnason, J.T and Yack, J.E and Smith, M.L
Phytomedicine, ISSN 0944-7113, 03/2014, Volume 21, Issue 4, pp. 435 - 442
We tested the hypothesis that alkamides from exert antifungal activity by disrupting the fungal cell wall/membrane complex. cells were treated separately with... 
Natural health product | Liposomes | Alcamides of Echinacea | Antifungal mode-of-action | QSAR | Cell wall disruption assay | LIPOPHILIC CHARACTER | CHEMISTRY, MEDICINAL | PERMEABILITY | DISCOVERY | PLANT SCIENCES | PEPTIDES | INTEGRATIVE & COMPLEMENTARY MEDICINE | ROOTS | PHARMACOLOGY & PHARMACY | ANTIFUNGAL | BINDING | ALKYLAMIDES | Antifungal Agents - pharmacology | Microbial Sensitivity Tests | Polyunsaturated Alkamides - chemistry | Antifungal Agents - analysis | Cell Wall - drug effects | Echinacea - chemistry | Plant Extracts - pharmacology | Polyunsaturated Alkamides - pharmacology | Antifungal Agents - chemistry | Saccharomyces cerevisiae | Cell Membrane - drug effects | Quantitative Structure-Activity Relationship | Medicinal plants | Pharmacology, Experimental | Antifungal agents | Research | Echinacea | Brewer's yeast | Health aspects | Index Medicus
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3. Full Text Effects of synthetic alkamides on Arabidopsis fatty acid amide hydrolase activity and plant development
by Faure, Lionel and Cavazos, Ronaldo and Khan, Bibi Rafeiza and Petros, Robby A and Koulen, Peter and Blancaflor, Elison B and Chapman, Kent D
Phytochemistry, ISSN 0031-9422, 02/2015, Volume 110, Issue C, pp. 58 - 71
Synthetic lipids structurally similar to naturally-occurring alkamides shed light on enzymatic properties of an Arabidopsis amidase and the metabolism of... 
Arabidopsis thaliana | Fatty acid amide hydrolase | Lipids | Affinin | Alkamide | N-Acylethanolamine | N-ACYLETHANOLAMINES | QUANTIFICATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANANDAMIDE | THALIANA SEEDLINGS | IDENTIFICATION | PLANT SCIENCES | OVEREXPRESSION | METABOLISM | GROWTH | SHOOT DEVELOPMENT | ROOT DEVELOPMENT | Amides - pharmacology | Amidohydrolases - metabolism | Hydrolases - metabolism | Polyunsaturated Alkamides - chemistry | Arabidopsis - enzymology | Plant Development | Amides - chemical synthesis | Arabidopsis - metabolism | Animals | Ethanolamines - metabolism | Polyunsaturated Alkamides - pharmacology | Amides - chemistry | Molecular Structure | Polyunsaturated Alkamides - chemical synthesis | Seedlings - metabolism | Enzymes | Hydrolases | Fatty acids | Analysis | Oligomers | Plant physiology | Plants | Ethanolamines | Index Medicus
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4. Full Text Antiprotozoal activity of Achillea ptarmica (Asteraceae) and its main alkamide constituents
by Althaus, Julia B and Kaiser, Marcel and Brun, Reto and Schmidt, Thomas J
Molecules, ISSN 1420-3049, 2014, Volume 19, Issue 5, pp. 6428 - 6438
In the course of our ongoing screening of plants of the family Asteraceae for antiprotozoal activity, a CH2Cl2-extract from the flowering aerial parts of... 
Plasmodium falciparum | Alkamide | Leishmania donovani | Trypanosoma brucei rhodesiense | Antiprotozoal activity | Achillea ptarmica | Trypanosoma cruzi | SECONDARY METABOLITES | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTOZOAN NEGLECTED DISEASES | alkamide | CHEMISTRY, MULTIDISCIPLINARY | SESQUITERPENE LACTONES | ECHINACEA | antiprotozoal activity | DRUGS | LEADS | PLANTS | AMIDES | Plant Extracts - chemistry | Leishmania donovani - drug effects | Plant Components, Aerial - chemistry | Plant Extracts - pharmacology | Fatty Acids, Unsaturated - pharmacology | Trypanocidal Agents - chemistry | Antiprotozoal Agents - chemistry | Plasmodium falciparum - drug effects | Antiprotozoal Agents - pharmacology | Polyunsaturated Alkamides - analysis | Plant Extracts - analysis | Trypanocidal Agents - pharmacology | Polyunsaturated Alkamides - pharmacology | Achillea | Inhibitory Concentration 50 | Trypanosoma cruzi - drug effects | Molecular Structure | Trypanosoma brucei rhodesiense - drug effects | Fatty Acids, Unsaturated - analysis | Index Medicus
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5. Full Text Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer
by Shaikh, J and Ankola, D.D and Beniwal, V and Singh, D and Kumar, M.N.V. Ravi
European Journal of Pharmaceutical Sciences, ISSN 0928-0987, 2009, Volume 37, Issue 3, pp. 223 - 230
Curcumin, a derived product from common spice turmeric that is safe and beneficial in several aliments was formulated into biodegradable nanoparticles with a... 
Nanoparticles | Curcumin | Piperine | Bioavailability | Oral | DESIGN | VIVO | STABILITY | FORMULATION | DELIVERY | THERAPY | PHARMACOKINETICS | ESTRADIOL | PHARMACOLOGY & PHARMACY | BEHAVIOR IN-VITRO | PLGA NANOPARTICLES | Intestinal Absorption - drug effects | Biological Availability | Male | Curcumin - administration & dosage | Tissue Distribution | Piperidines - pharmacology | X-Ray Diffraction | Drug Compounding | Microscopy, Atomic Force | Excipients | Alkaloids - pharmacology | Lactic Acid | Polyglycolic Acid | Curcumin - pharmacokinetics | Freeze Drying | Solubility | Rats | Rats, Sprague-Dawley | Particle Size | Animals | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Polyunsaturated Alkamides - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics | Electrochemistry | Benzodioxoles - pharmacology | Index Medicus
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6. Full Text Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes
by Jourdan, Tony and Godlewski, Grzegorz and Cinar, Resat and Bertola, Adeline and Szanda, Gergo and Liu, Jie and Tam, Joseph and Han, Tiffany and Mukhopadhyay, Bani and Skarulis, Monica C and Ju, Cynthia and Aouadi, Myriam and Czech, Michael P and Kunos, George
Nature Medicine, ISSN 1078-8956, 09/2013, Volume 19, Issue 9, pp. 1132 - 1140
Type 2 diabetes mellitus (T2DM) progresses from compensated insulin resistance to beta cell failure resulting in uncompensated hyperglycemia, a process... 
MEDICINE, RESEARCH & EXPERIMENTAL | ER STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | THIOREDOXIN-INTERACTING PROTEIN | DIET-INDUCED OBESITY | INDUCED INSULIN-RESISTANCE | NALP3 INFLAMMASOME | CELL BIOLOGY | CANNABINOID RECEPTORS | BODY-WEIGHT | CB1 RECEPTOR ANTAGONIST | MICE | ADIPOSE-TISSUE | Inflammasomes - metabolism | Endocannabinoids - pharmacology | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Male | Diabetes Mellitus, Type 2 - metabolism | Cannabinoid Receptor Agonists - pharmacology | Insulin-Secreting Cells - metabolism | RNA Interference | Islets of Langerhans - metabolism | Islets of Langerhans - cytology | Cell Line | Cell Survival | Mice, Inbred C57BL | Insulin Resistance | Rats | Arachidonic Acids - pharmacology | Mice, Knockout | Obesity - metabolism | Hyperglycemia - metabolism | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Insulin-Secreting Cells - drug effects | Polyunsaturated Alkamides - pharmacology | Mice | RNA, Small Interfering | Apoptosis | Type 2 diabetes | Physiological aspects | Genetic aspects | Macrophages | Endocannabinoids | Signal transduction | Insulin resistance | Diabetes | Pancreas | Index Medicus
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7. Full Text A new alkamide with an endoperoxide structure from Acmella ciliata (Asteraceae) and its in vitro antiplasmodial activity
by Silveira, Narjara and Saar, Julia and Santos, Alan Diego C and Barison, Andersson and Sandjo, Louis P and Kaiser, Marcel and Schmidt, Thomas J and Biavatti, Maique W
Molecules, ISSN 1420-3049, 06/2016, Volume 21, Issue 6, p. 765
From the aerial parts of Acmella ciliata (H.B.K.) Cassini (basionym Spilanthes ciliata Kunth; Asteraceae), three alkamides were isolated and identified by... 
Endoperoxide | Plasmodium falciparum | Alkamide | Asteraceae | Jambu | Antiplasmodial activity | Acmella ciliata | SPILANTHES-ACMELLA | antiplasmodial activity | CHEMISTRY, ORGANIC | jambu | MEDICINE | alkamide | endoperoxide | ANTIPROTOZOAL ACTIVITY | CONSTITUENTS | AMIDES | Polyunsaturated Alkamides - chemistry | Magnetic Resonance Spectroscopy | Stereoisomerism | Humans | Rats | Plasmodium falciparum - drug effects | Trypanosoma brucei brucei - drug effects | Asteraceae - chemistry | Animals | Trypanosoma brucei brucei - pathogenicity | Malaria - parasitology | Polyunsaturated Alkamides - pharmacology | Plasmodium falciparum - pathogenicity | Malaria - drug therapy | Polyunsaturated Alkamides - isolation & purification | Index Medicus
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8. Full Text Curcumin–piperine mixtures in self-microemulsifying drug delivery system for ulcerative colitis therapy
by Li, Qiuping and Zhai, Wenwen and Jiang, Qiaoli and Huang, Ruixue and Liu, Lehuan and Dai, Jundong and Gong, Weihong and Du, Shouying and Wu, Qing
International Journal of Pharmaceutics, ISSN 0378-5173, 07/2015, Volume 490, Issue 1-2, pp. 22 - 31
Curcumin (CUR) is a poorly water-soluble drug and its absorption is very low. In this study, CUR and piperine (PIP) were co-encapsulated into the... 
Anti-colitis activity | Curcumin | Piperine | Stability | SMEDDS | Preparation and characterization | DEXTRAN SULFATE SODIUM | INDUCED MURINE COLITIS | COLONIC INFLAMMATION | CROHNS-DISEASE | RATS | POLYMERIC MICELLES | ANTITUMOR-ACTIVITY | MULTIPLE-MYELOMA CELLS | INFLAMMATORY-BOWEL-DISEASE | ORAL BIOAVAILABILITY | PHARMACOLOGY & PHARMACY | Polyunsaturated Alkamides - chemistry | Piperidines - chemistry | Alkaloids - pharmacology | Chemistry, Pharmaceutical - methods | Emulsions - chemistry | Curcumin - chemistry | Drug Stability | Curcumin - pharmacology | Solubility | Male | Emulsions - pharmacology | Particle Size | Animals | Piperidines - pharmacology | Polyunsaturated Alkamides - pharmacology | Benzodioxoles - chemistry | Mice | Mice, Inbred BALB C | Colitis, Ulcerative - drug therapy | Drug Delivery Systems - methods | Alkaloids - chemistry | Benzodioxoles - pharmacology | Drugs | Drug delivery systems | Vehicles | Ulcerative colitis | Index Medicus
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9. Full Text Alkamides activate jasmonic acid biosynthesis and signaling pathways and confer resistance to botrytis cinerea in Arabidopsis thaliana
by Méndez-Bravo, Alfonso and Calderón-Vázquez, Carlos and Ibarra-Laclette, Enrique and Raya-González, Javier and Ramírez-Chávez, Enrique and Molina-Torres, Jorge and Guevara-García, Angel A and López-Bucio, José and Herrera-Estrella, Luis
PLoS ONE, ISSN 1932-6203, 11/2011, Volume 6, Issue 11, pp. e27251 - e27251
Alkamides are fatty acid amides of wide distribution in plants, structurally related to N-acyl-L-homoserine lactones (AHLs) from Gram-negative bacteria and to... 
DEFENSE RESPONSES | N-ACYLETHANOLAMINES | SALICYLIC-ACID | NICOTIANA-ATTENUATA | BIOLOGY | LATERAL ROOT DEVELOPMENT | GENE-EXPRESSION | NITRIC-OXIDE | PLANT-DISEASE RESISTANCE | QUORUM-SENSING SIGNALS | HOMOSERINE-LACTONE | Oligonucleotide Array Sequence Analysis | Plant Diseases - immunology | Infection Control | Plant Diseases - microbiology | Gene Expression Profiling | Arabidopsis Proteins - metabolism | Botrytis - pathogenicity | Plant Immunity - drug effects | Plant Leaves - drug effects | Real-Time Polymerase Chain Reaction | Biomarkers - metabolism | Arabidopsis Proteins - genetics | Arabidopsis - drug effects | RNA, Messenger - genetics | Plant Diseases - prevention & control | Blotting, Western | Arabidopsis - metabolism | Hydrogen Peroxide - metabolism | Arabidopsis - microbiology | Oxylipins - metabolism | Plant Leaves - metabolism | Signal Transduction - drug effects | Polyunsaturated Alkamides - pharmacology | Cyclopentanes - metabolism | Plant Growth Regulators - metabolism | Arabidopsis thaliana | Enzymes | Analysis | Nitric oxide | Amino acids | Amides | Genetic aspects | Biosynthesis | Genetic transcription | Fatty acids | Lactones | Hydrogen peroxide | Transcription | Lipids | Kinases | Immunity | Proteins | Fungi | Leaves | Signal transduction | Pathways | Metabolites | Bacteria | Gram-negative bacteria | Localization | Jasmonic acid | Salicylic acid | Pathogens | Plants (botany) | MAP kinase | Metabolism | Gene expression | Mutants | Signaling | Homoserine lactones | Conidia | Index Medicus
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10. Full Text The orphan receptor GPR55 is a novel cannabinoid receptor
by Ryberg, E and Larsson, N and Sjögren, S and Hjorth, S and Hermansson, N‐O and Leonova, J and Elebring, T and Nilsson, K and Drmota, T and Greasley, P J
British Journal of Pharmacology, ISSN 0007-1188, 12/2007, Volume 152, Issue 7, pp. 1092 - 1101
Background: The endocannabinoid system functions through two well characterized receptor systems, the CB1 and CB2 receptors. Work by a number of groups in... 
orphan receptor | rhoA | cannabinoid | GPR55 | G‐protein‐coupled receptor | Cannabinoid | Orphan receptor | G-protein-coupled receptor | PALMITOYLETHANOLAMIDE | RAT | KNOCKOUT MICE | CB2 RECEPTORS | SMALL MESENTERIC-ARTERY | PROTEIN-COUPLED RECEPTOR | ENDOCANNABINOIDS | MICROGLIAL CELL-MIGRATION | PHARMACOLOGY & PHARMACY | ABNORMAL-CANNABIDIOL | BRAIN | Guanosine 5'-O-(3-Thiotriphosphate) - pharmacology | Humans | Molecular Sequence Data | Structure-Activity Relationship | Polymerase Chain Reaction - methods | Receptors, Cannabinoid - drug effects | Cannabinoids | Cloning, Molecular | Cyclohexanols - pharmacology | Receptors, G-Protein-Coupled - drug effects | Binding Sites - drug effects | Endocannabinoids | Receptors, Cannabinoid - genetics | Amino Acid Sequence | Cell Line | RNA, Messenger - genetics | Rats | Cannabidiol - pharmacology | Down-Regulation - drug effects | Organ Specificity | Arachidonic Acids - pharmacology | Binding, Competitive - drug effects | Animals | Signal Transduction - drug effects | Polyunsaturated Alkamides - pharmacology | Ligands | Mice | Receptors, G-Protein-Coupled - genetics | Index Medicus | Research Papers
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11. Full Text Effect of piperine on inhibition of FFA induced TLR4 mediated inflammation and amelioration of acetic acid induced ulcerative colitis in mice
by Gupta, Rohit A and Motiwala, Meha N and Dumore, Nitin G and Danao, Kishor R and Ganjare, Anjali B
Journal of Ethnopharmacology, ISSN 0378-8741, 04/2015, Volume 164, pp. 239 - 246
Piperine, a main component of Linn. and Linn., is a plant alkaloid with a long history of medicinal use. Piperine exhibits antidepressant, hepatoprotective,... 
Free fatty acid (FFA) | Piperine | TNF-α | Toll like receptor (TLR4) | Ulcerative colitis | Toll like receptor(TLR4) | Freefattyacid(FFA) | Ulcerativecolitis | CHEMISTRY, MEDICINAL | RAT | TNF-alpha | BOWEL-DISEASE | PLANT SCIENCES | THERAPY | INTEGRATIVE & COMPLEMENTARY MEDICINE | BLACK PEPPER | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | STRESS | NF-KAPPA-B | Tumor Necrosis Factor-alpha - metabolism | Glutathione - metabolism | Colon - drug effects | Polyunsaturated Alkamides - therapeutic use | Male | Polyunsaturated Alkamides - toxicity | Toxicity Tests, Acute | Acetic Acid | Benzodioxoles - toxicity | Piperidines - pharmacology | Lipid Peroxidation - drug effects | Anti-Inflammatory Agents - therapeutic use | Fatty Acids, Nonesterified - blood | Benzodioxoles - therapeutic use | Colitis, Ulcerative - drug therapy | Superoxide Dismutase - metabolism | Malondialdehyde - metabolism | Piperidines - toxicity | Alkaloids - toxicity | Alkaloids - pharmacology | Anti-Inflammatory Agents - pharmacology | Colon - pathology | Anti-Inflammatory Agents - toxicity | Colitis, Ulcerative - metabolism | Colitis, Ulcerative - pathology | Toll-Like Receptor 4 - metabolism | Colon - metabolism | Animals | Colitis, Ulcerative - chemically induced | Piperidines - therapeutic use | Polyunsaturated Alkamides - pharmacology | Alkaloids - therapeutic use | Mice | Nitric Oxide - metabolism | Benzodioxoles - pharmacology | Acetic acid | Gene expression | Antidepressants | Analysis | Organic acids | Index Medicus
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12. Full Text Enhancing the bioavailability of resveratrol by combining it with piperine
by Johnson, Jeremy J and Nihal, Minakshi and Siddiqui, Imtiaz A and Scarlett, Cameron O and Bailey, Howard H and Mukhtar, Hasan and Ahmad, Nihal
Molecular Nutrition and Food Research, ISSN 1613-4125, 08/2011, Volume 55, Issue 8, pp. 1169 - 1176
Scope: Resveratrol (3,5,4'-trihydroxystilbene) is a phytoalexin shown to possess a multitude of health-promoting properties in pre-clinical studies. However,... 
Absorption | Piperine | Bioavailability | Pharmacokinetics | Resveratrol | RAT | FOOD SCIENCE & TECHNOLOGY | GLUCURONIDATION | CANCER CHEMOPREVENTIVE AGENT | METABOLISM | PROSTATE-CANCER | TRANS-RESVERATROL | MICE | HEALTHY-VOLUNTEERS | Alkaloids - pharmacology | Animals | Drug Interactions | Glucuronides - metabolism | Stilbenes - administration & dosage | Piperidines - pharmacology | Mice, Inbred C57BL | Polyunsaturated Alkamides - pharmacology | Stilbenes - pharmacokinetics | Biological Availability | Mice | Benzodioxoles - pharmacology | Index Medicus
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