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Journal Article
Scientific Reports, ISSN 2045-2322, 05/2016, Volume 6, Issue 1, pp. 27071 - 27071
Until now, there is not yet antitumor drug with dramatically improved efficacy on non-small cell lung cancer (NSCLC). Marine organisms are rich source of novel... 
SESQUITERPENE AMINOQUINONE | OXIDATIVE STRESS | THERAPY | INHIBITION | MECHANISM | MULTIDISCIPLINARY SCIENCES | ISOMALABARICANE TRITERPENES | SMENOSPONGINE | PROGRESSION | AAPTAMINE | MARINE SPONGE | Cyclin D1 - metabolism | RNA-Binding Proteins - genetics | Reactive Oxygen Species | Triterpenes - pharmacology | Microtubule-Associated Proteins - genetics | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Microtubule-Associated Proteins - metabolism | Humans | Cyclin-Dependent Kinase Inhibitor p27 - agonists | Gene Expression Regulation, Neoplastic | Autophagy-Related Protein 5 - genetics | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Autophagy - drug effects | Proto-Oncogene Proteins c-akt - genetics | TOR Serine-Threonine Kinases - antagonists & inhibitors | Cyclin-Dependent Kinase Inhibitor p27 - metabolism | Cyclin D1 - antagonists & inhibitors | TOR Serine-Threonine Kinases - genetics | Antineoplastic Agents - isolation & purification | Antineoplastic Agents - pharmacology | Porifera - chemistry | Proto-Oncogene Proteins c-akt - metabolism | Protein-Serine-Threonine Kinases - metabolism | A549 Cells | Signal Transduction | Protein-Serine-Threonine Kinases - genetics | G1 Phase Cell Cycle Checkpoints - genetics | Phosphatidylinositol 3-Kinases - genetics | Poly(ADP-ribose) Polymerases - metabolism | Animals | Poly(ADP-ribose) Polymerases - genetics | Cyclin D1 - genetics | Autophagy-Related Protein 5 - metabolism | Triterpenes - isolation & purification | Cell Proliferation - drug effects | G1 Phase Cell Cycle Checkpoints - drug effects | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | RNA-Binding Proteins - metabolism | Cyclin-Dependent Kinase Inhibitor p27 - genetics | Index Medicus
Journal Article
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 12/2014, Volume 13, Issue 12, pp. 2941 - 2954
Journal Article
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 17, pp. 28906 - 28921
Novel agents are still urgently expected for therapy of chronic myeloid leukemia (CML). The in vitro anti-leukemia activity of Stellettin B (Stel B), a... 
K562 | PI3K | Stellettin B | Combination | Apoptosis | ACTIVATION | METASTASIS | stellettin B | apoptosis | G1 ARREST | AUTOPHAGY | CANCER | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITOR | MARINE SPONGE | CELL BIOLOGY | THERAPY | ZSTK474 | RESISTANCE | combination | Phosphorylation | Caspase 9 - metabolism | Reactive Oxygen Species - metabolism | Triterpenes - pharmacology | Apoptosis - drug effects | Humans | Triterpenes - therapeutic use | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Drug Resistance, Neoplasm | Antineoplastic Agents - therapeutic use | Phosphatidylinositol 3-Kinases - metabolism | Membrane Potential, Mitochondrial - drug effects | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Proto-Oncogene Proteins c-bcl-2 - metabolism | STAT5 Transcription Factor - genetics | STAT5 Transcription Factor - metabolism | Imatinib Mesylate - therapeutic use | Flow Cytometry | RNA Interference | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Tumor Suppressor Proteins - genetics | Inhibitory Concentration 50 | bcl-Associated Death Protein - metabolism | Antineoplastic Agents - pharmacology | Porifera - chemistry | Proto-Oncogene Proteins c-akt - metabolism | Protein-Serine-Threonine Kinases - metabolism | Tumor Suppressor Proteins - metabolism | Imatinib Mesylate - pharmacology | bcl-2-Associated X Protein - metabolism | Mitochondria - metabolism | Mitochondria - drug effects | Drug Synergism | Animals | Signal Transduction - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Cell Cycle Checkpoints - drug effects | K562 Cells | Cell Proliferation - drug effects | RNA, Small Interfering - metabolism
Journal Article
Blood, ISSN 0006-4971, 09/2007, Volume 110, Issue 6, pp. 1942 - 1949
Journal Article
Pharmacology and Therapeutics, ISSN 0163-7258, 06/2016, Volume 162, pp. 1 - 9
Journal Article
Journal Article