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PLoS ONE, ISSN 1932-6203, 06/2017, Volume 12, Issue 6, pp. e0179610 - e0179610
Objective To assess the prognostic roles of BAP1, PBRM1, pS6, PTEN, TGase2, PD-L1, CA9, PSMA, and Ki-67 tissue biomarkers in localized renal cell carcinoma... 
SURVIVAL | MORTALITY | CARBONIC-ANHYDRASE-IX | PROTEIN | MULTIDISCIPLINARY SCIENCES | CANCER INCIDENCE | METASTASES | OUTCOMES | KI67 | EXPRESSION | TUMORS | Immunohistochemistry | Prognosis | Tissue Array Analysis | Humans | Middle Aged | Ki-67 Antigen - metabolism | Male | Kidney Neoplasms - metabolism | Porphyrins - metabolism | Neoplasm Recurrence, Local - mortality | Neoplasm Recurrence, Local - pathology | Glutamate Carboxypeptidase II - metabolism | Neoplasm Grading | Antigens, Neoplasm - metabolism | Antigens, Surface - metabolism | Biomarkers, Tumor - metabolism | Ubiquitin Thiolesterase - metabolism | Adult | Female | Carbonic Anhydrase IX - metabolism | Retrospective Studies | Tumor Suppressor Proteins - metabolism | Neoplasm Recurrence, Local - metabolism | Carcinoma, Renal Cell - pathology | PTEN Phosphohydrolase - metabolism | Nuclear Proteins - metabolism | Survival Rate | Kidney Neoplasms - mortality | Transcription Factors - metabolism | Carcinoma, Renal Cell - metabolism | Carcinoma, Renal Cell - mortality | Disease-Free Survival | B7-H1 Antigen - metabolism | Transglutaminases - metabolism | Sulfonamides - metabolism | Kidney Neoplasms - pathology | Aged | Neoplasm Staging | GTP-Binding Proteins - metabolism | Genetic aspects | Carcinoma, Renal cell | Research | Biological markers | Biometrics | Slopes | Metastasis | Kinases | Epidemiology | Cancer therapies | Urology | Proteins | Nephrectomy | Quality | Bioindicators | Growth factors | Age | Antigens | Markers | Hazards | Patients | Survival | Disease prevention | Hospitals | Medical prognosis | PD-L1 protein | Biomarkers | Death | Mutation | Diabetes | Prostate cancer | PTEN protein | Clear cell-type renal cell carcinoma | Cancer | Kidney transplantation | Tumors | Index Medicus
Journal Article
Atherosclerosis, ISSN 0021-9150, 2015, Volume 239, Issue 2, pp. 393 - 400
Abstract Objective The pathogenic events responsible for accelerated atherosclerosis in patients with chronic renal failure (CRF) are poorly understood. Here... 
Cardiovascular | MnTBAP | chronic renal failure | UCP-1 | Endothelial cells | uncoupling protein 1 | Urea | O-linked-N-acetylglucosamine | manganese tetrakis (4-benzoic acid) porphyrin | CRF | ROS | reactive oxygen species | GlcNAc | Prostacyclin synthase | Reactive oxygen species | Chronic renal failure | Manganese tetrakis (4-benzoic acid) porphyrin | Uncoupling protein 1 | CELLS | OXIDATIVE STRESS | ATHEROSCLEROSIS | INSULIN-RESISTANCE | CARDIOVASCULAR-DISEASE | GENE-EXPRESSION | HIGH GLUCOSE | PERIPHERAL VASCULAR DISEASE | CHRONIC KIDNEY-DISEASE | HYPERGLYCEMIC DAMAGE | Tumor Necrosis Factor-alpha - metabolism | Reactive Oxygen Species - metabolism | Oxidative Stress | Humans | Cytochrome P-450 Enzyme System - metabolism | Endothelium, Vascular - drug effects | Aorta - metabolism | Urea - chemistry | Antigens, CD - metabolism | Endoglin | Atherosclerosis - enzymology | Kidney Failure, Chronic - chemically induced | Chemokine CCL2 - metabolism | Endothelium - enzymology | Intramolecular Oxidoreductases - metabolism | Interleukin-6 - metabolism | Superoxide Dismutase - metabolism | Atherosclerosis - physiopathology | Endothelial Cells - metabolism | Mice, Inbred C57BL | Receptors, Cell Surface - metabolism | Random Allocation | Atherosclerosis - metabolism | Kidney Failure, Chronic - metabolism | Catalase - metabolism | Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating) - metabolism | Animals | Endothelium, Vascular - pathology | Mice | Vascular Cell Adhesion Molecule-1 - metabolism | Chronic kidney failure | Atherosclerosis | Endothelium | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 09/2016, Volume 538, Issue 7623, pp. 114 - 117
The common participation of oncogenic KRAS proteins in many of the most lethal human cancers, together with the ease of detecting somatic KRAS mutant alleles... 
TARGET | CRM1/XPO1 | ACTIVATION | MODELS | MULTIDISCIPLINARY SCIENCES | KINASE | YAP | MUTATIONS | INHIBITORS | IDENTIFICATION | Lung Neoplasms - drug therapy | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Lung Neoplasms - metabolism | Cell Survival - genetics | Lung Neoplasms - pathology | NF-kappa B - metabolism | Phosphoproteins - antagonists & inhibitors | Phosphoproteins - metabolism | DNA-Binding Proteins - metabolism | Cell Nucleus - metabolism | RNA Interference | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Female | Verteporfin | Protein-Serine-Threonine Kinases - metabolism | Carcinoma, Non-Small-Cell Lung - pathology | Follistatin-Related Proteins - genetics | Lung Neoplasms - genetics | Cell Survival - drug effects | NF-kappa B - antagonists & inhibitors | DNA-Binding Proteins - antagonists & inhibitors | Signal Transduction | Carcinoma, Non-Small-Cell Lung - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Porphyrins - pharmacology | Transcription Factors - metabolism | Xenograft Model Antitumor Assays | Animals | Karyopherins - metabolism | Active Transport, Cell Nucleus - drug effects | Genes, Lethal - genetics | NF-KappaB Inhibitor alpha - metabolism | Nuclear Proteins - antagonists & inhibitors | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | RNA, Small Interfering | Carcinoma, Non-Small-Cell Lung - drug therapy | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Cell Nucleus - drug effects | Karyopherins - antagonists & inhibitors | Receptors, Cytoplasmic and Nuclear - metabolism | Care and treatment | Genetic aspects | Gene mutations | Health aspects | Guanosine triphosphatase | Lung cancer | Genomics | Genomes | Kinases | Drug resistance | Gene expression | Drug dosages | Index Medicus
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 1931-857X, 08/2009, Volume 297, Issue 2, pp. 461 - 470
Recently, kidney fibrosis following transplantation has become recognized as a main contributor of chronic allograft nephropathy. In transplantation, transient... 
Ischemia-reperfusion | α-smooth muscle actin | Superoxide | Manganese(III) tetrakis(1-methyl-4-pyridyl) porphyrin | Interstitial fibrosis | alpha-smooth muscle actin | manganese(III) tetrakis(1-methyl-4-pyridyl) porphyrin | OXIDATIVE STRESS | ISCHEMIA/REPERFUSION INJURY | PHYSIOLOGY | REPERFUSION INJURY | ischemia-reperfusion | interstitial fibrosis | MAPK KINASE ACTIVATION | NITRIC-OXIDE | UROLOGY & NEPHROLOGY | INDUCED FUNCTIONAL INJURY | superoxide | SUPEROXIDE-DISMUTASE | URETERAL OBSTRUCTION | CHRONIC ALLOGRAFT NEPHROPATHY | IMMUNOSTIMULATED MACROPHAGES | Kidney - blood supply | Reactive Oxygen Species - metabolism | Kidney - pathology | Apoptosis - drug effects | S100 Calcium-Binding Protein A4 | Actins - metabolism | Male | Metalloporphyrins - pharmacology | Tyrosine - analogs & derivatives | Antigens, CD - metabolism | Kidney - metabolism | Time Factors | Lipid Peroxidation - drug effects | Reperfusion Injury - metabolism | Ischemia - pathology | Superoxide Dismutase - metabolism | Disease Models, Animal | Kidney - drug effects | Oxidation-Reduction | Reperfusion Injury - pathology | Ischemia - metabolism | S100 Proteins - metabolism | Antioxidants - pharmacology | Disease Progression | Hydrogen Peroxide - metabolism | Collagen - metabolism | Tyrosine - metabolism | Animals | Reperfusion Injury - prevention & control | Antigens, Differentiation, Myelomonocytic - metabolism | Fibrosis | Glucosephosphate Dehydrogenase - metabolism | HSP47 Heat-Shock Proteins - metabolism | Mice | Mice, Inbred BALB C | Oxidative Stress - drug effects | Proliferating Cell Nuclear Antigen - metabolism | Vitamin E - pharmacology | Proteins | Studies | Rodents | Oxidation | Kidney diseases | Gene expression | Cells | Index Medicus
Journal Article
1962, American lecture series, publication no. 481. A monograph in the Bannerstone Division in American lectures in living chemistry, 231
Book
1987, ISBN 0306426250, xv, 374 p., [1] leaf of plates
Book
Journal of Clinical Investigation, ISSN 0021-9738, 10/2014, Volume 124, Issue 10, pp. 4294 - 4304
Journal Article
Journal Article
Journal Article
American journal of physiology. Renal physiology, ISSN 1931-857X, 04/2018, Volume 314, Issue 4, pp. F658 - F666
Downregulation of aquaporins (AQPs) in obstructive kidney disease has been well demonstrated with elusive mechanisms. Our previous study indicated that... 
Free Radical Scavengers - pharmacology | Ureteral Obstruction - complications | Kidney - pathology | Receptors, Vasopressin - metabolism | Male | Ureteral Obstruction - metabolism | Metalloporphyrins - pharmacology | Aquaporin 1 - metabolism | Aquaporins - genetics | Kidney Diseases - genetics | Kidney - metabolism | Cyclooxygenase 2 - genetics | Aquaporin 4 - genetics | Ureteral Obstruction - genetics | Superoxide Dismutase - metabolism | Disease Models, Animal | Kidney Diseases - metabolism | Kidney - drug effects | Prostaglandin-E Synthases - metabolism | Signal Transduction | Kidney Diseases - pathology | Down-Regulation | Mice, Inbred C57BL | Aquaporins - metabolism | Mitochondria - metabolism | Mitochondria - drug effects | Aquaporin 3 - genetics | Aquaporin 1 - genetics | Aquaporin 2 - metabolism | Dinoprostone - metabolism | Aquaporin 3 - metabolism | Animals | Aquaporin 4 - metabolism | Ureteral Obstruction - pathology | Cyclooxygenase 2 - metabolism | Kidney Diseases - etiology | Oxidative Stress - drug effects | Aquaporin 2 - genetics | Oxidative stress | Mitochondria | Genetic aspects | Kidney diseases | Health aspects | Aquaporins | Aquaporin 4 | Benzoic acid | Prostaglandin E2 | Superoxide dismutase | Mitochondrial DNA | Tetrakis(4-benzoic acid)porphyrin | Western blotting | Prostaglandin endoperoxide synthase | Prostaglandin E | Thiobarbituric acid | Aquaporin 1 | Aquaporin 2 | Aquaporin 3 | Urine | Kidneys | Secretion | Prostaglandin-E synthase | Polymerase chain reaction | Cyclooxygenase-1 | Cyclooxygenase-2 | Manganese | Index Medicus
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2014, Volume 61, Issue 5, pp. 1088 - 1096
Background & Aims Although the growth suppressing Hippo pathway has been implicated in hepatocellular carcinoma (HCC) pathogenesis, it is unknown at which... 
Gastroenterology and Hepatology | Preneoplastic stages | HCC | Verteporfin | TCPOBOP | Hippo pathway | YES-ASSOCIATED PROTEIN | RAT | ORGAN SIZE CONTROL | REGENERATION | CELL-PROLIFERATION | LESIONS | CARCINOGENESIS | PATHWAY | HEPATOCELLULAR-CARCINOMA DEVELOPMENT | GASTROENTEROLOGY & HEPATOLOGY | TUMORIGENESIS | Adenoma, Liver Cell - drug therapy | Precancerous Conditions - etiology | Adenoma, Liver Cell - etiology | Humans | Middle Aged | Rats, Inbred F344 | Male | MicroRNAs - metabolism | Precancerous Conditions - metabolism | Phosphoproteins - metabolism | Liver Neoplasms - etiology | Precancerous Conditions - drug therapy | Young Adult | Liver Neoplasms, Experimental - metabolism | Carcinoma, Hepatocellular - drug therapy | Apoptosis Regulatory Proteins - genetics | Adult | Female | Antineoplastic Agents - pharmacology | Carcinoma, Hepatocellular - etiology | Protein-Serine-Threonine Kinases - metabolism | Gene Expression | Signal Transduction | Adenoma, Liver Cell - metabolism | Liver Neoplasms - drug therapy | Rats | Porphyrins - pharmacology | Liver Neoplasms, Experimental - etiology | Apoptosis Regulatory Proteins - metabolism | Animals | Liver Neoplasms, Experimental - drug therapy | Apoptosis Regulatory Proteins - antagonists & inhibitors | Liver Neoplasms - metabolism | Cell Line, Tumor | Aged | Cell Proliferation - drug effects | Mice | MicroRNAs - genetics | Adaptor Proteins, Signal Transducing - metabolism | Carcinoma, Hepatocellular - metabolism | Liver cancer | Health aspects | Index Medicus
Journal Article
Journal Article
Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 11/2017, Volume 21, Issue 11, pp. 2663 - 2676
Malignant mesothelioma is an aggressive cancer that is resistant to current therapy. The poor prognosis of mesothelioma has been associated with elevated... 
YAP | therapeutic target | Hippo pathway | mesothelioma | MEDICINE, RESEARCH & EXPERIMENTAL | HIPPO SIGNALING CASCADE | CANCER STEM-CELLS | CELL BIOLOGY | TISSUE GROWTH-FACTOR | MELANOMA | TEAD | GENE | PATHWAY | DYSREGULATION | MUTATIONS | PROGRESSION | RNA, Small Interfering - genetics | Phosphorylation | Epithelial Cells - metabolism | Prognosis | Mesothelioma - pathology | Epithelial Cells - drug effects | Humans | Lung Neoplasms - metabolism | Gene Expression Regulation, Neoplastic | Spheroids, Cellular - pathology | Lung Neoplasms - pathology | rhoA GTP-Binding Protein - metabolism | Phosphoproteins - antagonists & inhibitors | rhoA GTP-Binding Protein - genetics | Phosphoproteins - metabolism | RNA, Messenger - metabolism | DNA-Binding Proteins - metabolism | rho-Associated Kinases - metabolism | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | RNA, Messenger - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Spheroids, Cellular - drug effects | 3' Untranslated Regions | Nuclear Proteins - genetics | Genes, Reporter | Lung Neoplasms - genetics | DNA-Binding Proteins - antagonists & inhibitors | Signal Transduction | RNA, Messenger - genetics | Spheroids, Cellular - metabolism | rho-Associated Kinases - genetics | Epithelial Cells - pathology | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Mesothelioma - genetics | Phosphoproteins - genetics | Porphyrins - pharmacology | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Transcription Factors - metabolism | Mesothelioma - metabolism | Nuclear Proteins - antagonists & inhibitors | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Adaptor Proteins, Signal Transducing - metabolism | RNA, Small Interfering - metabolism | Immunohistochemistry | Yuan (China) | Mesothelioma | RNA | Analysis | Biotechnology | Transcription | siRNA | Yes-associated protein | Proteins | Signaling | 3' Untranslated regions | Cell lines | Inhibition | Viability | Cancer | Index Medicus | Original
Journal Article