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Journal of Pharmacy and Pharmacology, ISSN 0022-3573, 01/2020, Volume 72, Issue 1, pp. 84 - 91
Objectives To determine if diminished orthosteric agonist binding due to mutations in extracellular loops 1 or 2 of the cannabinoid receptor 1 (CB1) can be... 
G protein‐coupled receptor | cannabinoid receptor 1 | PSNCBAM‐1 | ligand binding | positive allosteric modulator
Journal Article
BBA - General Subjects, ISSN 0304-4165, 03/2014, Volume 1840, Issue 3, pp. 1194 - 1203
Among adenosine receptors (ARs) the A subtype exhibits low affinity for the endogenous agonist compared with the A , A , and A subtypes and is therefore... 
1-Benzyl-3-ketoindole derivatives | Positive allosteric modulators | GPCR allosteric modulators | A2B adenosine receptor | Negative allosteric modulators | Ligand–receptor interaction | adenosine receptor | Ligand-receptor interaction
Journal Article
Neuropharmacology, ISSN 0028-3908, 7/2018, Volume 137, pp. 50 - 58
Development of opioid tolerance and dependence hinders the use of opioids for the treatment of chronic pain. In searching for the mechanism and potential... 
AMPA | opioid tolerance | opioid dependence | positive allosteric modulator
Journal Article
Neuropharmacology, ISSN 0028-3908, 07/2014, Volume 82, pp. 161 - 173
Previous work has suggested that activation of mGlu5 receptor augments NMDA receptor function and thereby may constitute a rational approach addressing... 
Schizophrenia | Positive allosteric modulator | Neurotoxicity | Metabotropic glutamate receptor | Antipsychotic activity | METABOTROPIC GLUTAMATE-RECEPTOR | PROTEIN-KINASE-C | NEGATIVE SYMPTOMS | FRAGILE-X | NEUROSCIENCES | PREFRONTAL CORTEX | D-SERINE | PHARMACOLOGY & PHARMACY | LONG-TERM POTENTIATION | BINDING-SITES | ACUTE STRESS | METHYL-D-ASPARTATE | Antipsychotic Agents - toxicity | Neurons - pathology | Cricetulus | Rats, Wistar | Benzamides - pharmacokinetics | Allosteric Regulation | Humans | Male | Excitatory Amino Acid Agents - pharmacokinetics | Mice, 129 Strain | Necrosis - pathology | Excitatory Amino Acid Agents - chemistry | Oxadiazoles - toxicity | Receptor, Metabotropic Glutamate 5 - genetics | Necrosis - physiopathology | Neurotoxicity Syndromes - pathology | Neurons - physiology | Female | Cell Death - drug effects | Neurons - drug effects | Oxadiazoles - chemistry | Oxadiazoles - pharmacokinetics | Benzamides - chemistry | CHO Cells | Benzamides - toxicity | Brain - physiopathology | Cells, Cultured | Antipsychotic Agents - pharmacokinetics | Receptor, Metabotropic Glutamate 5 - metabolism | Rats, Sprague-Dawley | Mice, Knockout | Brain - drug effects | Excitatory Amino Acid Agents - toxicity | Animals | Antipsychotic Agents - chemistry | Cell Death - physiology | Neurotoxicity Syndromes - physiopathology | Brain - pathology | Methyl aspartate | Antipsychotic drugs | Glutamate | Index Medicus
Journal Article
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, ISSN 0304-4165, 03/2014, Volume 1840, Issue 3, pp. 1194 - 1203
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2020, Volume 186, p. 111881
A scaffold hopping strategy converted the known 1-[(1-methyl-1H-imidazol-2-yl)methyl]-4-phenylpiperidine core ( and ) by cyclization to a fused [6 + 5+6]... 
Scaffold hopping | Positive allosteric modulator | Dihydropyrazino-benzimidazoles | Pharmacophore based optimization | mGlu2 receptor
Journal Article
ACS MEDICINAL CHEMISTRY LETTERS, ISSN 1948-5875, 05/2019, Volume 10, Issue 5, pp. 800 - 805
T1R2/T1R3 belongs to G protein coupled receptors, which recognizes diverse natural and synthetic sweeteners. A novel class of positive allosteric modulators... 
T1R2/T1R3 receptor | CHEMISTRY, MEDICINAL | Positive allosteric modulators | MECHANISM | Sweetness enhancer | Class C GPCR | FAMILY | CLONING | Unnatural peptide | NUTRITION | KNOCKOUT | HUMAN SWEET TASTE | RECEPTORS
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 08/2018, Volume 154, pp. 243 - 254
Journal Article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, 01/2016, Volume 26, Issue 2, pp. 650 - 655
Selective activation of the M-1 receptor via a positive allosteric modulator (PAM) is a new approach for the treatment of the cognitive impairments associated... 
ACTIVATION | CHEMISTRY, MEDICINAL | SERIES | ALZHEIMERS-DISEASE | CHEMISTRY, ORGANIC | SCHIZOPHRENIA | XANOMELINE | Azaindole amide | AGONISTS | DISCOVERY | M-1 selective activator | MUSCARINIC ACETYLCHOLINE-RECEPTOR | M-1 positive allosteric modulator (PAM) | Intra-molecular hydrogen bond (IMHB) | IN-VIVO | CENTRAL-NERVOUS-SYSTEM
Journal Article
ACS Chemical Neuroscience, ISSN 1948-7193, 03/2018, Volume 9, Issue 3, pp. 522 - 534
Journal Article