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1. Full Text Postsynaptic density scaffold SAP102 regulates cortical synapse development through EphB and PAK signaling pathway
by Murata, Yasunobu and Constantine-Paton, Martha
The Journal of neuroscience, ISSN 0270-6474, 03/2013, Volume 33, Issue 11, pp. 5040 - 5052
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Disks Large Homolog 4 Protein | Immunoprecipitation | Visual Cortex - growth & development | Age Factors | Embryo, Mammalian | Humans | Receptors, N-Methyl-D-Aspartate - metabolism | Gene Expression Regulation, Developmental - genetics | Male | Green Fluorescent Proteins - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Synaptosomes - metabolism | Cyclic AMP-Dependent Protein Kinases - genetics | Neurons - ultrastructure | Transfection | Guanine Nucleotide Exchange Factors - metabolism | Neurons - physiology | Female | Lentivirus - genetics | Membrane Proteins - metabolism | Receptors, Eph Family - metabolism | Neuropeptides - genetics | Post-Synaptic Density - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Green Fluorescent Proteins - metabolism | Biotinylation | Receptors, Eph Family - genetics | Synapses - physiology | Visual Cortex - cytology | Cells, Cultured | Rats | Neuropeptides - metabolism | Signal Transduction - genetics | Nerve Tissue Proteins - metabolism | Animals | Analysis of Variance | Signal Transduction - physiology | Genetic Vectors - physiology | Visual Cortex - metabolism | RNA, Small Interfering - metabolism | Index Medicus
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2. Full Text Proteomic and genomic evidence implicates the postsynaptic density in schizophrenia
by Föcking, M and Lopez, L.M and English, J.A and Dicker, P and Wolff, A and Brindley, E and Wynne, K and Cagney, G and Cotter, D.R
Molecular psychiatry, ISSN 1359-4184, 04/2015, Volume 20, Issue 4, pp. 424 - 432
Biochemistry & Molecular Biology | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Psychiatry | Science & Technology | Schizophrenia - metabolism | Genomics | Humans | N-Methylaspartate - genetics | Male | Schizophrenia - pathology | Post-Synaptic Density - genetics | Tandem Mass Spectrometry | Schizophrenia - genetics | Gyrus Cinguli - pathology | Female | Gyrus Cinguli - drug effects | Post-Synaptic Density - metabolism | Haloperidol - pharmacology | Reproducibility of Results | Genetic Association Studies | N-Methylaspartate - metabolism | Gene Expression Regulation - genetics | Endocytosis - drug effects | Rats | Nerve Tissue Proteins - genetics | Gyrus Cinguli - metabolism | Endocytosis - physiology | Nerve Tissue Proteins - metabolism | Synaptotagmins - metabolism | Animals | Post-Synaptic Density - pathology | Signal Transduction - drug effects | Proteomics | Signal Transduction - physiology | Antipsychotic Agents - pharmacology | Psychological aspects | Schizophrenia | Genetic research | Development and progression | Genetic aspects | Research | Health aspects | Synapses | Psychiatric research | Potentiation | Enrichment | Medical research | Clathrin | Cortex (cingulate) | Mental disorders | Calcium | Long-term potentiation | Genomes | Glutamic acid receptors | Quantitation | Shotguns | Density | Calcium signalling | Proteins | Endocytosis | Dynamin | Postsynaptic density | N-Methyl-D-aspartic acid | Index Medicus
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3. Full Text Phase Transition in Postsynaptic Densities Underlies Formation of Synaptic Complexes and Synaptic Plasticity
by Zeng, Menglong and Shang, Yuan and Araki, Yoichi and Guo, Tingfeng and Huganir, Richard L and Zhang, Mingjie
Cell (Cambridge), ISSN 0092-8674, 08/2016, Volume 166, Issue 5, pp. 1163 - 1175.e12
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Disks Large Homolog 4 Protein | Protein Conformation, alpha-Helical | ras GTPase-Activating Proteins - metabolism | Hippocampus - embryology | ras GTPase-Activating Proteins - chemistry | Humans | Protein Multimerization | Rats | Intracellular Signaling Peptides and Proteins - metabolism | Hippocampus - cytology | Phase Transition | Animals | Membrane Proteins - chemistry | Intracellular Signaling Peptides and Proteins - chemistry | Neuronal Plasticity | HEK293 Cells | Membrane Proteins - metabolism | Mice | Neurons - metabolism | HeLa Cells | Post-Synaptic Density - metabolism | Proteins | Medical colleges | Neurosciences | Analysis | Yuan (China) | Index Medicus
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4. Full Text PSD-95 is required to sustain the molecular organization of the postsynaptic density
by Chen, Xiaobing and Nelson, Christopher D and Li, Xiang and Winters, Christine A and Azzam, Rita and Sousa, Alioscka A and Leapman, Richard D and Gainer, Harold and Sheng, Morgan and Reese, Thomas S
The Journal of neuroscience, ISSN 0270-6474, 04/2011, Volume 31, Issue 17, pp. 6329 - 6338
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Disks Large Homolog 4 Protein | Embryo, Mammalian | Microscopy, Electron, Transmission - methods | Lentivirus - physiology | Male | Neurons - cytology | Green Fluorescent Proteins - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Transfection - methods | Female | Membrane Proteins - metabolism | Post-Synaptic Density - metabolism | RNA Interference - physiology | Intracellular Signaling Peptides and Proteins - genetics | Receptors, AMPA - metabolism | Membrane Proteins - genetics | Synapses - physiology | Rats | Synapses - ultrastructure | Post-Synaptic Density - ultrastructure | Cytoskeleton - ultrastructure | Receptors, AMPA - ultrastructure | Hippocampus - cytology | Immunohistochemistry - methods | Animals | Models, Biological | Cytoskeleton - metabolism | Index Medicus
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5. Full Text Zinc transporter‐1: a novel NMDA receptor‐binding protein at the postsynaptic density
by Mellone, Manuela and Pelucchi, Silvia and Alberti, Lorenzo and Genazzani, Armando A and Di Luca, Monica and Gardoni, Fabrizio
Journal of neurochemistry, ISSN 0022-3042, 01/2015, Volume 132, Issue 2, pp. 159 - 168
postsynaptic density | dendritic spine | proteinߝprotein interaction | NMDA receptor | ZNT‐1 | Dendritic spine | Postsynaptic density | ZNT-1 | Protein protein interaction | protein-protein interaction | Biochemistry & Molecular Biology | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Calcium - metabolism | Zinc - metabolism | Receptors, N-Methyl-D-Aspartate - metabolism | Cercopithecus aethiops | Rats | Male | Dendrites - ultrastructure | Hippocampus - cytology | Rats, Sprague-Dawley | Protein Interaction Mapping | Excitatory Postsynaptic Potentials - physiology | Nerve Tissue Proteins - metabolism | Pregnancy | Hippocampus - metabolism | Animals | Cation Transport Proteins - metabolism | Neuronal Plasticity | Female | Ion Transport | Post-Synaptic Density - metabolism | Primary Cell Culture | COS Cells | Physiological aspects | Methyl aspartate | Chemical properties | Protein binding | Proteins | Neurochemistry | Zinc | Index Medicus
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6. Full Text Autocrine BDNF-TrkB signalling within a single dendritic spine
by Harward, Stephen C and Hedrick, Nathan G and Hall, Charles E and Parra-Bueno, Paula and Milner, Teresa A and Pan, Enhui and Laviv, Tal and Hempstead, Barbara L and Yasuda, Ryohei and McNamara, James O
Nature (London), ISSN 0028-0836, 09/2016, Volume 538, Issue 7623, pp. 99 - 103
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Brain-Derived Neurotrophic Factor - secretion | Green Fluorescent Proteins | Pyramidal Cells - metabolism | Membrane Glycoproteins - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Receptors, N-Methyl-D-Aspartate - metabolism | Male | Dendritic Spines - metabolism | Fluorescence Resonance Energy Transfer | Female | Hippocampus - ultrastructure | Brain-Derived Neurotrophic Factor - metabolism | Post-Synaptic Density - metabolism | Microscopy, Fluorescence, Multiphoton | Pyramidal Cells - ultrastructure | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism | Autocrine Communication | Signal Transduction | Tissue Culture Techniques | Mice, Inbred C57BL | Rats | Post-Synaptic Density - secretion | Dendritic Spines - secretion | Hippocampus - cytology | Microscopy, Electron | Hippocampus - metabolism | Animals | Long-Term Potentiation | Glutamic Acid - metabolism | Mice | Enzyme Activation | HeLa Cells | Dendritic Spines - ultrastructure | Proteins | Signal transduction | Phosphorylation | Dendritic cells | Kinases | Index Medicus
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7. Full Text Nanoscale molecular reorganization of the inhibitory postsynaptic density is a determinant of gabaergic synaptic potentiation
by Pennacchietti, Francesca and Vascon, Sebastiano and Nieus, Thierry and Rosillo, Christian and Das, Sabyasachi and Tyagarajan, Shiva K and Diaspro, Alberto and del Bue, Alessio and Petrini, Enrica Maria and Barberis, Andrea and Zanacchi, Francesca Cella
The Journal of neuroscience, ISSN 0270-6474, 02/2017, Volume 37, Issue 7, pp. 1747 - 1756
STORM | PALM | Plasticity | Model simulations | Clustering | Gephyrin | GABAA receptors | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Male | Long-Term Synaptic Depression - drug effects | N-Methylaspartate - pharmacology | Peptides - metabolism | GABAergic Neurons - cytology | Computer Simulation | 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology | Female | Membrane Proteins - metabolism | Post-Synaptic Density - drug effects | Post-Synaptic Density - metabolism | Long-Term Synaptic Depression - physiology | Mice, Inbred C57BL | Valine - analogs & derivatives | Cells, Cultured | GABAergic Neurons - drug effects | Excitatory Amino Acid Agonists - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Hippocampus - cytology | Algorithms | Animals | Carrier Proteins - metabolism | Mice | Receptors, GABA-A - metabolism | Models, Neurological | Valine - pharmacology | Index Medicus | model simulations | s | plasticity | clustering | gephyrin
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8. Full Text Switching antipsychotics: Imaging the differential effect on the topography of postsynaptic density transcripts in antipsychotic-naïve vs. antipsychotic-exposed rats
by de Bartolomeis, Andrea and Marmo, Federica and Buonaguro, Elisabetta F and Latte, Gianmarco and Tomasetti, Carmine and Iasevoli, Felice
Progress in neuro-psychopharmacology & biological psychiatry, ISSN 0278-5846, 10/2016, Volume 70, pp. 24 - 38
Amisulpride | Treatment resistant schizophrenia | Homer | Haloperidol | Neurosciences | Clinical Neurology | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Neurosciences & Neurology | Psychiatry | Science & Technology | Disks Large Homolog 4 Protein | Sulpiride - pharmacology | Gene Expression - drug effects | Male | Intracellular Signaling Peptides and Proteins - metabolism | RNA, Messenger - metabolism | Corpus Striatum - metabolism | Cerebral Cortex - metabolism | Sulpiride - analogs & derivatives | Drug Resistance - physiology | Cytoskeletal Proteins - metabolism | Membrane Proteins - metabolism | Post-Synaptic Density - drug effects | Cerebral Cortex - drug effects | Post-Synaptic Density - metabolism | Haloperidol - pharmacology | Homer Scaffolding Proteins - metabolism | Injections, Intraperitoneal | Random Allocation | Rats, Sprague-Dawley | Nerve Tissue Proteins - metabolism | Animals | Corpus Striatum - drug effects | Antipsychotic Agents - pharmacology | Drug Substitution | Proteins | Glutamate | Index Medicus
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9. Full Text CDKL5 controls postsynaptic localization of GluN2B-containing NMDA receptors in the hippocampus and regulates seizure susceptibility
by Okuda, Kosuke and Kobayashi, Shizuka and Fukaya, Masahiro and Watanabe, Aya and Murakami, Takuto and Hagiwara, Mai and Sato, Tempei and Ueno, Hiroe and Ogonuki, Narumi and Komano-Inoue, Sayaka and Manabe, Hiroyuki and Yamaguchi, Masahiro and Ogura, Atsuo and Asahara, Hiroshi and Sakagami, Hiroyuki and Mizuguchi, Masashi and Manabe, Toshiya and Tanaka, Teruyuki
Neurobiology of disease, ISSN 0969-9961, 10/2017, Volume 106, pp. 158 - 170
Ifenprodil | CDKL5 | Epilepsy | Excitatory synapses | Developmental disorders | SAP102 | NMDA receptors | Hippocampus | GluN2B | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Receptors, N-Methyl-D-Aspartate - metabolism | Disease Susceptibility - metabolism | Seizures - metabolism | Hippocampus - drug effects | RNA, Messenger - metabolism | Kainic Acid | Seizures - pathology | Piperidines - pharmacology | Membrane Proteins - metabolism | Post-Synaptic Density - drug effects | Post-Synaptic Density - metabolism | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | Tissue Culture Techniques | Mice, Inbred C57BL | Protein-Serine-Threonine Kinases - genetics | Excitatory Amino Acid Antagonists - pharmacology | Hippocampus - pathology | Mice, Knockout | Hippocampus - metabolism | Animals | Post-Synaptic Density - pathology | Guanylate Kinases - metabolism | N-Methylaspartate | Methyl aspartate | Brain | Aspartate | Seizures (Medicine) | Analysis | Index Medicus
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