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protein binding (38) 38
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1. Full Text Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer Aβ Oligomer Bound to Cellular Prion Protein
by Um, Ji Won and Kaufman, Adam C and Kostylev, Mikhail and Heiss, Jacqueline K and Stagi, Massimiliano and Takahashi, Hideyuki and Kerrisk, Meghan E and Vortmeyer, Alexander and Wisniewski, Thomas and Koleske, Anthony J and Gunther, Erik C and Nygaard, Haakon B and Strittmatter, Stephen M
Neuron, ISSN 0896-6273, 09/2013, Volume 79, Issue 5, pp. 887 - 902
Soluble amyloid-β oligomers (Aβo) trigger Alzheimer’s disease (AD) pathophysiology and bind with high affinity to cellular prion protein (PrP ). At the... 
SIGNAL-TRANSDUCTION | DENDRITIC SPINES | IN-VIVO | DISEASE BRAIN | LONG-TERM POTENTIATION | SYNAPTIC PLASTICITY | UP-REGULATION | NEUROSCIENCES | MOUSE MODELS | AMYLOID-PRECURSOR PROTEIN | FYN KINASE | Xenopus | Alzheimer Disease - physiopathology | Phosphorylation | Calcium - metabolism | Humans | Cells, Cultured | Elongation Factor 2 Kinase - metabolism | Receptors, Metabotropic Glutamate - physiology | Oocytes | Animals | Proto-Oncogene Proteins c-fyn - metabolism | Alzheimer Disease - metabolism | Amyloid beta-Peptides - metabolism | HEK293 Cells | Receptor, Metabotropic Glutamate 5 | Signal Transduction - physiology | Mice | Neurons - metabolism | Post-Synaptic Density - metabolism | PrPC Proteins - metabolism
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2. Full Text Phase Transition in Postsynaptic Densities Underlies Formation of Synaptic Complexes and Synaptic Plasticity
by Zeng, Menglong and Shang, Yuan and Araki, Yoichi and Guo, Tingfeng and Huganir, Richard L and Zhang, Mingjie
Cell, ISSN 0092-8674, 08/2016, Volume 166, Issue 5, pp. 1163 - 1175.e12
Postsynaptic densities (PSDs) are membrane semi-enclosed, submicron protein-enriched cellular compartments beneath postsynaptic membranes, which constantly... 
CORE | ORGANIZATION | RECOGNITION | FORM | BIOCHEMISTRY & MOLECULAR BIOLOGY | SYNGAP1 CAUSE | SUPERTERTIARY STRUCTURE | SCAFFOLD PROTEINS | MUTATIONS | DOMAINS | FAMILY | CELL BIOLOGY | Disks Large Homolog 4 Protein | Protein Conformation, alpha-Helical | ras GTPase-Activating Proteins - metabolism | Hippocampus - embryology | ras GTPase-Activating Proteins - chemistry | Humans | Protein Multimerization | Rats | Intracellular Signaling Peptides and Proteins - metabolism | Hippocampus - cytology | Phase Transition | Animals | Membrane Proteins - chemistry | Intracellular Signaling Peptides and Proteins - chemistry | Neuronal Plasticity | HEK293 Cells | Membrane Proteins - metabolism | Mice | Neurons - metabolism | HeLa Cells | Post-Synaptic Density - metabolism | Proteins | Medical colleges | Neurosciences | Analysis | Yuan (China)
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3. Full Text Proteomic and genomic evidence implicates the postsynaptic density in schizophrenia
by Föcking, M and Lopez, L.M and English, J.A and Dicker, P and Wolff, A and Brindley, E and Wynne, K and Cagney, G and Cotter, D.R
Molecular Psychiatry, ISSN 1359-4184, 04/2015, Volume 20, Issue 4, pp. 424 - 432
The postsynaptic density (PSD) contains a complex set of proteins of known relevance to neuropsychiatric disorders, and schizophrenia specifically. We enriched... 
NMDA RECEPTOR | PHOSPHORYLATION | PSYCHIATRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | FRONTAL-CORTEX | COMPONENTS | NEUROSCIENCES | PREFRONTAL CORTEX | PATHOPHYSIOLOGY | RISK LOCI | GENE-EXPRESSION | MUTATIONS | ELDERLY-PATIENTS | Schizophrenia - metabolism | Genomics | Humans | N-Methylaspartate - genetics | Male | Schizophrenia - pathology | Post-Synaptic Density - genetics | Tandem Mass Spectrometry | Schizophrenia - genetics | Gyrus Cinguli - pathology | Female | Gyrus Cinguli - drug effects | Post-Synaptic Density - metabolism | Haloperidol - pharmacology | Reproducibility of Results | Genetic Association Studies | N-Methylaspartate - metabolism | Gene Expression Regulation - genetics | Endocytosis - drug effects | Rats | Nerve Tissue Proteins - genetics | Gyrus Cinguli - metabolism | Endocytosis - physiology | Nerve Tissue Proteins - metabolism | Synaptotagmins - metabolism | Animals | Post-Synaptic Density - pathology | Signal Transduction - drug effects | Proteomics | Signal Transduction - physiology | Antipsychotic Agents - pharmacology | Psychological aspects | Schizophrenia | Genetic research | Development and progression | Genetic aspects | Research | Health aspects | Synapses | Psychiatric research
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4. Full Text PSD-95 family MAGUKs are essential for anchoring AMPA and NMDA receptor complexes at the postsynaptic density
by Xiaobing Chen and Jonathan M. Levy and Austin Hou and Christine Winters and Rita Azzam and Alioscka A. Sousa and Richard D. Leapman and Roger A. Nicoll and Thomas S. Reese
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2015, Volume 112, Issue 50, pp. E6983 - E6992
The postsynaptic density (PSD)-95 family of membrane-associated guanylate kinases (MAGUKs) are major scaffolding proteins at the PSD in glutamatergic... 
MAGUKs | NMDAR | Knockdown | EM tomography | AMPAR | knockdown | MOLECULAR-ORGANIZATION | GUANYLATE KINASES | QUANTAL SIZE | MULTIDISCIPLINARY SCIENCES | SYNAPTIC-TRANSMISSION | DENDRITIC SPINES | GLUTAMATE RECEPTORS | EXCITATORY SYNAPSES | RAT HIPPOCAMPUS | NEUROMUSCULAR-JUNCTION | SCAFFOLDING PROTEINS | Disks Large Homolog 4 Protein | Membrane Proteins - genetics | Cells, Cultured | Receptors, N-Methyl-D-Aspartate - metabolism | Rats | Intracellular Signaling Peptides and Proteins - metabolism | Gene Knockdown Techniques | Animals | Membrane Proteins - physiology | Membrane Proteins - metabolism | Post-Synaptic Density - metabolism | Intracellular Signaling Peptides and Proteins - physiology | Intracellular Signaling Peptides and Proteins - genetics | Receptors, AMPA - metabolism | Physiological aspects | Cell receptors | Phosphotransferases | Synapses | Agonists (Biochemistry) | Biological Sciences | PNAS Plus
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5. Full Text Autocrine BDNF-TrkB signalling within a single dendritic spine
by Harward, Stephen C and Hedrick, Nathan G and Hall, Charles E and Parra-Bueno, Paula and Milner, Teresa A and Pan, Enhui and Laviv, Tal and Hempstead, Barbara L and Yasuda, Ryohei and McNamara, James O
Nature, ISSN 0028-0836, 09/2016, Volume 538, Issue 7623, pp. 99 - 103
Brain-derived neurotrophic factor (BDNF) and its receptor TrkB are crucial for many forms of neuronal plasticity, including structural long-term potentiation... 
Brain-Derived Neurotrophic Factor - secretion | Green Fluorescent Proteins | Pyramidal Cells - metabolism | Membrane Glycoproteins - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Receptors, N-Methyl-D-Aspartate - metabolism | Male | Dendritic Spines - metabolism | Fluorescence Resonance Energy Transfer | Female | Hippocampus - ultrastructure | Brain-Derived Neurotrophic Factor - metabolism | Post-Synaptic Density - metabolism | Microscopy, Fluorescence, Multiphoton | Pyramidal Cells - ultrastructure | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism | Autocrine Communication | Signal Transduction | Tissue Culture Techniques | Mice, Inbred C57BL | Rats | Post-Synaptic Density - secretion | Dendritic Spines - secretion | Hippocampus - cytology | Microscopy, Electron | Hippocampus - metabolism | Animals | Long-Term Potentiation | Glutamic Acid - metabolism | Mice | Enzyme Activation | HeLa Cells | Dendritic Spines - ultrastructure | Proteins | Signal transduction | Phosphorylation | Dendritic cells | Kinases
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6. Full Text Postsynaptic density scaffold SAP102 regulates cortical synapse development through EphB and PAK signaling pathway
by Murata, Yasunobu and Constantine-Paton, Martha
Journal of Neuroscience, ISSN 0270-6474, 03/2013, Volume 33, Issue 11, pp. 5040 - 5052
Membrane-associated guanylate kinases (MAGUKs), including SAP102, PSD-95, PSD-93, and SAP97, are scaffolding proteins for ionotropic glutamate receptors at... 
DENDRITIC SPINE MORPHOGENESIS | NMDA RECEPTOR | LINKED MENTAL-RETARDATION | DEPENDENT REGULATION | AMPA RECEPTOR FUNCTION | EXCITATORY SYNAPSES | IN-VIVO | NUCLEOTIDE EXCHANGE FACTOR | PROTEINS | NEUROSCIENCES | PLASTICITY | Disks Large Homolog 4 Protein | Immunoprecipitation | Visual Cortex - growth & development | Age Factors | Embryo, Mammalian | Humans | Receptors, N-Methyl-D-Aspartate - metabolism | Gene Expression Regulation, Developmental - genetics | Male | Green Fluorescent Proteins - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Synaptosomes - metabolism | Cyclic AMP-Dependent Protein Kinases - genetics | Neurons - ultrastructure | Transfection | Guanine Nucleotide Exchange Factors - metabolism | Neurons - physiology | Female | Lentivirus - genetics | Membrane Proteins - metabolism | Receptors, Eph Family - metabolism | Neuropeptides - genetics | Post-Synaptic Density - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Green Fluorescent Proteins - metabolism | Biotinylation | Receptors, Eph Family - genetics | Synapses - physiology | Visual Cortex - cytology | Cells, Cultured | Rats | Neuropeptides - metabolism | Signal Transduction - genetics | Nerve Tissue Proteins - metabolism | Animals | Analysis of Variance | Signal Transduction - physiology | Genetic Vectors - physiology | Visual Cortex - metabolism | RNA, Small Interfering - metabolism
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7. Full Text PSD-95 is required to sustain the molecular organization of the postsynaptic density
by Chen, Xiaobing and Nelson, Christopher D and Li, Xiang and Winters, Christine A and Azzam, Rita and Sousa, Alioscka A and Leapman, Richard D and Gainer, Harold and Sheng, Morgan and Reese, Thomas S
Journal of Neuroscience, ISSN 0270-6474, 04/2011, Volume 31, Issue 17, pp. 6329 - 6338
PSD-95, a membrane-associated guanylate kinase, is the major scaffolding protein in the excitatory postsynaptic density (PSD) and a potent regulator of... 
GLUTAMATE RECEPTORS | DOMAIN | AMPA RECEPTORS | SYNAPTIC FUNCTION | GUANYLATE KINASES | MAGUK SCAFFOLDING PROTEINS | EXCITATORY SYNAPSES | TRAFFICKING | NMDA RECEPTOR SUBUNITS | EXPRESSION | NEUROSCIENCES | Disks Large Homolog 4 Protein | Embryo, Mammalian | Microscopy, Electron, Transmission - methods | Lentivirus - physiology | Male | Neurons - cytology | Green Fluorescent Proteins - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Transfection - methods | Female | Membrane Proteins - metabolism | Post-Synaptic Density - metabolism | RNA Interference - physiology | Intracellular Signaling Peptides and Proteins - genetics | Receptors, AMPA - metabolism | Membrane Proteins - genetics | Synapses - physiology | Rats | Synapses - ultrastructure | Post-Synaptic Density - ultrastructure | Cytoskeleton - ultrastructure | Receptors, AMPA - ultrastructure | Hippocampus - cytology | Immunohistochemistry - methods | Animals | Models, Biological | Cytoskeleton - metabolism
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8. Full Text Structural and Molecular Remodeling of Dendritic Spine Substructures during Long-Term Potentiation
by Bosch, Miquel and Castro, Jorge and Saneyoshi, Takeo and Matsuno, Hitomi and Sur, Mriganka and Hayashi, Yasunori
Neuron, ISSN 0896-6273, 04/2014, Volume 82, Issue 2, pp. 444 - 459
Synapses store information by long-lasting modifications of their structure and molecular composition, but the precise chronology of these changes has not been... 
CAMKII | F-ACTIN | SINGLE SYNAPSES | AMPA RECEPTOR TRAFFICKING | MEDIATED ACTIN DYNAMICS | LTP | SYNAPTIC PLASTICITY | NEUROSCIENCES | POSTSYNAPTIC DENSITY | PROTEIN-KINASE-II | COFILIN | Animals, Newborn | Transduction, Genetic | Glutamic Acid - pharmacology | Synapses - physiology | Humans | Cells, Cultured | Dendritic Spines - physiology | Rats | Synapses - ultrastructure | Post-Synaptic Density - ultrastructure | Synapses - genetics | Hippocampus - cytology | Nerve Tissue Proteins - metabolism | Animals | Neurons - ultrastructure | Models, Biological | Long-Term Potentiation - physiology | Luminescent Proteins - genetics | Mice | Receptors, Neurotransmitter - metabolism | Post-Synaptic Density - metabolism | Organ Culture Techniques | Dendritic Spines - ultrastructure | Luminescent Proteins - metabolism | Muscle proteins | Protein biosynthesis | Neurosciences | Proteins | Signal transduction | Kinases | Neurons | Experiments
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9. Full Text Balance and Stability of Synaptic Structures during Synaptic Plasticity
by Meyer, Daniel and Bonhoeffer, Tobias and Scheuss, Volker
Neuron, ISSN 0896-6273, 04/2014, Volume 82, Issue 2, pp. 430 - 443
Subsynaptic structures such as bouton, active zone, postsynaptic density (PSD) and dendritic spine, are highly correlated in their dimensions and also... 
LEARNING RULES | HIPPOCAMPAL SLICES | POSTSYNAPTIC DENSITY PROTEINS | FUNCTIONAL PLASTICITY | EXCITATORY SYNAPSES | LONG-TERM POTENTIATION | DENTATE GYRUS | NEUROSCIENCES | SINGLE DENDRITIC SPINES | N-CADHERIN | MORPHOLOGICAL-CHANGES | Disks Large Homolog 4 Protein | CA1 Region, Hippocampal - cytology | Rats, Wistar | Neuronal Plasticity - drug effects | Neurons - cytology | Dendritic Spines - metabolism | Green Fluorescent Proteins - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Neuronal Plasticity - physiology | Synapses - metabolism | Time Factors | Homer Scaffolding Proteins | Neurons - physiology | Membrane Proteins - metabolism | Post-Synaptic Density - metabolism | Neurons - drug effects | Intracellular Signaling Peptides and Proteins - genetics | Organ Culture Techniques | Plant Lectins - genetics | Animals, Newborn | Green Fluorescent Proteins - metabolism | Transduction, Genetic | Glutamic Acid - pharmacology | Membrane Proteins - genetics | Synapses - physiology | Rats | Synapses - ultrastructure | Animals | Carrier Proteins - metabolism | Plant Lectins - metabolism | Dendritic Spines - ultrastructure | Proteins | Glutamate | Studies | Microscopy | Neurons | Experiments
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10. Full Text Local palmitoylation cycles define activity-regulated postsynaptic subdomains
by Fukata, Yuko and Dimitrov, Ariane and Boncompain, Gaelle and Vielemeyer, Ole and Perez, Franck and Fukata, Masaki
Journal of Cell Biology, ISSN 0021-9525, 2013, Volume 202, Issue 1, pp. 145 - 161
Distinct PSD-95 clusters are primary landmarks of postsynaptic densities (PSDs), which are specialized membrane regions for synapses. However, the mechanism... 
DENSITY | GLUTAMATE RECEPTORS | AMPA RECEPTORS | NEURONAL DEVELOPMENT | MAGUK SCAFFOLDING PROTEINS | IN-VIVO | RECOMBINANT ANTIBODIES | NEUROLIGINS | FLUORESCENT PROTEINS | PSD-95 | CELL BIOLOGY | Disks Large Homolog 4 Protein | Green Fluorescent Proteins - metabolism | Lipoylation | Humans | Cercopithecus aethiops | Fluorescent Dyes - metabolism | Rats | Dendritic Spines - metabolism | Structure-Activity Relationship | Synaptic Transmission | Hippocampus - metabolism | Animals | Transfection | Dendritic Spines - drug effects | Neuronal Plasticity | Palmitates - pharmacology | Sensitivity and Specificity | HEK293 Cells | Guanylate Kinases - metabolism | Membrane Proteins - metabolism | Mice | Neurons - metabolism | Post-Synaptic Density - metabolism | COS Cells | Physiological aspects | Cell membranes | Research | Synapses | Cell cycle
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11. Full Text Autism-associated mutations in ProSAP2/Shank3 impair synaptic transmission and neurexin-neuroligin-mediated transsynaptic signaling
by Arons, Magali H and Thynne, Charlotte J and Grabrucker, Andreas M and Li, Dong and Schoen, Michael and Cheyne, Juliette E and Boeckers, Tobias M and Montgomery, Johanna M and Garner, Craig C
Journal of Neuroscience, ISSN 0270-6474, 10/2012, Volume 32, Issue 43, pp. 14966 - 14978
Mutations in several postsynaptic proteins have recently been implicated in the molecular pathogenesis of autism and autism spectrum disorders (ASDs),... 
ACTIVE ZONE | PROTEIN | MENTAL-RETARDATION | SPECTRUM DISORDER | GLUTAMATE | DENDRITIC SPINE MORPHOLOGY | CELL-ADHESION | SHANK3 | NEUROSCIENCES | POSTSYNAPTIC DENSITY | MOLECULAR-MECHANISMS | Cadherins - metabolism | Rats, Wistar | Synaptic Transmission - genetics | Embryo, Mammalian | Humans | Male | Green Fluorescent Proteins - genetics | Excitatory Postsynaptic Potentials - drug effects | Post-Synaptic Density - genetics | Transfection | Neurons - physiology | 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology | Female | Cell Adhesion Molecules, Neuronal - metabolism | Post-Synaptic Density - drug effects | Post-Synaptic Density - metabolism | Excitatory Postsynaptic Potentials - genetics | Signal Transduction | Vesicular Glutamate Transport Protein 1 - metabolism | Cells, Cultured | Rats | Excitatory Amino Acid Antagonists - pharmacology | Hippocampus - cytology | Mutation - genetics | Nerve Tissue Proteins - genetics | Cell Adhesion Molecules, Neuronal - genetics | Nerve Tissue Proteins - metabolism | Carrier Proteins - genetics | Patch-Clamp Techniques | Animals | Carrier Proteins - metabolism | Analysis of Variance | Quaternary Ammonium Compounds - metabolism | RNA, Small Interfering | Dizocilpine Maleate - pharmacology | Pyridinium Compounds - metabolism
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12. Full Text Nanoscale molecular reorganization of the inhibitory postsynaptic density is a determinant of gabaergic synaptic potentiation
by Pennacchietti, Francesca and Vascon, Sebastiano and Nieus, Thierry and Rosillo, Christian and Das, Sabyasachi and Tyagarajan, Shiva K and Diaspro, Alberto and del Bue, Alessio and Petrini, Enrica Maria and Barberis, Andrea and Zanacchi, Francesca Cella
Journal of Neuroscience, ISSN 0270-6474, 02/2017, Volume 37, Issue 7, pp. 1747 - 1756
Gephyrin is a key scaffold protein mediating the anchoring of GABAA receptors at inhibitory synapses. Here, we exploited superresolution techniques combined... 
STORM | PALM | Plasticity | Model simulations | Clustering | Gephyrin | GABAA receptors | STATES | SUPERRESOLUTION MICROSCOPY | plasticity | gephyrin | NEUROSCIENCES | RESPONSES | model simulations | AMPA RECEPTORS | SYNAPSES | clustering | PROTEINS | Male | Long-Term Synaptic Depression - drug effects | N-Methylaspartate - pharmacology | Peptides - metabolism | GABAergic Neurons - cytology | Computer Simulation | 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology | Female | Membrane Proteins - metabolism | Post-Synaptic Density - drug effects | Post-Synaptic Density - metabolism | Long-Term Synaptic Depression - physiology | Mice, Inbred C57BL | Valine - analogs & derivatives | Cells, Cultured | GABAergic Neurons - drug effects | Excitatory Amino Acid Agonists - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Hippocampus - cytology | Algorithms | Animals | Carrier Proteins - metabolism | Mice | Receptors, GABA-A - metabolism | Models, Neurological | Valine - pharmacology
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13. Full Text Loss of predominant shank3 isoforms results in hippocampus-dependent impairments in behavior and synaptic transmission
by Kouser, Mehreen and Speed, Haley E and Dewey, Colleen M and Reimers, Jeremy M and Widman, Allie J and Gupta, Natasha and Liu, Shunan and Jaramillo, Thomas C and Bangash, Muhammad and Xiao, Bo and Worley, Paul F and Powell, Craig M
Journal of Neuroscience, ISSN 0270-6474, 2013, Volume 33, Issue 47, pp. 18448 - 18468
The Shank3 gene encodes a scaffolding protein that anchors multiple elements of the postsynaptic density at the synapse. Previous attempts to delete the Shank3... 
GENE | SOCIAL-INTERACTION | SCAFFOLDING PROTEIN SHANK3 | MUTATIONS | RIM1-ALPHA | EXPRESSION | NEUROSCIENCES | MICE LACKING | FAMILY | HAPLOINSUFFICIENCY | CHILDREN | Locomotion - genetics | Synaptic Transmission - physiology | Synaptic Transmission - genetics | Male | Reflex, Startle - genetics | Synaptosomes - metabolism | Behavioral Symptoms - metabolism | Psychomotor Performance - physiology | Post-Synaptic Density - genetics | Exploratory Behavior - physiology | Protein Isoforms - metabolism | Adaptation, Physiological - genetics | Behavioral Symptoms - pathology | Post-Synaptic Density - metabolism | Mice, Inbred C57BL | Mice, Transgenic | Hippocampus - pathology | Mutation - genetics | Receptor, Metabotropic Glutamate 5 - metabolism | Nerve Tissue Proteins - genetics | Synaptosomes - ultrastructure | Nerve Tissue Proteins - metabolism | Hippocampus - metabolism | Motor Activity - genetics | Behavioral Symptoms - genetics | Animals | Maze Learning | Mice | Protein Isoforms - genetics
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14. Full Text Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice
by Vicidomini, C and Ponzoni, L and Lim, D and Schmeisser, M.J and Reim, D and Morello, N and Orellana, D and Tozzi, A and Durante, V and Scalmani, P and Mantegazza, M and Genazzani, A.A and Giustetto, M and Sala, M and Calabresi, P and Boeckers, T.M and Sala, C and