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Nature Neuroscience, ISSN 1097-6256, 11/2012, Volume 15, Issue 11, pp. 1488 - 1497
FUS/TLS (fused in sarcoma/translocated in liposarcoma) and TDP-43 are integrally involved in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia.... 
NEURODEGENERATIVE DISEASE | GENE | AMYOTROPHIC-LATERAL-SCLEROSIS | FAMILY PROTEINS | FUS PATHOLOGY | MUTATIONS | FRONTOTEMPORAL LOBAR DEGENERATION | BINDING | NEUROSCIENCES | BRAIN | NASCENT TRANSCRIPTION | RNA, Small Interfering - genetics | Protein Binding - genetics | Oligonucleotide Array Sequence Analysis | Humans | tau Proteins - metabolism | Gene Expression Profiling | RNA, Messenger - metabolism | Kv Channel-Interacting Proteins - metabolism | Brain - metabolism | Frontotemporal Dementia - metabolism | RNA Splicing - genetics | Frontotemporal Dementia - genetics | RNA-Binding Protein FUS - deficiency | Amyotrophic Lateral Sclerosis - genetics | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | RNA-Binding Protein FUS - genetics | Mice, Knockout | Motor Neurons - metabolism | Amyotrophic Lateral Sclerosis - pathology | Shal Potassium Channels - metabolism | Brain - pathology | Mice | Neurofilament Proteins - metabolism | RNA, Small Interfering - metabolism | Immunoprecipitation | Spinal Cord - metabolism | DNA-Binding Proteins - deficiency | DNA-Binding Proteins - metabolism | tau Proteins - genetics | Cell Cycle Proteins - genetics | Female | RNA Precursors - metabolism | Excitatory Amino Acid Transporter 2 - genetics | Membrane Proteins - metabolism | Frontotemporal Dementia - pathology | Gene Expression Regulation - genetics | Mice, Inbred C57BL | RNA, Messenger - genetics | RNA Precursors - genetics | Protein Structure, Tertiary - genetics | RNA-Binding Protein FUS - metabolism | DNA-Binding Proteins - genetics | Excitatory Amino Acid Transporter 2 - metabolism | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Histone-Lysine N-Methyltransferase - metabolism | Amyotrophic Lateral Sclerosis - metabolism | Neural Cell Adhesion Molecules - metabolism | Neural Stem Cells - metabolism | Cell Line, Transformed | Amyotrophic lateral sclerosis | Development and progression | Genetic aspects | Messenger RNA | Health aspects | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2011, Volume 6, Issue 9, pp. e25178 - e25178
Imbalance of the excitatory neurotransmitter glutamate and of the inhibitory neurotransmitter GABA is one of several causes of seizures. ATP has also been... 
HIPPOCAMPAL SLICES | ADENOSINE KINASE | P2X RECEPTOR | HEMICHANNELS | BIOLOGY | ASTROCYTE PROGENITORS | CENTRAL-NERVOUS-SYSTEM | RAT HIPPOCAMPUS | CHANNELS | CELL-CELL COMMUNICATION | ATP RELEASE | Potassium - metabolism | Seizures - prevention & control | Connexins - physiology | Epilepsy - metabolism | Neurons - cytology | Seizures - metabolism | Seizures - chemically induced | Brain - metabolism | Adenosine Triphosphate - metabolism | Behavior, Animal - drug effects | Neurons - metabolism | Astrocytes - cytology | Epilepsy - prevention & control | Brain - cytology | Nerve Tissue Proteins - physiology | Kainic Acid - pharmacology | Mice, Inbred C57BL | Cells, Cultured | Mice, Transgenic | Hippocampus - cytology | Blotting, Western | Hippocampus - metabolism | Animals | Epilepsy - chemically induced | Fluorescent Antibody Technique | Mice | Status Epilepticus - metabolism | Astrocytes - metabolism | Brain | Neurons | Epilepsy | GABA | Genetic engineering | Seizures (Medicine) | Glutamate | Neurosciences | Hyperactivity | Nervous system | Membrane channels | Channels | γ-Aminobutyric acid | Membrane conductance | Metabolites | Rodents | Cooperation | Physiology | Seizures | Seizing | Adenosine | Astrocytes | Transgenic mice | Pharmacology | Metabolism | Embryos | Resistance | Medicine | Signaling | Conductance | ATP | Kainic acid | Hippocampus | Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 10/2008, Volume 32, Issue 2, pp. 169 - 179
Elevated catecholamines in the heart evoke transcriptional activation of the Myocyte Enhancer Factor (MEF) pathway to induce a cellular response known as... 
HUMDISEASE | SIGNALING | COMPLEX | DEPENDENT REGULATION | PROTEIN-KINASE-D | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEART-FAILURE | NUCLEAR EXPORT | LONG-QT SYNDROME | CELLULAR-LOCALIZATION | HISTONE DEACETYLASE-5 | POTASSIUM CHANNEL | CELL BIOLOGY | Guanine Nucleotide Exchange Factors - physiology | Phosphorylation | Minor Histocompatibility Antigens | Humans | Cercopithecus aethiops | A Kinase Anchor Proteins - genetics | A Kinase Anchor Proteins - physiology | Phenylephrine - pharmacology | RNA Interference | Guanine Nucleotide Exchange Factors - metabolism | Protein Kinase C - metabolism | Active Transport, Cell Nucleus | A Kinase Anchor Proteins - metabolism | MEF2 Transcription Factors | Cyclic AMP-Dependent Protein Kinases - metabolism | Proto-Oncogene Proteins - metabolism | Cell Line | Guanine Nucleotide Exchange Factors - genetics | Signal Transduction | Gene Expression Regulation | Myogenic Regulatory Factors - metabolism | Rats | Histone Deacetylases - metabolism | Proto-Oncogene Proteins - genetics | 14-3-3 Proteins - metabolism | Myocytes, Cardiac - pathology | Animals | Myocytes, Cardiac - drug effects | Models, Biological | Proto-Oncogene Proteins - physiology | Myocytes, Cardiac - metabolism | COS Cells | Cardiomegaly - metabolism | Heart Ventricles - drug effects | Proteins | Catecholamines | RNA | Cardiology | Heart enlargement | Protein kinases | Index Medicus
Journal Article
Glia, ISSN 0894-1491, 10/2018, Volume 66, Issue 10, pp. 2233 - 2245
Astrocytes are a glial cell type, which is indispensable for brain energy metabolism. Within cells, the NADH/NAD + redox state is a crucial node in metabolism... 
NBCe1 | redox state | Peredox | astrocyte | NADH/NAD | OXIDATIVE-PHOSPHORYLATION | HIPPOCAMPAL SLICES | NAD(+)/NADH RATIO | NICOTINAMIDE-ADENINE DINUCLEOTIDE | GLUCOSE-UTILIZATION | EXTRACELLULAR K | NEUROSCIENCES | NADH/NAD(+) redox state | AEROBIC GLYCOLYSIS | BRAIN METABOLISM | ENERGY-METABOLISM | NAD(P)H FLUORESCENCE TRANSIENTS | L-Lactate Dehydrogenase - metabolism | Potassium - metabolism | Adenosine Triphosphate - administration & dosage | Oxidation-Reduction | Tissue Culture Techniques | Lactic Acid - metabolism | Mice, Inbred C57BL | Cells, Cultured | Cerebral Cortex - metabolism | Receptors, Purinergic - metabolism | Sodium-Bicarbonate Symporters - metabolism | Extracellular Space - metabolism | Glutamic Acid - administration & dosage | Animals | Adenosine Triphosphate - metabolism | Intracellular Space - metabolism | Cytosol - metabolism | Glutamic Acid - metabolism | Neurons - metabolism | NAD - metabolism | Astrocytes - metabolism | Neurons | Brain | Energy metabolism | Phosphorylation | Purine receptors | Brain slice preparation | Bicarbonates | Neuronal-glial interactions | Bicarbonate | Heterogeneity | Genetic code | Mitochondria | Receptors | NADH | Coding | Inhibition | Redox properties | Astrocytes | Cortex | Lactate dehydrogenase | Calibration | Metabolism | L-Lactate dehydrogenase | NAD | Neurotransmitters | Oxidative phosphorylation | Sodium | Nicotinamide adenine dinucleotide | Energy demand | Lactic acid | ATP | Potassium | Index Medicus
Journal Article
Cardiovascular Research, ISSN 0008-6363, 07/2013, Volume 99, Issue 1, pp. 164 - 174
Nucleotide-binding oligomerization domain-Like Receptor with a Pyrin domain 3 (NLRP3) is considered necessary for initiating a profound sterile inflammatory... 
Heart | Myocardial infarction | Inflammasome | Ischaemia-reperfusion | IL-1β | Potassium - metabolism | Up-Regulation | Inflammasomes - metabolism | Cytoskeletal Proteins - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Caspase 1 - metabolism | Male | NF-kappa B - metabolism | Interleukin-1beta - genetics | RNA, Messenger - metabolism | Myocardial Reperfusion Injury - pathology | Time Factors | Interleukin-1beta - metabolism | Adenosine Triphosphate - metabolism | Myocardial Infarction - physiopathology | Toll-Like Receptors - metabolism | Myocardial Reperfusion Injury - genetics | Disease Models, Animal | Fibroblasts - metabolism | Myocardial Reperfusion Injury - immunology | Rats | Receptors, Cytoplasmic and Nuclear - genetics | Myocardial Infarction - metabolism | Myocardial Reperfusion Injury - physiopathology | Mice, Knockout | Fibroblasts - drug effects | Lipopolysaccharides - pharmacology | Fibroblasts - immunology | Heart Ventricles - metabolism | Mice | Interleukin-18 - genetics | Interleukin-18 - metabolism | Myocardial Reperfusion Injury - prevention & control | Heart Ventricles - drug effects | Receptors, Cytoplasmic and Nuclear - metabolism | Myocardial Infarction - genetics | Rats, Wistar | Ventricular Function, Left | Heart Ventricles - immunology | Myocardial Infarction - immunology | Cytoskeletal Proteins - deficiency | Myocardial Infarction - pathology | Heart Ventricles - pathology | Myocardial Contraction | Mice, Inbred C57BL | Cells, Cultured | Inflammasomes - genetics | Carrier Proteins - genetics | Myocardial Reperfusion Injury - metabolism | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Heart Ventricles - physiopathology | CARD Signaling Adaptor Proteins | Apoptosis | Index Medicus
Journal Article
PLoS Pathogens, ISSN 1553-7366, 08/2009, Volume 5, Issue 8, pp. e1000559 - e1000559
The intraerythrocytic parasite Plasmodium-the causative agent of malaria-produces an inorganic crystal called hemozoin (Hz) during the heme detoxification... 
APOPTOSIS | INNATE IMMUNE RECEPTORS | INTERLEUKIN-1-BETA | MACROPHAGES | CASPASE-1 INFLAMMASOME | MICROBIOLOGY | KAPPA-B | NALP3 INFLAMMASOME | RESPONSES | VIROLOGY | IN-VIVO | MICE | PARASITOLOGY | Potassium - metabolism | Reactive Oxygen Species - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Protein-Tyrosine Kinases - metabolism | Humans | Caspase 1 - metabolism | Male | Caspase 1 - immunology | Intracellular Signaling Peptides and Proteins - metabolism | Hemeproteins - immunology | Signal Transduction - immunology | Calcium-Binding Proteins - immunology | Interleukin-1beta - metabolism | src-Family Kinases - metabolism | Cytoskeletal Proteins - metabolism | Female | Interleukin-1beta - biosynthesis | Phosphorylation - immunology | Malaria - metabolism | Syk Kinase | Carrier Proteins - immunology | Disease Models, Animal | Neutrophil Infiltration - immunology | Calcium-Binding Proteins - metabolism | Carrier Proteins - physiology | Apoptosis Regulatory Proteins - immunology | Plasmodium chabaudi - chemistry | Hemeproteins - metabolism | Malaria - immunology | Mice, Inbred C57BL | Cathepsin B - metabolism | Inflammation - immunology | Plasmodium chabaudi - metabolism | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Animals | Carrier Proteins - metabolism | Cytoskeletal Proteins - immunology | CARD Signaling Adaptor Proteins | Malaria - parasitology | Proteomics | HSP90 Heat-Shock Proteins - metabolism | Hemeproteins - physiology | Mice | Phagocytosis | Hostages | Inflammation | Malaria | Phosphotransferases | Index Medicus | Medical research | Salmonella | Phosphorylation | Lipids | Parasites | Experiments | Fever | Tropical diseases
Journal Article
Neuron, ISSN 0896-6273, 01/2015, Volume 85, Issue 2, pp. 346 - 363
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2007, Volume 282, Issue 26, pp. 18810 - 18818
Interleukin-1β (IL-1β) is a pro-inflammatory cytokine that plays an important role in host defense and inflammatory diseases. The maturation and secretion of... 
LISTERIA-MONOCYTOGENES | IL-1-BETA-CONVERTING ENZYME | IL-1-BETA SECRETION | MICE DEFICIENT | P2X RECEPTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | RELEASE | MATURATION | HUMAN MONOCYTES | ATP | INTERLEUKIN-1-BETA CONVERTING-ENZYME | Potassium - metabolism | Escherichia coli Infections - physiopathology | Lipopolysaccharides - metabolism | Caspase 1 - metabolism | Salmonella Infections - metabolism | Salmonella Infections - physiopathology | Salmonella typhimurium | Adenosine Triphosphate - pharmacology | Flagellin - pharmacology | Extracellular Space - metabolism | Mice, Mutant Strains | Adenosine Triphosphate - metabolism | Receptors, Purinergic P2 - genetics | Flagellin - metabolism | Macrophages - microbiology | Staphylococcus aureus | Staphylococcal Infections - metabolism | Calcium-Binding Proteins - metabolism | Listeriosis - metabolism | Escherichia coli Infections - metabolism | Apoptosis Regulatory Proteins - metabolism | Bacterial Infections - physiopathology | Receptors, Purinergic P2X7 | Macrophages - metabolism | Animals | Extracellular Space - microbiology | Listeriosis - physiopathology | Receptors, Purinergic P2 - metabolism | Lipopolysaccharides - pharmacology | Staphylococcal Infections - physiopathology | Cytosol - metabolism | Macrophages - drug effects | Cytosol - microbiology | Mice | Bacterial Infections - metabolism | Index Medicus
Journal Article