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Current medicinal chemistry, ISSN 0929-8673, 04/2013, Volume 20, Issue 10, pp. 1241 - 1285
... are: sleep disorders, anxiety, epilepsy, pain, etc. However, traditional channel blockers have multiple adverse events, mainly due to low specificity of mechanism of action... 
ASIC | TRP | Central nervous system | P2X | KCNQ | NMDA | CNS | Ion channels | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | GATED SODIUM-CHANNELS | SUBTYPE-SELECTIVE AGONIST | D-ASPARTATE RECEPTOR | ion channels | ACID-SENSING ION-CHANNEL-1 | central nervous system | GLYCINE ANTAGONIST GV150526 | TARANTULA TOXIN PSALMOTOXIN-1 | TRAUMATIC BRAIN-INJURY | ISCHEMIC CELL-DEATH | PHARMACOLOGY & PHARMACY | PERIPHERAL NEUROPATHIC PAIN | TRANSGENIC MOUSE MODEL | Ligand-Gated Ion Channels - antagonists & inhibitors | Transient Receptor Potential Channels - antagonists & inhibitors | Calcium Channels - metabolism | Humans | Calcium Channel Blockers - therapeutic use | Potassium Channel Blockers - therapeutic use | Sodium Channel Blockers - pharmacology | Calcium Channel Blockers - pharmacology | Ion Channels - antagonists & inhibitors | Potassium Channels - metabolism | Animals | Ion Channels - metabolism | Sodium Channels - chemistry | Calcium Channels - chemistry | Central Nervous System Diseases - drug therapy | Sodium Channels - metabolism | Calcium Channel Blockers - chemistry | Sodium Channel Blockers - therapeutic use | Potassium Channels - chemistry | Sodium Channel Blockers - chemistry | Transient Receptor Potential Channels - metabolism | Ligand-Gated Ion Channels - metabolism | Potassium Channel Blockers - chemistry | Potassium Channel Blockers - pharmacology
Journal Article
Journal Article
Journal Article
Journal Article
The Journal of neuroscience, ISSN 1529-2401, 2004, Volume 24, Issue 26, pp. 5922 - 5930
... channel agonist veratridine. The survival promoting effect of veratridine was reproduced by, but independent of, glial cell line-derived neurotrophic factor... 
Excitability | GDNF | Sodium | Channel | Trophic | Dopaminergic | TYROSINE-HYDROXYLASE | POTASSIUM CHANNELS | NEUROTROPHIC FACTOR | channel | trophic | NEUROSCIENCES | sodium | CYCLIC-AMP | excitability | CALCIUM-CHANNELS | SIGNALING PATHWAY | MEMBRANE-PROPERTIES | CENTRAL-NERVOUS-SYSTEM | dopaminergic | SMALL-CONDUCTANCE | PARKINSONS-DISEASE | Mesencephalon - cytology | Sodium-Potassium-Exchanging ATPase - physiology | Rats, Wistar | Apoptosis - drug effects | gamma-Aminobutyric Acid - metabolism | Cells, Cultured - cytology | Neurons - cytology | Sodium Channels - physiology | Apamin - pharmacology | Nerve Growth Factors - pharmacology | Neuroprotective Agents - pharmacology | Glial Cell Line-Derived Neurotrophic Factor | Ion Transport - drug effects | Neurons - metabolism | Aspirin - pharmacology | Tetrodotoxin - pharmacology | Neurons - drug effects | Dopamine - metabolism | Ouabain - pharmacology | Potassium Channel Blockers - pharmacology | Sodium - pharmacology | Cells, Cultured - drug effects | Nerve Tissue Proteins - physiology | Nifedipine - pharmacology | Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors | Biological Transport, Active - drug effects | Rats | Sodium Channel Blockers - pharmacology | Sodium Channels - drug effects | Calcium Channel Blockers - pharmacology | Nerve Tissue Proteins - drug effects | Veratridine - pharmacology | Scorpion Venoms - pharmacology | Animals | Calcium Channels, T-Type - drug effects | Serotonin - metabolism | Calcium Channel Agonists - pharmacology | Cells, Cultured - metabolism | Potassium Channels, Calcium-Activated - antagonists & inhibitors | Ion Channel Gating | Sodium - physiology | Tetrodotoxin | Neuroprotective Agents | Veratridine | Mesencephalon | Neurons and Cognition | Ouabain | Calcium Channel Agonists | Calcium Channels, T-Type | Potassium Channels, Calcium-Activated | Life Sciences | Biological Transport, Active | Sodium-Potassium-Exchanging ATPase | Ion Transport | Potassium Channel Blockers | gamma-Aminobutyric Acid | Aspirin | Apamin | Dopamine | Serotonin | Neurons | Sodium Channels | Cells, Cultured | Nerve Tissue Proteins | Nifedipine | Scorpion Venoms | Calcium Channel Blockers | Nerve Growth Factors | Sodium Channel Blockers | Apoptosis | Plasticity | Development | Repair
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 01/2020, Volume 10, Issue 1, pp. 52 - 9
4-Aminopyridine (4AP) is a specific blocker of voltage-gated potassium channels (K(V)1 family) clinically approved for the symptomatic treatment of patients with multiple sclerosis... 
RESTORES AXONAL CONDUCTION | IMPROVES CLINICAL SIGNS | LOCALIZATION | POTASSIUM CHANNELS | FAMPRIDINE | MULTIDISCIPLINARY SCIENCES | SENSITIVITY | SPINAL-CORD | ION CHANNELS | SHIVERER | AMINOPYRIDINES | Animal models | Multiple sclerosis | Potassium channels (voltage-gated) | Potassium | Physicochemical properties
Journal Article
Circulation (New York, N.Y.), ISSN 0009-7322, 2012, Volume 125, Issue 16, pp. 1988 - +
Journal Article
FEBS letters, ISSN 0014-5793, 2012, Volume 586, Issue 22, pp. 3996 - 4001
► ShK is a potent blocker of potassium channels. ► A new ShK analogue with a C-terminal Lys residue and amide was designed... 
Electrophysiology | Potential of mean force | Potassium channel | Umbrella sampling | C-terminal amide | ShK | ShK with a C-terminal Lys and amide | effector memory T-cells | ShK-K-amide | PMF | voltage-gated K+ channel | molecular dynamics | potential of mean force | K+ channel toxin from Stichodactyla helianthus | ShK-amide | TEM | C-terminally amidated ShK | MOLECULAR-DYNAMICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SEA-ANEMONE TOXIN | PEPTIDE | CELL BIOLOGY | BIOPHYSICS | AUTOIMMUNE-DISEASES | STICHODACTYLA-HELIANTHUS | RAT-BRAIN | INHIBITOR | MEMORY T-CELLS | FREE-ENERGY | K+ CHANNELS | Kv1.1 Potassium Channel - metabolism | Humans | Cnidarian Venoms - metabolism | Kv1.3 Potassium Channel - genetics | Cnidarian Venoms - pharmacology | Potassium Channel Blockers - metabolism | Kv1.1 Potassium Channel - physiology | Dose-Response Relationship, Drug | Ion Channel Gating - physiology | T-Lymphocytes - drug effects | Kv1.3 Potassium Channel - metabolism | Binding Sites | Potassium Channel Blockers - pharmacology | Binding, Competitive | Kv1.1 Potassium Channel - genetics | Protein Structure, Tertiary | Cells, Cultured | Models, Molecular | Kv1.3 Potassium Channel - physiology | Molecular Dynamics Simulation | Cnidarian Venoms - chemistry | Patch-Clamp Techniques | Algorithms | Animals | Ion Channel Gating - genetics | T-Lymphocytes - cytology | Amides - chemistry | Cell Line, Tumor | Protein Binding | Cell Proliferation - drug effects | Mice | Potassium Channel Blockers - chemistry | Ion Channel Gating - drug effects | Potassium channels | Peptides | T cells | Analysis | potassium channel | umbrella sampling | electrophysiology
Journal Article
British journal of pharmacology, ISSN 0007-1188, 11/2006, Volume 149, Issue 5, pp. 560 - 572
Background and purpose: The present study investigated whether calcium‐activated K+ channels are involved in acetylcholine... 
K+ channels | endothelium | superior mesenteric artery | nitric oxide | acetylcholine | CA2+ ENTRY | RESISTANCE ARTERIES | ENDOTHELIUM-DEPENDENT HYPERPOLARIZATION | PORCINE CORONARY-ARTERIES | ACTIVATED POTASSIUM CHANNELS | VASCULAR SMOOTH-MUSCLE | FACTOR-MEDIATED RESPONSES | RABBIT ARTERIES | CARBON-MONOXIDE | PHARMACOLOGY & PHARMACY | HYDROGEN-PEROXIDE | Rats, Wistar | Calcium - metabolism | Endothelium, Vascular - drug effects | Male | Penicillamine - analogs & derivatives | Apamin - pharmacology | Arginine - analogs & derivatives | Endothelium, Vascular - physiology | Dose-Response Relationship, Drug | Charybdotoxin - pharmacology | Indoles - pharmacology | Vasodilation - physiology | Potassium Channels, Calcium-Activated - physiology | Vasodilator Agents - pharmacology | Acetylcholine - pharmacology | Chlorides - pharmacology | Penicillamine - pharmacology | Rats | Imidazoles - pharmacology | Oxyhemoglobins - pharmacology | Indomethacin - pharmacology | Mesenteric Artery, Superior - drug effects | Mesenteric Artery, Superior - physiology | Barium Compounds - pharmacology | Nitric Oxide - secretion | Animals | Mesenteric Artery, Superior - metabolism | Endothelium, Vascular - metabolism | Arginine - pharmacology | Benzimidazoles - pharmacology | Potassium Channels, Calcium-Activated - antagonists & inhibitors | Vasodilation - drug effects | In Vitro Techniques | Nitric Oxide - metabolism | Research Papers
Journal Article