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The FEBS Journal, ISSN 1742-464X, 06/2015, Volume 282, Issue 12, pp. 2247 - 2259
The voltage‐gated potassium channel Kv1.3 is an important target for the treatment of autoimmune diseases and asthma. Blockade of Kv1.3 by the sea anemone... 
electrophysiology | molecular dynamics | N‐terminal extension | potassium channels | ShK | Electrophysiology | Molecular dynamics | Potassium channels | N-terminal extension | RHEUMATOID-ARTHRITIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SEA-ANEMONE TOXIN | SHK TOXIN | MULTIPLE-SCLEROSIS | AUTOIMMUNE-DISEASES | THERAPEUTIC TARGETS | FORCE-FIELD | INHIBITOR | MEMORY T-CELLS | LYMPHOCYTES | Recombinant Fusion Proteins - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Neurotoxins - genetics | Isoenzymes - chemistry | Structure-Activity Relationship | Cnidarian Venoms | Kv1.3 Potassium Channel - genetics | Potassium Channel Blockers - metabolism | Recombinant Fusion Proteins - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Mutant Proteins - pharmacology | Sea Anemones | Kv1.3 Potassium Channel - chemistry | Isoenzymes - metabolism | Drug Design | Kv1.3 Potassium Channel - metabolism | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Binding Sites | Oligopeptides - chemistry | Potassium Channel Blockers - pharmacology | Recombinant Proteins - metabolism | Cell Line | Neurotoxins - chemistry | Oligopeptides - genetics | Models, Molecular | Recombinant Proteins - chemistry | Mutant Proteins - metabolism | Recombinant Proteins - genetics | Kv1.3 Potassium Channel - antagonists & inhibitors | Oligopeptides - metabolism | Recombinant Fusion Proteins - chemistry | Molecular Dynamics Simulation | Neurotoxins - pharmacology | Patch-Clamp Techniques | Animals | Mutant Proteins - chemistry | Neurotoxins - metabolism | Protein Conformation | Mice | Kinetics | Oligopeptides - pharmacology | Isoenzymes - antagonists & inhibitors | Potassium Channel Blockers - chemistry | Proteins | Amino acids | Toxins | Autoimmune diseases | Lymphocytes | Asthma
Journal Article
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 11/2014, Volume 96, Issue 5, pp. 549 - 558
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 04/2013, Volume 20, Issue 10, pp. 1241 - 1285
Ion channel targeted drugs have always been related with either the central nervous system (CNS), the peripheral nervous system, or the cardiovascular system.... 
ASIC | TRP | Central nervous system | P2X | KCNQ | NMDA | CNS | Ion channels | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | GATED SODIUM-CHANNELS | SUBTYPE-SELECTIVE AGONIST | D-ASPARTATE RECEPTOR | ion channels | ACID-SENSING ION-CHANNEL-1 | central nervous system | GLYCINE ANTAGONIST GV150526 | TARANTULA TOXIN PSALMOTOXIN-1 | TRAUMATIC BRAIN-INJURY | ISCHEMIC CELL-DEATH | PHARMACOLOGY & PHARMACY | PERIPHERAL NEUROPATHIC PAIN | TRANSGENIC MOUSE MODEL | Ligand-Gated Ion Channels - antagonists & inhibitors | Transient Receptor Potential Channels - antagonists & inhibitors | Calcium Channels - metabolism | Humans | Calcium Channel Blockers - therapeutic use | Potassium Channel Blockers - therapeutic use | Sodium Channel Blockers - pharmacology | Calcium Channel Blockers - pharmacology | Ion Channels - antagonists & inhibitors | Potassium Channels - metabolism | Animals | Ion Channels - metabolism | Sodium Channels - chemistry | Calcium Channels - chemistry | Central Nervous System Diseases - drug therapy | Sodium Channels - metabolism | Calcium Channel Blockers - chemistry | Sodium Channel Blockers - therapeutic use | Potassium Channels - chemistry | Sodium Channel Blockers - chemistry | Transient Receptor Potential Channels - metabolism | Ligand-Gated Ion Channels - metabolism | Potassium Channel Blockers - chemistry | Potassium Channel Blockers - pharmacology
Journal Article
Nature Neuroscience, ISSN 1097-6256, 03/2012, Volume 15, Issue 3, pp. 477 - 486
Efforts to study the development and function of the human cerebral cortex in health and disease have been limited by the availability of model systems.... 
SUBTYPE | HUMAN ES | EVOLUTION | NEOCORTICAL NEURONOGENESIS | NEURONS | NEUROGENESIS | SUBVENTRICULAR ZONE | SPECIFICATION | DIFFERENTIATION | MODEL | NEUROSCIENCES | Disks Large Homolog 4 Protein | Embryonic Stem Cells - cytology | Humans | Synaptic Potentials - drug effects | Ki-67 Antigen - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Cerebral Cortex - cytology | Piperidines - pharmacology | Time Factors | 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology | Fetus | Membrane Proteins - metabolism | Tetrodotoxin - pharmacology | Cell Differentiation - physiology | Potassium Channel Blockers - pharmacology | Cell Line | Synapses - drug effects | Synaptic Potentials - physiology | Pluripotent Stem Cells - cytology | Glutamic Acid - pharmacology | Synapses - physiology | Pluripotent Stem Cells - physiology | Cells, Cultured | Gene Expression Regulation, Developmental - drug effects | Sodium Channel Blockers - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Transcription Factors - genetics | Nerve Tissue Proteins - genetics | Embryonic Stem Cells - physiology | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Patch-Clamp Techniques | Cerebral Cortex - embryology | Signal Transduction - drug effects | Cell Differentiation - drug effects | Neurogenesis - physiology | Pluripotent Stem Cells - drug effects | RNA, Messenger | Retinoids - pharmacology | Physiological aspects | Cerebral cortex | Research | Synapses | Stem cells
Journal Article
Journal Article
Journal Article
Toxicological Sciences, ISSN 1096-6080, 03/2017, Volume 156, Issue 1, pp. 25 - 38
Drug-induced proarrhythmia is a major safety issue in drug development. Developing sensitive in vitro assays that can predict drug-induced cardiotoxicity in... 
Drug-induced proarrhythmia | iPSC-CMs | Batch variations | ACTION-POTENTIALS | TORSADES-DE-POINTES | DOFETILIDE | CONTRACTILITY | drug-induced proarrhythmia | PROLONGATION | LONG-QT SYNDROME | VENTRICULAR MYOCYTES | MATURATION | IMPEDANCE |