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Insects, ISSN 2075-4450, 12/2018, Volume 9, Issue 4, p. 155
Potassium channels constitute a very diverse group involved in neural signaling, neuronal activity, membrane potential maintenance, and action potential... 
Anopheles gambiae | Patch-clamp | Toxicity | Fatty acids | Potassium channel | toxicity | fatty acids | MECHANISM | patch-clamp | INSECTICIDE RESISTANCE | PERMETHRIN | ENTOMOLOGY | SYNERGISM | MIXTURES | PROPOXUR | BIOPESTICIDES | potassium channel | K+ CHANNEL | INHIBITOR | BLOCKADE
Journal Article
Journal of Proteome Research, ISSN 1535-3893, 10/2015, Volume 14, Issue 10, pp. 4372 - 4381
Venomous marine cone snails produce a unique and remarkably diverse range of venom peptides (conotoxins and conopeptides) that have proven to be invaluable as... 
transcriptome | intraspecific variation | Conus catus | ω-conotoxin | glycosylation | κA-conotoxin | predatory-evoked venom | GASTROPOD GENUS CONUS | BIOCHEMICAL RESEARCH METHODS | CONSORS VENOM | OMEGA-CONOTOXINS | DISCOVERY | MARINE SNAIL | DUCT TRANSCRIPTOME | kappa A-conotoxin | NERVE-TERMINALS | EVOLUTION | A-SUPERFAMILY | DIVERSITY | omega-conotoxin | Predatory Behavior - physiology | Calcium Channels - metabolism | Conotoxins - isolation & purification | Species Specificity | Potassium Channel Blockers - isolation & purification | Transcriptome | Molecular Sequence Data | Motor Activity - drug effects | Potassium Channels - metabolism | Mollusk Venoms - chemistry | Mollusk Venoms - toxicity | Potassium Channel Blockers - toxicity | Calcium Channel Blockers - isolation & purification | Nicotinic Antagonists - toxicity | Amino Acid Sequence | Nicotinic Antagonists - isolation & purification | Mollusk Venoms - isolation & purification | Receptors, Nicotinic - metabolism | Molecular Sequence Annotation | Conus Snail - physiology | Aquatic Organisms | Conotoxins - chemistry | Conus Snail - chemistry | Calcium Channel Blockers - toxicity | Animals | Nicotinic Antagonists - chemistry | Calcium Channel Blockers - chemistry | Zebrafish - physiology | Potassium Channel Blockers - chemistry | Conotoxins - toxicity | Index Medicus
Journal Article
Molecular Biology and Evolution, ISSN 0737-4038, 2014, Volume 31, Issue 3, pp. 546 - 559
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 08/2017, Volume 329, pp. 309 - 317
Retigabine, currently used as antiepileptic drug, has a wide range of potential medical uses. Administration of the drug in patients can lead to QT interval... 
Cardiac arrhythmia | QT interval | Cardiomyocytes | Ion channels | Retigabine | Sympathetic ganglionic neurons | PHARMACOKINETIC INTERACTION | HEALTHY-SUBJECTS | CARDIAC-ARRHYTHMIAS | EZOGABINE RETIGABINE | PARTIAL-ONSET SEIZURES | PARTIAL EPILEPSY | TORSADE-DE-POINTES | PHARMACOLOGY & PHARMACY | RAT SYMPATHETIC NEURONS | TOXICOLOGY | CHANNEL OPENERS | Ganglionic Blockers - toxicity | Arrhythmias, Cardiac - chemically induced | Humans | Ion Channels - genetics | NAV1.5 Voltage-Gated Sodium Channel - metabolism | Arrhythmias, Cardiac - physiopathology | Dose-Response Relationship, Drug | Heart Rate - drug effects | Transfection | Time Factors | NAV1.5 Voltage-Gated Sodium Channel - drug effects | Voltage-Gated Sodium Channel Blockers - toxicity | Potassium Channel Blockers - toxicity | Action Potentials - drug effects | Induced Pluripotent Stem Cells - metabolism | Arrhythmias, Cardiac - metabolism | Cell Line | Guinea Pigs | Heart Conduction System - metabolism | Induced Pluripotent Stem Cells - drug effects | Risk Assessment | Isolated Heart Preparation | Ganglia, Sympathetic - metabolism | Heart Conduction System - drug effects | ERG1 Potassium Channel - metabolism | Rats, Sprague-Dawley | Anticonvulsants - toxicity | Ion Channels - antagonists & inhibitors | Calcium Channel Blockers - toxicity | Animals | Ganglia, Sympathetic - physiopathology | Myocytes, Cardiac - drug effects | Norepinephrine - metabolism | Heart Conduction System - physiopathology | Ion Channels - metabolism | Phenylenediamines - toxicity | Calcium Channels, L-Type - drug effects | Myocytes, Cardiac - metabolism | Calcium Channels, L-Type - metabolism | ERG1 Potassium Channel - antagonists & inhibitors | Ganglia, Sympathetic - drug effects | Carbamates - toxicity | Heart | Anticonvulsants | Calcium channels | Arrhythmia | Electrocardiogram | Stem cells | Electrocardiography | Noradrenaline | Electric properties | Analysis | Neurophysiology | Index Medicus | ECOLOGICAL CONCENTRATION | GUINEA PIGS | ELECTRICAL PROPERTIES | IONS | POTENTIALS | 60 APPLIED LIFE SCIENCES | CONCENTRATION RATIO | HEART | INHIBITION | ANTICONVULSANTS | STEM CELLS | AUTONOMIC NERVOUS SYSTEM | MODULATION | NERVE CELLS
Journal Article
Toxicology Letters, ISSN 0378-4274, 08/2017, Volume 277, pp. 64 - 68
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 01/2013, Volume 304, Issue 1, pp. 104 - 117
The use of computational models to predict drug-induced changes in the action potential (AP) is a promising approach to reduce drug safety attrition but... 
Drug-binding kinetics | Human ether-a-go-go-related gene ion channel | QT prolongation | Computational modeling | Torsades de pointes arrhythmia | DOFETILIDE | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | MYOCYTES | human ether-a-go-go-related gene ion channel | BLOCK | I-KR | QT INTERVAL PROLONGATION | PROARRHYTHMIC RISK | REPOLARIZATION | Torsades de Pointes arrhythmia | drug-binding kinetics | PERIPHERAL VASCULAR DISEASE | ION CHANNELS | computational modeling | VENTRICULAR ARRHYTHMIA | POTASSIUM CHANNEL | Markov Chains | Phenethylamines - toxicity | Cricetulus | Humans | Ether-A-Go-Go Potassium Channels - metabolism | Long QT Syndrome - chemically induced | ERG1 Potassium Channel | Potassium Channel Blockers - metabolism | Action Potentials | Dose-Response Relationship, Drug | Transfection | Computer Simulation | Potassium Channel Blockers - toxicity | CHO Cells | High-Throughput Screening Assays - methods | Propanolamines - toxicity | Cricetinae | Risk Assessment | Models, Cardiovascular | Torsades de Pointes - chemically induced | Torsades de Pointes - metabolism | Ether-A-Go-Go Potassium Channels - genetics | Ether-A-Go-Go Potassium Channels - antagonists & inhibitors | Long QT Syndrome - metabolism | Patch-Clamp Techniques | Animals | Dogs | Protein Binding | Sulfonamides - toxicity | Kinetics | Cisapride - toxicity | Toxicity Tests | Drugs | Pharmacogenetics | Safety and security measures | Drug interactions | Clinical trials | Genetic aspects | Research | Gene expression | Health aspects | Methods | Physiology | Pharmacology | Markov analysis | Protocol | Binding sites | Index Medicus
Journal Article
Journal Article
Circulation: Arrhythmia and Electrophysiology, ISSN 1941-3149, 04/2017, Volume 10, Issue 4, pp. e003560 - e003560
BACKGROUND—The widely used macrolide antibiotic azithromycin increases risk of cardiovascular and sudden cardiac death, although the underlying mechanisms are... 
calcium channel | sodium channels | mice | potassium channels | pharmacology | ARRHYTHMIAS | CELLS | TORSADES-DE-POINTES | POLYMORPHIC VENTRICULAR-TACHYCARDIA | CARDIAC & CARDIOVASCULAR SYSTEMS | PROTEIN | NA+ CHANNELS | TRAFFICKING | HEART | CARDIAC SODIUM-CHANNEL | QT-INTERVAL PROLONGATION | Arrhythmias, Cardiac - chemically induced | KCNQ1 Potassium Channel - genetics | Cricetulus | Humans | KCNQ1 Potassium Channel - metabolism | Azithromycin - toxicity | NAV1.5 Voltage-Gated Sodium Channel - metabolism | Arrhythmias, Cardiac - physiopathology | Action Potentials | Dose-Response Relationship, Drug | Young Adult | Heart Rate - drug effects | Transfection | Potassium Channels, Voltage-Gated - metabolism | Time Factors | NAV1.5 Voltage-Gated Sodium Channel - drug effects | HEK293 Cells | KCNQ1 Potassium Channel - antagonists & inhibitors | Female | Potassium Channels, Inwardly Rectifying - antagonists & inhibitors | Potassium Channel Blockers - toxicity | Anti-Bacterial Agents - toxicity | NAV1.5 Voltage-Gated Sodium Channel - genetics | CHO Cells | Potassium Channels, Voltage-Gated - genetics | Sodium Channel Blockers - toxicity | Arrhythmias, Cardiac - metabolism | Rabbits | Mice, Inbred C57BL | Potassium Channels, Inwardly Rectifying - genetics | Potassium Channels, Voltage-Gated - antagonists & inhibitors | Telemetry | Calcium Channel Blockers - toxicity | Animals | Calcium Channels, L-Type - genetics | Myocytes, Cardiac - drug effects | Calcium Channels, L-Type - drug effects | Myocytes, Cardiac - metabolism | Calcium Channels, L-Type - metabolism | Potassium Channels, Inwardly Rectifying - metabolism | Electrocardiography, Ambulatory | Index Medicus | Ion Channels | HL-1 cells | Membrane Transport | Electrophysiology | azithromycin | proarrhythmia | Translational Studies | mouse | Arrhythmias | Basic Science Research
Journal Article
Birth Defects Research Part B: Developmental and Reproductive Toxicology, ISSN 1542-9733, 10/2013, Volume 98, Issue 5, pp. 416 - 427
Journal Article
Biomedicine & Pharmacotherapy, ISSN 0753-3322, 10/2018, Volume 106, pp. 510 - 522
RSD921, the R,R enantiomer of the kappa (k) agonist PD117,302, lacks significant activity on opioid receptors. The pharmacological and toxicological actions... 
Local anesthetic | Antiarrhythmic | Toxicology | Neuromuscular | Electrophysiology | Langendorff | RSD921 | Sodium and potassium blocker | Pharmacokinetics | Myocyte | MEDICINE, RESEARCH & EXPERIMENTAL | ECG MEASURE RSH | MYOCARDIAL-ISCHEMIA | KAPPA-OPIOID RECEPTOR | LAMBETH CONVENTIONS | VENTRICULAR MYOCYTES | CORONARY-ARTERY | MYELINATED NERVE | ANTIARRHYTHMIC-DRUG-ACTION | LOCAL-ANESTHETICS | PHARMACOLOGY & PHARMACY | OUTWARD CURRENT | Antihypertensive Agents - pharmacology | Anti-Arrhythmia Agents - pharmacology | Humans | Male | Anesthetics, Local - toxicity | Anesthetics, Local - pharmacology | Arrhythmias, Cardiac - physiopathology | Action Potentials | Dose-Response Relationship, Drug | Heart Rate - drug effects | Time Factors | Sodium Channel Blockers - administration & dosage | Sodium Channels - metabolism | Pain Threshold - drug effects | Female | Blood Pressure - drug effects | Neural Conduction - drug effects | Anesthetics, Local - administration & dosage | Disease Models, Animal | Injections, Intradermal | Sodium Channel Blockers - toxicity | Arrhythmias, Cardiac - metabolism | Anesthetics, Local - pharmacokinetics | Arrhythmias, Cardiac - prevention & control | Guinea Pigs | Anti-Arrhythmia Agents - toxicity | Isolated Heart Preparation | Xenopus laevis | Rats | Thiophenes - pharmacology | Sodium Channel Blockers - pharmacology | Arrhythmias, Cardiac - etiology | Sodium Channels - drug effects | Anti-Arrhythmia Agents - pharmacokinetics | Anti-Arrhythmia Agents - administration & dosage | Rats, Sprague-Dawley | Papio | Administration, Intravenous | Pyrroles - pharmacology | Animals | Myocytes, Cardiac - drug effects | Dogs | Myocytes, Cardiac - metabolism | Mice | Sodium Channel Blockers - pharmacokinetics | Heart beat | Arrhythmia | Analysis | Anti-arrhythmia drugs | Muscles | Anesthesia | Enantiomers | Index Medicus
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 11/2015, Volume 25, Issue 22, pp. 5299 - 5305
Journal Article
Journal Article
eLife, ISSN 2050-084X, 05/2015, Volume 4, Issue MAY, pp. e06774 - e06774
Tarantula toxins that bind to voltage-sensing domains of voltage-activated ion channels are thought to partition into the membrane and bind to the channel... 
VOLTAGE-SENSOR TOXIN | DEPENDENT K+ CHANNEL | POTASSIUM CHANNELS | SODIUM-CHANNELS | BIOLOGY | ALPHA-SCORPION TOXIN | GATING MODIFIER TOXINS | MOLECULAR DETERMINANTS | PROTEIN-PROTEIN DOCKING | LIPID-MEMBRANES | STRUCTURE PREDICTION | Spider Venoms - chemical synthesis | Arthropod Proteins - toxicity | Acid Sensing Ion Channels - chemistry | Molecular Sequence Data | Acid Sensing Ion Channel Blockers - chemistry | Unilamellar Liposomes - chemistry | Acid Sensing Ion Channel Blockers - chemical synthesis | Oocytes - cytology | Peptides - chemical synthesis | Peptides - toxicity | Oocytes - drug effects | Arthropod Proteins - chemical synthesis | Shab Potassium Channels - antagonists & inhibitors | Spider Venoms - chemistry | Shab Potassium Channels - genetics | Amino Acid Sequence | Neurotoxins - chemistry | Gene Expression | Peptides - chemistry | Protein Structure, Secondary | Oocytes - metabolism | Shab Potassium Channels - chemistry | Xenopus laevis | Neurotoxins - toxicity | Recombinant Fusion Proteins - chemistry | Neurotoxins - chemical synthesis | Molecular Dynamics Simulation | Sequence Homology, Amino Acid | Arthropod Proteins - chemistry | Animals | Spiders | Spider Venoms - toxicity | Protein Binding | Recombinant Fusion Proteins - genetics | Acid Sensing Ion Channels - genetics | Molecular Docking Simulation | Acid Sensing Ion Channel Blockers - toxicity | Kinetics | Ion Channel Gating | Proteins | Sodium channels | Computer applications | Voltage | Lipids | Physiology | Ion channels | Acidity | Sensors | Index Medicus
Journal Article