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ACS Medicinal Chemistry Letters, ISSN 1948-5875, 10/2019, Volume 10, Issue 1, pp. 27 - 33
Recent research suggests that KCNQ isoforms, particularly the KCNQ4 and KCNQS subtypes expressed in smooth muscle cells, are involved in both establishing and... 
KCNQ channel | subtype selectivity | agonist | retigabine | CHEMISTRY, MEDICINAL | GATED POTASSIUM CHANNELS | K(V)7 CHANNELS | SELECTIVE ACTIVATION | SMOOTH-MUSCLE | GENE | TARGETS | KV7 CHANNELS | EXPRESSION
Journal Article
ACS MEDICINAL CHEMISTRY LETTERS, ISSN 1948-5875, 06/2019, Volume 10, Issue 6, pp. 929 - 935
Based on the potent K(v)7 agonist RL-81, we prepared new lead structures with greatly improved selectivity for K(v)7.2/K(v)7.3 over related potassium channels,... 
CHEMISTRY, MEDICINAL | K(v)7 | retigabine | DETERMINANTS | potassium channel agonist | KCNQ | RL-81 | DISCOVERY
Journal Article
PloS one, ISSN 1932-6203, 2017, Volume 12, Issue 5, p. e0177600
Arrhythmogenesis in acute myocardial infarction (MI) is associated with depolarization of resting membraine potential (RMP) and decrease of inward rectifier... 
Arrhythmias, Cardiac - prevention & control | Acute Disease | Cell Hypoxia - drug effects | Cricetulus | Rats | Male | Potassium Channels, Inwardly Rectifying - agonists | Rats, Sprague-Dawley | Arrhythmias, Cardiac - pathology | Myocytes, Cardiac - pathology | Arrhythmias, Cardiac - drug therapy | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Animals | Benzamides - therapeutic use | Myocytes, Cardiac - drug effects | Bridged Bicyclo Compounds, Heterocyclic - therapeutic use | Isoproterenol - pharmacology | Myocardial Ischemia - complications | Arrhythmias, Cardiac - complications | Benzamides - pharmacology | Action Potentials - drug effects | CHO Cells | Myocardial infarction | Heart | Conduction | Arrhythmia | Body weight | Cardiovascular disease | Ischemia | Temperature effects | Air temperature | Electrocardiography | Aorta | Physiology | Membrane potential | Antiarrhythmic agents | Cardiac muscle | Body temperature | Abnormalities | Coronary artery | Contractility | Gene expression | Mammals | Catecholamine | Laboratory tests | Sodium | Calcium channels (L-type) | Myocardium | Ventilation | Death | Cardiovascular diseases | Circulation | Drugs | Cardiac arrhythmia | Temperature | Calcium | Medical services | Action potential | Congestive heart failure | Format | Cerebral blood flow | Rodents | Ion channels | Excitation | Heart diseases | Age | Food | Calcium channels | Blocking | Cardiomyocytes | Pharmacology | Velocity | Coronary artery disease | In vivo methods and tests | Ventricle | Acidosis | Potassium
Journal Article
Scientific Reports, ISSN 2045-2322, 09/2016, Volume 6, Issue 1, p. 33684
Efficient lysosomal Ca release plays an essential role in lysosomal trafficking. We have recently shown that lysosomal big conductance Ca -activated potassium... 
Calcium release channels | Niemann-Pick disease | Lysosomal storage diseases | Potassium conductance | Drug delivery | Exocytosis | Fabry's disease | Mucolipidosis type IV | Mucolipidosis | Transient receptor potential proteins | Calcium conductance | Feedback | Membrane trafficking | Npc1 protein | Protein transport
Journal Article
by Zhai, XW and Zhang, L and Guo, YF and Yang, Y and Wang, DM and Zhang, Y and Li, P and Niu, YF and Feng, QL and Wu, BW and Cao, JM and Liu, QH
PLOS ONE, ISSN 1932-6203, 05/2017, Volume 12, Issue 5
Arrhythmogenesis in acute myocardial infarction (MI) is associated with depolarization of resting membraine potential (RMP) and decrease of inward rectifier... 
ACUTE MYOCARDIAL-ISCHEMIA | TRANSIENT OUTWARD CURRENT | ACTION-POTENTIAL DURATION | VENTRICULAR-TACHYCARDIA | MULTIDISCIPLINARY SCIENCES | POTASSIUM CURRENT | CARDIAC EXCITABILITY | GUINEA-PIG | RECTIFIER K+ CHANNELS | TRANSGENIC UP-REGULATION | ATRIAL-FIBRILLATION
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 06/2009, Volume 296, Issue 6, pp. 1949 - 1959
Journal Article
Journal Article
Frontiers in Pharmacology, ISSN 1663-9812, 08/2019, Volume 10
Intracellular Ca2+ overload, prolongation of the action potential duration (APD), and downregulation of inward rectifier potassium (IK1) channel are hallmarks... 
isoproterenol | zacopride | calcium overload | inward rectifier potassium channel | cardiac remodeling
Journal Article
Frontiers in pharmacology, ISSN 1663-9812, 2019, Volume 10, p. 929
Intracellular Ca overload, prolongation of the action potential duration (APD), and downregulation of inward rectifier potassium (I ) channel are hallmarks of... 
ARRHYTHMIAS | HOMEOSTASIS | HEART-FAILURE | BINDING-PROTEIN | isoproterenol | MODEL | inward rectifier potassium channel | LEFT-VENTRICULAR HYPERTROPHY | zacopride | REDUCTION | SIGNALING PATHWAY | cardiac remodeling | PHARMACOLOGY & PHARMACY | calcium overload | MODULATION | PROTEIN-KINASE-II
Journal Article
Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 04/2012, Volume 16, Issue 4, pp. 776 - 788
Journal Article
Science, ISSN 0036-8075, 5/2012, Volume 336, Issue 6081, pp. 597 - 601
Journal Article