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Current medicinal chemistry, ISSN 0929-8673, 04/2013, Volume 20, Issue 10, pp. 1241 - 1285
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 12/2014, Volume 111, Issue 52, pp. 18607 - 18612
Journal Article
Biochimica et biophysica acta. Molecular and cell biology of lipids, ISSN 1388-1981, 2015, Volume 1851, Issue 6, pp. 844 - 856
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2019, Volume 363, Issue 6429, pp. 875 - 880
Potassium (K ) channels have been evolutionarily tuned for activation by diverse biological stimuli, and pharmacological activation is thought to target these specific gating mechanisms... 
CONDUCTANCE | K-2P | HERG | POTASSIUM CHANNELS | STRUCTURAL BASIS | HIGH-THROUGHPUT | BK CHANNELS | MULTIDISCIPLINARY SCIENCES | CONSTANT-PRESSURE | PARTICLE MESH EWALD | MOLECULAR-DYNAMICS SIMULATIONS | Xenopus | Tetrazoles - pharmacology | ortho-Aminobenzoates - chemistry | ortho-Aminobenzoates - pharmacology | Cricetulus | Humans | Crystallography, X-Ray | Thiourea - pharmacology | Large-Conductance Calcium-Activated Potassium Channels - chemistry | Tetrazoles - chemistry | Chlorobenzenes - pharmacology | Drug Design | HEK293 Cells | Chlorobenzenes - chemistry | Protein Domains | CHO Cells | ERG1 Potassium Channel - chemistry | Large-Conductance Calcium-Activated Potassium Channels - agonists | ERG1 Potassium Channel - agonists | Thiourea - chemistry | Molecular Dynamics Simulation | Animals | Tetrahydronaphthalenes - chemistry | Tetrahydronaphthalenes - pharmacology | Thiourea - analogs & derivatives | Ion Channel Gating - drug effects | Molecular dynamics | Analysis | Pharmaceutical research | Potassium channels | Research | Pharmacokinetics | Calcium | Epilepsy | Activation | Potassium conductance | Selectivity | Drug development | Crystallography | Channels | X-ray crystallography | Pain | Occupancy | Potassium channels (voltage-gated) | Calcium channels | Channel gating | Calcium channels (voltage-gated) | Pharmacology | Functional analysis | Resistance | Dynamic tests | Calcium conductance | Conductance | Potassium | Calcium ions
Journal Article
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 10, pp. 3546 - 3561
Inwardly rectifying potassium (Kir) channels establish and regulate the resting membrane potential of excitable cells in the heart, brain, and other peripheral tissues... 
ISCHEMIA-REPERFUSION INJURY | RECTIFYING POTASSIUM CHANNELS | ACTIVATION | SULFHYDRATION | MECHANISM | K-ATP CHANNELS | BIOCHEMISTRY & MOLECULAR BIOLOGY | G-PROTEINS | H2S | CARDIOPROTECTION | PHOSPHOINOSITIDES | Hydrogen Sulfide - metabolism | Cricetulus | Sulfides - chemistry | Cystathionine gamma-Lyase - metabolism | Potassium Channels, Inwardly Rectifying - chemistry | Recombinant Fusion Proteins - metabolism | Oocytes - cytology | Phosphatidylinositol 4,5-Diphosphate - metabolism | G Protein-Coupled Inwardly-Rectifying Potassium Channels - metabolism | Potassium Channels, Inwardly Rectifying - antagonists & inhibitors | Sulfides - metabolism | Cystathionine gamma-Lyase - genetics | Phosphatidylinositol 4,5-Diphosphate - chemistry | G Protein-Coupled Inwardly-Rectifying Potassium Channels - antagonists & inhibitors | CHO Cells | Sulfides - pharmacology | Allosteric Regulation - drug effects | Recombinant Proteins - metabolism | Hydrogen Sulfide - pharmacology | Mutagenesis, Site-Directed | Oocytes - metabolism | Hydrogen Sulfide - chemistry | Xenopus laevis | G Protein-Coupled Inwardly-Rectifying Potassium Channels - chemistry | Models, Molecular | Recombinant Proteins - chemistry | Potassium Channels, Inwardly Rectifying - genetics | Recombinant Fusion Proteins - chemistry | G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics | Molecular Dynamics Simulation | Patch-Clamp Techniques | Animals | Protein Conformation | Mice | Mutation | Potassium Channels, Inwardly Rectifying - metabolism | Amino Acid Substitution | GIRK channels | Signal Transduction | phosphatidylinositol 4,5-bisphosphate (PIP2) | stroke | phosphoinositide | ischemia | KATP channels | gasotransmitters | hydrogen sulfide | potassium channel | Kir3 or GIRK channels | inwardly rectifying K+ (Kir) channels | Kir3
Journal Article
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2010, Volume 328, Issue 5974, pp. 67 - 73
Magnetic fields in galaxies are produced via the amplification of seed magnetic fields of unknown nature. The seed fields, which might exist in their initial... 
Electric potential | Amino acids | Cell membranes | Research Articles | Sensors | Chimeras | Electric current | Binding sites | Oocytes | P branes | Crystal structure | DEPENDENT K+ CHANNEL | TRANSMEMBRANE MOVEMENT | WILD-TYPE | S4 | ACTIVATION | FOCUSED ELECTRIC-FIELD | MULTIDISCIPLINARY SCIENCES | PORE | SHAKER POTASSIUM CHANNEL | DISPLACEMENT | TRANSITIONS | Shaker Superfamily of Potassium Channels - metabolism | Molecular Sequence Data | Tryptophan - chemistry | Crystallography, X-Ray | Recombinant Fusion Proteins - metabolism | Kv1.2 Potassium Channel - chemistry | Phenylalanine - chemistry | Shaker Superfamily of Potassium Channels - chemistry | Binding Sites | Amino Acid Sequence | Shab Potassium Channels - chemistry | Xenopus laevis | Models, Molecular | Rats | Recombinant Fusion Proteins - chemistry | Arginine - chemistry | Patch-Clamp Techniques | Shab Potassium Channels - metabolism | Animals | Kv1.2 Potassium Channel - metabolism | Electric Capacitance | Protein Conformation | Lysine - chemistry | Ion Channel Gating | Amino Acid Substitution | X-ray crystallography | Lysine | Electrophysiology | Research | Properties | Methods | Proteins | Enzymes | Membranes | Biochemistry | BASIC BIOLOGICAL SCIENCES | AMINO ACIDS | ENZYMES | LYSINE | GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE | MEMBRANES | ARGININE | national synchrotron light source | CRYSTALLOGRAPHY | MUTATIONS | SENSORS
Journal Article
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 03/2016, Volume 291, Issue 13, pp. 7097 - 7106
... as well as methicillin-resistant Staphylococcus aureus. Interestingly, electrophysiological experiments showed that BmKDfsin4,like scorpion potassium channel neurotoxins, could effectively inhibit... 
VENOM | PORE REGION | bacteria | TOXIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | structure-function | KV1.3 CHANNEL | STRUCTURAL BASIS | FUNGAL DEFENSIN | defensin | INSECT DEFENSINS | neurotoxin | potassium channel | MESOBUTHUS-MARTENSII | PROTEOMIC ANALYSIS | K+ CHANNELS | Kv1.2 Potassium Channel - antagonists & inhibitors | Humans | Micrococcus luteus - growth & development | Potassium Channel Blockers - metabolism | Bacillus subtilis - growth & development | Defensins - pharmacology | Kv1.3 Potassium Channel - metabolism | Potassium Channel Blockers - pharmacology | Kv1.1 Potassium Channel - genetics | Amino Acid Sequence | Gene Expression | Methicillin-Resistant Staphylococcus aureus - drug effects | Models, Molecular | Recombinant Proteins - chemistry | Methicillin-Resistant Staphylococcus aureus - growth & development | Scorpion Venoms - chemistry | Kv1.2 Potassium Channel - metabolism | Neurotoxins - metabolism | Anti-Bacterial Agents - pharmacology | Mice | Scorpion Venoms - biosynthesis | Potassium Channel Blockers - chemistry | Defensins - metabolism | Defensins - genetics | Kv1.1 Potassium Channel - metabolism | Molecular Sequence Data | Neurotoxins - genetics | Structure-Activity Relationship | Defensins - chemistry | Kv1.3 Potassium Channel - genetics | Micrococcus luteus - drug effects | Scorpions - physiology | Anti-Bacterial Agents - chemistry | Protein Interaction Domains and Motifs | Recombinant Proteins - metabolism | Neurotoxins - chemistry | Protein Structure, Secondary | Kv1.1 Potassium Channel - antagonists & inhibitors | Anti-Bacterial Agents - metabolism | Scorpions - chemistry | Recombinant Proteins - genetics | Kv1.3 Potassium Channel - antagonists & inhibitors | Recombinant Proteins - pharmacology | Neurotoxins - pharmacology | Kv1.2 Potassium Channel - genetics | Sequence Alignment | Animals | Structural Homology, Protein | Staphylococcus aureus - drug effects | Staphylococcus aureus - growth & development | Bacillus subtilis - drug effects | Index Medicus | Cell Biology
Journal Article