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Journal Article
Journal Article
Drug Design, Development and Therapy, ISSN 1177-8881, 07/2015, Volume 9, pp. 3695 - 3704
The hERG gene encodes the pore-forming a-subunit of the rapidly activating delayed rectifier potassium channel (I-Kr), which is important for cardiac... 
HERG potassium channels | Probucol | Nedd4-2 | SGK1 | Long QT | CHEMISTRY, MEDICINAL | hERG potassium channels | PHOSPHORYLATION | HEK293 CELLS | TRAFFICKING | CARDIAC-ARRHYTHMIA | SERUM | long QT | probucol | UBIQUITIN LIGASE NEDD4-2 | PHARMACOLOGY & PHARMACY | LONG-QT-SYNDROME | K+ CHANNEL | EXPRESSION | Anticholesteremic Agents - toxicity | Humans | Endosomal Sorting Complexes Required for Transport - metabolism | Protein-Serine-Threonine Kinases - genetics | Ubiquitin-Protein Ligases - metabolism | Long QT Syndrome - chemically induced | ERG1 Potassium Channel | Ether-A-Go-Go Potassium Channels - genetics | Probucol - toxicity | Probucol - administration & dosage | Dose-Response Relationship, Drug | Carbachol - pharmacology | Immediate-Early Proteins - genetics | Anticholesteremic Agents - administration & dosage | HEK293 Cells | Nedd4 Ubiquitin Protein Ligases | Phosphorylation - drug effects | Drugs | Complications and side effects | Carrier proteins | Genetic aspects | Cardiovascular diseases | Health aspects | Risk factors | Heart | Ubiquitin | Phosphorylation | HERG protein | Cardiovascular disease | Diabetic neuropathy | Pharmacology | Kinases | Chemical compounds | Experiments | Cholesterol | Membrane proteins | Proteins | Ubiquitination | Carbachol | Rectifiers | Torsades de pointes | Long QT syndrome | Potassium channels (voltage-gated) | Mutation | Potassium | Ubiquitin-protein ligase | Pore formation | Index Medicus
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 10/2016, Volume 311, Issue 4, pp. C559 - C571
Journal Article
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, ISSN 0363-6143, 10/2016, Volume 311, Issue 4, pp. C559 - C571
The skeletal muscle ATP-sensitive K+(K-ATP) channel is crucial in preventing fiber damage and contractile dysfunction, possibly by preventing damaging ATP... 
SENSITIVE POTASSIUM CHANNELS | glucose | PHYSIOLOGY | ACTIVATED PROTEIN-KINASE | MAMMALIAN SKELETAL | SLOW-TWITCH MUSCLE | CO2 | CARDIAC-MUSCLE | glycogen | CELL BIOLOGY | IN-VITRO | GLYCOGENOLYSIS | SKELETAL-MUSCLE FIBERS | R225W MUTATION | lactate | GLUCOSE-UPTAKE
Journal Article
Drug Design, Development and Therapy, ISSN 1177-8881, 10/2015, Volume 9, Issue default, pp. 5737 - 5747
Berberine (BBR), an isoquinoline alkaloid mainly isolated from plants of Berberidaceae family, is extensively used to treat gastrointestinal infections in... 
Berberine | hERG | Cardiotoxicity | Cavoline-1 | Pharmacological rescue | LQTS | TRAFFICKING INHIBITION | DOFETILIDE | CHEMISTRY, MEDICINAL | CHOLESTEROL | BLOCK | berberine | cardiotoxicity | AFFINITY | cavoline-1 | PROTEIN TRAFFICKING | PHARMACOLOGY & PHARMACY | LONG QT SYNDROME | MUTATIONS | BINDING | pharmacological rescue | POTASSIUM CHANNEL | Terfenadine - pharmacology | Tyrosine | Phenylalanine | Humans | Ether-A-Go-Go Potassium Channels - metabolism | Terfenadine - analogs & derivatives | Stilbenes - pharmacology | ERG1 Potassium Channel | Ether-A-Go-Go Potassium Channels - genetics | Action Potentials | Caveolin 1 - metabolism | Dose-Response Relationship, Drug | Ether-A-Go-Go Potassium Channels - antagonists & inhibitors | Berberine - pharmacology | Transfection | RNA Interference | HEK293 Cells | Resveratrol | Cell Membrane - metabolism | Kinetics | Mutation | Cell Membrane - drug effects | Potassium Channel Blockers - pharmacology | Ion transport | Ion channels | Genetic aspects | Gene expression | Properties | Health aspects | Caveolin-1 | HERG protein | Action potential | Cell surface | Proteins | Temperature effects | Penicillin | Long QT syndrome | Potassium channels (voltage-gated) | Caveolin | Cardiomyocytes | Pharmacology | Cell membranes | Fexofenadine | Cell membranes (biology) | Cholesterol | Regulatory mechanisms (biology) | Potassium | Binding sites | Index Medicus
Journal Article
Naunyn-Schmiedeberg's Archives of Pharmacology, ISSN 0028-1298, 11/2014, Volume 387, Issue 11, pp. 1079 - 1089
Arsenic trioxide (As2O3) is used to treat acute promyelocytic leukemia. However, the cardiotoxicity of long QT syndrome restricts its clinical application.... 
Neurosciences | hERG | Biomedicine | Arsenic trioxide (As 2 O 3 ) | Resveratrol | Hsp70/Hsp90 | ER stress | Pharmacology/Toxicology | DRUG | TARGET | TRAFFICKING | CANCER | ARSENIC TRIOXIDE | PHARMACOLOGICAL RESCUE | Arsenic trioxide (As2O3) | ANTIOXIDANT | PHARMACOLOGY & PHARMACY | LONG QT SYNDROME | MUTATIONS | Guinea Pigs | Endoplasmic Reticulum Stress - drug effects | Arsenicals | Ether-A-Go-Go Potassium Channels - deficiency | Humans | Oxides - toxicity | Cardiotoxicity - etiology | Cardiotonic Agents - pharmacology | Stilbenes - pharmacology | Down-Regulation - drug effects | ERG1 Potassium Channel | Blotting, Western | Antineoplastic Agents - toxicity | HSP70 Heat-Shock Proteins - metabolism | Patch-Clamp Techniques | Animals | Myocytes, Cardiac - drug effects | HEK293 Cells | HSP90 Heat-Shock Proteins - metabolism | Myocytes, Cardiac - metabolism | Heart Ventricles - metabolism | Action Potentials - drug effects | Cardiotoxicity - prevention & control | Heart Ventricles - drug effects | Animal experimentation | Medical colleges | Arsenic | Leukemia | Heart | Hsp90 protein | HERG protein | Immunoprecipitation | Toxicity | Medical services | Action potential | Myocytes | Proteins | Promyeloid leukemia | Calreticulin | Protein folding | Long QT syndrome | Potassium channels (voltage-gated) | Cardiac muscle | Activating transcription factor 6 | Arsenic trioxide | Hsp70 protein | Potassium channels | Calnexin | Membrane trafficking | Ventricle | Endoplasmic reticulum | Acute promyeloid leukemia | Index Medicus
Journal Article
Vascular Pharmacology, ISSN 1537-1891, 2012, Volume 56, Issue 3, pp. 142 - 149
Abstract It is likely that large-conductance Ca 2 + -activated K+ (BKCa ) channels channelopathy tightly involved in vascular malfunctions and arterial... 
Cardiovascular | Hypertension | Irradiation | Smooth muscle contractility | BKCa channels | RNA interference | CONDUCTANCE | RNA | CA2+-ACTIVATED K+ CHANNELS | SIRNAS | ACTIVATED POTASSIUM CHANNELS | MECHANISMS | SMOOTH-MUSCLE | ENDOTHELIAL-CELLS | PHARMACOLOGY & PHARMACY | ARTERY
Journal Article
FEBS Journal, ISSN 1742-464X, 03/2009, Volume 276, Issue 6, pp. 1680 - 1697
Journal Article
by Yan, M and Zhang, KP and Shi, YH and Feng, LF and Lv, L and Li, BX
DRUG DESIGN DEVELOPMENT AND THERAPY, ISSN 1177-8881, 2016, Volume 10, pp. 3573 - 3573
Yan M, Zhang KP, Shi YH, Feng LF, Lv L, Li BX. Drug Des Devel Ther. 2015 Oct 22;9:5737-5747.On page 5742, Figure 3C, an incorrect Western blot image is... 
PHARMACOLOGY & PHARMACY | CHEMISTRY, MEDICINAL | Berberine | Potassium channels (voltage-gated) | Pharmacology | HERG protein
Journal Article