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1. Full Text Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies
by Ciechanover, Aaron and Kwon, Yong T.ae
Experimental & molecular medicine, ISSN 1226-3613, 2015, Volume 47, Issue 3, pp. e147 - e147
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Proteostasis Deficiencies - metabolism | Humans | Ubiquitin - metabolism | tau Proteins - metabolism | Parkinson Disease - drug therapy | Molecular Targeted Therapy | Neurodegenerative Diseases - drug therapy | Amyotrophic Lateral Sclerosis - drug therapy | Autophagy - drug effects | DNA-Binding Proteins - metabolism | PrPSc Proteins - metabolism | Lysosomes - metabolism | Proteolysis | Amyloid beta-Peptides - metabolism | Parkinson Disease - metabolism | Huntington Disease - drug therapy | Superoxide Dismutase - metabolism | Prion Diseases - drug therapy | Alzheimer Disease - drug therapy | Neurodegenerative Diseases - metabolism | Huntington Disease - metabolism | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Huntingtin Protein | Animals | Alzheimer Disease - metabolism | Amyotrophic Lateral Sclerosis - metabolism | Huntington Disease - genetics | Mutation | Proteasome Endopeptidase Complex - metabolism | alpha-Synuclein - metabolism | Prion Diseases - metabolism | Index Medicus | Review
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2. Full Text Sustained translational repression by eIF2α-P mediates prion neurodegeneration
by Moreno, Julie A and Radford, Helois and Peretti, Diego and Steinert, Joern R and Verity, Nicholas and Martin, Maria Guerra and Halliday, Mark and Morgan, Jason and Dinsdale, David and Ortori, Catherine A and Barrett, David A and Tsaytler, Pavel and Bertolotti, Anne and Willis, Anne E and Bushell, Martin and Mallucci, Giovanna R
Nature (London), ISSN 0028-0836, 05/2012, Volume 485, Issue 7399, pp. 507 - 511
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Neurology | Organic mental disorders. Neuropsychology | Psychology. Psychoanalysis. Psychiatry | Adult and adolescent clinical studies | Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases | Psychopathology. Psychiatry | Biological and medical sciences | Medical sciences | Neurons - pathology | Neuroprotective Agents | Phosphorylation | Prions - genetics | Eukaryotic Initiation Factor-2 - chemistry | Neurodegenerative Diseases - etiology | PrPSc Proteins - analysis | Synapses - pathology | Thiourea - pharmacology | Phosphoproteins - metabolism | Repressor Proteins - analysis | PrPSc Proteins - metabolism | Synapses - metabolism | Phosphoproteins - analysis | Protein Folding - drug effects | Protein Phosphatase 1 - genetics | Eukaryotic Initiation Factor-2 - metabolism | Synaptic Transmission - drug effects | Cell Death - drug effects | PrPSc Proteins - toxicity | Neurons - drug effects | Repressor Proteins - metabolism | Prions - metabolism | Synapses - drug effects | Repressor Proteins - chemistry | Neurodegenerative Diseases - pathology | Mice, Inbred C57BL | Kaplan-Meier Estimate | Hippocampus - pathology | Prion Diseases - pathology | Neurodegenerative Diseases - metabolism | Hippocampus - cytology | Cinnamates - pharmacology | Eukaryotic Initiation Factor-2 - analysis | Hippocampus - metabolism | Protein Phosphatase 1 - metabolism | Animals | Prions - biosynthesis | Protein Biosynthesis - drug effects | Mice | Unfolded Protein Response - physiology | Thiourea - analogs & derivatives | Index Medicus
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3. Full Text Towards further reduction and replacement of animal bioassays in prion research by cell and protein misfolding cyclic amplification assays
by Boerner, Susann and Wagenführ, Katja and Daus, Martin L and Thomzig, Achim and Beekes, Michael
Laboratory animals (London), ISSN 0023-6772, 4/2013, Volume 47, Issue 2, pp. 106 - 115
Prion | Cell assay | Protein misfolding cyclic amplification (PMCA) | Prion protein | Reduction of animal bioassays | Veterinary Sciences | Life Sciences & Biomedicine | Zoology | Science & Technology | Prion Diseases - genetics | Protein Engineering - methods | Neuroglia - pathology | Humans | PrPC Proteins - chemistry | PrPSc Proteins - chemistry | PrPSc Proteins - metabolism | Cattle Diseases - metabolism | Cattle | Sensitivity and Specificity | Encephalopathy, Bovine Spongiform - metabolism | PrPC Proteins - metabolism | PrPC Proteins - genetics | Biological Assay - instrumentation | Protein Engineering - instrumentation | Cricetinae | Electrophoresis, Polyacrylamide Gel | Biological Assay - methods | Scrapie - metabolism | Blotting, Western | Protein Folding | PrPSc Proteins - genetics | Creutzfeldt-Jakob Syndrome - metabolism | Animals | Disinfection - methods | Neuroglia - metabolism | Sheep - metabolism | Prion Diseases - metabolism | Index Medicus
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4. Full Text Role of ADAMs in the Ectodomain Shedding and Conformational Conversion of the Prion Protein
by David R. Taylor and Edward T. Parkin and Sarah L. Cocklin and James R. Ault and Alison E. Ashcroft and Anthony J. Turner and Nigel M. Hooper
The Journal of biological chemistry, ISSN 0021-9258, 08/2009, Volume 284, Issue 34, pp. 22590 - 22600
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | ADAM17 Protein | Amyloid Precursor Protein Secretases - genetics | Humans | Immunoblotting | Aspartic Acid Endopeptidases - genetics | PrPSc Proteins - metabolism | Mass Spectrometry | Membrane Proteins - metabolism | PrPC Proteins - metabolism | PrPC Proteins - genetics | Recombinant Proteins - metabolism | Cell Line | Membrane Proteins - genetics | ADAM10 Protein | Recombinant Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | PrPSc Proteins - genetics | ADAM Proteins - metabolism | Amyloid Precursor Protein Secretases - metabolism | Animals | Aspartic Acid Endopeptidases - metabolism | Cell Line, Tumor | Mice | RNA, Small Interfering | ADAM Proteins - genetics | DNA, Complementary | Index Medicus | Protein Synthesis, Post-Translational Modification, and Degradation
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5. Full Text Prions disturb post-Golgi trafficking of membrane proteins
by Uchiyama, Keiji and Muramatsu, Naomi and Yano, Masashi and Usui, Takeshi and Miyata, Hironori and Sakaguchi, Suehiro
Nature communications, ISSN 2041-1723, 2013, Volume 4, Issue 1, pp. 1846 - 1846
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Humans | Male | Endosomes - metabolism | Brain - metabolism | PrPSc Proteins - metabolism | Endocytosis | Biotin - metabolism | Cell Membrane - metabolism | Membrane Proteins - metabolism | PrPC Proteins - metabolism | Cell Line | Prions - metabolism | Cricetinae | Signal Transduction | Subcellular Fractions - metabolism | Blotting, Western | Protein Transport | Insulin - metabolism | Animals | Models, Biological | Brain - pathology | Golgi Apparatus - metabolism | Receptor, Insulin - metabolism | Mice | Antibodies, Monoclonal - metabolism | Index Medicus
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6. Full Text Games Played by Rogue Proteins in Prion Disorders and Alzheimer's Disease
by Adriano Aguzzi and Christian Haass
Science (American Association for the Advancement of Science), ISSN 0036-8075, 10/2003, Volume 302, Issue 5646, pp. 814 - 818
Brain | Nervous system diseases | Presenilins | Neurons | Prions | Parkinson disease | Lead | Prion diseases | Biochemistry | Alzheimers disease | Reviews and Viewpoints | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Presenilin-2 | Presenilin-1 | Amyloid beta-Protein Precursor - chemistry | Humans | PrPC Proteins - chemistry | PrPSc Proteins - chemistry | Alzheimer Disease - pathology | Brain - metabolism | PrPSc Proteins - metabolism | Aspartic Acid Endopeptidases | Amyloid Precursor Protein Secretases | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Membrane Proteins - metabolism | PrPC Proteins - metabolism | PrPC Proteins - genetics | Endopeptidases - metabolism | Membrane Proteins - genetics | Terminology as Topic | Prion Diseases - pathology | PrPC Proteins - classification | Protein Folding | Creutzfeldt-Jakob Syndrome - metabolism | PrPSc Proteins - classification | Animals | Membrane Proteins - chemistry | Alzheimer Disease - metabolism | Brain - pathology | Creutzfeldt-Jakob Syndrome - pathology | Amyloid beta-Peptides - chemistry | Mutation | Prion Diseases - metabolism | Index Medicus
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7. Full Text Molecular Cross Talk between Misfolded Proteins in Animal Models of Alzheimer's and Prion Diseases
by Morales, Rodrigo and Estrada, Lisbell D and Diaz-Espinoza, Rodrigo and Morales-Scheihing, Diego and Jara, Maria C and Castilla, Joaquin and Soto, Claudio
The Journal of neuroscience, ISSN 0270-6474, 03/2010, Volume 30, Issue 13, pp. 4528 - 4535
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Prions - metabolism | Mice, Inbred C57BL | Mice, Transgenic | Prion Diseases - pathology | Prions - chemistry | PrPSc Proteins - chemistry | Protein Folding | Alzheimer Disease - pathology | Brain - metabolism | PrPSc Proteins - metabolism | Animals | Amyloid - metabolism | Alzheimer Disease - metabolism | Amyloid beta-Peptides - metabolism | Brain - pathology | Mice | Amyloid beta-Peptides - chemistry | Prion Diseases - metabolism | Index Medicus
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8. Full Text Roles of endoproteolytic α‐cleavage and shedding of the prion protein in neurodegeneration
by Altmeppen, Hermann C and Prox, Johannes and Puig, Berta and Dohler, Frank and Falker, Clemens and Krasemann, Susanne and Glatzel, Markus
The FEBS journal, ISSN 1742-464X, 09/2013, Volume 280, Issue 18, pp. 4338 - 4347
prion disease | α‐cleavage | β‐amyloid | neurotoxic oligomers | neurodegeneration | ADAM10 | shedding | Alzheimer's disease | prion protein | α-cleavage | β-amyloid | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Amyloid Precursor Protein Secretases - genetics | Prion Diseases - genetics | Humans | Alzheimer Disease - pathology | PrPSc Proteins - metabolism | Prion Diseases - enzymology | Amyloid beta-Peptides - genetics | Proteolysis | Amyloid beta-Peptides - metabolism | Membrane Proteins - metabolism | PrPC Proteins - metabolism | PrPC Proteins - genetics | Cell Line | Signal Transduction | Membrane Proteins - genetics | ADAM10 Protein | Prion Diseases - pathology | Alzheimer Disease - enzymology | Protein Folding | PrPSc Proteins - genetics | ADAM Proteins - metabolism | Amyloid Precursor Protein Secretases - metabolism | Protein Conformation | Protein Processing, Post-Translational | ADAM Proteins - genetics | Alzheimer Disease - genetics | Index Medicus
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