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Circulation, ISSN 0009-7322, 11/2010, Volume 122, Issue 21, pp. 2142 - 2151
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 01/2010, Volume 38, Issue 1, pp. 168 - 176
This study investigated the role of a multispecific organic anion transporter, Oatp1a4/ Slco1a4 , in drug transport across the blood-brain barrier. In vitro... 
LOCALIZATION | INVOLVEMENT | POLYPEPTIDE-2 | PENETRATION | PHARMACOLOGY & PHARMACY | RAT-BRAIN | OATP2 | BCRP/ABCG2 | 17-BETA-ESTRADIOL-D-17-BETA-GLUCURONIDE | CANCER RESISTANCE PROTEIN | P-GLYCOPROTEIN | Fluorobenzenes - pharmacokinetics | Gene Expression - genetics | Pyrimidines - blood | Humans | Ion Pumps - genetics | Fluorobenzenes - administration & dosage | Quinolines - administration & dosage | Pyrimidines - metabolism | Brain - metabolism | Quinolines - pharmacokinetics | Choroid Plexus - blood supply | ATP-Binding Cassette Transporters - genetics | Ochratoxins - administration & dosage | Cell Membrane - metabolism | Cerebral Cortex - drug effects | Capillaries - metabolism | Fluorobenzenes - metabolism | Tetrahydroisoquinolines - pharmacology | Organic Cation Transport Proteins - metabolism | Pravastatin - metabolism | Liver - metabolism | Rosuvastatin Calcium | Sulfonamides - pharmacokinetics | Blood-Brain Barrier - metabolism | Mice, Knockout | Brain - drug effects | Taurocholic Acid - administration & dosage | Pravastatin - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - administration & dosage | Pyrimidines - pharmacokinetics | Mice | Kinetics | Organic Cation Transport Proteins - genetics | Pravastatin - pharmacokinetics | Sulfonamides - administration & dosage | Quinolines - blood | Digoxin - metabolism | Taurocholic Acid - metabolism | Choroid Plexus - metabolism | Taurocholic Acid - blood | Ochratoxins - pharmacokinetics | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Ochratoxins - metabolism | Cerebral Cortex - metabolism | Organic Anion Transporters - metabolism | Brain - blood supply | Sulfonamides - blood | Organic Anion Transporters - genetics | Transfection | Fluorobenzenes - blood | Enkephalin, D-Penicillamine (2,5)- - pharmacokinetics | Recombinant Proteins - metabolism | Cell Line | Pyrimidines - administration & dosage | Mice, Inbred C57BL | Recombinant Proteins - genetics | Blood-Brain Barrier - drug effects | Digoxin - pharmacokinetics | Quinolines - metabolism | Taurocholic Acid - pharmacokinetics | Liver - blood supply | Pharmaceutical Preparations - metabolism | Animals | Digoxin - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - metabolism | Acridines - pharmacology | Sulfonamides - metabolism
Journal Article
Journal Article
Circulation, ISSN 0009-7322, 08/2004, Volume 110, Issue 9, pp. 1103 - 1107
Background-Experimental studies revealed proinflammatory properties of angiotensin II. We evaluated antiinflammatory effects of the angiotensin II subtype 1... 
Hypertension | Inflammation | Cholesterol | Angiotensin | Atherosclerosis | atherosclerosis | C-REACTIVE PROTEIN | CARDIAC & CARDIOVASCULAR SYSTEMS | WEIGHT-LOSS | PREVENTION | RANDOMIZED-TRIAL | RISK | HUMAN ENDOTHELIAL-CELLS | INFLAMMATORY MARKERS | DENSITY-LIPOPROTEIN CHOLESTEROL | inflammation | angiotensin | CARDIOVASCULAR-DISEASE | cholesterol | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | hypertension | Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage | Prospective Studies | Angiotensin II Type 1 Receptor Blockers - therapeutic use | Cholesterol - blood | Humans | Middle Aged | Imidazoles - administration & dosage | Hypertension - drug therapy | Male | Vasculitis - complications | Diabetes Mellitus, Type 2 - epidemiology | Hypertension - blood | Arteriosclerosis - epidemiology | Interleukin-6 - blood | Tetrazoles - administration & dosage | Lipids - blood | Female | Intercellular Adhesion Molecule-1 - blood | Imidazoles - therapeutic use | Receptor, Angiotensin, Type 1 - drug effects | Arteriosclerosis - blood | C-Reactive Protein - analysis | Drug Therapy, Combination | Pravastatin - therapeutic use | Angiotensin II Type 1 Receptor Blockers - administration & dosage | Olmesartan Medoxomil | Vasculitis - blood | Double-Blind Method | Comorbidity | Treatment Outcome | Chemokine CCL2 - blood | Tumor Necrosis Factor-alpha - analysis | Diabetes Mellitus, Type 2 - blood | Pravastatin - administration & dosage | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Vasculitis - drug therapy | Biomarkers | Hypertension - complications | Tetrazoles - therapeutic use | Aged
Journal Article
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 2006, Volume 346, Issue 1, pp. 26 - 32
Diabetic patients are often treated with a lipid lowering statin and an ACE inhibitor or angiotensin receptor antagonist against hypertension or albuminuria.... 
Microcirculation | Angiotensin receptor antagonist | Islet | Statin | Diabetes | Renin-angiotensin system | Insulin | ACE inhibitor | Blood flow | insulin | CHOLESTEROL | RAT | BIOCHEMISTRY & MOLECULAR BIOLOGY | INSULIN-SECRETION | angiotensin receptor antagonist | islet | microcirculation | INHIBITION | BIOPHYSICS | statin | REDUCTION | FREE FATTY-ACIDS | GLUCOSE | INFLAMMATION | SIMVASTATIN | blood flow | diabetes | renin-angiotensin system | Pravastatin - pharmacology | Islets of Langerhans - blood supply | Islets of Langerhans - drug effects | Palmitic Acid - pharmacology | Kidney - blood supply | Tetrazoles - pharmacology | Captopril - pharmacology | Rats, Wistar | Pancreas - drug effects | Rats | Male | Adrenal Glands - blood supply | Pancreas - blood supply | Insulin - blood | Animals | Regional Blood Flow - drug effects | Biphenyl Compounds - pharmacology | Blood Pressure - drug effects | Blood Glucose - metabolism | Hypertension | Captopril | Glucose | Peptide hormones | Pravastatin | Fatty acids | Dextrose | Hyperglycemia | Irbesartan | Angiotensin | Tetrazoles/pharmacology | Pravastatin/pharmacology | Rats; Wistar | Blood Glucose/metabolism | Regional Blood Flow/drug effects | Insulin/blood | Biphenyl Compounds/pharmacology | Palmitic Acid/pharmacology | Adrenal Glands/blood supply | Kidney/blood supply | Blood Pressure/drug effects | Islets of Langerhans/blood supply/drug effects | Pancreas/blood supply/drug effects | Captopril/pharmacology
Journal Article
Atherosclerosis, ISSN 0021-9150, 2015, Volume 241, Issue 2, pp. 427 - 432
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 2007, Volume 43, Issue 9, pp. 1255 - 1262
The receptor for advanced glycation endproducts (RAGE) is overexpressed at sites of vascular pathology. A soluble RAGE isoform (sRAGE) neutralizes the... 
Oxidative stress | ADMA | sRAGE | Free radicals | Hyperlipidemia | Statins | free radicals | ENDOTHELIAL DYSFUNCTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ATHEROSCLEROSIS | INDUCED VASCULAR INJURY | RECEPTOR | RISK | ASYMMETRIC DIMETHYLARGININE ADMA | statins | ENDOCRINOLOGY & METABOLISM | ENDPRODUCTS | oxidative stress | CORONARY-ARTERY-DISEASE | GLYCATION END-PRODUCTS | Dinoprost - blood | Anticholesteremic Agents - blood | Heptanoic Acids - therapeutic use | Humans | Hydroxymethylglutaryl-CoA Reductase Inhibitors - blood | Middle Aged | Hypercholesterolemia - urine | Nitric Oxide Synthase - antagonists & inhibitors | Male | Hypercholesterolemia - drug therapy | Arginine - analogs & derivatives | Female | Dinoprost - analogs & derivatives | Pyrroles - therapeutic use | Pravastatin - therapeutic use | Receptor for Advanced Glycation End Products | Receptors, Immunologic - blood | Nitric Oxide - biosynthesis | Hypercholesterolemia - blood | Atherosclerosis - drug therapy | Cross-Sectional Studies | Dinoprost - urine | Double-Blind Method | Pyrroles - blood | Atherosclerosis - blood | Atorvastatin Calcium | Pravastatin - blood | Anticholesteremic Agents - therapeutic use | Arginine - blood | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Nitric Oxide Synthase - metabolism | Heptanoic Acids - blood | Care and treatment | Hypercholesterolemia | Analysis | Low density lipoproteins | Nitrogen compounds | Knowledge-based systems | Cholesterol | Cardiovascular agents
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2012, Volume 7, Issue 12, p. e52438
Journal Article
Atherosclerosis, ISSN 0021-9150, 2011, Volume 219, Issue 2, pp. 526 - 531
Journal Article